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| 1 | The constraints of strain partitioning and geochronology in Luonan-Luanchuan tectonic belts on Qinling orogenic belt显示文摘The Luonan-Luanchuan tectonic belt lies between the North China Block and Qinling Mountains, in- cluding the Luonan-Luanchuan fault zone and the strong deformation zone to the north of the fault. The ductile shear zone, imbricate brittle fault and duplex structure in the fault zone now are the expression of the same tectonic event in different depth. Such lineation structure exists in the tectonic belts as mineral lineation, elongation lineation, crenulation lineation, sheath folds and so on, indicating NE-directed plate motion. Fold axes and thrusts in the strong deformation zone are inclined to the Luonan-Luanchuan fault zone at small angles. The structures with different natures show a regular pattern, produced during oblique convergence of plates. The convergence factors are as follows:The direction of plate convergence is 22°, 31° and the angle between the plate convergence direction and plate boundary is 73°, 82° respectively in the west and east segment. The Luonan-Luanchuan tectonic belt was deformed strongly in 372 Ma, resulted from Erlangping back-arc ocean basin subduction sin- istrally and obliquely to North China Block during the collision of North China Block and South China Block. | SONG ChuanZhong ZHANG GuoWei WANG YongSheng LI JiaHao CHEN ZeChao CAI ZhiChuan | 2009 | Science China Earth Sciences2009，52，3： | 9 |
| 2 | Recent progress of two-dimensional nanosheet membranes and composite membranes for separation applications显示文摘Two-dimensional(2D)materials have emerged as a class of promising materials to prepare high-performance 2D membranes for various separation applications.The precise control of the interlayer nano-channel/sub-nanochannel between nanosheets or the pore size of nanosheets within 2D membranes enables 2D membranes to achieve promising molecular sieving performance.To date,many 2D membranes with high permeability and high selectivity have been reported,exhibiting high separation performance.This review presents the development,progress,and recent breakthrough of different types of 2D membranes,including membranes based on porous and non-porous 2D nanosheets for various separations.Separation mechanism of 2D membranes and their fabrication methods are also reviewed.Last but not the least,challenges and future directions of 2D membranes for wide utilization are discussed in brief. | Wei Wang Yanying Wei Jiang Fan Jiahao Cai Zong Lu Li Ding Haihui Wang | 2021 | Frontiers of Chemical Science and Engineering2021，15，4： | 2 |
| 3 | Ru/NC heterointerfaces boost energy-efficient production of green H_(2)over a wide pH range显示文摘Green hydrogen(H_(2))is an import energy carrier due to the zero-carbon emission in the energy cycle.Nevertheless,green H_(2)production based on electrolyzer and photovoltaics(EZ/PV)remains limited due to the highly pH-dependant and energy exhausting overall water splitting.Herein,we report a series of Ru-nanocluster-modified mesoporous nanospheres(Rux@mONC)as pH-universal electrocatalysts towards both hydrogen evolution reaction(HER)and hydrazine oxidation reaction(HzOR).The optimal catalyst Ru_(2)0@mONC realizes remarkable catalytic activity and stability towards both HER and HzOR regardless of electrolytes.As a result,the electrode pair of Ru_(2)0@mONC//Ru_(2)0@mONC requires low cell-potentials of 39/429,405/926,and 164/1,141 mV to achieve the current density of 10/100 mA·cm^(−2),as well as the long-term stability for HzOR assisted electrochemical water splitting in alkaline,acidic,and neutral media,respectively.Those performances are more promising compared to the state-of-the-art electrocatalysts so far reported.A proof-of-concept test demonstrates an efficient production of green H_(2)powered by a single-junction silicon solar cell,which may inspire the use of a cost-effective EZ/PV system.Furthermore,a combined spectroscopic and theoretical study verifies the formation of abundant Ru/NC heterointerfaces in Ru_(2)0@mONC,which not only contributes to the balancing of H*adsorption/desorption in HER but also facilitates the*N_(2)H_(2)dehydrogenation in HzOR. | Qifeng Yang Botao Zhu Feng Wang Cunjin Zhang Jiahao Cai Peng Jin Lai Feng | 2022 | Nano Research2022，15，6： | 1 |
