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| 1 | 美国康复医疗现状与思考显示文摘2009年9月至2010年9月,笔者作为访问学者到美国纽约大学Rusk康复医院访问学习,对美国康复医疗现状有了一定的了解,现将学习体会报告如下。美国康复医学的“三级医疗网”一、美国医疗保险支付制度对康复医疗的导向作用美国康复医疗体系的建立离不开美国医疗保险支付制度的建立和发展,甚至整个医疗体系都在医疗保险制度的主导下, | 欧海宁 Bryan J O’Young | 2011 | 中华物理医学与康复杂志2011，33，6： | 16 |
| 2 | 卵巢原发性子宫内膜间质肉瘤27例临床病理分析:形态学和生物学行为特征类似于子宫低级别子宫内膜间质肉瘤显示文摘原发性子宫外的子宫内膜间质肿瘤非常罕见,作者报道27例卵巢原发性子宫内膜间质肉瘤的临床病理特征。患者年龄38—76岁,平均56岁。20例为单侧卵巢病变,7例累及双侧卵巢。肿瘤直径1—20cm,平均9.5cm。实性区域切面呈典型的黄褐色,6例伴出血和(或)坏死, | Oliva E Egger J F Young R H 康锶鹏 余英豪 | 2014 | 临床与实验病理学杂志2014，30，7： | 11 |
| 3 | Clinical course of subepithelial lesions detected on upper gastrointestinal endoscopy显示文摘AIM:To evaluate the natural history of subepithelial lesions.METHODS:We reviewed the medical records of 104 159 patients who underwent upper gastrointestinal endoscopy at the Center for Health Promotion of Samsung Medical Center between 1996 and 2003.Subepithelial lesions were detected in 795 patients(0.76%);252 patients were followed using upper gastrointestinal endoscopy for 82.5 ± 29.2 mo(range,12-160 mo;median,84 mo;1st quartile,60 mo;3rd quartile,105 mo).The median interval of follow-up endoscopy was 12 mo(range,6-105 mo;1st quartile,12 mo;3rd quartile,24 mo).RESULTS:The mean patient age was 53 years(range,22-80 years),and the male-to-female ratio was 2.36:1(177/75).The lesion size at initial measurement averaged 8.9 mm(range,2-25 mm;median,8 mm;1st quartile,5 mm;3rd quartile,10 mm).Of the 252 lesions,244(96.8%) were unchanged and 8(3.2%) were significantly increased in size(from 12.9 ± 6.0 to 21.2 ± 12.2 mm) after a mean interval of 59.1 ± 27.5 mo(range,12-86 mo).Surgical resection of lesions was performed when the lesions were ≥ 3 cm in diameter.Two lesions were diagnosed as gastrointestinal stromal tumors with an intermediate or high risk of malignancy and one lesion was classified as a schwannoma.CONCLUSION:Most small subepithelial lesions do not change as shown by endoscopic examination,and regular follow-up with endoscopy may be considered in small,subepithelial lesions,especially lesions < 1 cm in size. | Yeun Jung Lim Hee Jung Son Jong-Soo Lee Young Hye Byun Hyun Joo Suh Pool Lyul Rhee Jae J Kim Jong Chul Rhee | 2010 | World Journal of Gastroenterology2010，16，4： | 6 |
| 4 | Dementia and osteoporosis in a geriatric population: Is there a common link?显示文摘AIM To determine the existence of a common pathological link between dementia and osteoporosis through reviewing the current evidence base. METHODS This paper reviews the current literature on osteoporosis and dementia in order to ascertain evidence of a common predisposing aetiology. A literature search of Ovid MEDLINE(1950 to June 2016) was conducted. The keywords 'osteoporosis', 'osteoporotic fracture', 'dementia' and 'Alzheimer's disease'(AD) were used to determine the theoretical links with the most significant evidence base behind them. The key links were found to be vitamins D and K, calcium, thyroid disease, statins, alcohol and sex steroids. These subjects were then searched in combination with the previous terms and the resulting papers manually examined. Theoretical, in vitro and in vivo research were all used to inform this review which focuses on the most well developed theoretical common causes for dementia(predominantly Alzheimer's type) and osteoporosis.RESULTS Dementia and osteoporosis are multifaceted disease processes with similar epidemiology and a marked increase in prevalence in elderly populations. The existence of a common link between the two has been suggested despite a lack of clear pathological overlap in our current understanding. Research to date has tended to be fragmented and relatively weak in nature with multiple confounding factors reflecting the difficulties of in vivo experimentation in the population of interest. Despite exploration of various possible mechanisms in search for a link between the two pathologies, this paper found that it is possible that these associations are coincidental due to the nature of the evidence available. One finding in this review is that prior investigation into common aetiologies has found raised amyloid beta peptide levels in osteoporotic bone tissue, with a hypothesis that amyloid beta disorders are systemic disorders resulting in differing tissue manifestations. However, our