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| 1 | Identification of Odor Volatile Compounds and Deodorization ofPaphia undulata Enzymatic Hydrolysate显示文摘Unfavorable fishy odour is an inevitable problem in aquatic products. In the present study, headspace solid-phase microextraction gas chromatography mass spectrometry(HS-SPME-GC-MS) analysis of volatiles from untreated samples and three deodorized samples(under the optimal conditions) of Paphia undulata enzymatic hydrolysate revealed that the compounds contributing to the distinctive odor were 1-octen-3-ol, n-hexanal, n-heptanal, 2,4-heptadienal, and 2,4-decadienal, whereas n-pentanal, n-octanal, n-octanol, benzaldehyde, 2-ethylfuran and 2-pentylfuran were the main contributors to the aromatic flavor. The deodorizing effects of activated carbon(AC) adsorption, yeast extract(YE) masking and tea polyphenol(TP) treatment on a P. undulata enzymatic hydrolysate were investigated using orthogonal experiments with sensory evaluation as the index. The following optimized deodorization conditions were obtained: AC adsorption(35 mg mL^(-1), 80℃, 40 min), YE masking(7 mg mL^(-1), 45℃, 30 min) and TP treatment(0.4 mg mL^(-1), 40℃, 50 min). AC adsorption effectively removed off-flavor volatile aldehydes and ketones. YE masking modified the odor profile by increasing the relative contents of aromatic compounds and decreasing the relative contents of aldehydes and ketones. The TP treatment was not effective in reducing the odor score, but it significantly reduced the relative content of aldehydes while increasing that of alkanes. It is also notable that TP effectively suppressed trimethylamine(TMA) formation in a P. undulate hydrolysate solution for a period of 72 h. | CHEN Deke CHEN Xin CHEN Hua CAI Bingna WAN Peng ZHU Xiaolian SUN Han SUN Huili PAN Jianyu | 2016 | Journal of Ocean University of China2016，15，6： | 10 |
| 2 | Ultrasonic Extraction of Polysaccharides from Laminaria japonica and Their Antioxidative and Glycosidase Inhibitory Activities显示文摘In the present study, ultrasonic extraction technique(UET) is used to improve the yield of polysaccharides from Laminaria japonica(LJPs). And their antioxidative as well as glycosidase inhibitory activities are investigated. Box-Behnken design(BBD) combined with response surface methodology(RSM) is applied to optimize ultrasonic extraction for polysaccharides. The optimized conditions are obtained as extraction time at 54 min, ultrasonic power at 1050 W, extraction temperature at 80℃ and ratio of material to solvent at 1:50(g m L-1). Under these optimal ultrasonic extraction conditions, an actual experimental yield(5.75% ± 0.3%) is close to the predicted result(5.67%) with no significant difference(P > 0.05). Vitro antioxidative and glycosidase inhibitory activities tests indicate that the crude polysaccharides(LJP) and two major ethanol precipitated fractions(LJP1 and LJP2) are in a concentration-dependent manner. LJP2(30%-60% ethanol precipitated polysaccharides) possesses the strongest α-glucosidase inhibitory activity and moderate scavenging activity against hydroxyl radicals(66.09% ± 2.19%, 3.0 mg m L-1). Also, the inhibitory activity against α-glucosidase(59.08% ± 3.79%, 5.0 mg m L-1) is close to that of acarbose(63.99% ± 3.27%, 5.0 mg m L-1). LJP1(30% ethanol precipitated polysaccharides) exhibits the strongest scavenging activity against hydroxyl radicals(99.80% ± 0.00%, 3.0 mgm L-1) and moderate α-glucosidase inhibitory activity(47.76% ± 1.92%, 5.0 mg m L-1). LJP shows the most remarkable DPPH scavenging activity(66.20% ± 0.11%, 5.0 mg m L-1) but weakest α-glucosidase inhibitory activity(37.77% ± 1.30%, 5.0 mg m L-1). However, all these LJPs exert weak inhibitory effects against α-amylase. These results show that UET is an effective method for extracting bioactive polysaccharides from seaweed materials. LJP1 and LJP2 can be developed as a potential ingredient in hypoglycemic agents or functional food for the management of diabetes. This study provides scientific evidence and advances in the preparation technology and a hypoglycemic activities evaluation method for seaweed polysaccharides, especially glycosidase inhibition in combination with an antioxidative activity evaluation method. | WAN Peng YANG Xiaoman CAI Bingna CHEN Hua SUN Huili CHEN Deke PAN Jianyu | 2015 | Journal of Ocean University of China2015，14，4： | 6 |
