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| 1 | Recent developments and innovations in gastric cancer显示文摘Gastric cancer has an important place in the worldwide incidence of cancer and cancer-related deaths. It can metastasize to the lymph nodes in the early stages, and lymph node metastasis is an important prognostic factor. Surgery is a very important part of gastric cancer treatment. A D2 lymphadenectomy is the standard surgical treatment for c T1N+ and T2-T4 cancers, which are potentially curable. Recently, the TNM classification system was reorganized, and the margins for gastrectomy and lymphadenectomy were revised. Endoscopic, laparoscopic and robotic treatments of gastric cancer have progressed rapidly with development of surgical instruments and techniques, especially in Eastern countries. Different endoscopic resection techniques have been identified, and these can be divided into two main categories: endoscopic mucosal resection and endoscopic submucosal dissection. Minimally invasive surgery has been reported to be safe and effective for early gastric cancer, and it can be successfully applied to advanced gastric cancer with increasing experience. Cytoreductive surgery and hypertherm?c intraper?toneal chemotherapy were developed as a combined treatment modality from the results of experimental and clinical studies. Also, hyperthermia increases the antitumor activity and penetration of chemotherapeutics. Trastuzumab which is a monoclonal antibody interacts with human epidermal growth factor(HER) 2 and is related to gastric carcinoma. The anti-tumor mechanism of trastuzumab is not clearly known, but mechanisms such as interruption of the HER2-mediated cell signaling pathways and cell cycle progression have been reported previously. H. pylori is involved in 90% of all gastric malignancies and Japanese guidelines strongly recommend that all H. pylori infections should be eradicated regardless of the associated disease. In this review, we present innovations discussed in recent studies. | Mehmet Mihmanli Enver Ilhan Ufuk Oguz Idiz Ali Alemdar Uygar Demir | 2016 | World Journal of Gastroenterology2016，22，17： | 29 |
| 2 | Expression of COX-2, PCNA, Ki-67 and p53 in gastrointestinal stromal tumors and its relationship with histopathological parameters显示文摘AIM: To investigate the expression of Cyclooxygenase-2 (COX-2), proliferating cell nuclear antigen (PCNA), Ki-67 and p53 in gastrointestinal stromal tumors (GISTs) and its relationship with histopathological parameters. METHODS: Twenty-five GISTs were examined by light microscopy and immunohistochemistry. c-kit, CD34, SMA, S-100 protein, COX-2, PCNA, Ki-67 and p53 were detected immunohistochemically and the relationship was evaluated among histopathologic parameters such as mitotic index (MI), tumor grade, tumor size, COX-2, PCNA, Ki-67 and p53. RESULTS: COX-2 protein expression was found in 19 of 25 (76%) of the tumors, and expression was noted in the cytoplasm of the tumor cells. p53 was significantly related to MI and tumor grade but no relationship was found between COX-2, proliferation markers and MI, tumor grade and tumor size. CONCLUSION: COX-2 is expressed in most GISTs and it may play an important role in the proliferation and progression of these tumors or a useful marker to identify GIST. Although immunohistochemical assessment of p53 can be used for distinguishing the risk groups of GISTs, tumor size and mitotic rate should be considered at the same time. | Derya Gumurdulu Seyda Erdogan Fazilet Kayaselcuk Gulsah Seydaoglu Cem K Parsak Orhan Demircan Ilhan Tuncer | 2007 | World Journal of Gastroenterology2007，13，3： | 21 |
| 3 | C-reactive protein,procalcitonin,interleukin-6,vascular endothelial growth factor and oxidative metabolites in diagnosis of infection and staging in patients with gastric cancer显示文摘The current study was to determine the serum/plasmalevels of VEGF, IL-6, malondialdehyde (MDA), nitric oxide(NO), PCT and CRP in gastric carcinoma and correlation withthe stages of the disease and accompanying infection. | NevinIlhan NecipIlhan MehmetKcksu Yavuz Ilhan Handan Akbulut | 2004 | World Journal of Gastroenterology2004，10，8： | 18 |
