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| 1 | Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer显示文摘渗入肿瘤的 Tregs 的起源,肿瘤免疫力的抑制的批评调停人,是不清楚的。这里,,我们证明在人的乳癌的渗入肿瘤的天真的 CD4 + T 房间和 Tregs 有重叠 TCR 全部剧目几乎别与传播 Tregs 重叠,建议 intratumoral Tregs 主要在 situ 而非从招募的 Tregs 从天真的 T 房间发展。而且,许多天真的 CD4 + T 房间和 Tregs 密切被相关,两个显示的穷人为乳癌病人的预后。天真的 CD4 + T 房间与许多生产 CCL18 巨噬细胞成比例遵守肿瘤片。而且,采纳地转移的人的天真的 CD4 + T 房间以一种 CCL18 依赖的方式渗入人的乳癌 orthotopic 异种皮移植。在在人性化的鼠标的人的乳癌异种皮移植,由将 PITPNM3 的表达式击倒堵住天真的 CD4 + T 房间的招募进肿瘤, CCL18 受体,显著地减少 intratumoral Tregs 并且禁止肿瘤前进。这些调查结果建议那个乳房渗入肿瘤的 Tregs 从在 situ 区分进 Tregs 的传播天真的 CD4 + T 房间的趋化性产生。由防碍 CCL18 的 PITPNM3 识别禁止天真的 CD4 + T 房间招募进肿瘤可以是为 anticancer 免疫疗法的吸引人的策略。 | Shicheng Su Jianyou Liao Jiang Liu Di Huang Chonghua He Fei Chen LinBing Yang Wei Wu Jianing Chen Ling Lin Yunjie Zeng Nengtai Ouyang Xiuying Cui Herui Yao Fengxi Su Jian-dong Huang Judy Lieberman Qiang Liu Erwei Song | 2017 | Cell Research2017，27，4： | 19 |
| 2 | Combined Fenton process and sulfide precipitation for removal of heavy metals from industrial wastewater:Bench and pilot scale studies focusing on in-depth thallium removal显示文摘Thallium (Tl) in industrial wastewater is a public health concern due to its extremely high toxicity. However, there has been limited research regarding Tl removal techniques and engineering practices to date. In this investigation, bench and pilot studies on advanced treatment of industrial wastewater to remove Tl to a trace level were conducted. The treatment process involved a combination of hydroxide precipitation, Fenton oxidation, and sulfide precipitation. While hydroxide precipitation was ineffective for Tl^+ removal, it enabled the recovery of approximately 70%-80% of Zn as Zn hydroxide in alkaline conditions. The Fenton process provided good Tl removal (>95%) through oxidation and precipitation. Tl was then removed to trace levels (< 1.0 μg/L) via sulfide precipitation. Effective removal of other heavy metals was also achieved, with Cd < 13.4 μg/L, Cu < 39.6 μg/L, Pb < 5.32 μg/L, and Zn < 357 μg/L detected in the effluent. X-ray photoelectron spectroscopy indicated that T12S precipitate formed due to sulfide precipitation. Other heavy metals were removed via the formation of metal hydroxides during hydroxide precipitation and Fenton treatment, as well as via the formation of metal sulfides during sulfide precipitation. This combined process provides a scalable approach for the in-depth removal of Tl and other heavy metals from industrial wastewater. | Huosheng Li Hongguo Zhang Jianyou Long Ping Zhang Yongheng Chen | 2019 | Frontiers of Environmental Science & Engineering2019，13，4： | 6 |
| 3 | Fiber-shaped organic electrochemical transistors for biochemical detections with high sensitivity and stability显示文摘Precise and continuous monitoring of biochemicals by biosensors assists to understand physiological functions for various diagnostics and therapeutic applications.For implanted biosensors,small size and flexibility are essential for minimizing tissue damage and achieving accurate detection.However,the active surface area of sensor decreases as the sensor becomes smaller,which will increase the impedance and decrease the signal to noise ratio,resulting in a poor detection limit.Taking advantages of local amplification effect,organic electrochemical transistors(OECTs)constitute promising candidates for high-sensitive monitoring.However,their detections in deep tissues are rarely reported.Herein,we report a family of implantable,fiber-shaped all-in-one OECTs based on carbon nanotube fibers for versatile biochemical detection including H2O2,glucose,dopamine and glutamate.These fiber-shaped OECTs demonstrated high sensitivity,dynamical stability in physiological environment and antiinterference capability.After implantation in mouse brain,7-day dopamine monitoring in vivo was realized for the first time.These fiber-shaped OECTs could be great additions to the'life science'tool box and represent promising avenue for biomedical monitoring. | Xiaoying Wu Jianyou Feng Jue Deng Zhichang Cui Liyuan Wang Songlin Xie Chuanrui Chen Chengqiang Tang Zhengqi Han Hongbo Yu Xuemei Sun Huisheng Peng | 2020 | Science China Chemistry2020，63，9： | 3 |
