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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Implications of recent clinical trials for the national cholesterol education program adult treatment panel III guidelines 显示文摘 | Grundy SM Cleeman JI Merz CN | 2004 | Circulation2004，110，6： | 1 |
| 3 | Implications of recent clinical trials for the National Cholesterol Education Program Adult Panel Ⅲ Guidelines显示文摘 | Grandy SM Cleeman JI Merz CN | 2004 | J Am Coil Cardiol2004，44，： | 1 |
| 4 | Definition of Metabolic syndrome显示文摘 | Grundy SM Brewer HB Jr Cleeman JI | 2004 | Circulation2004，109，3： | 1 |
| 5 | Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association con- ference on scientific issues related to definition 显示文摘 | Grundy SM Brewer HB Jr Cleeman JI Smith SC Jr Lenfant C American Heart Association National Heart Lung and Blood In- stitute | 2004 | Circulation2004，109，3： | 1 |
| 6 | Impheations of recent clilical trials for the National Cholesterol Education Program Adult Treatment Panel Ⅲ guidelines 显示文摘 | Grundy SM Cleeman JI Merz CN | 2004 | Circulation2004，110，22： | 1 |
| 7 | Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel m Guide- lines 显示文摘 | Grundy SM Cleeman JI Merz CN | 2004 | Circulation2004，110，2： | 1 |
| 8 | Definition of metabolic syndrome:report of the National Heart,Lung,and Blood Institute/American Heart Association conference on scientific issues related to definition显示文摘 | Grundy SM Brewer HB Jr Cleemen JI | | 0，，： | 1 |
| 9 | Asthenozoospemia: Analysis of large population 显示文摘 | Curl SM Ariagno JI Chenlo PH | 2003 | Arch Androl2003，49，5： | 1 |
| 10 | Actinomycosis in obstructive tonsillar hypertrophy and recurrent tonsillitis显示文摘 | Pransky SM Feldman JI Keams DB | 1991 | Arch Otolarypgol Head Neck Surg1991，117，8： | 1 |
| 11 | Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement 显示文摘 | Grundy SM Cleeman JI Daniels SR | 2005 | Circulation2005，112，17： | 1 |
| 12 | Diagnosis and management of the metabolic syndrome an American heart association/national heart, lung, and blood institute scientific statement显示文摘 | Grundy SM Cleeman JI Daniels SR | 2005 | Circulation2005，112，： | 1 |
| 13 | Diagnosis and management of the metabolic syndrome:an American Heart Association/National Heart,Lung,and Blood Institute Scientific Statement显示文摘 | Grundy SM Cleeman JI Daniels SR | 2005 | Circulation2005，112，17： | 1 |
| 14 | Diagnosis and management of the metabolic syndrome : an Amer- ican Heart Association/National Heart, Lung, and Blood Institute Scientific Statement 显示文摘 | Grundy SM Cleeman JI Daniels SR | 2005 | Circulation2005，112，17： | 1 |
| 15 | Diagnosis and management of themetabolic syndrome.An American Heart Association/National Heart,Lung,and Blood Institute Scientific Statement显示文摘 | Grundy SM Cleeman JI Daniels SR | | 0，，： | 1 |
| 16 | Implication of re- cent clinical trials for the National Choiosterol Education Program Adult Treatment Panel Ⅲ Guidelines 显示文摘 | Ground SM Cleeman JI Merz CN | 2004 | Am Coil Cardiol2004，44，3： | 1 |
| 17 | Ozone exposure and mortality: an empiric bayes metaregression analysis显示文摘 | Levy JI Chemerynski SM Sarnat JA | 2005 | Epidemiology2005，16，4： | 1 |
| 18 | Definition of Metabolic Syndrome Report of the National Heart, Lung and Blood Institute/American Heart Association Conference on Scientific Issues Retated to Definition 显示文摘 | Grundy SM Brewer Jr HB Cleeman JI | 2004 | Circulation2004，109，： | 1 |
| 19 | Implication of recent clinical trials for the national cholesterol education program adult treatment panel Ⅲ guidelines显示文摘 | Grundy SM Cleeman JI Merz CN | 2004 | Circulation2004，110，6： | 1 |
| 20 | Asthenozoospernia : anal- ysis of a large population 显示文摘 | Curl SM Ariagno JI Chenlo PH | 2003 | Arch Androl2003，49，5： | 1 |
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