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| 1 | Variations of geochemical compositions and the paleoclimatic significance of a loess-soil sequence from Garzê County of western Sichuan Province,China显示文摘The West Sichuan Plateau is located in the southeast margin of the Tibetan Plateau, where the climate is mainly influenced by the Indian southwest summer monsoon and the Tibetan Plateau monsoon. In this study, detailed geochemical analysis has been carried out on Ganzisi loess-paleosol sequence in Ganzê County of western Sichuan Province. The results indicate that Ganzê loess and paleosol have experienced the incipient stage of chemical weathering in dust source regions, characterized by the decomposition of plagioclase which caused the depletion of mobile elements Na and Ca. The post-depositional chemical weathering is characterized by carbonate dissolution and oxidation of Fe2+. The variations of some geochemical indexes (such as CIA values, Na/K and Fe2+/ Fe3+ ratios) in Ganzisi loess-paleosol sequence indicate a gradually decreased chemical weathering intensity in the dust source regions and deposition areas since 1.15 Ma BP consistent with the general increase of global ice volume, reflecting that the arid trend since 1.15 Ma BP in the southeast Tibetan Plateau is a regional response to the global climate change. The geochemical indexes in this section also reveal an obvious drying step occurred at about 250 ka BP in this region. We interpret this drying step as a result of decreased influence of the Indian southwest summer monsoon. This decrease in monsoon moisture is probably attributable to the uplift of the southeast margin of the Tibetan Plateau at about 250 ka BP. | QIAO YanSong ZHAO ZhiZhong WANG Yan FU JianLi WANG ShuBing JIANG FuChu | 2009 | Chinese Science Bulletin2009，54，24： | 13 |
| 2 | A Preliminary Study on the Soft–Sediment Deformation Structures in the Late Quaternary Lacustrine Sediments at Tashkorgan, Northeastern Pamir, China显示文摘This study identified soft–sediment deformation structures(SSDS) of seismic origin from lacustrine sediments in the late Quaternary paleo–dammed lake at Tashkorgan, northeastern Pamir. The observed deformation structures include sand dykes, liquefied diapir and convolute structures, gravity induced SSDS, and thixotropic pillar and tabular structures. We conducted a preliminary study on the morphology, formation and trigger mechanisms of pillar and tabular structures formed by liquefaction of underlying coarse sand and thixotropy of the upper silty clay. The regional tectonic setting and distribution of lacustrine strata indicate that the most probable trigger for the SSDS in lacustrine sediments was seismic activity, with an approximate earthquake magnitude of M>6.0; the potential seismogenic fault is the southern part of the Kongur normal fault extensional system. AMS 14 C dating results indicate that the SSDS were formed by seismic events occurring between 26050±100 yr BP and 22710±80 yr BP, implying intense fault activity in this region during the late Pleistocene. This study provides new evidence for understanding tectonic activity and regional geodynamics in western China. | LIANG Lianji DAI Fuchu JIANG Hanchao ZHONG Ning | 2018 | Acta Geologica Sinica(English Edition)2018，92，4： | 10 |
| 3 | LSECtin on tumor-associated macrophages enhances breast cancer sternness via interaction with its receptor BTN3A3显示文摘Macrophages have bee n suggested to con tribute to con structing a cancer stem cell(CSC)niche.However,whether and how macrophages regulate the activity of CSCs through juxtacrine signaling are poorly understood.Here we report LSECtin,a transmembrane protein highly expressed on tumor-associated macrophages(TAMs),enhances sternness of breast cancer cells(BCCs).We identified BTN3A3,a B7 family member with previously unknown functions as the receptor for LSECtin on BCCs responsible for stemness-promoting effect of LSECtin.In mice bearing human tumor xenografts,either macrophage-specific ablation of LSECtin or silencing of BTN3A3 in BCCs decreased CSC frequency and tumor growth.Admixture of LSECtin-positive macrophages increased the tumorigenic activity of BCCs dependent on BTN3A3.Disruption of the LSECtin-BTN3A3 axis with BTN3A3-Fc or anti-BTN3A3 mAb has a therapeutic effect on breast cancer.These findings define a juxtacrine signaling mechanism by which TAMs promote cancer stemness.Targeting this axis in the CSC niche may provide potential therapies to breast cancer. | Di Liu Qian Lu Xing Wang Jun Wang Ning Lu Zefei Jiang Xiaopeng Hao Jianbin Li Jing Liu Pengbo Cao Guilin Peng Yuandong Tao Dianyuan Zhao Fuchu He Li Tang | 2019 | Cell Research2019，29，5： | 8 |
