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| 1 | Fractional Flow Reserve Guided Percutaneous Coronary ntervention Improves Clinical Outcome with Reduced Cost in Contemporary Clinical Practice显示文摘 | Po Hu Meng-Yao Tang Wen-Chao Song Jun Jiang Yong Sun Xian-Bao Liu Chang-Ling Li Xin-Yang Hu Jian-An Wang | 2015 | Chinese Medical Journal2015，，15： | 19 |
| 2 | Propofol differentially induces unconsciousness and respiratory depression through distinct interactions between GABAa receptor and GABAergic neuron in corresponding nuclei显示文摘Propofol is the most commonly used intravenous anesthetic worldwide.It can induce loss of consciousness prior to the occurrence of severe respiratory suppression,which is also a pharmacodynamic feature of all general anesthetics.However,the neural mechanisms underlying this natural phenomenon are controversial and highly related to patient safety.In the present study,we demonstrated that the pharmacodynamic effects of propofol(50 and 100 μM)on suppression of consciousness-related excitatory postsynaptic currents in the medial prefrontal cortex(mPFC)and centromedian nucleus of the thalamus(CMT)were lower than those in the kernel respiratory rhythmogenesis nucleus pre-Botzinger complex(PrBo).Furthermore,we unexpectedly found that the GABAa receptor β3 subunit is the key target for propofol's action and that it is mutually and exclusively expressed in GABAergic neurons.It is also more abundant in the mPFC and CMT,but mainly co-localized with GABAergic neurons in the PrBo.As a result,the differentiated expression pattern should mediate more neuron suppression through the activation of GABAergic neurons in the mPFC and CMT at low doses of propofol(50 μM).However,PrBo GABAergic neurons were only activated by propofol at a high dose(100 μM).These results highlight the detailed pharmacodynamic effects of propofol on consciousness-related and respiration-related nuclei and provide the distinct interaction mechanism between the β3 subunit and GABAergic neurons in mediating the suppression of consciousness compared to the inhibition of respiration. | Junli Jiang Yingfu Jiao Po Gao Wen Yin Wei Zhou Yunchun Zhang Yanjun Liu Daxiang Wen Yuan Wang Liang Zhou Tian Yu Weifeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 11 |
| 3 | 太极锻炼对血脂的临床疗效:随机对照试验的meta分析(英文)显示文摘目的:探讨太极锻炼是否能改善血脂水平。创新点:明确太极锻炼对血脂的影响,为非药物调脂治疗提供新手段。方法:通过筛选太极锻炼持续4周以上,PEDro评分3分以上,且观察太极锻炼对血脂影响的成人随机对照试验,meta分析太极锻炼对总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯的影响。结论:通过meta分析最终入选的6项研究(共445例患者)的结果显示,太极锻炼能显著降低血甘油三酯水平,且有降低总胆固醇的趋势,但是对于低密度脂蛋白胆固醇和高密度脂蛋白胆固醇未发现有明显影响。 | Xiao-hong PAN Amina MAHEMUTI Xue-hua ZHANG Ya-ping WANG Po HU Ju-bo JIANG Mei-xiang XIANG Gang LIU Jian-an WANG | 2016 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2016，17，8： | 5 |
| 4 | FN-λ: A new spotlight in innate immunity against influenza virus infection显示文摘 | Yeping Sun Jingwen Jiang Po Tien Wenjun Liu Jing Li | 2018 | Protein & Cell2018，9，10： | 5 |
| 5 | Plastic limit load analysis for pressure pipe with incomplete welding defects based on the extended Net Section Collapse Criteria显示文摘With von Mises yield criterion,the loading range of Net Section Collapse(NSC) Criteria is extended from combined tension and bending loadings to combined bending,torsion and internal pressure loadings.A new theoretical analyzing method of plastic limit load for pressure pipe with incomplete welding defects based on the extended NSC Criteria is presented and the correlative formulas are deduced,the influences of pipe curvature,circumferential length and depth of incomplete welding defects on the plastic limit load of pressure pipe are considered as well in this method.Meanwhile,according to the orthogonal experimental design method,the plastic limit loads are calculated by the finite element method and compared with the theoretical values.The results show that the expressions of plastic limit load of pressure pipe with incomplete welding defects under bending,torsion and internal pressure based on extended NSC criteria are reliable.The study provides an important theoretical basis for the establishment of safety assessment measure towards pressure pipe with incomplete welding defects. | Zhi-jiang JIN Cheng-hang JIANG Xian-ping WAN Po CHEN Xiao-fang WANG | 2010 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2010，11，6： | 4 |
