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| 1 | Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation显示文摘Genome-wide association studies(GWASs) have been instrumental in understanding complex phenotypic traits. However, they have rarely been used to understand lineage-specific pathways and functions that contribute to the trait. In this study, by integrating lineage-specific enhancers from mesenchymal and myeloid compartments with bone mineral density loci, we were able to segregate osteoblast-and osteoclast(OC)-specific functions. Specifically, in OCs, a PU.1-dependent transcription factor(TF)network was revealed. Deletion of PU.1 in OCs in mice resulted in severe osteopetrosis. Functional genomic analysis indicated PU.1 and MITF orchestrated a TF network essential for OC differentiation. Several of these TFs were regulated by cooperative binding of PU.1 with BRD4 to form superenhancers. Further, PU.1 is essential for conformational changes in the superenhancer region of Nfatc1. In summary, our study demonstrates that combining GWASs with genome-wide binding studies and model organisms could decipher lineage-specific pathways contributing to complex disease states. | Heather A.Carey Blake E.Hildreth III Jennifer A.Geisler Mara C.Nickel Jennifer Cabrera Sankha Ghosh Yue Jiang Jing Yan James Lee Sandeep Makam Nicholas A.Young Giancarlo R.Valiente Wael N.Jarjour Kun Huang Thomas J.Rosol Ramiro E.Toribio Julia F.Charles Michael C.Ostrowski Sudarshana M.Sharma | 2018 | Bone Research2018，6，1： | 4 |
| 2 | Perturbation effects on mode propagation in highly elliptical core two-mode fibers显示文摘 | Huang Shangyuan James N Blake Byoung Yoon Kim | 1990 | Journal of Lightwave Technology1990，8，1： | 1 |
| 3 | Auditory neuropathy spectrum disorder (ANSD) and cochlear implantation显示文摘 | Robert V. Harrison Karen A. Gordon Blake C. Papsin Jaina Negandhi Adrian L. James | 2015 | International Journal of Pediatric Otorhinolaryng2015，，： | 1 |
| 4 | Sharing the wealth: social comparisons and pay dispersion in the CEO’s top team显示文摘 | James W.Fredrickson AlisonDavis‐Blake WM. GerardSanders | 2010 | Strat. Mgmt. J2010，，10： | 1 |
| 5 | SNR Enhancement of Intensity Noise-Limited FOGs 显示文摘 | Renato C Rabelo Ricardo T de Carvalho James Blake | 2000 | Journal of Lightwave Technology(S0733-8724)2000，18，12： | 1 |
| 6 | The lotus range extender engine 显示文摘 | James Turner Darren Blake Jason Moore | 2010 | SAE Int J Engines2010，3，2： | 1 |
| 7 | Stool DNA Testing for Screening Detection of Colorectal Neoplasia in Alaska Native People显示文摘 | Diana G Redwood Elvin D Asay Ian D Blake Pamela E Sacco Claudia M Christensen Frank D Sacco James J Tiesinga Mary E Devens Steven R Alberts Douglas W Mahoney Tracy C Yab Patrick H Foote Thomas C Smyrk Ellen M Provost David A Ahlquist | 2016 | Mayo Clinic Proceedings2016，，： | 1 |
| 8 | Major genes for Na+ exclusion, Naxl and Nax2 ( wheat HKT1 ~ 4 and HKT1 5), decrease Na+ accumulation in bread wheat leaves under saline and waterlogged conditions显示文摘 | James R A Blake C Byrt C S | 2011 | Journal of Experimental Botany2011，62，8： | 1 |
| 9 | The role of anticholinergics in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia:a systematic review and metaanalysis显示文摘 | BLAKEJAMES BT RASHIDIAN A IKEDA Y | 2007 | BJU Int2007，99，1： | 1 |
| 10 | ERBB2 Amplifications in Esophageal Adenocarcinoma显示文摘 | Peter S. Dahlberg Blake A. Jacobson Ganesh Dahal James M. Fink Robert A. Kratzke Michael A. Maddaus Lance J. Ferrin | 2004 | The Annals of Thoracic Surgery2004，，5： | 1 |
| 11 | Major genes for Na+ exclusion,Naxl and Nax2 (wheat HKT1 ;4 and HKT1 ;5),decrease Na+ accumulation in bread wheat leaves under saline and waterlogged conditions显示文摘 | JAMES R A BLAKE C BYRT C S | 2011 | J Exp Bot2011，62，8： | 1 |
| 12 | Aberrations of optical domes显示文摘 | Blake G C Dean B M James P M | 1998 | Proceedings of SPIE1998，3482，： | 1 |
| 13 | SNR enhancement of intensity noise-limited FOGs 显示文摘 | Renato C Rabelo Ricardo T de Carvalho James Blake | 2000 | Journal of Lightwave Technology2000，18，12： | 1 |
