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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Chronic intermittent hypoxia is a major trigger for non-alcoholic fatty liver disease in morbid obese显示文摘 | Judith Aron-Wisnewsky Caroline Minville Joan Tordjman Patrick Lévy Jean-Luc Bouillot Arnaud Basdevant Pierre Bedossa Karine Clément Jean-Louis Pépin | 2011 | Journal of Hepatology2011，，1： | 2 |
| 3 | P-Selectin Expression and Kupffer Cell Activation in Rat Acute Pancreatitis显示文摘 | Emma Folch Neus Prats Georgina Hotter Santiago López Emilio Gelpi Joan Roselló-Catafau Daniel Closa | 2000 | Digestive Diseases and Sciences2000，，8： | 2 |
| 4 | The effects of 5-aza-2′-deoxycytidine (Decitabine) on the platelet count in patients with intermediate and high-risk myelodysplastic syndromes显示文摘 | Joan van den Bosch Michael Lübbert Gregor Verhoef P.W Wijermans | 2004 | Leukemia Research2004，，8： | 2 |
| 5 | Jones and michael horowitz pathophysiology and management of gastroparesis expert review of gastroenterology & hepatology显示文摘 | Joan Khoo Christopher K Rayner Karen L | 2009 | April2009，3，2： | 1 |
| 6 | HLA-G: a human pregnancy-related immunomodulator显示文摘 | Joan S Hunt Daudi L Langat | 2009 | Current Opinion in Pharmacology2009，，4： | 1 |
| 7 | Preparation of the yeast Pichia pastoris for transmission electron microscopy 显示文摘 | Benjamin A Y Joan L C Geoff P L C | 2006 | Microscopy Today2006，14，5： | 1 |
| 8 | Feet First:Diabetes Care显示文摘 | Joan E Halpin L Sharon G | 1999 | American Journal of Nursing1999，99，2： | 1 |
| 9 | Role of Nr13 in regulation of programmed cell death in the bursa of Fabricius 显示文摘 | RUEY M L GERMAIN G JOAN B | 1999 | Genes & Dev1999，13，6： | 1 |
| 10 | Hormonal contraceptive use,pregnancy and parity,and the risk of cervical intraepithelial neoplasia 3 among oncogenic HPV DNA-positive women with equivocal or mildly abnormal cytology显示文摘 | Philip E Castle Joan L Walker Mark Schiffman | 2005 | Int J Cancer2005，17，6： | 1 |
| 11 | Role of Nr13 in regulation of programmed cell death in the bursa of Fabricius显示文摘 | RUEY M L GERMAIN G JOAN B | 1999 | Genes & Dev1999，13，6： | 1 |
| 12 | Heterologous protein expression in the methylotrophic yeast Pichia pastoris显示文摘 | JOAN L C JAMES M C | 2000 | FEMS Microbiology Reviews2000，24，： | 1 |
| 13 | A Spectrophotometric Method for Quantitative Determination of Allicin and Total Garlic Thiosulfinates 显示文摘 | Joan Han Larry l awson Grace Han | 1995 | Anatytical Biochemistry1995，225，： | 1 |
| 14 | Evidence-based systematic review:Effects of oral motor interventions on feeding and swallowing in preterm infants显示文摘 | Joan A Healther C Cathy L | 2010 | American Journal of Speech-Language Pathology2010，19，： | 1 |
| 15 | Major hepatectomies are safe in patients with cholangiocarcinoma and jaundice显示文摘 | Joan Figueras Antoni Codina-Barreras Santiago López-Ben Jordi Soriano Berta Pardina Laia Falgueras Ernesto Castro Silvia Torres-Bahi Rosa Ortiz Esther Diaz Albert Maroto Eugeni Canals | 2009 | Cirugía Espa?ola (English Edition)2009，，5： | 1 |
| 16 | Sustained accumulation of methyl salicylate alters antioxidant protection and reduces tolerance of holm oak to heat stress显示文摘 | JOAN L JISEO P SERGU M B | 2005 | Physiologia Plantarum2005，124，3： | 1 |
| 17 | RORIB: An economic and efficient solution for realtime online remote information backup显示文摘 | Lloyd S J Joan P Jian L | 2003 | Journal of Database Management2003，14，3： | 1 |
| 18 | The effect of geographic mobility on male labor-force participants in the United States显示文摘 | Joan R Rodgers John L Rodgers | 2000 | Journal of Labor Research2000，，21： | 1 |
| 19 | Effects of water recycling in hydrothermal carbonization of loblolly pine 显示文摘 | Uddin M H Reza M T Joan G L | 2014 | Environmental Progress & Sustainable Energy2014，33，4： | 1 |
| 20 | Effects of water recycling in hydrothermal carbonization of loblolly pine 显示文摘 | Uddin M H Reza M T Joan G L | 2014 | Environmental Progress & Sustainable Energy2014，33，4： | 1 |
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