| 4 | Comparative study of nuclear masses in the relativistic mean-field model显示文摘With experimental masses updated from AME11,the predictive power of relativistic mean-field(RMF) mass model is carefully examined and compared with HFB-17,FRDM,WS*,and DZ28 mass models.In the relativistic mean-field model,the calculation with the PC-PK1 has improved significantly in describing masses compared to the TMA,especially for the neutron-deficient nuclei.The corresponding rms deviation with respect to the known masses falls to 1.4 MeV.Furthermore,it is found that the RMF mass model better describes the nuclei with large deformations.The rms deviation for nuclei with the absolute value of quadrupole deformation parameter greater than 0.25 falls to 0.93,crossing the 1 MeV accuracy threshold for the PC-PK1,which may indicate the new model is more suitable for those largely-deformed nuclei.In addition,the necessity of new high-precision experimental data to evaluate and develop the nuclear mass models is emphasized as well. | HUA XueMin HENG TaiHua NIU ZhongMing SUN BaoHua GUO JianYou | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，12： | 3 |
| 5 | Nuclear uncertainties in the s-process simulation显示文摘The heavy elements in the Universe are formed during the s- and r-processes mainly in AGB stars and supernovae, respectively. Simulation of s- and r-nucleosynthesis critically depends on the neutron capture and weak decay rates for all the nuclei on the reaction chain. The present work analyzes systematically the neutron capture rates (cross sections) for the s-process nuclei, including ~3000 rates on ~200 nuclei. The network calculations for the constant temperature s-process have been performed using the different data sets selected as the nuclear inputs to investigate the uncertainties in the predicted s-abundances. We show that the available cross sections of neutron capture on many s-process nuclei still carry large uncertainties, which lead to low accuracy in the determination of s-process isotope abundances. We analyze the neutron capture cross section data for the same unique isobar nucleus accorded by year from previous work. Such an analysis indicates that the s-process has been studied for more than fifty years and there exist two research stages around 1976 and 2002, respectively. The needs and opportunities for future experiments and theoretical tools are highlighted to remove the existing shortcomings in the neutron capture rates. | ZHANG YouJin CHEN YongShou GUO JianYou HOU SuQing LI ZhiHong SHI JianRong | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，5： | 2 |
| 6 | Influence of traffic on the temperature field of tunnel in cold region:A case study on the world’s longest highway spiral tunnel显示文摘The impact of the piston wind caused by vehicle traffic on the temperature field distribution of the tunnel cannot be ignored,especially in spiral tunnels,where the temperature field distribution is more complicated than that in straight tunnels.Based on the world’s longest highway spiral tunnel,this study explores the influence of traffic on the temperature fields of spiral and straight tunnels,and proposes a new design method for laying length of insulation layer.The results show that traffic has a significant effect on the temperature field dis-tribution in the tunnel.The influence degree of different traffic elements decreases in the following order:average vehicle speed>daily traffic>morning rush hour>evening rush hour.The temperature field distribution of spiral tunnels is asymmetry on the left and right compared with straight tunnels,while the influence degree of traffic on the outside of spiral tunnels is similar to that of straight tunnels.Due to the difference of wind direction and traffic direction at different tunnel openings,an asymmetric insulation layer laying method is proposed.It is suggested that the lengths of the insulation layers of the Jinjiazhuang Tunnel should be 1200 m for the right tunnel inlet,700 m for the right tunnel outlet,700 m for the left tunnel inlet,and 1400 m for the left tunnel outlet. | Yifan Jiang Jianyou Yu Ping Zhou Feicong Zhou Jiayong Lin Jinyi Li Ming Lin Feiya Lei Zhijie Wang | 2023 | Underground Space2023，，1： | 2 |