| 6 | The role of pineal microRNA-325 in regulating circadian rhythms after neonatal hypoxic-ischemic brain damage显示文摘Circadian rhythm disorder is a common,but often neglected,consequence of neonatal hypoxic-ischemic brain damage(HIBD).However,the underlying molecular mechanisms remain largely unknown.We previously showed that,in a rat model of HIBD,up-regulation of microRNA-325(miR-325)in the pineal gland is responsible for the suppression of Aanat,a key enzyme involved in melatonin synthesis and circadian rhythm regulation.To better understand the mechanism by which miR-325 affects circadian rhythms in neonates with HIBD,we compared clinical samples from neonates with HIBD and samples from healthy neonates recruited from the First Affiliated Hospital of Soochow University(Dushuhu Branch)in 2019.We found that circulating miR-325 levels correlated positively with the severity of sleep and circadian rhythm disorders in neonates with HIBD.Furthermore,a luciferase reporter gene assay revealed that LIM homeobox 3(LHX3)is a novel downstream target of miR-325.In addition,in miR-325 knock-down mice,the transcription factor LHX3 exhibited an miR-325-dependent circadian pattern of expression in the pineal gland.We established a neonatal mouse model of HIBD by performing doublelayer ligation of the left common carotid artery and exposing the pups to a low-oxygen environment for 2 hours.Lhx3 mRNA expression was significantly down-regulated in these mice and partially rescued in miR-325 knockout mice subjected to the same conditions.Finally,we showed that improvement in circadian rhythm-related behaviors in animals with HIBD was dependent on both miR-325 and LHX3.Taken together,our findings suggest that the miR-325-LHX3 axis is responsible for regulating circadian rhythms and provide novel insights into the identification of potential therapeutic targets for circadian rhythm disorders in patients with neonatal HIBD.The clinical trial was approved by Institutional Review Board of Children’s Hospital of Soochow University(approval No.2015028)on July 20,2015.Animal experiments were approved by Animal Care and Use Committee,School of Medicine,Soochow University,China(approval No.XD-2016-1)on January 15,2016. | Ning Sha Hua-Wei Wang Bin Sun Min Gong Po Miao Xiao-Lu Jiang Xiao-Feng Yang Mei Li Li-Xiao Xu Chen-Xi Feng Yuan-Yuan Yang Jie Zhang Wen-Jing Zhu Yuan-Yuan Gao Xing Feng Xin Ding | 2021 | Neural Regeneration Research2021，16，10： | 4 |
| 7 | Activation of anterior thalamic reticular nucleus GABAergic neurons promotes arousal from propofol anesthesia in mice显示文摘Propofol is widely used for the induction and maintenance of anesthesia,which causes a rapid loss of consciousness.However,the mechanisms underlying the hypnosis effect of propofol are still not fully understood.The thalamic reticular nucleus(TRN)is crucial for regulating wakefulness,sleep rhythm generation,and sleep stability,while the role of TRN in the process of propofol-induced anesthesia is still unknown.Here,we investigated the function of the anterior TRN in propofol general anesthesia.Our results demonstrated that the neural activity of anterior TRN is suppressed during propofol anesthesia,whereas it is robustly activated from anesthesia by recording the calcium signals using fiber photometry technology.The results showed that the activation of anterior TRN neurons by chemogenetic and optogenetic methods shortens the emergency time without changing the induction time.Conversely,chemogenetic or optogenetic inhibition of the TRN neurons leads to a delay in the recovery time.Our study showed that anterior TRN is crucial for behavioral arousal without affecting the induction time of propofol anesthesia. | Yanjun Liu Bing Chen Yirong Cai Yuan Han Ying Xia Nanqi Li Bingqian Fan Tianjie Yuan Junli Jiang Po Gao Weifeng Yu Yingfu Jiao Wenxian Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 3 |
