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| 1 | Nestin-positive progenitor cells isolated from human fetal pancreas have phenotypic markers identical to mesenchymal stem cells显示文摘AIM: To isolate nestin-positive progenitor cells from human fetal pancreas and to detect their surface markers and their capability of proliferation and differentiation into pancreatic islet endocrine cells in vitro.METHODS: Islet-like cell clusters (ICCs) were isolated from human fetal pancreas by using collagenase digestion. The free-floating ICCs were handpicked and cultured in a new dish. After the ICCs developed into monolayer epithelium-like cells, they were passaged and induced for differentiation. Reverse transcription polymerase chain reaction (RT-PCR), immunofluorescence stain, fluorescenceactivated cell sorting (FACS) and radioimmunoassay (RIA)were used to detect the expression of cell markers. RESULTS: (1) The monolayer epithelium-like cells had highly proliferative potential and could be passaged more than 16 timesin vitro; (2) RT-PCR analysis and immunofluorescence stain showed that these cells expressed both nestin and ABCG2, two of stem cellmarkers; (3) FACS analysis revealed that CD44, CD90and CD147 were positive, whereas CD34, CD38, CD45, CD71, CD117, CD133 and HLA-DR were negative on the nestin-positive cells; (4) RT-PCR analysis showed that the mRNA expression of insulin, glucagon and pancreaticduodenal homeobox gene-1 was detected, whereas the expression of nestin and neurogenin 3 disappeared in these cells treated with serum-free media supplemented with the cocktail of growth factors. Furthermore, the intracellular insulin content was detected by RIA after the induction culture.CONCLUSION: Nestin-positive cells isolated from human fetal pancreas possess the characteristics of pancreatic progenitor cells since they have highly proliferative potential and the capability of differentiation into insulinproducing cells in vitro. Interestingly, the nestin-positive pancreatic progenitor cells share many phenotypic markers with mesenchymal stem cells derived from bone marrow. | LingZhang Tian-PeiHong JiangHu Yi-NanLiu Yong-HuaWu Ling-SongLi | 2005 | World Journal of Gastroenterology2005，11，19： | 26 |
| 2 | A large carbon pool in lake sediments over the arid/semiarid region, NW China显示文摘Carbon burial in lake sediments is an important component of the global carbon cycle. However, little is known about the magnitude of carbon sequestered in lake sediments over the arid/semiarid region of China(ASAC).In this study, we estimate both organic and inorganic carbon burial since *AD 1800 based on nine lakes in ASAC,and discuss the most plausible factors controlling carbon burial. Our estimates show that the annual organic carbon burial rate(OCBR) ranges from 5.3 to 129.8 g cm-2year-1(weighted mean of 49.9 g cm-2year-1), leading to a standing stock of 1.1–24.0 kg cm-2(weighted mean of 8.6 kg cm-2)and a regional sum of *108 Tg organic carbon sequestered since *AD 1800. The annual inorganic carbon burial rate(ICBR) ranges from 11.4 to 124.0 g cm-2year-1(weighted mean of 48.3 g cm-2year-1), which is slightly lower than OCBR. The inorganic carbon standing stock ranges from2.4 to 26.0 kg cm-2(weighted mean of 8.1 kg cm-2),resulting in a sum of *101 Tg regional inorganic carbon burial since *AD 1800, which is slightly lower than the organic carbon sequestration. OCBR in ASAC shows a continuously increasing trend since *AD 1950, which is possibly due to the high autochthonous and allochthonous primary production and subsequently high sedimentation rate in the lakes. This increasing carbon burial is possibly related to both climatic changes and enhanced anthropogenic activities, such as land use change, deforestation, and eutrophication in the lake. Furthermore, OCBR and ICBR are expected to continuously increase under the scenario of increasing precipitation and runoff and enhanced anthropogenic activities.The results of this research show that the buried carbon in lake sediments of the ASAC region constitutes a significant and large carbon pool, which should be considered and integrated into the global carbon cycle. | Jianghu Lan Hai Xu Bin Liu Enguo Sheng Jiangtao Zhao Keke Yu | 2015 | Chinese Journal Of Geochemistry2015，34，3： | 10 |
