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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Porcine mannan-binding lectin A binds to actinobacillus snis and Hatmophilus parasuu显示文摘 | Brandon N L Jutta D H Janet I M | 2006 | Developmental and Comparative Immunology2006，30，： | 1 |
| 3 | Porcine mannan-binding leetin A binds to Actinobacillus suis and Haemophilus parasuis 显示文摘 | Brandon N Jutta D Janet I | 2006 | Developmental and ComparativeImmunology2006，30，： | 1 |
| 4 | Long-term repeatability of induced sputum cells and inflammatory markersin stable, moderately severe COPD显示文摘 | Kai M Beeh M D Jutta Beier | 2003 | Chest2003，123，： | 1 |
| 5 | Porcine mannan-binding lectin A bind to Actinobacillus suis and Haemophilus parasuis显示文摘 | Brandon N L Jutta D H Janet I M | 2006 | Developmental and comparative immunology2006，30，10： | 1 |
| 6 | Porcine mannan-binding lectin A binds to Actinobacillus suis and Haemophilus parasuis 显示文摘 | Brandon N Jutta D Janet I | 2006 | Developmental and Comparative hnmunology2006，30，： | 1 |
| 7 | Structure and chromosomal location of the rat gene encoding the heart fatty acid-binding protein显示文摘 | Jun Z Jutta RH Ian D | 1999 | Eur J Biochem1999，266，： | 1 |
| 8 | Determination of polychlorinated biphenyls and chlorinated pesticides in human bodyfluids and tissues 显示文摘 | Klaus A B Jutta B Gerhard W Lothar D | 1996 | Journal of Chromatography A1996，754，： | 1 |
| 9 | Coexpression of Avian Influenza Virus H5 and N1 by Recombinant Newcastle disease virus and the impact on immune response in chickens显示文摘 | Kristina R Jutta V Daniela D | 2011 | Avi- an Diseases2011，55，3： | 1 |
| 10 | Exopolysaccharide production and texture-promoting abilities of mixed-strain starter cultures in yogurt production显示文摘 | FATOUMA B JUTTA C MICHEL D | 1997 | J Dairy Sci1997，80，： | 1 |
| 11 | Rating scales for the assessment of empathic communication in medical interviews (REM): scale development, reliability and validity显示文摘 | Jennifer N Ralf D Jutta H | 2007 | J Clin Psychol Med Settings2007，14，： | 1 |
| 12 | Tolerance to ischemia of hypertrophied human hearts during valve replacement显示文摘 | Jutta Schaper M. D. F. Schwarz M. D. W. Flameng M. D. F. Hehrlein M. D | 1978 | Basic Research in Cardiology1978，，2： | 1 |
| 13 | Newcastle disease virus expressing H5 hemagglutinin gene protects chickens against Newcastle disease and avian influenza显示文摘 | Jutta V Wiesner D Fuchs W | 2006 | PNAS2006，103，： | 1 |
| 14 | Pilot randomized trial of selective internal radiation therapy vs. chemoembolization in unresectable hepatocellular carcinoma显示文摘 | Frank T. Kolligs Jose I. Bilbao Tobias Jakobs Mercedes I?arrairaegui Jutta M. Nagel Macarena Rodriguez Alexander Haug Delia D’Avola Mark op den Winkel Antonio Martinez‐Cuesta Christoph Trumm Alberto Benito Klaus Tatsch Christoph J. Zech Ralf‐Thorsten Hoff | 2015 | Liver Int2015，，6： | 1 |
| 15 | Porcine mannanbinding lectin n binds to Actinobacillus suis and Haemophilus parasuis显示文摘 | BRANDON N JUTTA D HAMMERMUELLER | 2006 | Developmental and Comparative Immunology2006，30，： | 1 |
| 16 | Porcine mannan-binding lectin A bind to Actinobacillus suis and Haemophilus parasuis 显示文摘 | BRANDON N L JUTTA D H JANET I M | 2006 | Developmental and Comparative Immunology2006，30，： | 1 |
| 17 | An improved dot-blot method forvirus detection in chicken embryo fibroblast cultures显示文摘 | Jutta D Hammermueller Perter J Krell J Brain Derbyshire | 1991 | J Virol Methods1991，31，： | 1 |
| 18 | Developing Internet Ecommerce Benchmarks 显示文摘 | Jutta D Bodorik P Wang Y | 1999 | Information System1999，24，6： | 1 |
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