| 4 | Identification of publication characteristics and research trends in the management of gallbladder cancer显示文摘Background:To date,no comprehensive analysis of gallbladder cancer(GBC)management has been reported.We aimed to identify the publication characteristics and research trends in managing GBC over the past three decades.Methods:We selected the 100 most cited articles and performed a bibliometric analysis to summarize the publication characteristics,explore research hotspots,and identify research trends in the management of GBC.Results:The total citations of the included articles ranged from 123 to 1822.Period II(2001–2010)yielded the highest number of included articles,whereas the lowest was in Period III(2011–2020).The United States and Japan published the most papers,in which the Memorial Sloan–Kettering Cancer Center and Nagoya University were the leading institutions,respectively.The most influential authors were Blumgart LH and Fong YM from the United States.Cooperation among countries,institutions,and authors was weak.The Annals of Surgery contributed the most articles with the highest number of total citations.The most researched topic was surgery,followed by systemic therapy and adjuvant therapy.Since Period I,the percentage of surgery-related publications continuously decreased(Periods II and III versus Period I,both p<0.001),with a concomitant increase in those of adjuvant therapy(Period III versus Period I,p=0.004)and systemic therapy(Period II versus Period I,p=0.004;Period III versus Period I,p=0.002).Conclusions:Surgery remains the preferred treatment,while there is a tendency toward adjuvant and systemic therapy in GBC management.An increase in local and international collaboration for managing GBC is required. | Jiasheng Cao Jiahao Hu Jiliang Shen Bin Zhang Win Topatana Shijie Li Tianen Chen Sarun Jeungpanich Yitong Tian Ziyi Lu Shuyou Peng Xiujun Cai Mingyu Chen | 2022 | iLIVER2022，1，2： | 0 |
| 5 | The Combined Impact of Magnetic Field and Chloride Ion Concentration on Corrosion Behavior of Al-Mg Alloys显示文摘The impact of magnetic field on the corrosion behavior of Al-Mg-xR_(E)/Fe alloys in NaCl solutions with concentrations of 1.5wt%,3.5wt%,and 5.5wt%were studied by microstructure observation,immersion test,and electrochemical test.The combined impacts of magnetic field and chloride ion concentration on the corrosion behavior of Al-Mg alloys with various electrode potential phases were discussed.The results indicate that Al-3.0Mg-xR_(E)/Fe alloys corrode faster and have a higher pitting corrosion potential in the NaCl solution with a higher concentration.In addition,a magnetic field can lower the pitting sensitivity and corrosion rate of Al-3.0Mg and Al-3.0Mg-0.2R_(E)/Fe alloys in NaCl solution with different concentrations.However,at a higher concentration of NaCl solution,the magnetic field has a weaker inhibiting effect on corrosion rate and pitting sensitivity.In NaCl solutions with concentrations of 1.5wt%and 3.5wt%,the corrosion rate and pitting sensitivity of Al-3.0Mg-1.0R_(E)/Fe alloys can be reduced by a magnetic field.However,in NaCl solution with the concentration of 5.5wt%,the corrosion rate of the alloys is increased by a magnetic field. | 张欣 HUANG Lianpeng TAO Jiahao WANG Zehua ZHOU Zehua CAI Xin WEN Tao | 2022 | Journal of Wuhan University of Technology(Materials Science)2022，37，6： | 0 |
| 6 | Two-dimensional(n=1)ferroelectric film solar cells显示文摘Molecular ferroele ctrics that have excellent ferroelectric properties,a low processing temperature,narrow bandgap,and which are lightweight,have shown great potential in the photovoltaic field.However,two-dimensional(2D)perovskite solar cells with high tunability,excellent photo-physical properties and superior long-term stability are limited by poor out-of-plane conductivity from intrinsic multi-quantum-well electronic structures.This work uses 2D molecular ferroelectric film as the absorbing layer to break the limit of multiple quantum wells.Our 2D ferroelectric solar cells achieve the highest open-circuit voltage(1.29 V)and the best efficiency(3.71%)among the 2D(n=1)Ruddlesden-Popper perovskite solar cells due to the enhanced out-of-plane charge transport induced by molecular ferroelectrics with a strong saturation polarization,high Curie temperature and multiaxial characteristics.This work aims to break the inefficient out-of-plane charge transport caused by the limit of the multi-quantum-well electronic structure and improve the efficiency of 2D ferroelectric solar cells. | Chen Wang Jiahao Gu Jun Li Jianyu Cai Lutao Li Junjie Yao Zheng Lu Xiaohan Wang Guifu Zou | 2023 | National Science Review2023，10，7： | 0 |