| 4 | Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial显示文摘 | Florian Lordick Yoon-Koo Kang Hyun-Cheol Chung Pamela Salman Sang Cheul Oh Gy?rgy Bodoky Galina Kurteva Constantin Volovat Vladimir M Moiseyenko Vera Gorbunova Joon Oh Park Akira Sawaki Ilhan Celik Heiko G?tte Helena Melezínková Markus Moehler | 2013 | Lancet Oncology2013，，6： | 14 |
| 5 | Influence of H pylori on plasma ghrelin in patients without atrophic gastritis显示文摘AIM:To determine the association between H pylori infection and serum ghrelin levels in patients without atrophic gastritis.METHODS:Fifty consecutive patients(24 males and 26 females)with either H pylori-positive gastritis(n = 34)or H pylori-negative gastritis(n = 16)with normal gastric acid secretion determined by 24-h pHmetry and without atrophic gastritis in histopathology were enrolled in this study.Thirty-four H pylori-infected patients were treated with triple therapy consisting of a daily regimen of 30 mg lansoprazole bid,1 g amoxicillin bid and 500 mg clarithromycin bid for 14 d,followed by an additional 4 wk of 30 mg lansoprazol treatment.H pylori infection was eradicated in 23 of 34(67.6%)patients.H pylori-positive patients were given eradication therapy.Gastric acidity was determined via intragastric pH catethers.Serum ghrelin was measured by radioimmunoassay(RIA).RESULTS:There was no signifficant difference in plasma ghrelin levels between H pylori-positive and H pylori-negative groups(81.10 ± 162.66 ng/L vs 76.51 ± 122.94 ng/L).In addition,there was no significant difference in plasma ghrelin levels and gastric acidity levels measured before and 3 mo after the eradication therapy.CONCLUSION:H pylori infection does not influence ghrelin secretion in patients with chronic gastritis without atrophic gastritis. | Mehmet Cindoruk Ilhan Yetkin Serpil Muge Deger Tarkan Karakan Erdal Kan Selahattin Unal | 2007 | World Journal of Gastroenterology2007，13，10： | 13 |
| 6 | Atherosclerosis and the role of immune cells显示文摘Atherosclerosis is a chronic inflammatory disease arising from lipids, specifically low-density lipoproteins, and leukocytes. Following the activation of endothelium with the expression of adhesion molecules and monocytes, inflammatory cytokines from macrophages, and plasmacytoid dendritic cells, high levels of interferon(IFN)-α and β are generated upon the activation of tolllike receptor-9, and T-cells, especially the ones with Th1 profile, produce pro-inflammatory mediators such as IFN-γ and upregulate macrophages to adhere to the endothelium and migrate into the intima. This review presents an exhaustive account for the role of immunecells in the atherosclerosis. | Fulya Ilhan Sevgi Tas Kalkanli | 2015 | World Journal of Clinical Cases2015，3，4： | 10 |
| 7 | Diffusion-weighted and diffusion-tensor imaging of normal and diseased uterus显示文摘Owing to technical advances and improvement of the software, diffusion weighted imaging and diffusion tensor imaging(DWI and DTI) greatly improved the diagnostic value of magnetic resonance imaging(MRI) of the pelvic region. These imaging sequences can exhibit important tissue contrast on the basis of random diffusion(Brownian motion) of water molecules in tissues. Quantitative measurements can be done with DWI and DTI by apparent diffusion coefficient(ADC) and fractional anisotropy(FA) values respectively. ADC and FA values may be changed by various physiological and pathological conditions providing additional information to conventional MRI. The quantitative DWI assists significantly in the differentiation of benign and malignant lesions. It can demonstrate the microstructural architecture and celluler density of the normal and diseased uterine zones. On the other hand, DWI and DTI are useful for monitoring the treatment outcome of the uterine lesions. In this review, we discussed advantages of DWI and DTI of the normal and diseased uterus. | Duygu Kara Bozkurt Murat Bozkurt Mehmet Ali Nazli Ilhan Nahit Mutlu Ozgur Kilickesmez | 2015 | World Journal of Radiology2015，7，7： | 9 |