| 3 | The selection of a primary marker for the Anthropocene显示文摘Since Homo sapiens appeared,the planet has experienced continuing environmental changes[1,2].In 2000,Crutzen and Stoermer[3]systematically analysed the global changes caused by human activity over the previous 300 years and suggested that the Holocene epoch ended in the 1750s and a new geological age,the Anthropocene,began.Afterwards,the Anthropocene drew a lot of attention from both scientific community and the general public.The recognition and placement of the Anthropocene/Holocene boundary has been a subject of heated debates over the past two decades.At the 35th International Geological Congress(2016;IGC),the Anthropocene Working Group(AWG)recommended the Anthropocene to be formalised with an epoch rank,with the 1950s as its lower boundary[4]. | Tianli Wang Liangcheng Tan Hai Xu Jingjie Zang Dong Li Jianghu Lan Yongming Han Li Li | 2019 | Science Bulletin2019，64，22： | 4 |
| 4 | Biogenic silica contents of Lake Qinghai sediments and its environmental significance显示文摘在在湖沉积的源於生物的硅石(BSi%) 的层次的变化广泛地被使用了以便学习湖生产率和 palaeoclimatic 变化。然而,源於生物的硅石(BSi ) 的起源需要为每个湖被调查,特别为大湖,作为做在 BSi 和相关环境因素的层次之间的关系。在这研究,我们测量了在金海湖集水以内在湖沉积,河沉积,和表面土壤包含的 BSi 的百分比,并且在抽取过程前后比较了硅藻和 phytoliths 的数量和形状。结果建议在湖沉积的 BSi 首先从内长的硅藻被导出;因此, BSi 层次能被用来在湖以内在主要生产率反映变化。进一步的比较证明在长期的 timescales 上,在 BSi% 的变化与在全部的器官的碳(TOC ) 和谷物尺寸的那些通常一致,反映在金海湖的主要生产率上的降水的主导的影响。然而,在短期的 timescales 上,在 BSi% 之间的关系和在 BSi% 和谷物尺寸之间的 TOC 和那不清楚或稳定。例如, BSi% 有时有谷物的 covaried 尺寸,而是它与谷物尺寸有关有时从阶段与或甚至相反地。我们推测那气候和环境过程例如冲淡效果,影响短期的 BSi% 和它的相关环境意义。作为结果, BSi% 应该在不同时间规模上有选择地被用作气候的变化的指示物。 | Bin LIU Hai XU Jianghu LAN Enguo SHENG Shuai CHE Xinying ZHOU | 2014 | Frontiers of Earth Science2014，8，4： | 4 |
| 5 | Dust storms in northern China during the last 500 years显示文摘The history and mechanisms of dust storms in northern China remain unclear owing to the paucity of reliable longterm,high-resolution geological records.In this study,we reconstructed the dust storm history of the last~500 years in northern China,based on sedimentary coarse fraction(>63μm)of a well-dated core from Lake Daihai,Inner Mongolia.The highresolution data reveal three intervals of frequent dust storms:AD 1520–1580,AD 1610–1720,and AD 1870–2000.The dust storm events in the Lake Daihai area were broadly synchronous with those inferred from other historical or geological records and generally occurred during cold intervals.Changes in the intensity of Siberian High and the westerlies modulated by temperature variations are the likely major factors controlling dust storm dynamics.An interesting feature is that although the intensities of dust storms have been systematically increased during the recent warming period,a clear decreasing trend within this period is evident.The recent increase in average dust storm intensity may be ascribed to an increase in particle supply resulting from a rapid increase in human activity,whereas the weakening trend was likely caused by decreases in average wind speed resulting from the recent global warming. | Shuang ZHANG Hai XU Jianghu LAN Yonaton GOLDSMITH Adi TORFSTEIN Guilin ZHANG Jin ZHANG Yunping SONG Kang’en ZHOU Liangcheng TAN Sheng XU Xiaomei XU Yehouda ENZEL | 2021 | Science China Earth Sciences2021，64，5： | 3 |
