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| 1 | Parishin C's prevention of Aβ_(1–42)-induced inhibition of long-term potentiation is related to NMDA receptors显示文摘The rhizome of Gastrodia elata(GE), a herb medicine, has been used for treatment of neuronal disorders in Eastern Asia for hundreds of years. Parishin C is a major ingredient of GE. In this study, the i.c.v. injection of soluble Aβ1–42oligomers model of LTP injury was used. We investigated the effects of parishin C on the improvement of LTP in soluble Aβ1–42oligomer–injected rats and the underlying electrophysiological mechanisms. Parishin C(i.p. or i.c.v.) significantly ameliorated LTP impairment induced by i.c.v. injection of soluble Aβ1–42oligomers. In cultured hippocampal neurons,soluble Aβ1–42oligomers significantly inhibited NMDAR currents while not affecting AMPAR currents and voltage-dependent currents. Pretreatment with parishin C protected NMDA receptor currents from the damage induced by Aβ. In summary, parishin C improved LTP deficits induced by soluble Aβ1–42oligomers. The protection by parishin C against Aβ-induced LTP damage might be related to NMDA receptors. | Zhihui Liu Weiping Wang Nan Feng Ling Wang Jiangong Shi Xiaoliang Wang | 2016 | Acta Pharmaceutica Sinica B2016，6，3： | 25 |
| 2 | Sesquiterpene glycosides from the roots of Codonopsis pilosula显示文摘Three new sesquiterpene glycosides,named codonopsesquilosides A C(1 3),were isolated from an aqueous extract of the dried roots of Codonopsis pilosula.Their structures including absolute configurations were determined by spectroscopic and chemical methods.These glycosides are categorized as C_(15) carotenoid(1),gymnomitrane(2),and eudesmane(3)types of sesquiterpenoids,respectively.Compound 1 is the first diglycoside of C_(15) carotenoids to be reported.Compound 2 represents the second reported example of gymnomitrane-type sesquiterpenoids from higher plants.The absolute configurations were supported by comparison of the experimental circular dichroism(CD)spectra with the calculated electronic CD(ECD)spectra of 13,their aglycones,and model compounds based on quantummechanical time-dependent density functional theory.The influences of the glycosyls on the calculated ECD spectra of the glycosidic sesquiterpenoids,as well as some nomenclature and descriptive problems with gymnomitrane-type sesquiterpenoids are discussed. | Yueping Jiang Yufeng Liu Qinglan Guo Chengbo Xu Chenggen Zhu Jiangong Shi | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 16 |
| 3 | Acetylenes and fatty acids from Codonopsis pilosula显示文摘Four new acetylenes(1–4) and one new unsaturated ω-hydroxy fatty acid(5),together with 5known analogues,were isolated from an aqueous extract of Codonopsis pilosula roots.Their structures were determined by spectroscopic and chemical methods.The new acetylenes are categorized as an unusual cyclotetradecatrienynone(1),tetradecenynetriol(2),and rare octenynoic acids(3 and 4),respectively,and 3 and 4 are possibly derived from oxidative metabolic degradation of 1 and/or 2.The absolute configuration of 1 was assigned by comparison of the experimental circular dichroism(CD)spectrum with the calculated electronic circular dichroism(ECD) spectra of stereoisomers based on the quantum-mechanical time-dependent density functional theory,while the configuration of 2 was assigned by using modified Mosher's method based on the MPA determination rule of ΔδRSvalues for diols. | Yueping Jiang Yufeng Liu Qinglan Guo Zhibo Jiang Chengbo Xu Chenggen Zhu Yongchun Yang Sheng Lin Jiangong Shi | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 15 |
| 4 | Indole alkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity显示文摘Six new indole alkaloid sulfonic acids(1–6), together with two analogues(7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their structures including the absolute configurations were determined by spectroscopic data analysis, combined with enzyme hydrolysis and comparison of experimental circular dichroism and calculated electronic circular dichroism spectra. In the preliminary assay, compounds 2 and 4 showed antiviral activity against Coxsackie virus B3 and influenza virus A/Hanfang/359/95(H3N2), respectively. | Lingjie Meng Qinglan Guo Yufeng Liu Minghua Chen Yuhuan Li Jiandong Jiang Jiangong Shi | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 14 |