| 8 | Neuroprotective effect of systemic and/or intravitreal rosuvastatin administration in rat glaucoma model显示文摘AIM:To evaluate the neuroprotective effect of rosuvastatin,in a rat experimental glaucoma model.· METHODS:Ocular hypertension was induced in right eyes of Long-Evans rats(n=30) by cauterization of three episcleral veins.Left eyes were defined as controls.Rats were divided into five groups:oral rosuvastatin,intravitreal rosuvastatin,oral +intravitreal rosuvastatin,intravitreal sham and glaucoma without intervention.Rats were sacrificed at day 14.Retinal ganglion cell(RGC) number was assessed by histopathological analysis.Terminal deoxynucleotidyl transferase-mediated dUTP-nick end-labeling(TUNEL) staining and the expression of glial fibrillary acidic protein(GFAP) in RGC layer was also examined.· RESULTS:A significant intraocular pressure(IOP)elevation was seen(P=0.002).Elevated IOP resulted in a significant decrease in number of RGCs in group 5(70.33±8.2 cells/mm^2) when compared with controls(92.50±13.72 cells/mm^2;P=0.03).The RGC number in group 1(92.4±7.3 cells/mm^2) was significantly higher than group 5(P=0.03).The numbers of RGC in groups 2,3(57.3±8.2 cells/mm^2,60.5±12.9 cells/mm^2) were comparable with that of group 5(P=0.18 and P=0.31).The apoptosis rates with TUNEL staining were also parallel to RGC number.Animals with experimentally induced glaucoma showed an increase in retinal GFAP immunoreactivity.· CONCLUSION:Decrease in RGC loss and apoptosis suggest the neuroprotective potential of oral rosuvastatin treatment in a rat model of ocular hypertension.However intravitreal rosuvastatin showed a contrary effect and further studies are required. | Metin Unlu Zeynep Aktas Pinar Uyar Gocun Sevil Ozger Ilhan Murat Hasanreisoglu Berati Hasanreisoglu | 2016 | International Journal of Ophthalmology(English edition)2016，9，3： | 7 |
| 9 | Increased oxidative damage of sperm and seminal plasma in men with idiopathic infertility is higher in patients with glutathione S-transferase Mu-1 null genotype显示文摘瞄准:检验一种关系是否与自发的不孕从病人在 glutathioneS-transferase Mu-1 (GSTM1 ) 基因多型性和精子和精液的血浆的危险性之间存在到氧化应力。方法:有自发的不孕的 52 个人和 60 个健康的肥沃的人被招募到这研究。GSTM1 基因多型性被聚合酶链反应(PCR ) 和两个决定不肥沃并且我们根据他们的 GSTM1 基因再划分进空的 GSTM1 和 GSTM1 积极的组的控制个人组织。Wecompared 反应的氧种类(ROS ) 产生, malondialdehyde (MDA ) ,蛋白质羰基和谷胱甘肽(GSH ) 集中,和在从关于 GSTM1 遗传型的不肥沃的病人和控制的精液的血浆和精子的谷胱甘肽 S-transferase (GST ) 活动。结果: 显著地,氧化应力和损坏标记的高水平与 GSTM1 积极遗传型与那些相比与 GSTM1 空遗传型在自发的不肥沃的人被发现。在为在自发的不肥沃的题目和肥沃的题目之间的 GSTM1 变体的遗传型分发没有重要差别。有 GSTM1 空遗传型的病人也与 GSTM1 积极遗传型比那些有更低的精子集中。结论:我们的结果建议到氧化应力的精子和精液的血浆的危险性与拥有基因的那些相比在有 GSTM1 空遗传型的自发的不肥沃的人是显著地更大的。因此,在有自发的不孕的病人,, GSTM1 多型性可能是在到氧化损坏的精子的危险性的变化的重要来源。 | Birsen Aydemir Ilhan Onaran Ali R. Kiziler Bulent Alici Mehmet C. Akyolcu | 2007 | Asian Journal of Andrology2007，9，1： | 7 |
| 10 | Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: Pooled analysis of the CRYSTAL and OPUS randomised clinical trials显示文摘 | Carsten Bokemeyer Eric Van Cutsem Philippe Rougier Fortunato Ciardiello Steffen Heeger Michael Schlichting Ilhan Celik Claus-Henning K?hne | 2012 | European Journal of Cancer2012，，10： | 5 |
| 11 | Exploration of the shared pathophysiological mechanisms of gestational diabetes and large for gestational age offspring显示文摘Gestational diabetes mellitus (GDM) and large for gestational age (LGA) offspring are two common pregnancy complications. Connections also exist between the two conditions, including mutual maternal risk factors for the conditions and an increased prevalence of LGA offspring amongst pregnancies affected by GDM. Thus, it is important to elucidate potential shared underlying mechanisms of both LGA and GDM. One potential mechanistic link relates to macronutrient metabolism. Indeed, derangement of carbohydrate and lipid metabolism is present in GDM, and maternal biomarkers of glucose and lipid control are associated with LGA neonates in such pregnancies. The aim of this paper is therefore to reflect on the existing nutritional guidelines for GDM in light of our understanding of the pathophysiological mechanisms of GDM and LGA offspring. Lifestyle modification is first line treatment for GDM, and while there is some promise that nutritional interventions may favourably impact outcomes, there is a lack of definitive evidence that changing the macronutrient composition of the diet reduces the incidence of either GDM or LGA offspring. The quality of the available evidence is a major issue, and rigorous trials are needed to inform evidence-based treatment guidelines. | Sofia Nahavandi Sarah Price Priya Sumithran Elif Ilhan Ekinci | 2019 | World Journal of Diabetes2019，10，6： | 5 |
