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| 1 | PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy显示文摘Mitophagy 是为损坏线粒体的特定的消除的选择 autophagy 的一种重要类型。(PINK1 )导致 PTEN 的通常认为的 kinase 蛋白质 1 催化 ubiquitin (Ub ) 的 phosphorylation 在 PINK1-Parkin-mediated mitophagy 的发作起一个关键作用。(PTEN-L ) 磷酸酶和 tensin 相当或相同的事物(PTEN ) 长是 PTEN 的最新识别的 isoform,与到它的 N 终点的 173 氨基酸的增加。这里,我们报导 PTEN-L 是经由它对 phosphorylated ubiquitin 的蛋白质磷酸酶活动的 mitophagy 的一个新奇否定管理者。我们发现 PTEN-L 在外部 mitochondrial 膜(OMM ) 本地化,而 PTEN-L 的删除支持, PTEN-L 的 overexpression 禁止, mitophagy 由各种各样的损坏线粒体的代理人导致了。机械学地, PTEN-L 能够有效地阻止 Parkin mitochondrial translocation,减少 Parkin phosphorylation,维持它的关上的不活跃的符合构造,并且禁止它的 E3 ligase 活动。更重要地, PTEN-L 在 vivo 减少 phosphorylated ubiquitin (pSer65-Ub ) 的水平,并且在 vitro,磷酸酶试金经由它的蛋白质磷酸酶活动证实那 PTEN-L dephosphorylates pSer65-Ub,独立于它的类脂化合物磷酸酶功能。一起拿,我们的调查结果为 ubiquitin 作为蛋白质磷酸酶表明 PTEN-L 的新奇功能,它抵抗在 mitophagy 正式就职和 mitophagy 的最终的抑制导致前馈控制机制的阻塞的调停 PINK1 的 ubiquitin phosphorylation。因此,理解 PTEN-L 的这新奇功能在控制 mitophagy 的分子的难题提供一关键错过片,在包括象 Parkinsons 那样的 neurodegenerative 混乱的许多重要人的疾病的一个批评过程疾病。 | Liming Wang Yik-Lam Cho Yancheng Tang Jigang Wang Jung-Eun Park Yajun Wu Chunxin Wang Yan Tong Ritu Chawla Jianbin Zhang Yin Shi Shuo Deng Guang Lu Yihua Wu Hayden Weng-Siong Tan Pornteera Pawijit Grace Gui-Yin Lim Hui-Ying Chan Jingzi Zhang Lei Fang Hanry Yu Yih-Cherng Liou Mallilankaraman Karthik Boon-Huat Bay Kah-Leong Lim Siu-Kwan Sze Celestial T. Yap Han-Ming Shen | 2018 | Cell Research2018，28，8： | 25 |
| 2 | Deformation mechanism and stability control of roadway along a fault subjected to mining显示文摘It is difficult to maintain the roadway around a fault because of the fractured surroundings,complex stress environment,and large and intense deformation in the mining process.Based on a tailgate of panel S2205 in Tunliu colliery,in Shanxi province,China,we investigated the evolution of stress and displacement of rocks surrounding the roadway during the drivage and mining period using theoretical analysis,numerical simulation and field trial methods.We analyzed the deformation and failure mechanisms of the tailgate near a fault.The deformation of surrounding rock caused by unloading in the drivage period is large and asymmetric,the roadway convergence increases with activation of the fault and secondary fracture develops in the mining period.Therefore,we proposed a specific control technique of the roadway along a fault as follows:(1) High-strength yielding bolt not only supports the shallow rock to loadbearing structures,but also releases primary deformation energy by use of a pressure release device in order to achieve high resistance to the pressure retained;(2) Grouting of near-fault ribside after initial stabilization of the rock deformation is used to reinforce the broken rock,and to improve the integral load-bearing capacity of the roadway.The research results were successfully applied to a field trial. | Yan Shuai Bai Jianbiao Li Wenfeng Chen Jigang Li Lei | 2012 | International Journal of Mining Science and Technology2012，22，4： | 11 |
| 3 | Characterization of a novel plant growth-promoting bacteria strain Delftia tsuruhatensis HR4 both as a diazotroph and a potential biocontrol agent against various plant pathogens显示文摘 | Jigang Han Lei Sun Xiuzhu Dong Zhengqiu Cai Xiaolu Sun Hailian Yang Yunshan Wang Wei Song | 2004 | Systematic and Applied Microbiology2004，，1： | 2 |
| 4 | Polarization of plane wave propagating inside elastic hexagonal system solids显示文摘Based on the reported physical parameters for hexagonal system solids,we have calculated the effects of anisotropy on polarization of plane P-wave propagation.Herein we report the results of calculations and the newly observed physical phenomena.It is found that,for a given propagation,if the polarization is parallel to the wave vector,so also to the Poynting vector.In such a case,the phase velocity is identical to the energy velocity;the quasi P-wave degenerates to a pure P-wave along the propagation.It is also noted that if the polarization is parallel to the Poynting vector but not to the wave