5篇
您的检索式：作者名="Jianpei Xu"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Correction of β-thalassemia mutant by base editor in human embryos显示文摘 | Puping Liang Chenhui Ding Hongwei Sun Xiaowei Xie Yanwen Xu Xiya Zhang Ying Sun Yuanyan Xiong Wenbin Ma Yongxiang Liu Yali Wang Jianpei Fang Dan Liu Zhou Songyang Canquan Zhou Junjiu Huang | 2017 | Protein & Cell2017，8，11： | 34 |
| 2 | A novel virtual sample genera-tion method based on Gaussian distribution显示文摘 | Yang Jing Yu Xu Zhang Jianpei | 2011 | Knowledge-Based Systems2011，，24： | 1 |
| 3 | Mining and Ranking Important Nodes in Complex Network by K-Shell and Degree Difference显示文摘 | Jianpei Zhang Hui Xu Jing Yang Lijun Lun | 2018 | 国际计算机前沿大会会议论文集2018，，1： | 1 |
| 4 | Measurement of Nodes Importance for Complex Networks Structural-Holes-Oriented显示文摘Mining important nodes in the complex network should not only consider the core nodes, but also consider the locations of the nodes in the network. Despite many researches on discovering important nodes, the importance of nodes in the structural holes is still ignored easily. Therefore, this paper proposes a method of local centrality measurement based on structural holes, which evaluates the nodes importance both by direct and indirect constraints caused by the lack of structural holes around the nodes. In this method, the attributes and locations of the nodes and their first-order and second-order neighbors are taken into account simultaneously. Deliberate attack simulation is carried out through selective deletion in a certain proportion of network nodes. Calculating the decreased ratio of network efficiency is to quantitatively describe the importance of nodes in before-and-after attacks. Experiments indicate that this method has more advantages to mine important nodes compared to clustering coefficient and k-shell decomposition method. And it is suitable for the quantitative analysis of the nodes importance in large scale networks. | Hui Xu Jianpei Zhang Jing Yang Lijun Lun | 2016 | 国际计算机前沿大会会议论文集2016，，1： | 0 |
| 5 | Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis显示文摘Mesenchymal stem cells(MSCs)experience substantial viability issues in the stroke infarct region,limiting their therapeutic efficacy and clinical translation.High levels of deadly reactive oxygen radicals(ROS)and proinflammatory cytokines(PC)in the infarct milieu kill transplanted MSCs,whereas low levels of beneficial ROS and PC stimulate and improve engrafted MSCs’viability.Based on the intrinsic hormesis effects in cellular biology,we built a microglia-inspired MSC bioengineering system to transform detrimental high-level ROS and PC into vitality enhancers for strengthening MSC therapy.This system is achieved by bioorthogonally arming metabolic glycoengineered MSCs with microglial membrane-coated nanoparticles and an antioxidative extracellular protective layer.In this system,extracellular ROSscavenging and PC-absorbing layers effectively buffer the deleterious effects and establish a microlivable niche at the level of a single MSC for transplantation.Meanwhile,the infarct’s inanimate milieu is transformed at the tissue level into a new living niche to facilitate healing.The engineered MSCs achieved viability five times higher than natural MSCs at seven days after transplantation and exhibited a superior therapeutic effect for stroke recovery up to 28 days.This vitality-augmented system demonstrates the potential to accelerate the clinical translation of MSC treatment and boost stroke recovery. | Jianpei Xu Yinzhe Sun Yang You Yuwen Zhang Dan Huang Songlei Zhou Yipu Liu Shiqiang Tong Fenfen Ma Qingxiang Song Chengxiang Dai Suke Li Jigang Lei Zhihua Wang Xiaoling Gao Jun Chen | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员