| 5 | 8,4′-Oxyneolignane glucosides from an aqueous extract of“ban lan gen”(Isatis indigotica root)and their absolute configurations显示文摘Three pairs of glycosidic 8,4′-oxyneolignane diastereoisomers, named isatioxyneolignosides A-F(1–6), were isolated from an aqueous extract of Isatis indigotica roots. Their structures and absolute configurations were elucidated by comprehensive spectroscopic data analysis and enzyme hydrolysis. The validity of Δδ_(C8-C7) values to distinguish threo and erythro aryl glycerol units and Cotton effects at 235±5 nm to determine absolute configurations at C-8 in 1–6 and their aglycones(1a–6a) are discussed. | Lingjie Meng Qinglan Guo Yufeng Liu Jiangong Shi | 2017 | Acta Pharmaceutica Sinica B2017，7，6： | 13 |
| 6 | Analysis for retrieval and validation results of FY-3 Total Ozone Unit (TOU)显示文摘Retrieval experiment was made for global total column ozone using the first year measurements of Total Ozone Unit (TOU) on board the second generation polar orbiting meteorological satellite of China, FY-3/A. The retrieval results were analyzed and validated by comparison with AURA/OMI, Meteop/GOME-2 global ozone products and ground-based ozone measurement data. The qualititative comparisons over the globe especially over Antarctica and the Tibetan Plateau show that the spatial and temporal distribution characteristics are consistent with OMI and GOME-2 products. The quantitative comparisons with ground-based measurements and AURA/OMI ozone product were made over 74 stations, the TOU total ozone retrieval has a 3% rms relative error compared with AURA/OMI ozone product and 4.2% rms relative error with ground-based measurements. The maximum difference between satellite retrieval and ground-based measurements was found in the Antarctica ozone hole. The TOU global ozone product is operational and distributed to all users. | WANG WeiHe ZHANG XingYing AN XingQin ZHANG Yan HUANG FuXiang WANG YongMei WANG YingJian ZHANG ZhongMou LU JianGong FU LiPing JIANG Fang LIU GuoYang | 2010 | Chinese Science Bulletin2010，55，26： | 12 |
| 7 | Three pairs of alkaloid enantiomers from the root of Isatis indigotica显示文摘Three pairs of enantiomerically pure alkaloids with diverse structure features, named isatindigoticoic acid A and epiisatindigoticoic acid A [(—)-1 and(+)-1], phaitanthrin A and epiphaitanthrin A [(—)-2 and(+)-2], and isatindopyrromizol A and epiisatindopyrromizol A [(—)-3and(+)-3], respectively, were isolated from an aqueous extract of the roots of Isatis indigotica. Racemic and scalemic mixtures of these enantiomers were separated by HPLC on a chiral semi-preparative column.Their structures including absolute configurations were determined by extensive spectroscopic analysis in conjunction with the calculation of electronic circular dichroism(ECD) spectra. The enantiomer pairs possess parent structures of 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid, indolo[2,1-b]quinazolinone, and 3-thioxohexahydro-1H-pyrrolo[1,2-c]imidazol-1-one, respectively. Except for phaitanthrin A[(—)-2] which the configuration was previously undetermined, these compounds are new enantiomeric natural products. | Yufeng Liu Xiaoliang Wang Minghua Chen Sheng Lin Li Li Jiangong Shi | 2016 | Acta Pharmaceutica Sinica B2016，6，2： | 12 |
| 8 | Correction of Observation Interference on Z component of Geomagnetic Field From DC Power Lines显示文摘为减小直流输电线路对地磁场观测的干扰,采用数学计算的方法精确求解了线路对地磁Z分量的干扰水平。以观测点为原点建立了地磁仪器观测点坐标系,推导了观测点坐标系各坐标轴在地心坐标系中的单位矢量表达式。根据空间矢量点积的定义,得到了空间电流磁场矢量投影到地磁Z分量方向的求解公式。利用推导的公式和直流线路电流磁场三维计算模型,最终求得直流线路对地磁Z分量观测的干扰水平。由此,开发了"直流线路对地磁观测干扰校正系统",并开展了地磁台站和野外联合地磁观测干扰实验。结果表明,直流线路和地磁观测台站距离不超过10km时,提出的数学模型和计算方法误差不超过5%。 | TANG Bo ZHANG Jiangong MENG Suimin LIU Xingfa DENG Changzheng | 2012 | 中国电机工程学报2012，32，30： | 8 |
| 9 | Aromatic compounds from an aqueous extract of “ban lan gen” and their antiviral activities显示文摘A pair of new diphenyl glycerol ether enantiomers(-)-l and(+)-l and two new methyl benzamidobenzoates 2 and 3,named(-)-(R)-and(+)-(S)-isatindigotrioic acid[(-)-l and(+)-l]and isatindigoticamides A(2) and B(3),respectively,were isolated from an aqueous decoction of the roots of Isatis indigotica(ban lan gen).Their structures were elucidated by spectroscopic data analysis including2 D NMR experiments.The absolute configurations of(-)-l and(+)-l were assigned based on the CD exciton chirality method.Compounds 2 and 3 exhibited antiviral activities against HSV-1 with IC_(50)values of 4.87 and 25.87μmol/L,respectively.Compound 2 was also found active against Coxsackie virus B3 and LPS-induced NO production. | Yufeng Liu Minghua Chen Qinglan Guo Yuhuan Li Jiandong Jiang Jiangong Shi | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 8 |