| 7 | Development of synthetic lethality in cancer:molecular and cellular classification显示文摘Recently,genetically targeted cancer therapies have been a topic of great interest.Synthetic lethality provides a new approach for the treatment of mutated genes that were previously considered unable to be targeted in traditional genotype-targeted treatments.The increasing researches and applications in the clinical setting made synthetic lethality a promising anticancer treatment option.However,the current understandings on different conditions of synthetic lethality have not been systematically assessed and the application of synthetic lethality in clinical practice still faces many challenges.Here,we propose a novel and systematic classification of synthetic lethality divided into gene level,pathway level,organelle level,and conditional synthetic lethality,according to the degree of specificity into its biological mechanism.Multiple preclinical findings of synthetic lethality in recent years will be reviewed and classified under these different categories.Moreover,synthetic lethality targeted drugs in clinical practice will be briefly discussed.Finally,we will explore the essential implications of this classification as well as its prospects in eliminating existing challenges and the future directions of synthetic lethality. | Shijie Li Win Topatana Sarun Juengpanich Jiasheng Cao Jiahao Hu Bin Zhang Diana Ma Xiujun Cai Mingyu Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 8 | Acid-Stable CoWO_(4)/WO_(3)-Microrod Coated by a Thin Carbon-Layer as Efficient Pt Co-Catalysts for Methanol Oxidation and Oxygen Reduction显示文摘Insufficient activity and instability(poisoning)of Pt-based electrocatalysts for methanol oxidation and oxygen reduction reactions(MOR/ORR)impede the development of direct methanol fuel cells.Here,CoWO_(4) nanoparticles-loaded WO_(3) microrods coated by a thin carbon-layer are used as Pt-supports/co-catalysts for MOR/ORR.WO_(3) grows along the(110)crystal plane to form microrod(diameter of~0.6 um),which is coated by a carbon-layer(~5 nm).Pt-CoWO_(4)/WO_(3)@NCL-mr(850℃)shows a higher mass activity(2208 mA mg^(-1)_(pt))than the commercial Pt/C(659.4 mA mg^(-1)_(pt)).CoWO_(4)/WO_(3) heterojunction on the microrod surface with abundant oxygen vacancies allows the generation of surface-adsorbed hydroxyl to facilitate CO elimination and regeneration of the occupied Pt active-sites(promising stability).PtCo WO_(4)/WO_(3)@NCL-mr(850℃)has higher half-wave(0.46 V)and onset(0.54 V)potentials than Pt/C(0.41 and 0.50 V)for ORR.The microrod structure of Co WO_(4)/WO_(3)@NCL facilitates the dispersibility of Pt NPs to increase the utilization of Pt active sites and relieve the self-aggregation of Pt to obtain a promising synergy between Pt and CoWO_(4)(Co^(2+))for ORR in acid media.This study provides insights not only into the synthesis of acid-resistant WO_(3)@NCL microrod as active Pt co-catalyst,but also into the effective utilization of surface oxygen vacancies and Co^(2+) for MOR/ORR. | Jiahuan Li Jiahao Xie Xinyu Wang Ying Dai Xiaoqin Xu Jin Liu Zhuang Cai Xin Meng Jinlong Zou | 2022 | Chinese Journal of Structural Chemistry2022，41，7： | 0 |
| 9 | Study on Optimization of Passenger Flow at a Metro Station Based on AnyLogic-Case Study of Youfangqiao Station of Nanjing Metro Line 2显示文摘In this study,simulation software AnyLogic was used to establish a station simulation model for a metro line.First,a basic model of the environment of the metro station was drawn,and accordingly,reasonable assumptions and simplifications were proposed.Then,a diagram of the passenger walking path was created and the simulation variables and functions for passenger flow management were designed.Considering Youfangqiao Station of Nanjing Metro Line 2 in China as an example,the real passenger flow data of this station were statistically analyzed.To simulate the station passenger flow management,input parameters such as the passenger space diameter,passenger flow generation rate,delay rate of automatic fare collection equipment and security check machine,and the number of gates were considered.Passenger flow management was optimized for the morning and evening peak periods,and reasonable suggestions were proposed based on the optimization results,providing a theoretical basis for the construction planning and pre-evaluation of station operation capacities of urban rail transit systems. | Weihong Ni Jiahao Yu Hong Cai Meimei Bai Bin Wu | 2021 | Complex System Modeling and Simulation2021，1，3： | 0 |