| 4 | Magnetostratigraphic and paleoclimatic studies on the Red Earth Formation from the Chengdu Plain in Sichuan Province,China显示文摘Two red earth sections from the Chengdu Plain in Sichuan Province are dated using geomagnetic methods. The Brunhes/Matuyama (B/M) reversal boundary is recognized within the upper parts of the two sections,and the Jaramillo normal subzone occurs in the middle-lower parts of the vermiculated red soil (VRS),which indicate that the parent material for the VRS deposited in the middle Quaternary. Sedimentologic and geochemical studies suggest that the Chengdu Clay and part of the parent material for the VRS are of aeolian origin. Pollen analysis indicates that the Chengdu Plain was mainly covered by needle-leaved forest with a cool to cool temperate humid climate when the parent material for the VRS deposited. The relatively cool to cool temperate climatic condition in the Chengdu Plain in the middle Quaternary,which may be caused by the uplift of the Tibetan Plateau,was a response to the geo-environmental changes of global significance. | ZHAO ZhiZhong QIAO YanSong WANG Yan FU JianLi WANG ShuBing LI ChaoZhu YAO HaiTao JIANG FuChu | 2007 | Science China Earth Sciences2007，50，6： | 7 |
| 5 | Status quo and development trend of lost foam casting technology显示文摘Lost foam casting(LFC)technology has been widely applied to cast iron and cast steel.However,the development of LFC for Al and Mg alloys was relatively slower than that for cast iron and cast steel.The application of LFC to Al and Mg alloys needs more effort,especially in China.In this paper,the development history of LFC is reviewed,and the application situations of LFC to Al and Mg alloys are mainly discussed.Meanwhile,the key problems of LFC for Al and Mg alloys are also pointed out.Finally,the prospects for LFC technology are discussed,and some special new LFC technologies are introduced for casting Al and Mg alloys.In future,the development trends of green LFC technology mainly focus on the special new LFC methods,metal material,coating,heat treatment,new foam materials as well as purification technology of tail gas,etc. | Fan Zitian Jiang Wenming Liu Fuchu Xiao Botao | 2014 | China Foundry2014，11，4： | 6 |
| 6 | Plasma biomarker screening for liver fibrosis with the N-terminal isotope tagging strategy显示文摘A non-invasive diagnostic approach is crucial for the evaluation of severity of liver disease,treatment decisions,and assessing drug efficacy.This study evaluated plasma proteomic profiling via an N-terminal isotope tagging strategy coupled with liquid chromatography/Fourier transform ion cyclotron resonance mass spectrometry measurement to detect liver fibrosis staging.Pooled plasma from different liver fibrosis stages,which were assessed in advance by the current gold-standard of liver biopsy,was quantitatively analyzed.A total of 72 plasma proteins were found to be dysregulated during the fibrogenesis process,and this finding constituted a valuable candidate plasma biomarker bank for follow-up analysis.Validation results of fibronectin by Western blotting reconfirmed the mass-based data.Ingenuity Pathways Analysis showed four types of metabolic networks for the functional effect of liver fibrosis disease in chronic hepatitis B patients.Consequently,quantitative proteomics via the N-terminal acetyl isotope labeling technique provides an effective and useful tool for screening plasma candidate biomarkers for liver fibrosis.We quantitatively monitored the fibrogenesis process in CHB patients.We discovered many new valuable candidate biomarkers for the diagnosis of liver fibrosis and also partly identified the mechanism involved in liver fibrosis disease.These results provide a clearer understanding of liver fibrosis pathophysiology and will also hopefully lead to improvement of clinical diagnosis and treatment. | LI ShuLong LIU Xin WEI Lai WANG HuiFen ZHANG JiYang WEI HanDong QIAN XiaoHong JIANG Ying HE FuChu | 2011 | Science China(Life Sciences)2011，54，5： | 6 |
| 7 | Geochemical Characteristics of Eolian Deposits in the Chengdu Plain of Sichuan Province and the Implications for Provenance显示文摘In this study Chengdu Red Earth(CRE)from the Chengdu Plain(CP),Sichuan province,was analyzed for its elemental(major and trace elements)and isotopic(Sm-Nd)geochemistry and compared with Pleistocene loess and paleosol samples from the Chinese Loess Plateau(CLP)in Northern China.The geochemical composition of CRE is similar to north China loess,and also resembles the average UCC.This indicates that CRE,as loess deposits in Northern China,was derived from well-mixed sedimentary protoliths that have undergone numerous upper crustal recycling processes.However,obvious differences in the geochemical characteristics of CRE and the north China loess are also revealed in our results.For chemically stable elements,CRE has higher Ti,Zr,Hf and lowerΣREE,Ba contents in comparison with loess samples from the CLP.Further analysis shows that CRE has higher TiO2/Al2O3,SiO2/Al2O3,Ba/Rb and lower Ce/Yb,Eu/Yb,LaN/YbN andΣLREE/ΣHREE