findings were that the most compelling evidence of a common yet independent aetiology lies in the APOE4 allele, which is a well-established risk for AD but also carries an independent association with fracture risk. The mechanism behind this is thought to be the reduced plasma vitamin K levels in individuals exhibiting the APOE4 allele which may be amplified by the nutritional deficiencies associated with dementia, which are known to include vitamins K and D. The vitamin theory postulates that malnutrition and reduced exposure to sunlight in patients with AD leads to vitamin deficiencies. CONCLUSION Robust evidence remains to be produced regarding potential links and regarding the exact aetiology of these diseases and remains relevant given the burden of dementia and osteoporosis in our ageing population. Future research into amyloid beta, APOE4 and vitamins K and D as the most promising aetiological links should be welcomed. | Candice L Downey Adam Young Emily F Burton Simon M Graham Robert J Macfarlane Eva-Maria Tsapakis Eleftherios Tsiridis | 2017 | World Journal of Orthopedics2017，8，5： | 6 |
| 5 | 伴有假乳头状结构的卵巢粒层细胞瘤显示文摘 | Irving J A Young R H. 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，3： | 6 |
| 6 | Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study显示文摘 | Hedy L Kindler Tatsuya Ioka Dirk J Richel Jaafar Bennouna Richard Létourneau Takuji Okusaka Akihiro Funakoshi Junji Furuse Young Suk Park Shinichi Ohkawa Gregory M Springett Harpreet S Wasan Peter C Trask Paul Bycott Alejandro D Ricart Sinil Kim Eric Van | 2011 | Lancet Oncology2011，，3： | 4 |
| 7 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 8 | Irreversible electroporation and the pancreas:What we know and where we are going?显示文摘Pancreatic adenocarcinoma continues to have a poor prognosis with 1 and 5 years survival rates of 27% and 6% respectively. The gold standard of treatment is resection, however, only approximately 10% of patients present with resectable disease. Approximately 40% of patients present with disease that is too locally advancedto resect. There is great interest in improving outcomes in this patient population and ablation techniques have been investigated as a potential solution. Unfortunately early investigations into thermal ablation techniques, particularly radiofrequency ablation, resulted in unacceptably high morbidity rates. Irreversible electroporation(IRE) has been introduced and is promising as it does not rely on thermal energy and has shown an ability to leave structural cells such as blood vessels and bile ducts intact during animal studies. IRE also does not suffer from heat sink effect, a concern given the large number of blood vessels surrounding the pancreas. IRE showed significant promise during preclinical animal trials and as such has moved on to clinical testing. There are as of yet only a few studies which look at the applications of IRE within humans in the setting of pancreatic adenocarcinoma. This paper reviews the basic principles, techniques, and current clinical data available on IRE. | Shamar J Young | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 3 |
| 9 | Mortality Risk for Dialysis Patients With Different Levels of Serum Calcium, Phosphorus, and PTH: The Dialysis Outcomes and Practice Patterns Study (DOPPS)显示文摘 | Francesca Tentori Margaret J. Blayney Justin M. Albert Brenda W. Gillespie Peter G. Kerr Jürgen Bommer Eric W. Young Tadao Akizawa Takashi Akiba Ronald L. Pisoni Bruce M. Robinson Friedrich K. Port | 2008 | American Journal of Kidney Diseases2008，，3： | 3 |
| 10 | Indications and surgical options for small bowel, large bowel and perianal Crohn's disease显示文摘Despite advancements in medical therapy of Crohn's disease(CD), majority of patients with CD will eventually require surgical intervention, with at least a third of patients requiring multiple surgeries. It is important to understand the role and timing of surgery, with the goals of therapy to reduce the need for surgery without increasing the odds of emergency surgery and its associated morbidity, as well as to limit surgical recurrence and avoid intestinal failure. The profile of CD patients requiring surgical intervention has changed over the decades with improvements in medical therapy with immunomodulators and biological agents. The most common