| 6 | Late Holocene hydroclimatic variations and possible forcing mechanisms over the eastern Central Asia显示文摘Hydroclimatic variations over the eastern Central Asia are highly sensitive to changes in hemispheric-scale atmospheric circulation systems. To fully understand the long-term variability and relationship between hydroclimate and atmospheric circulation system, we present a high-resolution lascustrine record of late Holocene hydroclimate from Lake Sayram, Central Tianshan Mountains, China, based on the total organic carbon, total nitrogen, and carbonate contents, carbon/nitrogen ratios, and grain size. Our results reveal four periods of substantially increased precipitation at the interval of 4000–3780, 3590–3210, 2800–2160, and 890–280 cal yr BP, and one period of slightly increased precipitation from 1700–1370 cal yr BP. These wetter periods broadly coincide with those identified in other records from the mid-latitude Westerlies-dominated eastern Central Asia, including the northern Tibetan Plateau. As such, a similar hydroclimatic pattern existed over this entire region during the late Holocene. Based on a close similarity of our record with reconstruction of North Atlantic Oscillation indices and solar irradiance, we propose that decreased solar irradiance and southern migration of the entire circum-North Atlantic circulation system, particularly the main pathway of the mid-latitude Westerlies, significantly influenced hydroclimate in eastern Central Asia during the late Holocene. Finally, the inferred precipitation at Lake Sayram has increased markedly over the past 100 years, although this potential future changes in hydroclimate in Central Asia need for further investigation. | Jianghu LAN Hai XU Keke YU Enguo SHENG Kangen ZHOU Tianli WANG YuANDa YE Dongna YAN Huixian WU Peng CHENG Waili ABULIEZI Liangcheng TAN | 2019 | Science China Earth Sciences2019，62，8： | 3 |
| 7 | BSA-seq-based identification of a major additive plant height QTL with an effect equivalent to that of Semi-dwarf 1 in a large rice F_(2) population显示文摘Bulked-segregant analysis is a time-and cost-saving strategy for identifying major quantitative trait loci(QTL) in a mapping population. Bulked-segregant analysis combined with whole-genome sequencing(BSA-seq) was performed to rapidly identify QTL for heading date, plant height, and panicle length in a large F_(2) population derived from two landraces: Chuan 7(C7) and Haoboka(HBK). Twenty plants with extremely low or high phenotypic values for the target traits were selected from an F_(2) population of 940 plants to construct low-and high-value bulks. Three pairs of bulks for the three traits were constructed, resulting in six DNA pools. BSA-seq revealed nine QTL: four for heading date, three for plant height, and two for panicle length. These QTL were validated in a random F_(2) population or BC_(4)F_(2) populations. The major novel plant height QTL, qPH8, acting additively with an effect equivalent to that of semi-dwarf 1(sd1), is potentially valuable for hybrid rice breeding. qPH8 controls mainly the elongation of basal internodes. The C7 allele of qPH8 reduces plant height and increases lodging resistance without yield penalty, suggesting a potential role for qPH8 in improving rice plant architecture. | Bo Zhang Feixiang Qi Gang Hu Yikai Yang Li Zhang Jianghu Meng Zhongmin Han Xiangchun Zhou Haiyang Liu Mohammed Ayaad Yongzhong Xing | 2021 | The Crop Journal2021，9，6： | 3 |
| 8 | Conservation and divergence of both phosphate‐ and mycorrhiza‐regulated physiological responses and expression patterns of phosphate transporters in solanaceous species显示文摘 | AiqunChen JiangHu ShubinSun GuohuaXu | 2006 | New Phytologist2006，，4： | 1 |
| 9 | Modification of Outcomes After Acute Kidney Injury by the Presence of CKD显示文摘 | Neesh Pannu Matthew James Brenda R. Hemmelgarn Jianghu Dong Marcello Tonelli Scott Klarenbach | 2011 | American Journal of Kidney Diseases2011，，2： | 1 |
| 10 | Structural and optical properties of BST thin films prepared by the sol-gol process 显示文摘 | Tianjin Zhang Haoshuang Gu Jianghu Liu | 2003 | Microelectrnic engineering2003，66，： | 1 |