| 3 | Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population显示文摘 | Yanli Li Shen-Chih Chang Binh Y. Goldstein William L. Scheider Lin Cai Nai-Chieh Y. You Heather P. Tarleton Baoguo Ding Jinkou Zhao Ming Wu Qingwu Jiang Shunzhang Yu Jianyu Rao Qing-Yi Lu Zuo-Feng Zhang Lina Mu | 2011 | Cancer Epidemiology2011，，4： | 2 |
| 4 | Mitochondrial 12S rRNA variants in 1642 Han Chinese pediatric subjects with aminoglycoside-induced and nonsyndromic hearing loss显示文摘 | Jianxin Lu Zhiyuan Li Yi Zhu Aifen Yang Ronghua Li Jing Zheng Qin Cai Guanghua Peng Wuwei Zheng Xiaowen Tang Bobei Chen Jianfu Chen Zhisu Liao Li Yang Yongyan Li Junyan You Yu Ding Hong Yu Jindan Wang Dongmei Sun Jianyue Zhao Ling Xue Jiying Wang Min-Xin | 2010 | Mitochondrion2010，，4： | 1 |
| 5 | Trimethylamine Adsorption Mechanism on Activated Carbon and Removal in Water and Oyster Proteolytic Solution显示文摘In this study,seven coal-based activated carbons(ACs)were adopted to remove trimethylamine(TMA)in an aqueous solution as environmentally friendly and harmless adsorbents.The results showed that columnar AC(CAC)had a clear scale and honeycomb structures with few fragments and micropores,contributing to superior TMA removal capacity compared to granular AC(GAC)(71.67%for 6.0 mm CAC and 69.92%for 40–60 mesh GAC).In addition,the process of adsorption was accompanied by desorption,and the recommended absorbed time was 120–180 min.The short time to achieve equilibrium indicated that adsorption was kinetically controlled,and pseudo-second-order kinetics was more appropriate than pseudo-first-order kinetics in explaining the adsorption mechanism in both water and oyster enzymatic hydrolysate.The intraparticle diffusion model presented that the adsorption processes could be divided into three steps for GAC and two steps for CAC.The adsorption processes were consistent with the Freundlich model,indicating the existence of physisorption and chemisorption as multilayer adsorption.The results indicated that AC,especially CAC,has great potential for TMA elimination in aquatic product processing. | CHEN Deke WAN Peng CAI Bingna YE Ziqing CHEN Hua CHEN Xin SUN Huili PAN Jianyu | 2021 | Journal of Ocean University of China2021，20，6： | 1 |
| 6 | Ursolic acid prevents endoplasmic reticulum stress-mediated apoptosis induced by heat stress in mouse cardiac myocytes显示文摘 | Ying Yang Changwu Li Xi Xiang Zhaolai Dai Jianyu Chang Ming Zhang Hong Cai Hua Zhang Meijia Zhang Yuming Guo Zhenlong Wu | 2014 | Journal of Molecular and Cellular Cardiology2014，，： | 1 |
| 7 | Progress in the Researches on Insect Mitochondrial Genome and Analysis of Gene Order显示文摘Insect mitochondrial genome is a double-stranded circular genomes which range from 14 503 bp to 19 571 bp in size.Nearly all the sequenced insect mitochondrial genomes encode 37 genes:two for rRNAs,13 for proteins and 22 for tRNAs.This review compares and summarizes the features of complete mitochondrial genomes from 175 sequenced species of insects in 22 orders.The genomic organization, contents,gene order,and rearrangements of gene order are analyzed. | Hu Li Jianyu Gao Haiyu Liu Wanzhi Cai | 2009 | Science Foundation in China2009，17，2： | 0 |
| 8 | Two-dimensional(n=1)ferroelectric film solar cells显示文摘Molecular ferroele ctrics that have excellent ferroelectric properties,a low processing temperature,narrow bandgap,and which are lightweight,have shown great potential in the photovoltaic field.However,two-dimensional(2D)perovskite solar cells with high tunability,excellent photo-physical properties and superior long-term stability are limited by poor out-of-plane conductivity from intrinsic multi-quantum-well electronic structures.This work uses 2D molecular ferroelectric film as the absorbing layer to break the limit of multiple quantum wells.Our 2D ferroelectric solar cells achieve the highest open-circuit voltage(1.29 V)and the best efficiency(3.71%)among the 2D(n=1)Ruddlesden-Popper perovskite solar cells due to the enhanced out-of-plane charge transport induced by molecular ferroelectrics with a strong saturation polarization,high Curie temperature and multiaxial characteristics.This work aims to break the inefficient out-of-plane charge transport caused by the limit of the multi-quantum-well electronic structure and improve the efficiency of 2D ferroelectric solar cells. | Chen Wang Jiahao Gu Jun Li Jianyu Cai Lutao Li Junjie Yao Zheng Lu Xiaohan Wang Guifu Zou | 2023 | National Science Review2023，10，7： | 0 |