| 10 | Effect of Yiqihuoxue prescription on myocardial energy metabolism after myocardial infarction via cross talk of liver kinase B1-depen-dent Notch1 and adenosine 5'-monophosphate-activated protein kinase显示文摘OBJECTIVE: To investigate the effect of Yiqihuoxue prescription(YQHX) from Traditional Chinese Medicine(TCM) on myocardial glucose and lipid metabolism after myocardial infarction via the cross talk between the liver kinase B1(LKB1)-dependent Notch1 and adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK). YQHX was prepared with substances with properties that benefit, to activate blood circulation based on the TCM theory.METHODS: Animal models of myocardial infarction were established by ligating Sprague Dawley rats' left anterior descending coronary arteries. The animals were randomly divided into a myocardial infarction(MI) group, a YQHX group, a perindopril group, a γ-secretase inhibitor, Notch signal inhibitor(DAPT) group, a DAPT+YQHX group and a sham group. The related drugs were administered on the second day after operation, and changes in the relevant indexes were examined on weeks 1 and 4.Changes in cardiac structure and function were examined by echocardiography. The glucose and free fatty acids(FFA) were examined by ELISA. The expression of Notch, LKB1 and AMPK m RNA was examined by a real-time fluorescence quantitative method. The expression of glucose transporter 4(GLUT4), and the expression of total acetyl-Co A carboxylase(ACC) and its phosphorylation were examined by western blotting.RESULTS: Compared with the sham group, the expression of Notch, LKB1 and AMPK m RNA in the MI group was lower. Compared with the MI group, the expression of these m RNAs in the YQHX and perindopril groups was higher, and their expression in the DAPT group was lower. At all time points, the protein expression of GLUT4 and p ACC decreased in the MI group. On week 1, the expression of p ACC protein was higher. In the DAPT group, the expression of p ACC protein decreased. Compared with the YQHX group, the expression of p ACC protein in the DAPT + YQHX group was lower. On week 4,compared with the MI group, the expression of GLUT4 protein in the YQHX group and the perindo-pril group was higher. The expression of GLUT4 protein in the DAPT group decreased. Compared with the YQHX group, the expression of GLUT4 protein in the DAPT+YQHX group was lower. There was no significant difference in the expression of ACC protein between the groups.CONCLUSION: YQHX promoted cross talk between the LKB1-dependent Notch1 and AMPK in myocardial tissue after myocardial infarction. Furthermore,it regulated the glucose and lipid metabolism of cardiomyocytes at different time points, thereby ameliorating the cardiac energy metabolism via different mechanisms and protecting the heart. | Wu Jiangong Chen Xi Guo Shuwen Liu Wenchen Zhang Lu Li Fanghe Wu Jiani Huang Xiaolou Cai Qian Tan Xiaobo Wang Hui | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 7 |
| 11 | Natural and unnatural anthraquinones isolated from the ethanol extract of the roots of Knoxia valerianoides显示文摘Eight new 9,10-anthraquinones(1-8)including three acetonide derivatives of 3-hydroxy-2-hydroxymethyl-9,10-anthraquinones(68)were isolated from an ethanol extract of the roots of Knoxia valeriamoides.On the basis of chemical transformation reactions of the co-occurring 14 and 15 combined with HPLC-DAD-ESI-MS analysis of the extracts,the previously and newly isolated 2-methoxymethy-and 2-ethoxymethyl-9,10-anthraquinones(4,5,and 9-13),as well as the 3-hydroxy-2-hydroxymethyl-9,10-anthraquinone acetonide derivatives(68),were shown to be solvolytic artifacts.In the in vitro assays,compound 4 was active to protect hepatocyte(WB-F344)damage. | Feng Zhao Sujuan Wang Sheng Lin Chenggen Zhu Zhenggang Yue Yang Yu Bo Liu Xiuli Wu Yongchun Yang Yan Li Jiangong Shi | 2012 | Acta Pharmaceutica Sinica B2012，2，3： | 7 |