| 11 | Fixation of hybrid sterility genes and favorable alleles of key yield-related genes with dominance contribute to the high yield of the Yongyou series of intersubspecific hybrid rice显示文摘In rice,the Yongyou series of Xian-Geng intersubspecific hybrids have excellent production performance,as shown by their extremely high yield.However,the mechanisms underlying the success of these rice hybrids are unclear.In this study,three F2 populations are generated from three Yongyou hybrids to determine the genetic basis of the extremely high yield of intersubspecific hybrids.Genome constitution analysis reveals that the female and male parental lines belong to the Geng and Xian subspecies,respectively,although introgression of 20%of the Xian ancestry and 14%of the Geng ancestry are observed.Twenty-five percent of the hybrid genomes carries homozygous Xian or Geng fragments,which harbors hybrid sterility genes such as Sd,Sc,f5,and q S12 and favorable alleles of key yield-related genes,including NAL1,Ghd7,and Ghd8.None of the parents carries the S5+killer of the S5 killer-protector system.Compatible allele combinations of hybrid sterility genes ensure the fertility of these intersubspecific hybrids and overcome the bottleneck in applying intersubspecific hybrids.Additive effects of favorable alleles of yield-related genes fixed in both parents enhances midparent values.Many QTLs for yield and its key component spikelets per panicle shows dominance and the net positive dominant effects lead to heterosis.These factors result in an extremely high yield of the hybrids.These findings will aid in the development of new intersubspecific rice hybrids with diverse genetic backgrounds. | Pengfei Wang Feixiang Qi Honglin Yao Xingbing Xu Wenjun Li Jianghu Meng Qinglu Zhang Weibo Xie Yongzhong Xing | 2022 | Journal of Genetics and Genomics2022，49，5： | 1 |
| 12 | Conservation and divergence of both phosphate‐ and mycorrhiza‐regulated physiological responses and expression patterns of phosphate transporters in solanaceous species显示文摘 | AiqunChen JiangHu ShubinSun GuohuaXu | 2006 | New Phytologist2006，，4： | 1 |
| 13 | A multiple-proxy stalagmite record reveals historical deforestation in central Shandong, northern China显示文摘Evaluating anthropogenic impacts on regional vegetation changes during historical time is not only important for a better understanding of the Anthropocene but also valuable in improving the vegetation-climate models.In this study,we analyzed stable isotopes(δ^18O,δ^13C)and trace elements(Mg/Ca,Sr/Ca)of a stalagmite from Huangchao Cave in central Shandong,northern China.230Th and AMS14C dating results indicate the stalagmite deposited during 174BC and AD1810,with a hiatus between AD638 and 1102.Broad similarities of theδ^18O and trace elements in the stalagmite suggest they are reliable precipitation indexes.Theδ^13C of the stalagmite,a proxy of vegetation change,was generally consistent with local precipitation and temperature variations on a centennial-scale before the 15th century.It typically varied from–9.6‰to–6.3‰,indicating climate controlled C3 type vegetation during this period.However,a persistent and marked increasing trend in theδ^13C record was observed since the 15th century,resulting inδ^13C values from–7.7‰to–1.6‰in the next four centuries.This unprecedentedδ^13C change caused by vegetation deterioration cannot be explained by climate change but is fairly consistent with the dramatically increasing population and farmland in Shandong.We suggest that the increasing deforestation and reclamation in central Shandong began to affect vegetation in the mountain region of central Shandong since the 15th century and severely destroyed or even cleared the forest during the 16th–18th century. | Liangcheng TAN Wen LIU Tianli WANG Peng CHENG Jingjie ZANG Xiqian WANG Le MA Dong LI Jianghu LAN R.Lawrence EDWARDS Hai CHENG Hai XU Li AI Yongli GAO Yanjun CAI | 2020 | Science China Earth Sciences2020，63，10： | 1 |
| 14 | The multifractal spectrum of a sea clutter using a random walk model显示文摘The radar echo signal of a sea clutter is nonlinear, nonstationary and time varying. A multifractal measure analysis can describe the local singularity of a physics system. The random walk model of a sea clutter scattering is analysed to disclose the intrinsic physical characteristics and laws of the sea clutter. Stochastic differential equations are given for the physical quality of the sea clutter. A diffusion process model is established using It o formula. The singularity of the random walk model is tested by a multifractal spectroscopy, and the accuracy of this model is proven by the multifractal spectroscopy of a real-life IPIX radar data set. Thus, the random walk model is effective for describing the dynamics mechanism of the sea clutter. | HE Jingbo XU Jianghu | 2017 | Acta Oceanologica Sinica2017，36，9： | 0 |