| 10 | Two-dimensional Cu-porphyrin nanosheet membranes for nanofiltration显示文摘A kind of two-dimensional(2D)metal-organic framework(MOF)material,Cu-meso-tetrakis(4-carboxyphenyl)porphine(Cu-TCPP)nanosheets with wrinkled and flat morphologies are used as building blocks to assemble membranes by vacuum filtration(VF)and electrophoretic deposition(EPD)as energy-efficient nanofiltration(NF)membranes to remove dyes from water.Since the nanosheets with wrinkled structure can provide additional water transport channels,thereby increasing the water permeance,in the premise of a high rejection(>97.0%)for the dye brilliant blue G(BBG)(1.60 nm×1.90 nm),the water permeance of the membrane assembled by the wrinkled nanosheets(~1170 nm)is about 4 times that of the membrane assembled by the flat nanosheets(~530 nm),reaching 16.39 L·m^(−2)·h^(−1)·bar^(−1).Additionally,the use of the relatively flat nanosheets and the membrane preparation method of electrophoretic deposition is more conducive to stack nanosheets orderly and reduce defects.Therefore,the water permeance of the membrane prepared by EPD(~1170 nm)with flat nanosheets is about twice that of the membrane prepared by VF(~530 nm),achieving 9.40 L·m^(−2)·h^(−1)·bar^(−1)with similar rejection(>97.0%)of dye evans blue(EB)(3.10 nm×1.20 nm).Furthermore,these membranes still exhibit good separation performance at high pressure of 0.6 MPa.Nanosheets with diverse structures and various membrane fabrication processes provide new directions for the separation performance optimization of 2D MOF materials for water purification. | Jiahao Cai Shizheng Song Lijie Zhu Qipeng Lu Zong Lu Yanying Wei Haihui Wang | 2023 | Nano Research2023，16，5： | 0 |
| 11 | Prognostic model for prostate cancer based on glycolysis-related genes and non-negative matrix factorization analysis显示文摘Background:Establishing an appropriate prognostic model for PCa is essential for its effective treatment.Glycolysis is a vital energy-harvesting mechanism for tumors.Developing a prognostic model for PCa based on glycolysis-related genes is novel and has great potential.Methods:First,gene expression and clinical data of PCa patients were downloaded from The Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO),and glycolysis-related genes were obtained from the Molecular Signatures Database(MSigDB).Gene enrichment analysis was performed to verify that glycolysis functions were enriched in the genes we obtained,which were used in nonnegative matrix factorization(NMF)to identify clusters.The correlation between clusters and clinical features was discussed,and the differentially expressed genes(DEGs)between the two clusters were investigated.Based on the DEGs,we investigated the biological differences between clusters,including immune cell infiltration,mutation,tumor immune dysfunction and exclusion,immune function,and checkpoint genes.To establish the prognostic model,the genes were filtered based on univariable Cox regression,LASSO,and multivariable Cox regression.Kaplan–Meier analysis and receiver operating characteristic analysis validated the prognostic value of the model.A nomogram of the risk score calculated by the prognostic model and clinical characteristics was constructed to quantitatively estimate the survival probability for PCa patients in the clinical setting.Result:The genes obtained from MSigDB were enriched in glycolysis functions.Two clusters were identified by NMF analysis based on 272 glycolysis-related genes,and a prognostic model based on DEGs between the two clusters was finally established.The prognostic model consisted of LAMPS,SPRN,ATOH1,TANC1,ETV1,TDRD1,KLK14,MESP2,POSTN,CRIP2,NAT1,AKR7A3,PODXL,CARTPT,and PCDHGB2.All sample,training,and test cohorts from The Cancer Genome Atlas(TCGA)and the external validation cohort from GEO showed significant differences between the high-risk and low-risk groups.The area under the ROC curve showed great performance of this prognostic model.Conclusion:A prognostic model based on glycolysis-related genes was established,with great performance and potential significance to the clinical application. | ZECHAO LU FUCAI TANG HAOBIN ZHOU ZEGUANG LU WANYAN CAI JIAHAO ZHANG ZHICHENG TANG YONGCHANG LAI ZHAOHUI HE | 2023 | BIOCELL2023，47，2： | 0 |