vector,the propagating wave cannot be a pure P-wave.Furthermore,the polarization in a quasi P-wave may deviate from the wave vector for more than 45°,but the deviation from the Poynting vector is always less than 45°.The energy velocity of a quasi SV-wave can be larger than that of the quasi P-wave in some propagation directions,even though the phase velocity of a quasi SV-wave may never be larger than either the phase velocity or energy velocity of the quasi P-wave.Finally,in case of parameters ε=0 and δ*≠0,the polarization of a quasi P-wave has an observed symmetry at a 45°phase angle.The anisotropy of a hexagonal system solid determines if a pure P-wave can be created and what the propagation direction is for a plane wave propagating inside such a hexagonal system solid. | FA Lin ZHAO MeiShan LIU YongChang WANG Lei WANG YanQiang SUN JiGang | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，2： | 2 |
| 5 | Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell–matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis显示文摘 | Yan Chen Zheng Li Yan He Dandan Shang Jigang Pan Hongmei Wang Huamei Chen Zhuxia Zhu Lei Wan Xudong Wang | 2014 | Toxicology and Applied Pharmacology2014，，： | 1 |
| 6 | Evaluation of novel saponins from Psammosilene tunicoides and their analogs as immunomodulators显示文摘 | Jigang Zhang Wenjie Cao Junmian Tian Rongcai Yue Li Li Baoyu Guo Lei Shan Biao Yu Weidong Zhang | 2012 | International Immunopharmacology2012，，1： | 1 |
| 7 | Diversity of Culturable Bacteria Isolated from Root Domains of Moso Bamboo (Phyllostachys edulis)显示文摘 | Jigang Han Dongliang Xia Lubin Li Lei Sun Kai Yang Liping Zhang | 2009 | Microbial Ecology2009，，2： | 1 |
| 8 | Characterization of a novel plant growth-promoting bacteria strain Delftia tsunahatensis HR4 both as a diazotroph and a potential biocontrol agent against various plant pathogens显示文摘 | HAN Jigang SUN Lei DONG Xiuzhu | 2005 | Systematic and Applied Microbiology2005，28，1： | 1 |
| 9 | A Molecular Framework of Light-Controlled Phytohormone Action in Arabidopsis显示文摘 | Shangwei Zhong Hui Shi Chang Xue Lei Wang Yanpeng Xi Jigang Li Peter H. Quail Xing Wang Deng Hongwei Guo | 2012 | Current Biology2012，，16： | 1 |
| 10 | Histological evaluation of bone biopsy results during PVP or PKP ofvertebral compression fractures显示文摘 | Lei Zhang Jigang Li Huilin Yang Zongping Luo Jun Zou | 2013 | Oncology Letters2013，，1： | 1 |
| 11 | Development of a visual loop-mediated isothermal amplification method for rapid detection of the bacterial pathogen Pseudomonas putida of the large yellow croaker ( Pseudosciaena crocea )显示文摘 | Zhijuan Mao Yangyu Qiu Lei Zheng Jigang Chen Jifang Yang | 2012 | Journal of Microbiological Methods2012，，3： | 1 |
| 12 | Efficient Heuristic Algorithms for Path-based Hardware/software Partitioning显示文摘 | Wu Jigang Thambipillai Srikanthan Ting Lei | 2010 | Mathematical and Computer Modelling2010，51，： | 1 |
| 13 | Conjugated polymerized bimetallic phthalocyanine based electrocatalyst with Fe-N_(4)/Co-N_(4) dual-sites synergistic effect for zinc-air battery显示文摘The bifunctional oxygen catalyst is essential for zinc-air batteries(ZABs).Here,an efficient bifunctional oxygen catalyst,PPcFeCo/3D-G,is obtained throughπ-πinteraction between the conjugated polymerized iron-cobalt phthalocyanine(PPcFeCo)with excellent thermal stability and three-dimensional graphene(3D-G).The bimetallic synergistic effect of PPcFeCo,verified by DFT(Density functional theory)calculation,andπ-πinteractions enhances the catalytic activity and durability of the PPcFeCo/3D-G.Regarding electrochemical performance,the PPcFeCo/3D-G with a high electron transfer number(3.98,@0.768 V vs.RHE)has excellent half-wave potential(E_(1/2)=0.890 V vs.RHE)and exhibits outstanding reversibility(ΔE=0.700 V,ΔE=Ej=10-E_(1/2)).The liquid ZAB(LZAB)employed PPcFeCo/3D-G displays a high power density(222 m W cm^(-2)),a specific capacity(792 m A h g-1),and excellent durability(120 h).This work has guiding significance for the preparation of high-efficiency bifunctional catalysts. | Shuaifeng Wang Zhongfang Li Wenjie Duan Peng Sun Jigang Wang Qiang Liu Lei Zhang Yanqiong Zhuang | 2023 | Journal of Energy Chemistry2023，，11： | 0 |
