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| 1 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 2 | Intectual functioning and memory deficits in schizophrenia显示文摘 | Juan Carlos Ruiz Mar'a Jose' Soler Irma Fuentes | 2007 | Comprehensive Psychiatry2007，48，： | 1 |
| 3 | Involvement of the pancreas in AIDS: a prospective study of 109 post-mortems显示文摘 | Ethel Z Chehter Maria Antonieta Longo Antonio A Laudanna Maria Irma S Duarte | 2000 | AIDS2000，，13： | 1 |
| 4 | Platelet glycoprotein IIIA PIA1/A2 polymorphism in young patients with ST elevation myocardial infarction and idiopathic ischemic stroke显示文摘 | Blanca Elsa Rivera-García Juan Carlos Esparza-García Jose Luis Aceves-Chimal Alfredo Lea?os-Miranda Abraham Majluf-Cruz Irma Isordia-Salas | 2013 | Molecular and Cellular Biochemistry (-)2013，，1： | 1 |
| 5 | Herpes Simplex Virus Type 1/adeno-associated Virus Hybrid Vectors Mediated Site-specific Integration at the Adeno-associated Virus Preitegration Site, AAVS1, on Human Chromosome 19显示文摘 | Irma H Mathias A | 2002 | Journal of Virology2002，76，： | 1 |
| 6 | Seroprevalence and national distribution of human toxoplasmosis in Mexico: analysis of the 2000 and 2006 National Health Surveys显示文摘 | Heriberto Caballero-Ortega Felipe Javier Uribe-Salas Carlos J. Conde-Glez Carlos Cedillo-Pelaez José Antonio Vargas-Villavicencio Héctor Luna-Pastén Irma Ca?edo-Solares Luz Belinda Ortiz-Alegría Dolores Correa | 2012 | Transactions of the Royal Society of Tropical Medicine and Hygiene2012，，11： | 1 |
| 7 | Disposable diapers biodegradation by the fungus Pleurotus ostreatus显示文摘 | Rosa María Espinosa-Valdemar Sylvie Turpin-Marion Irma Delfín-Alcalá Alethia Vázquez-Morillas | 2011 | Waste Management2011，，8： | 1 |
| 8 | The Minimal conditions for a financial crisis: A muhiregional intertemporal CGE model of the Asian Crisis 显示文摘 | Irma A Erinc Y | 2000 | World Development2000，28，6： | 1 |
| 9 | Indication for CDKN2A-mutation analysis in familial pancreatic cancer families without melanomas显示文摘 | Femme Harinck Irma Kluijt Nienke van der Stoep Rogier A Oldenburg Anja Wagner Cora M Aalfs Rolf H Sijmons Jan-Werner Poley Ernst J Kuipers Paul Fockens Theo A M van Os Marco J Bruno | 2012 | Journal of Medical Genetics2012，，6： | 1 |
| 10 | Perturbation analysis of power system:Effects of second and third-order nonlinear terms on system dynamic behavior 显示文摘 | Irma Martinez Messina A R Barocio E | 2004 | Electric Power Systems Research2004，71，： | 1 |
| 11 | Comprehensive molecular diagnosis of 179 Leber congenital amaurosis and juvenile retinitis pigmentosa patients by targeted next generation sequencing显示文摘 | Xia Wang Hui Wang Vincent Sun Han-Fang Tuan Vafa Keser Keqing Wang Huanan Ren Irma Lopez Jacques E Zaneveld Sorath Siddiqui Stephanie Bowles Ayesha Khan Jason Salvo Samuel G Jacobson Alessandro Iannaccone Feng Wang David Birch John R Heckenlively Gerald A | 2013 | Journal of Medical Genetics2013，，10： | 1 |
| 12 | Perturbation analysis of power systems: effects of second-and third-order nonlinear terms on system dynamic behavior 显示文摘 | Irma Martinez A R Messina E Barocio | 2004 | Electric Power Systems Research2004，71，2： | 1 |
| 13 | Laboratory study on the bioreme-diation of petrochemical sludge contaminated soil显示文摘 | Irma Susana Morelli María Teresa Del Panno Graciela Lil-iana De Antoni | 2005 | International Biodeterioration & Biodegradation2005，55，： | 1 |
| 14 | Perturbation analysis of power systems:effects of second-and third-order nonlinear terms on system dynamic behavior显示文摘 | Messina A R Barocio E | 2004 | Electric Power Systems Research2004，71，2： | 1 |
| 15 | The ( G > A ) rs11573191 Polymorphism of PLA2G5 Gene Is Associated with Premature Coronary Artery Disease in the Mexican Mestizo Population: The Genetics of Atherosclerotic Disease Mexican Study显示文摘 | Gilberto Vargas-Alarcón Carlos Posadas-Romero Teresa Villarreal-Molina Edith Alvarez-León Javier Angeles-Martinez María Elena Soto Irma Monroy-Mu?oz Juan Gabriel Juárez Carlos Jerges Sánchez-Ramírez Julian Ramirez-Bello Silvestre Ramírez-Fuentes José Manu | 2014 | BioMed Research International2014，，： | 1 |
| 16 | Levels and correlates of knowledge about cancer risk factors among 13,293 public school students in Morelos,Mexico显示文摘 | Irma P Betania A Silvia R | 2004 | Preventive Medicine2004，3，9： | 1 |
| 17 | Molecularly defined adult-type hypolactasia among working age people with reference to milk consumption and gastrointestinal symptoms显示文摘AIM: To study milk consumption and subjective milk- related symptoms in adults genotyped for adult-type hypolactasia. METHODS: A total of 1900 Finnish adults were genotyped for the C/T-13910 variant of adult-type hypolactasia and filled in a structured questionnaire concerning milk consumption and gastrointestinal problems. RESULTS: The C/C-13910 genotype of adult-type hypolactasia was present in 18% of the study population. The prevalence of the C/C-13910 genotype was higher among subjects who were undergoing investigations because of abdominal symptoms (24%, P < 0.05). Those with the C/C-13910 genotype drank less milk than subjects with either the C/T-13910 or the T/T-13910 genotype of lactase persistence (18% vs 38%; 18% vs 36%, P < 0.01). Subjects with the C/C-13910 genotype had experienced more gastrointestinal symptoms (84%) during the preceding three-month period than those with the C/T-13910 (79%, P < 0.05) or the T/T-13910 genotype (78 %, P < 0.05). Only 9% (29/338) of the subjects with the C/C-13910 genotype consumed milk and reported no symptoms from it.CONCLUSION: Gastrointestinal symptoms are more common among adults with the C/C-13910 genotype of adult-type hypolactasia than in those with genotypes of lactase persistence. | Sari R Anthoni Heli A Rasinper Antti J Kotamies Hanna A Komu Harri K Pihlajamki Kaija-Leena Kolho Irma E Jrvel | 2007 | World Journal of Gastroenterology2007，13，8： | 1 |
| 18 | Perturbation analysis of power systems:effects of second-and third-order nonlinear terms on system dynamic behavior显示文摘 | Irma Martinez A R Messina E Barocio | 2004 | Electric Power Systems Research2004，71，2： | 1 |
| 19 | The effect of nutri-tion on the neural mechanisms potentially involved inmelatonin-stimulated LH secretion in female Mediter-ranean goats显示文摘 | Luis A Z Irma C Jose L G | 2011 | Journal of Endocrinology2011，211，： | 1 |
| 20 | Development Economics:A Reassessment of Goals 显示文摘 | Irma A | 1975 | The American Economic Review1975，65，2： | 1 |
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