ratios.In Sm-Nd isotopic geochemistry,Sm and Nd content and theεNd(0)value in CRE are significantly higher than those in north China loess.The higher TiO2content in CRE coincided with a high background concentration of Ti in the Sichuan Basin and the surrounding regions.The lowerΣREE and higher Sm,Nd,εNd(0)values are related to the wide distribution of basalt in the southwest Sichuan Basin.The elemental and isotopic geochemistry of CRE indicates that eolian materials in the CP predominantly come from the Sichuan Basin and the surrounding regions,which differs from loess deposits in the CLP. | TAN Yuanlong QIAO Yansong ZHAO Zhizhong WANG Yan QI Lin FU Jianli LIU Zongxiu YAO Haitao WANG Shubing JIANG Fuchu | 2013 | Acta Geologica Sinica(English Edition)2013，87，6： | 3 |
| 8 | An integrated view of the correlations between genomic and phenomic variables显示文摘Genome sequencing opened the flood gate of '-omics' studies,among which the research about correlations between genomic and phenomic variables is an important part. With the development of functional genomics and systems biology,genome-wide investigation of the correlations between many genomic and phenomic variables became possible. In this review,five genomic variables,such as evolution rate(or 'age' of the gene) ,the length of intron and ORF(protein length) in one gene,the biases of amino acid composition and codon usage,along with the phenomic variables related to expression patterns(level and breadth) are focused on. In most cases,genes with higher mRNA/protein expression level tend to evolve slowly,have less intronic DNA,code for smaller proteins,and have higher biases of amino acid composition and codon usage. In addition,broadly expressed proteins evolve more slowly and are shorter than tissue-specific proteins. Studies in this field are helpful for deeper understanding the signatures of selection mediated by the features of gene expression and are of great significance to enrich the evolution theory. | Dong Yang,Ying Jiang,Fuchu He State Key Laboratory of Proteomics,Beijing Proteome Research Center,Beijing Institute of Radiation Medicine,Beijing 102206,China | 2009 | Journal of Genetics and Genomics2009，36，11： | 2 |
| 9 | Formation of the Yellow River, inferred from loess-palaeosol sequence in Mangshan and lacustrine sediments in Sanmen Gorge, China 显示文摘 | Jiang Fuchu Fu Jianli Wang Shubing | 2007 | Quaternary International2007，175，： | 1 |
| 10 | Grain-size distribution function of polymodal sediments in hydraulic and aeolian environments, and numerical partitioning of the sedimentary components显示文摘 | Donghuai Sun J Bloemendal D.K Rea J Vandenberghe Fuchu Jiang Zhisheng An Ruixia Su | 2002 | Sedimentary Geology2002，，3： | 1 |
| 11 | The Palaeoclimate Variations in the Central Plains Since the Interstade of the Last Glacial Stage显示文摘Through the study of a high-resolution loess record in the Central Plains, the short-term palaeoclimatic variations since the interstade of the last glacial stage have been discussed in this paper. The palaeoclimate in the East Asian monsoon areas shows different variation patterns in summer and winter. A correlation of the palaeomonsoon records of loess with the δ18O records of the ice core and deep sea is made, and some of the causes for their differences are also discussed. | XIAO Huaguo WU Xihao JIANG Fuchu XUE Bin TIAN Guoqiang LIU Ke | 1998 | Acta Geologica Sinica(English Edition)1998，72，1： | 1 |
| 12 | Late Cenozoic Geology and Paleo-environment Change in the Eastern Edge of Qinghai-Xizang Plateau显示文摘在 Qinghai-Xizang 高原的东方边有迟了的新生代湖的存款和黄土和红泥土和冰碛。各种各样的基因沉积在迟了的新生代 paleo 环境变化上记录了富有的信息。Xigeda 湖在在那里的 4.2 妈 B.P.-2.6 妈 B.P 期间形成了是 9 周期的温暖寒冷的引申。在西方的四川的 Eolian 免职在黄土土壤序列连续地记录了的 1.15 妈 B.P 开始了 14 个 paleo 季风气候周期。自从在那里的 1.13 妈 B.P 是在东方 Qinghai-Xizang 高原的 4.3 妈 B.P 的一个旧冰川的时期,在 Chengdu 平原的红土记录了 paleoclimatic 阶段的 5 个阶段。在期间第四级,有与 5 冻结成冰相应的 5 个极端 paleoclimatic 事件。 | ZHAO Zhizhong QIAO Yansong WANG Shubing YAO Haitao WANG Yan LI Chaozhu FU Jianli LIU Zongxiu LI Mingze MIAO Qi JIANG Fuchu | 2008 | Acta Geologica Sinica(English Edition)2008，82，5： | 0 |
| 13 | Time of the Tengchong-Lianghe Movement in Southwest Yunnan显示文摘The Tengchong-Lianghe movement,proposed and named by Chen et al(1991),is an important tectonic event occurred from the late stage of middle Pleistocene to the early stage of the late Pleistocene in the Tenchong Block of southwest Yunnan.It reactivated the old faults in the region,and tilted,folded and fractured the Q1 and Q2strata,resulting in the common angular unconformity between them.In addition,this region entered into an erosion-cutting stage,with its cutting depth reaching up to tens of meters,and formed very striking high lake terraces. | WANG Shubing WANG Yuzhen JIANG Fuchu TIAN Guoqiang | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 0 |
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