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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Apoptosis as a possible cause of gradual devel-opment of complete heart block and fatal arrhythmias associated with absence of the ANnode sinus node and internodal pathways显示文摘 | James TN Martin ES Willis III PW | 1996 | Circulation1996，9，3： | 1 |
| 3 | Mid- and near-infrared spectroscopic assessment of soil compositional parameters and structural indices in two Ferralsols显示文摘 | Beáta E. Madari James B. Reeves Pedro L.O.A. Machado Cleber M. Guimar?es Eleno Torres Gregory W. McCarty | 2006 | Geoderma2006，，1： | 1 |
| 4 | Argon beam coagulation in the management of placenta accreta显示文摘 | Slephen ES James GR Michael LM | 1999 | Obstet Gynecol1999，94，： | 1 |
| 5 | Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis显示文摘BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular carcinoma.Apolipoprotein E(protein:ApoE,gene:APOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver damage.AIM To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODS This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)OLT.Liver injury severity was assessed using different criteria,including METAVIR and models for endstage liver disease.APOE polymorphisms were analyzed by quantitative real-time polymerase chain reaction.RESULTS The APOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)P=0.048,in patients carrying the APOE4 allele when compared to non-APOE4.In addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;P=0.043)and(A1F4,57.4%vs A3F4,0.0%;P=0.024)in APOE4 patients when compared to APOE3 carriers.The fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(P=0.006).CONCLUSION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients. | José Carlos Rodrigues Nascimento Lianna C Pereira Juliana Magalhães C Rêgo Ronaldo P Dias Paulo Goberlânio B Silva Silvio Alencar C Sobrinho Gustavo R Coelho Ivelise Regina C Brasil Edmilson F Oliveira-Filho James S Owen Pierluigi Toniutto Reinaldo B Oriá | 2021 | World Journal of Gastroenterology2021，27，11： | 1 |
| 6 | CCBE1 Is Essential for Mammalian Lymphatic Vascular Development and Enhances the Lymphangiogenic Effect of Vascular Endothelial Growth Factor-C In Vivo显示文摘 | Frank L. Bos Maresa Caunt Josi Peterson-Maduro Lara Planas-Paz Joe Kowalski Terhi Karpanen Andreas van Impel Raymond Tong James A. Ernst Jeroen Korving Johan H. van Es Eckhard Lammert Henricus J. Duckers Stefan Schulte-Merker | 2011 | Circulation Research2011，，5： | 1 |
| 7 | Use of biomarkers for the assessment of chemotherapy induced cardiac toxicity 显示文摘 | Christenson ES James T Agrawal V | 2015 | Clin Biocbem2015，48，45： | 1 |
| 8 | Applicability of hybrid linear ion trap-high resolution mass spectrometry and quadrnpole -linear ion trap-mass spectrometry for mycotoxin analysis in baby food 显示文摘 | Rubert J James KJ Ma~es J | 2012 | Journal of Chromatography A2012，1223，3： | 1 |
| 9 | Influence of Gestational Age and Body Weight on the Pharmacokinetics of Labetalol in Pregnancy 显示文摘 | James HF Gloria ES Jennifer H | 2014 | Clinical Pharmacokinetics2014，53，4： | 1 |
| 10 | Effect of potent topical steroids on plasma-cortisol levels of infants and children with eczema显示文摘 | Feiwel M James VH Barnett ES | 1969 | Lan- cet1969，1，： | 1 |
| 11 | A Source of Systematic Error in Transient-Flow Air Permeamter Measurements显示文摘 | James ES Michel JL.Robin David EE | | 0，，： | 1 |
| 12 | Effects of sleep on wake-induced c-fos expression显示文摘 | Radhika B Jonathan ES James IM | 1997 | J Neurosci1997，17，： | 1 |
| 13 | Hand-assisted laparoscopic nephroureterectomy:analysis of distal ureterectomy technique,margin status,and surgical outcomes显示文摘 | James AB Stephen ES Eric C | 2005 | Urology2005，66，6： | 1 |
| 14 | A clinical decision ride for identifying children with thoracic injuries after blunt torso trauma显示文摘 | James FH Peter ES Willian EB | 2002 | Ann Emerg Med2002，39，5： | 1 |
| 15 | The second reductase of fungal melanin biosynthesis in Magnporthe grise 显示文摘 | James E Thompson ES | 2000 | Bioloical Chemistry2000，275，34： | 1 |
| 16 | Intradialytic verusome vased exercise training in hemodialysis patients: A randomized controlled trial显示文摘 | Kirsten PK Robert GF James ES | 2009 | BMC Nephrol2009，10，2： | 1 |
| 17 | Structures of cytochrome P450 3A4显示文摘 | Emily ES James RH | 2005 | Trends Biochem Sci2005，30，1： | 1 |
| 18 | Cardiac effects of some simple aliphatic aldehyde显示文摘 | James TN Bear ES | 1968 | J Pharmacol Exp Ther1968，163，2： | 1 |
| 19 | The epidemiology of cardiovascular disease in type 2 diabetes mellitus:how sweet it is…or is it?显示文摘 | James M Daniedl ES | 1997 | The Lancet1997，7，： | 1 |
| 20 | Antithrombotic therapy in atrial fibrillation :the seventh ACCP conference on antithrombotic and thrombolytic therapy显示文摘 | Daniel ES Gregory WA James E | 2004 | Chest2004，126，4： | 1 |
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