| 12 | Lung parenchymal changes in patients with ankylosing spondylitis显示文摘AIM: To assess lung parenchymal changes in ankylosing spondylitis (AS) using high resolution computed tomography (HRCT). METHODS: We included 78 AS patients whose average age was 33.87 (18-56) years with a ratio of 53 males to 25 females who were followed up for 3.88 (1-22) years on average. neumonia and tuberculosis were excluded. In a detailed examination of lung HRCT findings, we investigated the presence of parenchymal micronodules,parenchymal bands, subpleural bands, interlobular and intralobular septal thickening, irregularity of interfaces,ground glass opacity, consolidation, mosaic pattern,bronchial wall thickening, bronchial dilatation, tracheal dilatation, pleural thickening, emphysema, thoracic cage asymmetry, honeycomb appearance, structural distortion, apical fibrosis and other additional findings.RESULTS: In detailed HRCT evaluations, lung parenchymal changes were found in 46 (59%) of all patients. We found parenchymal bands in 21 (27%) cases, interlobular septal thickening in 9 (12%), emphysema in 9 (12%), apical fibrosis in 8 (10%), ground-glass opacities in 7 (9%), parenchymal micronodules in 5 (6%), irregularity in interfaces in 3 (4%), bronchial dilatation in 3 (4%), mosaic pattern in 2 (3%), pleural thickening in 2 (3%), consolidation in 1 (1%), bronchial wall thick ening in 1 (1%) and a subpleural band in 1 (1%) case. Furthermore, we detected subsegmental atelectasis in 2 patients and a cavitary lesion in 1 patient. CONCLUSION: Our study had the highest number of AS cases of all previous studies in evaluating lung paren chymal changes. The rate of lung parenchymal changes was slightly lower than that reported in recent literature. | Zehra Isik Hasiloglu Nuri Havan Aylin Rezvani Mustafa Akif Sariyildiz Halil Eren Erdemli Ilhan Karacan | 2012 | World Journal of Radiology2012，4，5： | 3 |
| 13 | Epidemiological and clinical features of paediatric open globe injuries in southwestern Turkey显示文摘AIM:To evaluate the epidemiologic,anatomic,and clinical features of open globe injuries in children.METHODS:The medical files of patients under the age of 16 who had been operated for an open globe injury at Akdeniz University Hospital's Department of Ophthalmology were retrospectively evaluated.RESULTS:A total of 90 patients were evaluated in this study.Among these patients,26(28.9%)were female and64(71.1%)were male.The mean age of the patients was7.7±4.2 years.The male/female ratio was observed to increase with increasing age(P=0.006,P=7.48).Injuries were most likely to occur in spring and autumn(P=0.028).The time interval between the injury and the surgical repair was 9.36±27.4h.Forty(44.4%)of the injuries occurred in the home,27(30%)occurred in the yard,and 21(23.3%)happened while playing in the street.The most common causes of injury were sharp metal objects(P<0.001).Injury to the cornea occurred in47(52.2%)of the patients(P<0.001).The most common complication to occur was cataract formation.Additional operations were necessary for 37(41.1%)of the patients.The final visual acuity was correlated with both the initial visual acuity of the wounded eye prior to surgery and the length of the wound(P<0.001,r=0.502 and P<0.001,r=-0.442,respectively).CONCLUSION:Open globe injuries that are suffered in childhood generally occur either at home,in the yard,or on the street,with sharp metal objects being the most common cause of injury.The initial visual acuity and the length of the wound are the most important determinants of the final visual acuity. | Hatice Deniz Ilhan Ahmet Burak Bilgin Ash Cetinkaya Mustafa Unal Iclal Yucel | 2013 | International Journal of Ophthalmology(English edition)2013，6，6： | 3 |
| 14 | Single port laparoscopic liver surgery:A minireview显示文摘Nowadays,the trend is to perform surgeries with'scarless'incisions.In light of this,the single-port laparoscopic surgery(SPLS)technique is rapidly becoming widespread due to its lack of invasiveness and its cosmetic advantages,as the only entry point is usually hidden in the umbilicus.The interest in'scarless'liver resections did not grow as rapidly as the interest in other scarless surgeries.Hepatopancreatobiliary surgeons are reluctant to operate a malignant lesion through a narrowincision with limited exposure.There are concerns over adverse oncological outcomes for single-port laparoscopic liver resections(SPL-LR)for hepatocellular carcinoma or metastatic colorectal cancer.In addition,getting familiar with using the operating instruments through a narrow incision with limited exposure is very challenging.In this article,we reviewed the published literature to describe history,indications,contraindications,ideal patients for new beginners,technical difficulty,advantages,disadvantages,oncological concern and the future of SPL-LR. | Ilhan Karabicak Kagan Karabulut | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，12： | 3 |