indication for surgery is obstruction from stricturing disease, followed by abscesses and fistulae. The risk of gastrointestinal bleeding in CD is high but the likelihood of needing surgery for bleeding is low. Most major gastrointestinal bleeding episodes resolve spontaneously, albeit the risk of re-bleeding is high. The risk of colorectal cancer associated with CD is low. While current surgical guidelines recommend a total proctocolectomy for colorectal cancer associated with CD, subtotal colectomy or segmental colectomy with endoscopic surveillance may be a reasonable option. Approximately 20%-40% of CD patients will need perianal surgery during their lifetime. This review assesses the practice parameters and guidelines in the surgical management of CD, with a focus on the indications for surgery in CD(and when not to operate), and a critical evaluation of the timing and surgical options available to improve outcomes and reduce recurrence rates. | James WT Toh Peter Stewart Matthew JFX Rickard Rupert Leong Nelson Wang Christopher J Young | 2016 | World Journal of Gastroenterology2016，22，40： | 2 |
| 11 | Electrodeposition of p-i-n type CuInSe2 multilayers for photovoltaic applications显示文摘 | Chaure N B Young J Samantilleke A P | 2004 | Solar Energy Materials & Solar Cells2004，81，1： | 2 |
| 12 | GI symptoms in diabetes mellitus are associated with both poor glycemic control and diabetic complications显示文摘 | Peter Bytzer Nicholas J Talley Johann Hammer Lisa J Young Michael P Jones Michael Horowitz | 2002 | The American Journal of Gastroenterology2002，，3： | 2 |
| 13 | Sound field calculations for an ultrasonic linear phased array with a spherical liquid lens显示文摘 | Yoon Young J Benkeser Paul J | 1992 | IEEE Transactions on Ultrasonics Ferroelectronics and Frequency Control1992，39，2： | 2 |
| 14 | Methylation of TIMP3 in esophageal squamous cell carcinoma显示文摘AIM: To measure the frequency of DNA methylation of the tissue inhibitor of metalloproteinase 3 (TIMP3) promoter and relate this to any change of gene expression in esophageal squamous cell carcinoma in patients from a region of high incidence in China.METHODS: Cancer cell lines were treated with or without the demethylating reagent 5-aza-2’-deoxycytidine. Methylation of the TIMP3 promoter was assessed in three regions by melt curve analysis and its expression was assessed by real-time RT-PCR. Tumors and proximal resection margins were obtained from 64 patients with esophageal squamous cell carcinoma from a region of high incidence in China. Methylation was assessed by melt curve analysis and expression by immunohistochemistry.RESULTS: Methylation in one of the three promoter regions assessed correlated with gene silencing in esophageal cell lines. A degree of methylation of TIMP3 was found in only four esophageal squamous cell carcinomas, and partial loss of TIMP3 protein expression in just one.CONCLUSION: Methylation and loss of expression of TIMP3 occurs infrequently in esophageal squamous cell carcinoma in a region of high incidence in China. | Eric Smith Neville J De Young Zi-Qiang Tian Maria Caruso Andrew R Ruszkiewicz Jun-Feng Liu Glyn G Jamieson Paul A Drew | 2008 | World Journal of Gastroenterology2008，14，2： | 2 |
| 15 | The occurrence of sleep-disordered breathing among middle-aged adults 显示文摘 | Young T Palta M Dempsey J | 1993 | N Engl J Med1993，328，17： | 2 |
| 16 | A comparison of residents’ attitudes towards tourism in 10 New Zealand destinations显示文摘 | RW Lawson J Williams T Young J Cossens | 1998 | Tourism Management1998，，3： | 2 |
| 17 | A method for rapid determination of lactose显示文摘 | Teles F F Young C K Stull J W | 1978 | J Dairy Sci1978，61，： | 2 |
| 18 | Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors显示文摘 | Wan Zhihong Zhi Ning Wong Susan Keyvanfar Keyvan Liu Delong Raghavachari Nalini Munson Peter J Su Su Malide Daniela Kajigaya Sachiko Young Neal S | 2010 | Journal of Clinical Investigation2010，，10： | 2 |
| 19 | BaTiO3 particles prepared by microwave-assisted hydrothermal reaction using titanium acylate precursors 显示文摘 | GUANG J C HYUN S K YOUNG S C | 1999 | Material Letters1999，41，： | 2 |
| 20 | Rootstook and seion chilling effects on apple and peach bud break显示文摘 | YOUNG E WERNER D J | 1984 | Compact Fruit Tree1984，17，： | 2 |
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