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| 1 | Transitions of the Understanding and Definition of Primary Glaucoma显示文摘Objective:In previous decades,glaucoma has been primarily attributed to elevated intraocular pressure (IOP),but this has gradually been replaced by the development of optic neuropathy as the central concept of glaucoma in developed countries.However,there still remain strong controversies in the definition of glaucoma in China.In this current review,we are going to discuss these controversies and elaborate on the historical transitions of the definition of glaucoma both in China and developed countries.Furthermore,we will briefly describe the 'ocular-cranial pressure gradient'theory and discuss the relationship between glaucoma and degenerative diseases of the central nervous system (CNS)in order to show the complex pathogenesis of glaucoma and the importance for the modification to the definition of glaucoma. Data Sources:We performed a comprehensive search in both PubMed and SinoMed using the following keywords:(a)'primary glaucoma'and 'guideline,'(b)'ocular-cranial pressure gradient,'and (c)'glaucoma,''Alzheimer's disease,'and 'Parkinson's disease.' The literature search included the related articles with no restrictions on publication date. Study Selection:The primary references were Chinese and English articles including (a)original guidelines and expert consensuses of primary glaucoma,(b)reviews focusing on the differences between various versions of these guidelines and consensuses,and (c)papers about ocular-cranial pressure gradient theory and the relationship between glaucoma and CNS degenerative diseases. Results:The definitions and classifications of both primary open-angle glaucoma and primary angle-closure glaucoma differ between Chinese glaucoma consensuses and international primary glaucoma guidelines.Chinese definitions and classifications put more emphasis on the IOP,while international guidelines put more emphasis on the presence of optic neuropathy.The ocular-cranial pressure gradient theory and the research on the relationship between glaucoma and CNS degenerative diseases have provided new directions for exploring the pathogenesis of glaucoma. Conclusions:As regards the definition and classification of primary glaucoma,we find that there are still some discrepancies between Chinese expert consensuses and international guidelines.Glaucoma is a disease with complex etiologies,while its common characteristic is a specific optic neuropathy.The current definition and understanding of glaucoma is an ongoing and evolving process,reflecting our latest available evidence on its pathogenesis.Chinese ophthalmology community may need to update our guidelines,accommodating these latest developments. | Si-An Liu Zhen-Ni Zhao Nan-Nan Sun Ying Han Jeremy Chen Zhi-Gang Fan | 2018 | Chinese Medical Journal2018，，23： | 6 |
| 2 | Tumour suppressor HLJ1: A potential diagnostic, preventive and therapeutic target in non-small cell lung cancer显示文摘Lung cancer is the leading cause of cancer-related mortality throughout the world. Non-small cell lung cancer(NSCLC) accounts for 85% of all diagnosed lung cancers. Despite considerable progress in the diagnosis and treatment of the disease, the overall 5-year survival rate of NSCLC patients remains lower than 15%. The most common causes of death in lung cancer patients are treatment failure and metastasis. Therefore, developing novel strategies that target both tumour growth and metastasis is an important and urgent mission for the next generation of anticancer therapy research. Heat shock proteins(HSPs), which are involved in the fundamental defence mechanism for maintaining cellular viability, are markedly activated during environmen-tal or pathogenic stress. HSPs facilitate rapid cell division, metastasis, and the evasion of apoptosis in cancer development. These proteins are essential players in the development of cancer and