| 8 | Hypothalamic paraventricular nucleus neurons activated by estrogen GPER1 receptors promote anti-inflammation effects in the early stage of colitis显示文摘The hypothalamus-pituitary-adrenal(HPA)axis is known to mediate gut-brain interaction,and the pathological inflammatory process in the intestine can induce HPA axis involved'fight or flight response to suppress or facilitate intestinal inflammation.Hypothalamic paraventricular nucleus(PVN)neurons are responsible for controlling the HPA axis activity,but their exact role in modulating intestinal inflammation remains unclear.In this study,we used the dextran sulfate sodium(DSS)-induced mice colitis model,gene editing,and RNA interference to determine the effects of PVN neurons on intestinal inflammation.We found that at the early stage(third day)after DSS treatment,there was a mild inflammation in the colorectal area and an increased neuron activatio n in the PVN but not in the adjace nt area.At the same time,~80% of activated PVN n eurons also expressed novel estrogen GPER1 receptor.The colitis noticeably worsened in GPER1-knockout mice and local PVN GPER1-knockdown mice.These results indicated that PVN GPER1 positive neurons potentially have a protective function during the early stages of DSS-induced colitis,and this may be a mechanism by which the central nervous system attempts to suppress intestinal inflammation to achieve self-protection. | Tao Jiang Ruoxi Wang Wen Yin Yuxi Zhou Dexu Kong Saihong Xu Po Gao Weifeng Yu Yingfu Jiao Daxiang Wen | 2019 | Acta Biochimica et Biophysica Sinica2019，51，12： | 1 |
| 9 | Atrial Fibrillation Begets Atrial Fibrillation: Autonomic Mechanism for Atrial Electrical Remodeling Induced by Short-Term Rapid Atrial Pacing显示文摘 | Zhibing Lu Benjamin J. Scherlag Jiaxiong Lin Guodong Niu Kar-Ming Fung Lichao Zhao Muhammad Ghias Warren M. Jackman Ralph Lazzara Hong Jiang Sunny S. Po | 2008 | Circulation: Arrhythmia and Electrophysiology2008，，： | 1 |
| 10 | Distance,Correlation and Mutual Information Among Portraits of Organisms Based on Complete Genomes显示文摘 | Yu Zuguo Jiang Po | 2001 | Physics Letters A2001，286，1： | 1 |
| 11 | Changes of photosynthetic capacity of some plant species under very high CO_2 concentrations in Biosphere 2显示文摘THE responses of plant photosynthesis to elevated CO2 could be divided into short-term re-sponse and long-term response or acclimation.In the short-term response,photosynthesiscan be enhanced at the beginning of high CO2 treatment for most C3 carbon fixation species,but the photosynthetic rate may decrease when the plants are exposed to that high CO2 for | JIANG Gaoming and LIN Guanghui1. Ecological Research Center, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China 2. Biosphere 2 Research and Education Center, Columbia University, PO Box 689, Oracle, Arizona 85623, USA | 1997 | Chinese Science Bulletin1997，42，10： | 1 |
| 12 | Distance, Correlation and Mutual Information among Portraits of Organisms Based on Complete Genomes显示文摘 | Yu Zuguo Jiang Po | 2001 | Physics Letters A2001，286，1： | 1 |
| 13 | Identification of the Myelin Oligodendrocyte Glycoprotein as a Cellular Receptor for Rubella Virus显示文摘 | Cong Haolong Jiang Yue Tien Po | 2011 | Journal of virology2011，85，11： | 1 |
| 14 | Aspirin Inhibits Matrix Metalloproteinase -2 Activity, Increases E - Cadherin Production, and Inhibits in Vitro Invasion of Tumor Cells 显示文摘 | Ming - Chung Jiang Ching - Fong Liao Po - Huang Lee | 2001 | Biochemical and Biophysical Research Communications2001，671，： | 1 |
| 15 | A Prospective and Randomized Comparison of Limited Versus Extensive Atrial Substrate Modification After Circumferential Pulmonary Vein Isolation in Nonparoxysmal Atrial Fibrillation显示文摘 | YENN‐JIANG LIN SHIH‐LIN CHANG LI‐WEI LO YU‐FENG HU ERIC CHONG TZE‐FAN CHAO FA‐PO CHUNG JONAN LIAO CHENG‐HUNG LI HSUAN‐MING TSAO TSAIR KAO YUN‐YU CHEN JIN‐LONG HUANG SHIH‐ANN CHEN | 2014 | J Cardiovasc Electrophysiol2014，，： | 1 |
| 16 | Interactions between atrial electrical remodeling and autonomic remodeling: How to break the vicious cycle显示文摘 | Lilei Yu Benjamin J. Scherlag Yong Sha Shaolong Li Tushar Sharma Hiroshi Nakagawa Warren M. Jackman Ralph Lazzara Hong Jiang Sunny S. Po | 2012 | Heart Rhythm2012，，5： | 1 |
| 17 | Identification of the Myelin Oligodendrocyte Glycoprotein as a Cellular Receptor for Rubella Virus显示文摘 | Cong Haolong Jiang Yue Tien Po | 2011 | JOURNAL OF VIROLOGY2011，85，11： | 1 |
| 18 | SPM transport in the Bohai Sea field experiments and numerical modelling显示文摘 | JIANG W PO H L MAN N T SUN J | 2004 | Journal of Marine Systems2004，44，34： | 1 |
| 19 | 长日照对光周期敏感型大豆顶生花序发育的影响显示文摘顶生花序是识别大豆类型的重要组分,在本研究中,选用晚熟且对光周期敏感的大豆,研究长日照对此大豆顶生花序形成和发育的影响。出苗后,大豆幼苗经12h短日照,光周期13d,以便诱导顶生花序的开始。然后, | Yan Jiang Cunxiang Wu Lingxiao Zhang Po Hu Wensheng Hou Wei Zu Tianfu Han 尚占江 | 2012 | 大豆科技2012，，1： | 0 |
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