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| 1 | Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice显示文摘BACKGROUND Non-alcoholic fatty liver disease (NAFLD) has become an epidemic largely due to the worldwide increase in obesity. While lifestyle modifications and pharmacotherapies have been used to alleviate NAFLD, successful treatment options are limited. One of the main barriers to finding safe and effective drugs for long-term use in NAFLD is the fast initiation and progression of disease in the available preclinical models. Therefore, we are in need of preclinical models that (1) mimic the human manifestation of NAFLD and (2) have a longer progression time to allow for the design of superior treatments. AIM To characterize a model of prolonged high-fat diet (HFD) feeding for investigation of the long-term progression of NAFLD. METHODS In this study, we utilized prolonged HFD feeding to examine NAFLD features in C57BL/6 male mice. We fed mice with a HFD (60% fat, 20% protein, and 20% carbohydrate) for 80 wk to promote obesity (Old-HFD group, n = 18). A low-fat diet (LFD)(14% fat, 32% protein, and 54% carbohydrate) was administered for the same duration to age-matched mice (Old-LFD group, n = 15). An additional group of mice was maintained on the LFD (Young-LFD, n = 20) for a shorter duration (6 wk) to distinguish between age-dependent and age-independent effects. Liver, colon, adipose tissue, and feces were collected for histological and molecular assessments.RESULTS Prolonged HFD feeding led to obesity and insulin resistance. Histological analysis in the liver of HFD mice demonstrated steatosis, cell injury, portal and lobular inflammation and fibrosis. In addition, molecular analysis for markers of endoplasmic reticulum stress established that the liver tissue of HFD mice have increased phosphorylated Jnk and CHOP. Lastly, we evaluated the gut microbial composition of Old-LFD and Old-HFD. We observed that prolonged HFD feeding in mice increased the relative abundance of the Firmicutes phylum. At the genus level, we observed a significant increase in the abundance of Adercreutzia, Coprococcus, Dorea, and Ruminococcus and decreased relative abundance of Turicibacter and Anaeroplasma in HFD mice. CONCLUSION Overall, these data suggest that chronic HFD consumption in mice can mimic pathophysiological and some microbial events observed in NAFLD patients. | Kandy T Velázquez Reilly T Enos Jackie E Bader Alexander T Sougiannis Meredith S Carson Ioulia Chatzistamou James A Carson Prakash S Nagarkatti Mitzi Nagarkatti E Angela Murphy | 2019 | World Journal of Hepatology2019，11，8： | 6 |
| 2 | Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth显示文摘 | Michael S O’Reilly Thomas Boehm Yuen Shing Naomi Fukai George Vasios William S Lane Evelyn Flynn James R Birkhead Bjorn R Olsen Judah Folkman | 1997 | Cell1997，，2： | 3 |
| 3 | Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial显示文摘 | John Primrose Stephen Falk Meg Finch-Jones Juan Valle Derek O’Reilly Ajith Siriwardena Joanne Hornbuckle Mark Peterson Myrddin Rees Tim Iveson Tamas Hickish Rachel Butler Louise Stanton Elizabeth Dixon Louisa Little Megan Bowers Sian Pugh O James Garden D | 2014 | Lancet Oncology2014，，6： | 2 |
| 4 | Removing orbital debris with lasers显示文摘 | Claude R. Phipps Kevin L. Baker Stephen B. Libby Duane A. Liedahl Scot S. Olivier Lyn D. Pleasance Alexander Rubenchik James E. Trebes E. Victor George Bogdan Marcovici James P. Reilly Michael T. Valley | 2012 | Advances in Space Research2012，，9： | 1 |
| 5 | Nitrate removal from a drinking water supply with large free - surface constructed wetlands prior to groundwater recharge 显示文摘 | James F Reilly | 2000 | Ecological Engineering2000，14，： | 1 |
| 6 | The impact of maternal age, body mass index and maternal weight gain on the glucose challenge test in pregnancy 显示文摘 | Hackmon R James R O'Reilly Green C | 2007 | J Matern Fetal Neonatal Med2007，20，： | 1 |