| 15 | Ice-volume and insolation influences on hydroclimate changes in central eastern China during the antepenultimate glacial period显示文摘The rainfall changes in East Asian summer monsoon(EASM)regions on the orbital timescale remain controversial due to the lack of reliable rainfall records.Here,we present new multiproxy records(δ^(18)O,δ^(13)C,Sr/Ca and Mg/Ca)of a230Thdated stalagmite from Hulu Cave in central eastern China.Multiproxy records reconstruct a regional hydroclimate history from 340 to 261 kyr BP(thousand years before present),approximately covering the antepenultimate glacial period.Theδ^(18)O record is dominated by the precessional cycles,suggesting that EASM responds to changes in Northern Hemisphere summer insolation(NHSI)on the orbital timescale.Significant correlations amongst theδ^(13)C,Sr/Ca and Mg/Ca suggest that a common factor,i.e.,the local hydrological cycle,controlled their variability,and their leading principal component can be used as a proxy linked to regional rainfall.This composite record bears a good similarity to those from the Chinese Loess Plateau,showing a gradually decreasing rainfall during the antepenultimate glacial period,consistent with changes in global ice volume.Superimposed on the long-term trend,three relative wetter intervals were responding to the higher NHSI periods,suggesting that EASM rainfall variability was induced by integrated effects of global ice volume and NHSI.The increased ice sheets and lower NHSI resulted in an increased meridional temperature gradient and southward shift of the westerlies,which shortened the duration of Meiyu and midsummer rainfall.The differences between the rainfall record and the stalagmiteδ^(18)O record indicate that the latter represents the overall EASM intensity linked to monsoon circulation,but does not directly reflect the rainfall changes at the cave sites. | Quan WANG Shayue YUAN Yijia LIANG Kan ZHAO Qingfeng SHAO Zhenqiu ZHANG Junji ZHU Xinggong KONG Yongjin WANG Jianghu LAN Hai CHENG Chengwei XIA Yi LI | 2023 | Science China Earth Sciences2023，66，1： | 0 |
| 16 | Nonvolatile resistive memory and synaptic learning using hybrid flexible memristor based on combustion synthesized Mn-ZnO显示文摘Memristors have been seen as promising candidates for next-generation nonvolatile memory and neuromorphic computing.Solution-processed memristors can offer many advantages,such as low-cost fabrication,large-area uniformity,and high versatility.However,the high annealing temperature of the solution process and unsatisfactory performance are impeding the advancement of flexible memristors.In this work,the combustion method was proposed to fabricate the Mn-ZnO-based memristor without a hightemperature process on the flexible substrate.The device demonstrates stable bipolar resistive switching behavior with ultralow switching voltage(-0.6 V/0.71 V),high on/off ratio(>2×10~3),multilevel storage capability,and uniform resistance distribution(σ/μ=18%/16%).The flexible device with a bend radius of 10 mm shows no obvious performance degeneration compared with the device in the flat state.Furthermore,tunable repetitively synaptic weight was achieved by the memristor.Synaptic plasticity functions,such as excitatory postsynaptic current,paired-pulse facilitation,and learning/forgetting behaviors,have been emulated.This work provides a simple and feasible strategy for fabricating the flexible highperformance memristor,with the expectation to facilitate the development of flexible electronics. | Qi Xue Tao Hang Jianghu Liang Chun-Chao Chen Yunwen Wu Huiqin Ling Ming Li | 2022 | Journal of Materials Science & Technology2022，，24： | 0 |