are prime therapeutic targets. In this review, we focus on the current understanding of the molecular mechanisms responsible for HLJ1's role in lung cancer carcinogenesis and progression. HLJ1, a member of the human HSP 40 family, has been characterised as a tumour suppressor. Research studies have also reported that HLJ1 shows promising dual anticancer effects, inhibiting both tumour growth and metastasis in NSCLC. The accumulated evidence suggests that HLJ1 is a potential biomarker and treatment target for NSCLC. | Meng-Feng Tsai Chi-Chung Wang Jeremy JW Chen | 2014 | World Journal of Clinical Oncology2014，5，5： | 6 |
| 3 | Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions显示文摘Brain tumors are dynamic complex ecosystems with multiple cell types.To model the brain tumor microenvironment in a reproducible and scalable system,we developed a rapid three-dimensional(3D)bioprinting method to construct clinically relevant biomimetic tissue models.In recurrent glioblastoma,macrophages/microglia prominently contribute to the tumor mass.To parse the function of macrophages in 3D,we compared the growth of glioblastoma stem cells(GSCs)alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel,with or without macrophage.Bioprinted constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival,maintenance of stemness,invasion,and drug resistance.Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs,relative to sphere culture.Multicellular bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity,cellular crosstalk,invasion,context-specific functional dependencies,as well as immunologic interactions in a species-matched neural environment. | Min Tang Qi Xie Ryan C.Gimple Zheng Zhong Trevor Tam Jing Tian Reilly L.Kidwell Qiulian Wu Briana C.Prager Zhixin Qiu Aaron Yu Zhe Zhu Pinar Mesci Hui Jing Jacob Schimelman Pengrui Wang Derrick Lee Michael H.Lorenzini Deobrat Dixit Linjie Zhao Shruti B.hargava Tyler E.Miller Xueyi Wan Jing Tang Bingjie Sun Benjamin F.Cravatt Alysson R.Muotri Shaochen Chen Jeremy N.Rich | 2020 | Cell Research2020，30，10： | 6 |
| 4 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 5 | Forecasting crashes: trading volume, past returns, and conditional skewness in stock prices显示文摘 | Joseph Chen Harrison Hong Jeremy C Stein | 2001 | Journal of Financial Economics2001，，3： | 3 |
| 6 | A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs显示文摘 | Mihaela Crisan Solomon Yap Louis Casteilla Chien-Wen Chen Mirko Corselli Tea Soon Park Gabriella Andriolo Bin Sun Bo Zheng Li Zhang Cyrille Norotte Pang-Ning Teng Jeremy Traas Rebecca Schugar Bridget M. Deasy Stephen Badylak Hans-J?rg B?hring Jean-Paul Gi | 2008 | Cell Stem Cell2008，，3： | 3 |
| 7 | Objective assessment of bradykinesia in Parkinson’s disease using evolutionary algorithms:clinical validation显示文摘Background:There is an urgent need for developing objective,effective and convenient measurements to help clinicians accurately identify bradykinesia.The purpose of this study is to evaluate the accuracy of an objective approach assessing bradykinesia in finger tapping(FT)that uses evolutionary algorithms(EAs)and explore whether it can be used to identify early stage Parkinson’s disease(PD).Methods:One hundred and seven PD,41 essential tremor(ET)patients and 49 normal controls(NC)were recruited.Participants performed a standard FT task with two electromagnetic tracking sensors attached to the thumb and index finger.Readings from the sensors were transmitted to a tablet computer and subsequently analyzed by using EAs.The output from the device(referred to as'PD-Monitor')scaled from−1 to+1(where higher scores indicate greater severity of bradykinesia).Meanwhile,the bradykinesia was rated clinically using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale(MDS-UPDRS)FT item.Results:With an increasing MDS-UPDRS FT score,the PD-Monitor score from the same hand side increased correspondingly.PD-Monitor score correlated well with MDS-UPDRS FT