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| 1 | Effect of vitamin E and human placenta cysteine peptidase inhibitor on expression of cathepsins B and L in implanted hepatoma Morris 5123 tumor model in Wistar rats显示文摘AIM: To examine the effectiveness of human placental inhibitors, by injecting vitamin E to rats with transplanted Norris-5123 hepatoma, on the expression of cathepsins B and L in tumor, liver, lung and blood sera after transplantation of Norris 5123 hepatoma.METHODS: Animals were divided into 10 groups receiving three different concentrations of vitamin E and inhibitors along or in combination and compared with negative control (healthy rats) and positive control (tumor rats). Effectiveness of treatment was evaluated with regard to survival time,tumor response and determination of the activities of proteolytic enzymes and their inhibitors using flurogenic substrates.RESULTS: Cathepsins B and L activities were elevated by 16-fold in comparison with negative control tissues, and their endogenous inhibitor activity decreased by 1.2-fold before treatment. In several cases, tumors completely disappeared following vitamin E plus human placental cyteine protease inhibitor (CPI) compared with controls.The number of complete tumor responses was higher when 20 m/kg vitamin E plus 400 μg of CPI was used, i.e.7/10 rats survived more than two mo. Cathepsins B and L were expressed significantly in tumor, liver, lung tissues and sera in parallel to the increasing of the endogenous inhibitor activity compared with the controls after treatment (P<0.0001).CONCLUSION: The data indicate formation of metastasis significantly reduced in treated rats, which might provide a therapeutic basis for anti-cancer therapy. | Tadeusz Sebzda Piotr Hanczyc Yousif Saleh Bernice F Akinpelumi Maciej Siewinski Jerzy Rudnicki | 2005 | World Journal of Gastroenterology2005，11，4： | 2 |
| 2 | Circulating vascular endothelial growth factor and its soluble receptors in patients with liver cirrhosis: Possible association with hepatic function impairment显示文摘 | JERZY J MARCIN J ROBERT F | 2008 | Cytokine2008，44，1： | 1 |
| 3 | Interactions of egg yolk lipo protein fraction with boar spermatozoa assessed with a fluo rescent memberane probe显示文摘 | Leyland F Lukasz Z Jerzy S | 2010 | Folia histochemiea et cytobio logiea2010，48，2： | 1 |
| 4 | Volumetric intravascular ultrasound evidence that distal embolization during acute infarct intervention contributes to inadequate myocardial perfusion grade显示文摘 | Jun-ichi Kotani Gary S Mintz Jerzy Pregowski Lukasz Kalinczuk Augusto D Pichard Lowell F Satler William O Suddath Ron Waksman Neil J Weissman | 2003 | The American Journal of Cardiology2003，，： | 1 |
| 5 | Heuristic algorithm for integrated allocation and transportation in three-stage supply network显示文摘 | GRZEGORZ F JERZY J | | 0，，： | 1 |
| 6 | An improved synthesis of galanthamine 显示文摘 | JERZY S ANITA H L CARROLL F I | 1988 | Journal Hete-rocylic Chemistry1988，25，： | 1 |
| 7 | Interactions between potato leafroll virus and potato plants and their implications for assessment of infection resistance 显示文摘 | Bogdan F Jerzy S Iwona W | 2005 | American Journal of Potato Research2005，82，： | 1 |
| 8 | XRD and 29 Si MAS NMR spectroscopic studies of carbon materials obtained from pyrolyses of a coal tar pitch modified with various silicon-bearing additives显示文摘 | Cezary Czosnek Wiktoria Ratuszek Jerzy F Janik Zbigniew Olejniczak | 2002 | Fuel Processing Technology2002，，3： | 1 |
| 9 | The influence of carbon nanotubes on the corrosion behaviour of AZ31B magnesium alloy显示文摘 | HIROYUKI F JERZY A S KATSUYOSHI K RICHARD C | 2010 | Corrosion Science2010，52，12： | 1 |
| 10 | Diffractive scanning mechansim for laser marker显示文摘 | Edward F P Jerzy S W Krzysztof M A | 2000 | Optics & Loser Technology2000，32，： | 1 |
| 11 | Perfluorooctanesulfonate and related fluorinated hydrocarbons in marine mammals, fishes, and birds from coasts of the Baltic and the Mediterranean seas显示文摘 | Kurunthachalam K Simonetta C Jerzy F Giinter O Silvano F Giesy JP | 2002 | Environmental Science Technology2002，36，15： | 1 |
| 12 | Biocompatibility studies of new muhiblock poly (ester-ester) s composed of poly ( butylene terephthalate) and dimerized fatty acid 显示文摘 | Piotr P Miroslawa E F Jerzy S | 2002 | Biomaterials2002，23，14： | 1 |
| 13 | Solar chimney power generation project:the case for Botswana显示文摘 | CLEVER K JERZY K F OMPHEMETSE O S | 2008 | Renewable and Sustainable Energy Reviews2008，12，7： | 1 |
| 14 | 显示文摘 | Jerzy RN Beate K Manfred F | 2001 | Athero sclerosis2001，161，： | 1 |
| 15 | Dynamics of water droplet distortion and breakup in a uniform electric field显示文摘 | Kazimierz A Jerzy M F | 2011 | IEEE Transactions on Industry Application2011，47，6： | 1 |
| 16 | Leptin: the tale of an obesity gene显示文摘 | Jose F Caro Madhur K Sina Jerzy W | 1996 | Diabetes1996，45，8： | 1 |
| 17 | Calculation of Phase Equilibria for AISI M2 High-speed Steel显示文摘 | Goiczewski Jerzy Fischmeister Hellmut F | 1992 | Steel Research1992，63，8： | 1 |
| 18 | Numerical investigation of reaction zone structure and flame lift off of DI diesel sprays with complex chemistry显示文摘 | Tao F Jerzy C | 2002 | SAE Transactions2002，111，3： | 1 |
| 19 | Is fish a major source of fluorinated surfactants and repellents in humans living on the baltic coast 显示文摘 | Jerzy F Sachi T Anna G | 2006 | Environmental Science & Technology2006，40，： | 1 |
| 20 | Mobility of Trace Elements from Selected Australian Fly Ashes and Its Potential Impact on Aquatic Ecosystems 显示文摘 | Jerzy J Colin R W David F | 2006 | Fuel2006，85，2： | 1 |
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