| 7 | Occurrence of boscalid and other selected fungicides in surface water and groundwater in three targeted use areas in the United States显示文摘 | Timothy J. Reilly Kelly L. Smalling James L. Orlando Kathryn M. Kuivila | 2012 | Chemosphere2012，，3： | 1 |
| 8 | Characterization of surface-breaking cracks using one tangential component of magnetic leakage field measurements显示文摘 | Reza Khalaj Amineh Natalia K Nikolova James P Reilly | 2008 | IEEE Transactions on Magnetics2008，44，4： | 1 |
| 9 | Selection and Dosing of Medications for Management of Diabetes in Patients with Advanced Kidney Disease显示文摘 | James B Reilly Jeffrey SB | 2010 | Semin Dial2010，23，2： | 1 |
| 10 | Isoflavone phytoestrogens consumed in soy decrease F2-isoprostane concentrations and increase resistance of; ow density lipoprotein to oxidation in humans1, 2, 3, American 显示文摘 | Helen Wiseman James D Reilly O | 2000 | Journal of Clinical Nutrition2000，，： | 1 |
| 11 | HYPERBARIC OXYGEN THERAPY FOR DIABETIC ULCERS: SYSTEMATIC REVIEW AND META-ANALYSIS显示文摘 | Daria O’Reilly Anjori Pasricha Kaitryn Campbell Natasha Burke Nazila Assasi James M. Bowen Jean-Eric Tarride Ron Goeree | 2013 | International Journal of Technology Assessment in Health Care2013，，3： | 1 |
| 12 | Nitrate removal from a drinking water supply with large free-surface constructed wetlands prior to groundwater recharge显示文摘 | James F. Reilly Alex J. Horne Craig D. Miller | 2000 | Ecological Engineering2000，，1： | 1 |
| 13 | Counting On China? Australia’s Strategic Response to Economic Interdependence显示文摘 | James Reilly | 2012 | Chinese Journal of International Politics2012，，4： | 1 |
| 14 | Isoflavone phytoestrogens consumed in soy decrease F2 -iso- prostane concentrations and increase resistance of low - density lipoprotiein to oxidation in humans 1, 2,3 显示文摘 | Wiseman H James D Reilly O | 2000 | Journal of Clinical Nutrition2000，72，2： | 1 |
| 15 | Technology and Technical Change in the MIT EPPA Model 显示文摘 | HENRY D JACOBY JOHN M REILLY JAMES R M | 2006 | Energy Economics2006，，28： | 1 |
| 16 | Miller nirrate mmoval from a drinking water supply with large free surface constructed wetlands prior to groundwater recharge显示文摘 | James F Reilly Alex J Homeb Craig D | 2000 | Ecological Engineering2000，14，： | 1 |
| 17 | Thermodynamics of the a,β and 7 polymorphs of AIH3 显示文摘 | Jason Graetz James J Reilly | 2006 | Journal of Alloys and Compounds2006，424，： | 1 |
| 18 | Decomposition kinetics of the AIH3 polymorphs显示文摘 | Graetz Jason Reilly James J | 2005 | J Phys Chem B2005，109，22： | 1 |
| 19 | A Norm-Taker or a Norm-Maker? China’s ODA in Southeast Asia显示文摘As China expands its official development assistance (ODA) in Southeast Asia,is Chinese aid beginning to emulate international norms and practices or instead establishing its own distinct approach to development assistance? This essay argues that China’s socialization into international norms varies with the thickness of the institutional environment. In Cambodia and Laos,China’s aid program shows signs of alignment with international aid practices. At the regional level,however,China is beginning to act more like a norm-maker. Through expanding its financial support for select regional initiatives,Beijing is bolstering its ability to shape the norms and practices of regional developmental institutions. China’s rising ODA in Southeast Asia poses a potential challenge to Australia’s influence in the region,but also provides opportunities for greater diplomatic engagement and cooperation in support of regional development. | James Reilly | 2011 | Contemporary International Relations2011，21，3： | 1 |
| 20 | Relationship of emphysema and airway disease assessed by CT to exercise capacity in COPD显示文摘 | Alejandro A. Diaz Brian Bartholmai Raúl San José Estépar James Ross Shin Matsuoka Tsuneo Yamashiro Hiroto Hatabu John J. Reilly Edwin K. Silverman George R. Washko | 2010 | Respiratory Medicine2010，，8： | 1 |
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