score(right side:r=0.819,P=0.000;left side:r=0.783,P=0.000).Moreover,PD-Monitor scores in 97 PD patients with MDS-UPDRS FT bradykinesia and each PD subgroup(FT bradykinesia scored from 1 to 3)were all higher than that in NC.Receiver operating characteristic(ROC)curves revealed that PD-Monitor FT scores could detect different severity of bradykinesia with high accuracy(≥89.7%)in the right dominant hand.Furthermore,PD-Monitor scores could discriminate early stage PD from NC,with area under the ROC curve greater than or equal to 0.899.Additionally,ET without bradykinesia could be differentiated from PD by PD-Monitor scores.A positive correlation of PD-Monitor scores with modified Hoehn and Yahr stage was found in the left hand sides.Conclusions:Our study demonstrated that a simple to use device employing classifiers derived from EAs could not only be used to accurately measure different severity of bradykinesia in PD,but also had the potential to differentiate early stage PD from normality. | Chao Gao Stephen Smith Michael Lones Stuart Jamieson Jane Alty Jeremy Cosgrove Pingchen Zhang Jin Liu Yimeng Chen Juanjuan Du Shishuang Cui Haiyan Zhou Shengdi Chen | 2018 | Translational Neurodegeneration2018，7，1： | 3 |
| 8 | Innate Immune Tolerance and the Role of Kupffer Cells in Differential Responses to Interferon Therapy Among Patients with HCV Genotype 1 Infection显示文摘 | Daryl T.-Y. Lau Amina Negash Jie Chen Nanette Crochet Mala Sinha Yuhong Zhang Jeremie Guedj Sharon Holder Takeshi Saito Stanley M. Lemon Bruce A. Luxon Alan S. Perelson Michael Gale | 2012 | Gastroenterology2012，，： | 2 |
| 9 | Understanding bike trip patterns leveraging bike sharing system open data显示文摘 | Longbiao CHEN Xiaojuan MA Thi-Mai-Trang NGUYEN Gang PAN Jeremie JAKUBOWICZ | 2017 | Frontiers of Computer Science2017，11，1： | 2 |
| 10 | Forecasting crashes: trading volume, past returns, and conditional skewness in stock prices显示文摘 | Joseph Chen Harrison Hong Jeremy C Stein | 2001 | Journal of Financial Economics2001，，3： | 1 |
| 11 | Shunt current calcu- lation of fuel cell stack using Simulink-R 显示文摘 | Jeremy A Schaeffer Lea-Der Chen etc | 2008 | Journal of Power Sources2008，182，2： | 1 |
| 12 | Above ground biomass estimation in an African tropical forest with lidar and hyperspectral data显示文摘 | Gaia Vaglio Laurin Qi Chen Jeremy A. Lindsell David A. Coomes Fabio Del Frate Leila Guerriero Francesco Pirotti Riccardo Valentini | 2014 | ISPRS Journal of Photogrammetry and Remote Sensing2014，，： | 1 |
| 13 | Effectiveness, safety, and drug sustainability of biologics in elderly patients with inflammatory bowel disease: A retrospective study显示文摘BACKGROUND Biologic therapy resulted in a significant positive impact on the management of inflammatory bowel disease(IBD) however data on the efficacy and side effects of these therapies in the elderly is scant.AIM To evaluate retrospectively the drug sustainability, effectiveness, and safety of the biologic therapies in the elderly IBD population.METHODS Consecutive elderly(≥ 60 years old) IBD patients, treated with biologics [infliximab(IFX), adalimumab(ADAL), vedolizumab(VDZ), ustekinumab(UST)] followed at the McGill University Inflammatory Bowel Diseases Center were included between January 2000 and 2020.Efficacy was measured by clinical scores at 3, 6-9 and 12-18 mo after initiation of the biologic therapy. Patients completing induction therapy were included. Adverse events(AEs) or serious AE were collected during and within three months of stopping of the biologic therapy.RESULTS We identified a total of 147 elderly patients with IBD treated with biologicals during the study period, including 109 with Crohn’s disease and 38 with ulcerative colitis. Patients received the following biologicals: IFX(28.5%), ADAL(38.7%), VDZ(15.6%), UST(17%). The mean duration of biologic treatment was 157.5(SD = 148) wk. Parallel steroid therapy was given in 34% at baseline,19% at 3 mo, 16.3% at 6-9 mo and 6.5% at 