| 14 | Hepatic COX1 loss leads to impaired autophagic flux and exacerbates nonalcoholic steatohepatitis显示文摘The mechanisms underlying autophagic defects in nonalcoholic steatohepatitis(NASH)remain largely unknown.We aimed to elucidate the roles of hepatic cyclooxygenase 1(COX1)in autophagy and the pathogenesis of diet-induced steatohepatitis in mice.Human nonalcoholic fatty liver disease(NAFLD)liver samples were used to examine the protein expression of COX1 and the level of autophagy.Cox1^(Δhepa)mice and their wildtype littermates were generated and fed with 3 different NASH models.We found that hepatic COX1 expression was increased in patients with NASH and diet induced NASH mice models accompanied by impaired autophagy.COX1 was required for basal autophagy in hepatocytes and liver specific COX1 deletion exacerbated steatohepatitis by inhibiting autophagy.Mechanistically,COX1 directly interacted with WD repeat domain,phosphoinositide interacting 2(WIPI2),which was crucial for autophagosome maturation.Adeno-associated virus(AAV)-mediated rescue of WIPI2 reversed the impaired autophagic flux and improved NASH phenotypes in Cox1^(Δhepa)mice,indicating that COX1 deletion-mediated steatohepatitis was partially dependent on WIPI2-mediated autophagy.In conclusion,we demonstrated a novel role of COX1 in hepatic autophagy that protected against NASH by interacting with WIPI2.Targeting the COX1 WIPI2 axis may be a novel therapeutic strategy for NASH. | Qian Yu Chang Li Qinghui Niu Jigang Wang Zhaodi Che Ke Lei He Ren Boyi Ma Yixing Ren Pingping Luo Zhuming Fan Huan Zhang Zhaohui Liu George L.Tipoe Jia Xiao | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 0 |
| 15 | Bioorthogonal microglia-inspired mesenchymal stem cell bioengineering system creates livable niches for enhancing ischemic stroke recovery via the hormesis显示文摘Mesenchymal stem cells(MSCs)experience substantial viability issues in the stroke infarct region,limiting their therapeutic efficacy and clinical translation.High levels of deadly reactive oxygen radicals(ROS)and proinflammatory cytokines(PC)in the infarct milieu kill transplanted MSCs,whereas low levels of beneficial ROS and PC stimulate and improve engrafted MSCs’viability.Based on the intrinsic hormesis effects in cellular biology,we built a microglia-inspired MSC bioengineering system to transform detrimental high-level ROS and PC into vitality enhancers for strengthening MSC therapy.This system is achieved by bioorthogonally arming metabolic glycoengineered MSCs with microglial membrane-coated nanoparticles and an antioxidative extracellular protective layer.In this system,extracellular ROSscavenging and PC-absorbing layers effectively buffer the deleterious effects and establish a microlivable niche at the level of a single MSC for transplantation.Meanwhile,the infarct’s inanimate milieu is transformed at the tissue level into a new living niche to facilitate healing.The engineered MSCs achieved viability five times higher than natural MSCs at seven days after transplantation and exhibited a superior therapeutic effect for stroke recovery up to 28 days.This vitality-augmented system demonstrates the potential to accelerate the clinical translation of MSC treatment and boost stroke recovery. | Jianpei Xu Yinzhe Sun Yang You Yuwen Zhang Dan Huang Songlei Zhou Yipu Liu Shiqiang Tong Fenfen Ma Qingxiang Song Chengxiang Dai Suke Li Jigang Lei Zhihua Wang Xiaoling Gao Jun Chen | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 16 | Human adipose, placenta, and umbilical cord-derived mesenchymal stem cells ameliorate imiquimod-induced psoriatic mice via reducing T cells infiltration显示文摘Psoriasis is an autoimmune-related chronic inflammatory disease with an approximate prevalence of 2–3%around the world,involving increased keratinocyte proliferation.Indeed,Th17 cells and IL-17 play critical roles in the pathogenesis of psoriasis.The monoclonal antibodies