| 15 | Correlations between the Maximum Standard Uptake Value of Positron Emission Tomography/Computed Tomography and Laboratory Parameters before and after Treatment in Patients with Lymphoma显示文摘 | Edip Ucar Hulya Yalcin Gamze Hande Kavvasoglu Gul Ilhan | 2018 | Chinese Medical Journal2018，，15： | 3 |
| 16 | Acute abdomen caused by nontraumatic hemoperitoneum is the first manifestation of gastric low grade stromal tumor显示文摘BACKGROUND:Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal tumors of the gastrointestinal tract in adults.We treated surgically a man with acute abdomen caused by non-traumatic hemoperitoneum and diagnosed by low grade gastric GIST.METHODS:A 51-year-old Caucasian man came to the hospital for abdominal pain for 3 hours.He had no history of abdominal trauma.On admission,he was conscious and alert,and he had hypotension(80/50 mmHg) and moderate tachycardia.Abdominal ultrasonography showed the presence of free peritoneal fluid.Abdominal magnetic resonance imaging(MRI) showed diffuse intraabdominal hemorrhage and solid mass lesion at the greater curvature of the stomach.At an emergency laparotomy,a pedunculated,fragile mass of 5x6 cm originating from the posterior wall of the stomach was seen.The tumor was resected.Histopathologically a gastrointestinal stromal tumor was detected.RESULTS:The patient had an uneventful postoperative course and was discharged on the sixth postoperative day.Follow-up showed no recurrence of the tumor 8 months after surgery.CONCLUSION:Intraabdominal bleeding is a rare presentation of gastrointestinal stromal tumors.The diagnosis of the tumor should be based on whether sudden abdominal pain occurs in patients with an intraabdominal mass. | Savas Yakan Enver Ilhan Fevzi Cengiz Hülya Mollamehmetoglu Kemal Emre Telciler | 2012 | World Journal of Emergency Medicine2012，3，3： | 2 |
| 17 | Ingested gastrointestinal foreign bodies: predisposing factors for complications in children having surgical or endoscopic removal显示文摘 | Baran Tokar Alper A. Cevik Huseyin Ilhan | 2007 | Pediatric Surgery International2007，，2： | 2 |
| 18 | Primary angiitis of the central nervous system: unusual clinical presentation显示文摘 | Ilhan A Budak F | 2000 | International Journal of Angiology2000，9，1： | 2 |
| 19 | A literature survey on energy–growth nexus显示文摘 | Ilhan Ozturk | 2009 | Energy Policy2009，，1： | 2 |
| 20 | Comparison of the impact of epigallocatechin gallate and ellagic acid in an experimental cataract model induced by sodium selenite显示文摘AIM:To compare the potential protective effects of epigallocatechin gallate(EGCG) and ellagic acid(EA) in an experimental cataract model.●METHODS:Twenty-eight Spraque-Dawley rat pups were assigned into four groups.All the rats,except for those in the control group,were injected subcutaneously sodium selenite to induce experimental cataract on the postpartum ninth day,and between 10 th and 14 th days.Rats in the sham,EGCG,and EA groups were intraperitoneally administered 50 mg/(kg·d) saline solution,50 mg/(kg·d) EGCG and 200 mg/(kg·d) EA,respectively.The reduced glutathione(GSH) and malondialdehyde(MDA) levels,total antioxidant status(TAS) and total oxidant status(TOS) in lens supernatants were measured.RESULTS:The mean cataract gradings in EGCG and EA groups were found to be significantly lower than that in sham group(P<0.001).The mean GSH levels and TASs in EGCG and EA groups were significantly higher than that in sham group while mean MDA levels and TOSs in EGCG and EA groups were significantly lower than that in the sham group(P<0.001).CONCLUSION:EGCG and EA have protective effects on cataract development via the inhibition of oxidative stress. | Irfan Ergen Burak Turgut Nevin Ilhan | 2017 | International Journal of Ophthalmology(English edition)2017，10，4： | 2 |
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