| 9 | Structural characterization of oligosaccharide from Spirulina platensis and its effect on the faecal microbiota in vitro显示文摘In the present study,an oligosaccharide SPO-1 from Spirulina platensis was prepared by glycosidase from a marine bacterium.The prebiotic activity of SPO-1 on the growth of Lactobacillus paracasei and Bifidobacterium animalis,and its effect on human gut microbiota were examined in vitro.The molecular weight of the tetrasaccharide SPO-1 was 650.2 Da,and it was mainly composed of glucose with α-type glycosidic linkages.The prebiotic activity score of SPO-1 was the highest for the growth of probiotic strains L.paracasei and B.animalis.Furthermore,as fermentation proceeded,SPO-1 was gradually degraded and utilized by intestinal bacteria.The results showed that after treatment with SPO-1,carbohydrate consumption and short-chain fatty acids levels were increased,especially those of i-butyric and i-valeric acids.Moreover,SPO-1 significantly promoted the abundance,diversity and composition of gut microbiota,especially stimulating the growth of Bacteroides,Escherichia-Shigella and Megamonas.In addition,the change in intestinal microbiota function predicted by phylogenetic investigation of communities by reconstruction of unobserved states(PICRUSt)after treatment with SPO-1 is mainly related to the terms“carbohydrate metabolism”and“amino acid metabolism”.These results suggest that SPO-1 is a potential oligosaccharide in regulation of intestinal microbiota. | Bingna Cai Xiangxi Yi Qian Han Jianyu Pan Hua Chen Huili Sun Peng Wan | 2022 | Food Science and Human Wellness2022，11，1： | 0 |
| 10 | Chromene-based BioAIEgens:‘in-water’synthesis,regiostructure-dependent fluorescence and ER-specific imaging显示文摘Exploration of artificial aggregation-induced emission luminogens(AIEgens)has garnered extensive interest in the past two decades.In particular,AIEgens possessing natural characteristics(BioAIEgens)have received more attention recently due to the advantages of biocompatibility,sustainability and renewability.However,the extremely limited number of BioAIEgens extracted from natural sources have retarded their development.Herein,a new class of BioAIEgens based on the natural scaffold of chromene have been facilely synthesized via green reactions in a water system.These compounds show regiostructure-,polymorphism-and substituent-dependent fluorescence,which clearly illustrates the close relationship between the macroscopic properties and hierarchical structure of aggregates.Due to the superior biocompatibility of the natural scaffold,chromene-based BioAIEgens can specifically target the endoplasmic reticulum(ER)via the introduction of tosyl amide.This work has provided a new chromene scaffold for functional BioAIEgens on the basis of green and sustainable‘in-water’synthesis,applicable regiostructure-dependent fluorescence,and effective ER-specific imaging. | Xu-Min Cai Yuting Lin Jianyu Zhang Ying Li Zhenguo Tang Xuedan Zhang Ying Jia Wenjin Wang Shenlin Huang Parvej Alam Zheng Zhao Ben Zhong Tang | 2023 | National Science Review2023，10，11： | 0 |
| 11 | Expression of Bcl-2 in cells with different telomerase activities显示文摘Both tclomerase and Bcl-2 are important genes in controlling apoptosis. The activation of telomerase and the abnormal regulation of Bcl-2 are also closely related to carcinogenesis. However, little is known about the linkage between telomerase and Bcl-2. The effect of activated telomerase on the expression of Bcl-2 has been investigated. It is demonstrated that in tumor and transformed cells with higher telomerase activity, Bcl-2 expression is significantly lower than that in telomerase negative or less telomerose activity cells. Further study showed that in the telomerase gene-transformed 2BS-fibroblasts, Bcl-2 expression is inhibited significantly while the exogenous telomerase catalyticsubunit gene is re-expressed in flbroblasts. Results indicated that there might be a certain linkage between the expression of telomerase and Bcl-2, and overexpression of exogenous telomerase gene might down regulate the expression of Bcl-2. | CHEN Jing REN Jianguo ZHENG Jianyu CAI Guoping DAI Yaoren | 2001 | Chinese Science Bulletin2001，46，23： | 0 |
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