| 12 | Aconapelsulfonines A and B,seco C_(20)-diterpenoid alkaloids deriving via Criegee rearrangements of napelline skeleton from Aconitum carmichaelii显示文摘Two sulfo nated seco C_(20)-diterpenoid alkaloids,aconapelsulfonines A(1) and B(2),were isolated from an aqueous extract of the raw material of 'Fu Zi'(the Aconitum carmichaelii lateral roots),of which the structures were elucidated by various spectroscopic data,combined with X-ray crystallogra phic analysis.The unprecedented skeletons are biogenetically proposed to be derived via Criegee rearrangements of the napelline-type architecture.The two compounds exhibited dose-depended analgesic activities on an acetic acid-induced mice writhing test. | Hui Liu Yuzhuo Wu Qinglan Guo Shuai Shao Chengbo Xu Tiantai Zhang Jiangong Shi | 2021 | Chinese Chemical Letters2021，32，1： | 6 |
| 13 | Robust H_∞ guaranteed cost satisfactory fault-tolerant control for discrete-time systems with quadratic D stabilizability显示文摘The problem of robust H∞ guaranteed cost satisfactory fault-tolerant control with quadratic D stabilizability against actuator failures is investigated for a class of discrete-time systems with value-bounded uncertainties existing in both the state and control input matrices.Based on a more practical and general model of actuator continuous gain failures,taking the transient property,robust behaviour on H∞ performance and quadratic cost performance requirements into consideration,sufficient conditions for the existence of satisfactory fault-tolerant controller are given and the effective design steps with constraints of multiple performance indices are provided.Meanwhile,the consistency of the regional pole index,H∞ norm-bound constraint and cost performance indices is set up for fault-tolerant control.A simulation example shows the effectiveness of the proposed method. | Xiaodong Han Jiangong Liu Dexiao Xie Dengfeng Zhang Zhiquan Wang | 2010 | Journal of Systems Engineering and Electronics2010，21，3： | 5 |
| 14 | Nonlinear health evaluation for lithium-ion battery within full-lifespan显示文摘Lithium-ion batteries(LIBs), as the first choice for green batteries, have been widely used in energy storage, electric vehicles, 3C devices, and other related fields, and will have greater application prospects in the future. However, one of the obstacles hindering the future development of battery technology is how to accurately evaluate and monitor battery health, which affects the entire lifespan of battery use. It is not enough to assess battery health comprehensively through the state of health(SoH) alone, especially when nonlinear aging occurs in onboard applications. Here, for the first time, we propose a brand-new health evaluation indicator—state of nonlinear aging(SoNA) to explain the nonlinear aging phenomenon that occurs during the battery use, and also design a knee-point identification method and two SoNA quantitative methods. We apply our health evaluation indicator to build a complete LIB full-lifespan grading evaluation system and a ground-to-cloud service framework, which integrates multi-scenario data collection, multi-dimensional data-based grading evaluation, and cloud management functions. Our works fill the gap in the LIBs’ health evaluation of nonlinear aging, which is of great significance for the health and safety evaluation of LIBs in the field of echelon utilization such as vehicles and energy storage. In addition, this comprehensive evaluation system and service framework are expected to be extended to other battery material systems other than LIBs, yet guiding the design of new energy ecosystem. | Heze You Jiangong Zhu Xueyuan Wang Bo Jiang Hao Sun Xinhua Liu Xuezhe Wei Guangshuai Han Shicong Ding Hanqing Yu Weihan Li Dirk Uwe Sauer Haifeng Dai | 2022 | Journal of Energy Chemistry2022，31，9： | 4 |