| 17 | Resolving Mixed Intermediate Phases in Methylammonium-Free Sn-Pb Alloyed Perovskites for High-Performance Solar Cells显示文摘The complete elimination of methylammonium(MA)cations in Sn-Pb composites can extend their light and thermal stabilities.Unfortunately,MA-free Sn-Pb alloyed perovskite thin films suffer from wrinkled surfaces and poor crystallization,due to the coexistence of mixed intermediate phases.Here,we report an additive strategy for finely regulating the impurities in the intermediate phase of Cs_(0.25)FA_(0.75)Pb_(0.6)Sn_(0.4)I_(3)and,thereby,obtaining high-performance solar cells.We introduced d-homoserine lactone hydrochloride(D-HLH)to form hydrogen bonds and strong Pb-O/Sn-O bonds with perovskite precursors,thereby weakening the incomplete complexation effect between polar aprotic solvents(e.g.,DMSO)and organic(FAI)or inorganic(CsI,PbI_(2),and SnI_(2))components,and balancing their nucleation processes.This treatment completely transformed mixed intermediate phases into pure preformed perovskite nuclei prior to thermal anneal-ing.Besides,this D-HLH substantially inhibited the oxidation of Sn^(2+) species.This strategy generated a record efficiency of 21.61%,with a Voc of 0.88 V for an MA-free Sn-Pb device,and an efficiency of 23.82%for its tandem device.The unencapsulated devices displayed impressive thermal stability at 85℃ for 300 h and much improved continuous operation stability at MPP for 120 h. | Zhanfei Zhang Jianghu Liang Jianli Wang Yiting Zheng Xueyun Wu Congcong Tian Anxin Sun Zhenhua Chen Chun-Chao Chen | 2022 | Nano-Micro Letters2022，14，10： | 0 |
| 18 | Variations in monsoon precipitation over southwest China during the last 1500 years and possible driving forces显示文摘Understanding hydroclimatic patterns and their possible driving mechanisms during distinct climate periods over the last 1500 years—such as the Medieval Warm Period(MWP),the Little Ice Age(LIA),and the Current Warm Period—is crucial for predicting future changes to monsoon precipitation in southwest China under global warming scenarios.In this study,based on ^(210)Pb and ^(137)Cs dating of surface sediments and AMS ^(14)C dating of terrestrial plant residues,we establish a robust age model that covers the last~1500 years(AD 439–2012)at Lake Yihai in southwest China.We use analyses of multiple geochemical proxy indices,including loss on ignition at 550℃,total organic carbon,total nitrogen,C/N ratios,and stable carbon isotopes of organic matter to reconstruct changes in summer monsoon precipitation at Lake Yihai during the last~1500 years.The results show that,over southwest China,warm and dry climate conditions prevailed during the MWP(AD 1000–1400)and the past 200 years,whereas conditions during the LIA(AD 1400–1800)were cold and wet.This is consistent with evidence from other geological records over southwest China,such as stalagmite and lake sediment data.Similar hydroclimatic patterns have occurred over the last 1500 years in adjacent tropical/subtropical monsoon regions where the climate is similarly dominated by the Indian summer monsoon(e.g.,South China,the South China Sea,Southeast Asia,Northeast India).We suggest that the meridional migration of the mean position of the Inter-tropical Convergence Zone,and El Niño/Southern Oscillation conditions which are linked to tropical Pacific sea surface temperature,are responsible for centennial-scale hydroclimatic patterns over southwest China and adjacent areas during the last 1500 years. | Bin LIU Enguo SHENG Keke YU Kang’en ZHOU Jianghu LAN | 2022 | Science China Earth Sciences2022，65，5： | 0 |
| 19 | 每一条马嘉鱼都要恋爱显示文摘一望无际的壮阔水面。蓝天白云,阳光淡泊温暖。我深深地吸了一口气。我想就在这里,我可以把一切忘掉,从头开始。我注视浩龙的眼睛,第一次发现他有和陈锦平一模一样纯净的黑眸。 | 宋杰 jianghu | 2008 | 大众文艺(下半月)(浪漫)2008，0，5： | 0 |
| 20 | 南蔷和左棠显示文摘她冷笑着从柜子最上方摸出一把钥匙,打开一个抽屉,从里面抽出一张照片,这就是蒋一鸣,他是病死的,你看他那气色,就知道他是不是病着。我拿过照片,那男人其实一点都不像我,照片上有一小行娟秀的字:怀念一鸣…… | 水湄伊人 jianghu | 2008 | 大众文艺(下半月)(浪漫)2008，0，5： | 0 |
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