12-18 mo. The remission rates at 3, 6-9 and 12-18 mo were not significantly different among biological therapies. Kaplan-Meyer analysis did not show statistical difference for drug sustainability(P = 0.195), time to adverse event(P = 0.158) or infection rates(P = 0.973) between the four biologics studied. The most common AEs that led to drug discontinuation were loss of response, infusion/injection reaction and infection.CONCLUSION Current biologics were not different regarding drug sustainability, effectiveness, and safety in the elderly IBD population. Therefore, we are not able to suggest a preferred sequencing order among biologicals. | Gustavo Drugg Hahn Jean-Frederic LeBlanc Petra Anna Golovics Panu Wetwittayakhlang Abdulrahman Qatomah Anna Wang Levon Boodaghians Jeremy Liu Chen Kiow Maryam Al Ali Gary Wild Waqqas Afif Alain Bitton Peter Laszlo Lakatos Talat Bessissow | 2022 | World Journal of Gastroenterology2022，28，33： | 1 |
| 14 | Combined optical and atropine penalization for the treatment of strabismic and anisometropic amblyopia显示文摘 | Stephen B. Kaye Sean I. Chen Gary Price Lesley C. Kaye Carmel Noonan Ajay Tripathi Pammal Ashwin Nolan Cota David Clark Jeremy Butcher | 2002 | Journal of AAPOS2002，，5： | 1 |
| 15 | Radiogenomic Analysis to Identify Imaging Phenotypes Associated with Drug Response Gene Expression Programs in Hepatocellular Carcinoma显示文摘 | Michael D. Kuo Jeremy Gollub Claude B. Sirlin Clara Ooi Xin Chen | 2007 | Journal of Vascular and Interventional Radiology2007，，7： | 1 |
| 16 | Stable chloroplast transformation in cabbage (Brassica oleracea L. var. capitata L.) by particle bombardment显示文摘 | Cheng-Wei Liu Chin-Chung Lin Jeremy J. W. Chen Menq-Jiau Tseng | 2007 | Plant Cell Reports2007，，10： | 1 |
| 17 | The sources of heat generation in vibrothermography显示文摘 | Jeremy Renshaw John C. Chen Stephen D. Holland R. Bruce Thompson | 2011 | NDT and E International2011，，8： | 1 |
| 18 | Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial显示文摘 | John J Bissler J Christopher Kingswood El?bieta Radzikowska Bernard A Zonnenberg Michael Frost Elena Belousova Matthias Sauter Norio Nonomura Susanne Brakemeier Petrus J de Vries Vicky H Whittemore David Chen Tarek Sahmoud Gaurav Shah Jeremie Lincy David | 2013 | The Lancet . 2013 (9869)2013，，： | 1 |
| 19 | Electrocardiographic findings in Emergency Department patients with pulmonary embolism显示文摘 | Peter B Richman Hassan Loutfi Steven J Lester Patricia Cambell Jessica Matthews Jeremy Friese Joseph Wood David Kasper Frederick Chen Mark Mandell | 2004 | Journal of Emergency Medicine2004，，2： | 1 |
| 20 | Strengthened Regulation of the Onset of the South China Sea Summer Monsoon by the Northwest Indian Ocean Warming in the Past Decade显示文摘Traditionally,a delayed(early)onset of the South China Sea summer monsoon(SCSSM)has been observed to follow a warm(cold)El Niño-Southern Oscillation(ENSO)event in winter,supporting high seasonal predictability of SCSSM onset.However,the empirical seasonal forecasting skill of the SCSSM onset,solely based on ENSO,has deteriorated since 2010.Meanwhile,unexpected delayed onsets of the SCSSM have also occurred in the past decade.We attribute these changes to the Northwest Indian Ocean(NWIO)warming of the sea surface.The NWIO warming has teleconnections related to(1)suppressing the seasonal convection over the South China Sea,which weakens the impacts of ENSO on SCSSM onset and delays the start of SCSSM,and(2)favoring more high-frequency,propagating moist convective activities,which enhances the uncertainty of the seasonal prediction of SCSSM onset date.Our results yield insight into the predictability of the SCSSM onset under the context of uneven ocean warming operating within the larger-scale background state of global climate change. | Yang AI Ning JIANG Weihong QIAN Jeremy Cheuk-Hin LEUNG Yanying CHEN | 2022 | Advances in Atmospheric Sciences2022，39，6： | 1 |
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