against cytokines have been shown to have effectively immunosuppressive effects on human psoriasis.However,there are still some patients that have no response to these treatments.Some patients have even serious side-effects which may affect their life.Mesenchymal stem cells have the ability of immunosuppressive and anti-inflammatory effects,which may be an alternative therapy with more safety and efficacy for human psoriasis.Moreover,the underlying mechanisms by which the MSCs prevent or ameliorate psoriasis are still poorly understood.Here,we first isolated and characterized human adipose,placenta,and umbilical cord-derived mesenchymal stem cells(haMSCs,hpMSCs,and huMSCs).After that,the animal model of imiquimod(IMQ)-induced psoriasis in C57BL/6 mice was confirmed.We investigated the impact of haMSCs,hpMSCs,and huMSCs on this model by H&E staining,immunohistochemistry staining,and quantitative real-time PCR.Data analysis showed that mice subcutaneously injected with these MSCs had a significantly decreased epidermal thickness,which was caused by obviously reduced hyper-proliferation of keratinocytes.Furthermore,our findings revealed that the infiltration of T cells to psoriatic lesions in IMQ-induced psoriasis mice was markedly downregulated by intradermal administration of haMSCs,hpMSCs,and huMSCs,respectively.Consequently,the production of IL-17 from Th17 cells was reduced,which inhibits the proliferation of keratinocytes in lesioned skin of IMQ-induced psoriasis mice.These data suggest that haMSCs,hpMSCs,and huMSCs can inhibit the effects of proinflammatory Th17 cells on the development of psoriasis,which may be potential therapeutic candidates for skin inflammatory disease or other autoimmune diseases. | JIGANG LEI ZHENYAO XU SUKE LI MENG LI ZHIKAI WANG PING LI JING WANG YINGLU CHEN X IAOLE SONG CHENGJIE REN MEIPING SHEN CHENGXIANG DAI | 2021 | BIOCELL2021，45，3： | 0 |
| 17 | Fam198a, a member of secreted kinase, secrets through caveolae biogenesis pathway显示文摘 | Zhuang Wei Tao Liu Jigang Lei Yuan Wu Shilong Wang Kan Liao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，10： | 0 |
| 18 | Epidemiological study of a von Hippel-Lindau family in northwest China显示文摘von Hippel-Lindau(VHL)disease is a rare,inherited neoplastic disease characterized by hemangioblastomas(HBL)of the central nervous system(CNS),retinal angiomas,renal cell carcinomas(RCC),pancreatic endocrine tumors(PETs),pheochromocytomas,paragangliomas,and visceral cysts.We encountered a large VHL family in northwest China and conducted a systematic screening of the family members based on their epidemiological and clinical characteristics.A self-designed questionnaire was used to collect the general sociodemographic and health information of the family members.For the preliminary family screening,physical examination and abdomen B ultrasonography were performed.The suspected patients were subjected to cranial computerized tomography and fundus examination.The clinical data of the patients with confirmed VHL disease were collected from hospital records.A total of 63 lineal descendants in six generations were observed in the family(generations O,A,B,C,D,E),including 9 dead suspected cases(6 males,3 females)and 10 living cases(2 males,8 females).Among the 10 living cases,4,2,1,3,4,8,and 2 manifested HBLs of the CNS,PETs,RCC,pancreatic cysts,renal cysts,pheochromocytomas(4 hemi and 4 bilateral),and paragangliomas,respectively.Data showed that the morbidity of VHL disease in generation C was lower than that in generation B,but the age of onset was younger.This study is the first to report VHL disease in northwest China and VHL-associated PET cases in Chinese.Therefore,follow-up checkups of the family should be focused on younger generations.Proper family screening protocols should be followed for the treatment of patients with VHL disease. | Jingyao Zhang Dapeng Wu Hong Ai Jigang Bai Shunbin Dong Qinling Yang Kai Qu Lei Zhou Xinsen Xu Chang Liu | 2013 | Frontiers of Medicine2013，7，3： | 0 |
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