| 15 | Application and testing of a vertical angle control for a boom-type road header显示文摘Automatic profiling control using a boom-type roadheader requires an understanding of horizontal and vertical swing angles of the cutting boom. In this study the vertical angle of the cutting boom is discussed. First, a vertical swing detection model for the cutting boom is established. Then, a kinematic analysis of the vertical swing mechanism is made and formulae describing the geometrical relationship between the vertical swing of the cutting boom and the telescopic length of vertical hydraulic lift cylinders and vertical swing angle of the boom are presented. Various factors such as complexity of the calculation model, the difficulty of installing the sensor and the cost are compared for two methods. Finally, directly measuring the vertical swing angle of the cutting boom with a tilt sensor is decided to be the more simple and effective method. The detection sensitivity and the vertical cutting error of a tilt sensor are studied. Vibration tests on an EBZ160 roadheader were performed in a coal mine. The characteristic vibration frequencies are analyzed. A design of a vibration isolation mount for the tilt sensor is presented. It makes the detection device work more reliably under conditions where vibration is present and lays a foundation for the implementation of an automatic roadhead cutter. A tilt sensor is installed on an EBZ160 and an EBZ200, and experiments have been done in a coal mine. The results show that the experimental result is favorable and achieves the goal of automatic control of the vertical swing of the cutting boom. | TIAN Jie CHEN Guoqiang YANG Yang WANG Hongyao LIU Jiangong WU Miao | 2010 | Mining Science and Technology2010，20，1： | 4 |
| 16 | Two unique C21-diterpenoid alkaloids from Aconitum carmichaelii显示文摘Two sulfonated diterpenoid alkaloids possessing different but related novel carbon skeletons,named aconidenusulfonine A(1)and 12,16-secoaconidenusulfonine A(2),respectively,were isolated as minor components from an aqueous extract of the lateral roots of Aconitum carmichaelii('Fu Zi').The structures of 1 and 2,representing the first two C21-diterpenoid alkaloids from nature,were determined by analysis of various spectroscopic data and chemical transformation,of which 1 was further proved by single-crystal X-ray diffraction.Especially,1 exhibited dose-depended analgesic activity consistent with the clinical function of Fu Zi. | Jingfang Zhang Xiaoqiang Lei Yazi Wei Hui Liu Qinglan Guo Tiantai Zhang Jiangong Shi | 2022 | Chinese Chemical Letters2022，33，12： | 4 |
| 17 | Development in Researches on Reradiation Interference from UHV Power Lines显示文摘Reradiation interference(RRI) from ultra high voltage(UHV) power lines has become a hotspot for researches in electromagnetic(EM) interference between UHV power grids and adjacent radio stations.The mechanism of RRI,numerical simulations,methods of protecting distance calculation,and resonance characteristics of RRI are reviewed in this paper using results of works reported by IEEE and Chinese publications.We conclude in this review that RRI at short and medium wavelengths can be simulated using method of moment(MoM) and two commonly used models,the wire model and the surface model,which have different applicable conditions.We indicate that the accurate simulation of RRI at higher frequencies using uniform geometrical theory of diffraction is still beyond our capability because it requires studies of the relative simulation methods.We also suggest that further researches of the mechanism of RRI and the prediction of resonance frequencies above 1.7 MHz are necessary for dealing with the interference between the existing power lines and radio stations because resonance frequencies proposed by IEEE are less than 1.7 MHz. | TANG Bo ZHAO Zhibin ZHANG Jiangong LIU Xingfa CHEN Bin | 2013 | 高电压技术2013，39，10： | 3 |
| 18 | General synthesis of hollow mesoporous conducting polymers by dual-colloid interface co-assembly for high-energy-density micro-supercapacitors显示文摘Rational design and precise regulation over the morphology, structure, and pore size of functional conducting mesoporous polymers with enriched active sites and shorten electron–ion transport pathway are extremely important for developing high-performance micro-supercapacitors (MSCs), but still remain a great challenge. Herein, a general dual-colloid interface co-assembly strategy is proposed to fabricate hollow mesoporous polypyrrole nano-bowls (mPPy-nbs) for high-energy-density solid-state planar MSCs. By simply adjusting the size of block copolymer micelles, the diameter of polystyrene nanospheres and the amount of pyrrole monomer, mesopore size