| 12 | Atomistic simulation study of favored compositions of Ni-Nb-Al metallic glasses显示文摘This study investigates the formation process of Ni-Nb-Al metallic glasses. To this end, a long-range n-body potential was constructed for the Ni-Nb-Al ternary metal system, and applied to atomistic simulations. The simulations not only showed the physical origins of the amorphous phase formation, but also quantitatively predicted a hexagonal compositional region that energetically favors the glass formation. The energy difference between the solid solution and metallic glass, which generates the amorphization driving force(ADF), was suggested to indicate the glass-formation ability(GFA) of each alloy. Based on the computed ADFs, the Ni55 Nb25 Al20 alloy exhibited the highest GFA among the Ni-Nb-Al members, implying that the glass formed by this amorphous alloy is more thermodynamically stable than other alloys in the system. In a Voronoi tessellation analysis, the knee point of the coordination-number distribution curve corresponded to the glass-formation region of the Ni-NbAl system. | CAI Bei YANG MengHao LIU JianBo LI JiaHao LIU BaiXin | 2018 | Science China(Technological Sciences)2018，61，12： | 0 |
| 13 | Causal relationship between 14 site-specific cancers and venous thromboembolism显示文摘Background:It has been observed that cancer and venous thromboembolism(VTE)are associated,but anticancer therapy may violate the causality.Therefore,this study aimed to elucidate the causal relationship of various cancers to VTE using Mendelian randomization(MR).Methods:Three MR methods were used to estimate causal effects:Inverse variance weighted(IVW),MR-Egger and weighted median.Sensitivity analyses included Cochran's Q-test,MR-Egger intercept test and MRPRESSO.Gene ontology enrichment analysis was performed to elucidate the underlying mechanisms of VTE development in cancer patients.Results:The primary IVW approach showed that non-Hodgkin's lymphoma(NHL)might increase the risk of VTE(odds ratio[OR]:1.20,95%confidence interval[95%CI]:1.00–1.44,p=0.045),while melanoma possibly reduced the risk of VTE(OR:0.89,95%CI:0.82–0.97,p=0.006),although there was no significance after adjustment for multiple testing.No association was observed between VTE risk and other site-specific cancers.Gene ontology enrichment analysis revealed that vitamin D played an important role in the development of VTE in cancer patients.Conclusions:Our findings suggested that genetically predicted NHL was associated with higher VTE risk,whereas melanoma had lower VTE risk compared with other site-specific cancers.Moreover,this study suggested that anticancer therapy and increased extensive examination might play a more important role in VTE development than the nature of cancer. | Xiong Chen Xiaosi Hong Shulu Luo Jiahao Cai Guiwu Huang Runnan Shen Lin Lv Gaochen Bai Wen Fu Li Yan Guochang Liu Kai Huang Qinchang Chen | 2022 | Cancer Innovation2022，1，4： | 0 |
| 14 | The mitophagy pathway and its implications in human diseases显示文摘Mitochondria are dynamic organelles with multiple functions.They participate in necrotic cell death and programmed apoptotic,and are crucial for cell metabolism and survival.Mitophagy serves as a cytoprotective mechanism to remove superfluous or dysfunctional mitochondria and maintain mitochondrial fine-tuning numbers to balance intracellular homeostasis.Growing evidences show that mitophagy,as an acute tissue stress response,plays an important role in maintaining the health of the mitochondrial network.Since the timely removal of abnormal mitochondria is essential for cell survival,cells have evolved a variety of mitophagy pathways to ensure that mitophagy can be activated in time under various environments.A better understanding of the mechanism of mitophagy in various diseases is crucial for the treatment of diseases and therapeutic target design.In this review,we summarize the molecular mechanisms of mitophagy-mediated mitochondrial elimination,how mitophagy maintains mitochondrial homeostasis at the system levels and organ,and what alterations in mitophagy are related to the development of diseases,including neurological,cardiovascular,pulmonary,hepatic,renal disease,etc.,in recent advances.Finally,we summarize the potential clinical applications and outline the conditions for mitophagy regulators to enter clinical trials.Research advances in signaling transduction of mitophagy will have an important role in developing new therapeutic strategies for precision medicine. | Shouliang Wang Haijiao Long Lianjie Hou Baorong Feng Zihong Ma Ying Wu Yu Zeng Jiahao Cai Da-wei Zhang Guojun Zhao | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
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