| 14 | A review of recent advances(2018–2021)on tropical cyclone intensity change from operational perspectives,part 1:Dynamical model guidance显示文摘This review summarizes the rapporteur report on tropical cyclone(TC)intensity change from the operational perspective,as presented to the 10th International Workshop on TCs(IWTC-10)held in Bali,Indonesia,from Dec.5–9,2022.The accuracy of TC intensity forecasts issued by operational forecast centers depends on three aspects:real-time observations,TC dynamical model forecast guidance,and techniques and methods used by forecasters.The rapporteur report covers the progress made over the past four years(2018–2021)in all three aspects.This review focuses on the progress of dynamical model forecast guidance.The companion paper(Part II)summarizes the advance from operational centers.The dynamical model forecast guidance continues to be the main factor leading to the improvement of operational TC intensity forecasts.Here,we describe recent advances and developments of major operational regional dynamical TC models and their intensity forecast performance,including HWRF,HMON,COAMPS-TC,Met Office Regional Model,CMA-TYM,and newly developed HAFS.The performance of global dynamical models,including NOAA's GFS,Met Office Global Model(MOGM),JMA's GSM,and IFS(ECMWF),has also been improved in recent years due to their increased horizontal and vertical resolution as well as improved data assimilation systems.Recent challenging cases of rapid intensification are presented and discussed. | Zhan Zhang Weiguo Wang James D.Doyle Jonathan Moskaitis William A.Komaromi Julian Heming Linus Magnusson John P.Cangialosi Levi Cowan Michael Brennan Suhong Ma Ananda Kumar Das Hosomi Takuya Peter Clegg Thomas Birchard John A.Knaff John Kaplan Mrutyunjay Mohapatra Monica Sharma Ikegami Masaaki Liguang Wu Eric Blake | 2023 | Tropical Cyclone Research and Review2023，12，1： | 0 |
| 15 | A review of recent advances(2018–2021)on tropical cyclone intensity change from operational perspectives,part 2:Forecasts by operational centers显示文摘This paper summarizes the progress and activities of tropical cyclone(TC)operational forecast centers during the last four years(2018–2021).It is part II of the review on TC intensity change from the operational perspective in the rapporteur report presented to the 10th International Workshop on TCs(IWTC)held in Bali,Indonesia,from Dec.5–9,2022.Part I of the review has focused on the progress of dynamical model forecast guidance.This part discusses the performance of TC intensity and rapid intensification forecasts from several operational centers.It is shown that the TC intensity forecast errors have continued to decrease since the 9th IWTC held in 2018.In particular,the improvement of rapid intensification forecasts has accelerated,compared with years before 2018.Consensus models,operational procedures,tools and techniques,as well as recent challenging cases from 2018 to 2021 identified by operational forecast centers are described.Research needs and recommendations are also discussed.©2023 The Shanghai Typhoon Institute of China Meteorological Administration.Publishing services by Elsevier B.V.on behalf of KeAi Communication Co.Ltd.This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/). | Weiguo Wang Zhan Zhang John P.Cangialosi Michael Brennan Levi Cowan Peter Clegg Hosomi Takuya Ikegami Masaaki Ananda Kumar Das Mrutyunjay Mohapatra Monica Sharma John A.Knaff John Kaplan Thomas Birchard James D.Doyle Julian Heming Jonathan Moskaitis Suhong Ma Charles Sampson Liguang Wu Eric Blake | 2023 | Tropical Cyclone Research and Review2023，12，1： | 0 |
| 16 | 我的主场 布雷克眼中的美网显示文摘我第一次去美网是10岁那年,和爸爸一起去看资格赛。我们在外场看一个叫做菲尔·威廉姆森的美国人与澳大利亚人沃里·马苏的比赛。能看到自己认识的人,并且是和爸爸很熟的人在美网比赛真是太高兴了,对我们来说,场内外一切都令人敬畏——巨大的体育场,伟大的明星在训练,准备在这项世界最著名的赛事中一展身手。而我,就在现场。 | James Blake 邵琳 | 2007 | 网球大师2007，0，5： | 0 |
| 17 | 温哥华公寓显示文摘温哥华公寓的建成预示着这个年轻的城市正在打开城市政策制定的新局面。它将成为从Granville大桥进入温哥华市中心的城市大门。塔楼和群房的设计是对新城市主义地域类型中的'温哥华主义'建筑的全新解读,配合一座纤细的塔楼,试图保留城市视觉通廊并激活步行通道。住宅塔楼借助高度和毗邻河流的地理位置,是唯一可以同时享受水景和山景的建筑,坐拥温哥华广袤的自然风光。 | Carl McDonald Melissa Bauld Aaron Mark Alan Tansey Alex Wu Alexandra Gustafsson Alina Tamosiunaite Amina Blacksher Aran Coakley Arash Adel Ahmadian Armen Menendian Barbora Srpkova Ben Zunkeler Benjamin Caldwell Benjamin Novacinski Bennett Gale Birk Daugaard Blake Theodore Smith Brian Foster Brian Rome Carolien Schippers Christopher James Malcolm Jr. Christopher Junkin Christopher Tron David Brown David Dottelonde Deborah Campbell Doug Stechschulte Douglass Alligood Edward Yung Elena Bresciani Filip Milovanovic Francesca Portesine Gabriel Hernandez Solano Gabriel Jewell-Vitale Hector Garcia Ivy Hume Jan Leenknegt Janice Rim John Kim Josiah Poland Julian Liang Julianne Gola Julie Kaufman Karol Bogdan Borkowski Kurt Nieminen Lauren Turner Lorenz Krisai Lucio Santos Marcella Martinez Martin Voelkle Matthew Dlugosz Megan Ng Michael Robert Taylor Otilia Pupezeanu Paula Domka Phillip MacDougall Ryan Yang Sean Franklin Sebastian Grogaard Simon Scheller Spencer Hayden Taylor Fulton Terrence Chew Terry Lallak Thomas Smith Tianqi Zhang Tobias Hjortdal Tran Le Valentina Mele Xinyu Wang Yaziel Juarbe Yoanna Shivarova Zach Walters Zhifei Xu Andrew Latreille Glotman Simpson Urban YVR 运小红(译) | 2019 | 城市环境设计2019，0，2： | 0 |
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