of the shell, void and shell thickness of mPPy-nbs can be simultaneously controlled. Importantly, this strategy can be further utilized to synthesize other hollow mesoporous polymers, including poly(tris(4-aminophenyl)amine), poly(1,3,5-triaminobenzene) and their copolymers, demonstrative of excellent universality. The structurally optimized mPPy-nb exhibits high specific surface area of 122 m^(2) g^(−1)and large capacitance of 225 F g^(−1) at 1 mV s^(−1). Furthermore, the MSCs assembled by mPPy-nbs deliver impressive volumetric capacitance of 90 F cm^(−3) and energy density of 2.0 mWh cm^(−3), superior to the most reported polymers-based MSCs. Also, the fabricated MSCs present excellent flexibility with almost no capacitance decay under varying bending states, and robust serial/parallel self-integration for boosting voltage and capacitance output. Therefore, this work will inspire the new design of mesoporous conducting polymer materials toward high-performance microscale supercapacitive devices. | Jing Cui Fei-Fei Xing Hao Luo Jie-Qiong Qin Yan Li Yonghui Zhong Facai Wei Jianwei Fu Chengbin Jing Jiangong Cheng Zhong-Shuai Wu Shaohua Liu | 2021 | Journal of Energy Chemistry2021，30，11： | 3 |
| 19 | Quasiperiodic Solutions for Nonlinear Differential Equations of Second Order with Symmetry | Liu Bin Department of Mathematics Peking University Beijing,100871 China You Jiangong Department of Mathematics Nanjing University Nanjing,210008 China | 1994 | Acta Mathematica Sinica,English Series1994，10，3： | 2 |
| 20 | Autophagosome activity in macrophage for atherosclerotic plaques in ApoE^-/-mice enhanced by Tiaozhi Tongmai Granules显示文摘Objective:Atherosclerosis is the fundamental pathophysiologic component of cardiovascular disease,and Tiaozhi Tongmai Granules show great efficiency in the treatment of the disease.However,the mechanism of Tiaozhi Tongmai Granules is still unclear.In this study,we have combined experiments with network pharmacology to explore the antiatherosclerosis mechanism of Tiaozhi Tongmai Granules.Method:120 male ApoE/mice were randomly divided into three groups:the model group,Chinese herb group and Atorvastatin group.The model group,Atorvastatin group and Chinese herb group were fed with a high-fat diet,a high-fat diet plus atorvastatin(5.1 mg/kg/d)and a high-fat diet plus Tiaozhi Tongmai Granules(16.5 g/kg/d)for 16 weeks,respectively.Atherogenesis was identified by H&E staining.The colocalization of neutral lipid stain BODIPY and microtubule-associated protein 1 light chain 3(LC3)and the colocalization of BODIPY and lysosomal-associated membrane protein 1(LAMP1)within ApoE/mice aortic plaques were tested using fluorescence confocal microscopy and the Pearson’s coefficients were calculated.To further explore the anti-atherosclerosis mechanism of Tiaozhi Tongmai Granules,the network pharmacology was used to construct the herb-compound-target network.Results:The size of the aortic lipid plaque in the Chinese herb group and Atorvastatin group were smaller compared with the model group on the 16th week.Compared with the model group on the 16th week,the BODIPY and LC3 colocalization rate,the BODIPY and LAMP1 colocalization rate of the Chinese herb group and Atorvastatin group all presented significant increase in the aortic plaque(P<.001),showing that Tiaozhi Tongmai Granules could enhance autophagosome activity in the macrophage.In the herb-compound-target network,17 active compounds and 27 targets were obtained through literature searching and using LHRI&DAVID Bioinformatics.It was found that 23 targets were correlated with the macrophage.Some of them participated in macrophage inflammatory response,and the other targets could promote/inhibit phagocytosis of the macrophage.It was hypothesized that the active compounds of Tiaozhi Tongmai Granules were acting on these targets and having y the biological effects.Conclusions:In the progression stage of atherosclerosis,Tiaozhi Tongmai Granules can still make the macrophage have higher autophagosome activity,and play a role of anti-atherogenesis. | Chenglong Zheng Qing Sun Lu Zhang Shuwen Guo Min Zheng Yan Tang Jiangong Wu Jiani Wu Wenchen Liu Zhaoduo Su Xi Chen | 2015 | Journal of Traditional Chinese Medical Sciences2015，2，3： | 2 |
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