| 7 | Polysaccharide conjugate vaccine:A kind of vaccine with great development potential显示文摘Diseases caused by microbial bacteria such as Haemophilus influenzae type b(Hib),Streptococcus pneumoniae and Neisseria meningitidis are still very serious disease,which has brought a lot of burden to many countries.Development of vaccine has brought hope for the prevention of such diseases.Polysaccharide conjugate vaccines have been shown to have very good effects in preventing such diseases.The polysaccharide co njugate vaccine adds the positive characteristics of protein antigens to the polysaccharide antigen,thereby improving the immunogenicity of the polysaccharide antigen,solving the problem that the polysaccharide vaccine cannot be effectively applicated in toddler or children,which greatly promoting the development of this vaccine.This review introduces the progress of polysaccharide conjugate vaccines.We introduce the typical polysaccharide conjugate vaccines currently on the market firstly,and then elucidate the protein carriers,the coupling chemistry methods and quality control that required in the preparation of polysaccharide conjugate vaccines.We can see that polysaccharide conjugate vaccine is a kind of vaccine with great development potential,which can be a sharp edge for us to prevent diseases. | Jing Zhao Gang Hud Yi Huang Yingchun Huang Xin Wei Jianyou Shi | 2021 | Chinese Chemical Letters2021，32，4： | 2 |
| 8 | Recent advances in the development of protein–protein interactions modulators:mechanisms and clinical trials显示文摘Protein–protein interactions(PPIs)have pivotal roles in life processes.The studies showed that aberrant PPIs are associated with various diseases,including cancer,infectious diseases,and neurodegenerative diseases.Therefore,targeting PPIs is a direction in treating diseases and an essential strategy for the development of new drugs.In the past few decades,the modulation of PPIs has been recognized as one of the most challenging drug discovery tasks.In recent years,some PPIs modulators have entered clinical studies,some of which been approved for marketing,indicating that the modulators targeting PPIs have broad prospects.Here,we summarize the recent advances in PPIs modulators,including small molecules,peptides,and antibodies,hoping to provide some guidance to the design of novel drugs targeting PPIs in the future. | Haiying Lu Qiaodan Zhou Jun He Zhongliang Jiang Cheng Peng Rongsheng Tong Jianyou Shi | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 9 | High-purity water production by RO/EDI integrated membrane processes显示文摘 | Wang Jianyou Wang Shichang Wang Yuxin | 2003 | Fluid/Particle Sep J2003，15，1： | 1 |
| 10 | A study of electrodeionization process 显示文摘 | Wang Jianyou Wang Shichang Jin Manrong | 2000 | Desalination2000，132，： | 1 |
| 11 | Ischemia-modified albumin is increased in patients with unstable angina:a new potential diagnostic biomarker of this acute coronary syndrome?显示文摘 | Shaoqing JU Juan NI Jianyou SU | 2008 | Lab Med2008，，39： | 1 |
| 12 | Proliferation and gene expression of osteoblasts cultured in DMEM containing the ionic products of dicalcium silicate coating显示文摘 | Junying Sun Jianyou Li Xuanyong Liu Li Wei Guocheng Wang Fanhao Meng | 2009 | Biomedicine & Pharmacotherapy2009，，9： | 1 |
| 13 | Recovery of nickel ions from simulated electroplating rinse water by electrodeionization process 显示文摘 | LU Huixia WANG Jianyou YAN bo | 2010 | Water Science and Technology2010，61，3： | 1 |
| 14 | Collective Motion in System with General Multiplar- Deformations 显示文摘 | Guo Jianyou Xu Fuxin Ruan Tunan | 2000 | High Energy Phys and Nucl Phys2000，24，： | 1 |
| 15 | High-purity water production by RO/EDI integrated membrane processes显示文摘 | WANG Jianyou WANG Shichang WANG Yuxin | 2003 | Fluid/Particle Separation Journal2003，15，1： | 1 |
| 16 | Mathematical Models' Establishment of Hot-Air Drying for Spratelloides gracilis显示文摘 | Ding Yuting Hu Yiming Zhang Jianyou | 2012 | Aquatic Food Product Technology2012，21，： | 1 |
| 17 | Numerical and experimental investigation for heat transfer in triplex concentric tube with phase change material for thermal energy storage显示文摘 | Jianyou L | 2008 | Solar Energy2008，82，： | 1 |
| 18 | On the solution of region-based planar four-bar motion generation显示文摘 | Han Jianyou Qian Weixiang | 2009 | Mechanism and Machine Theory2009，44，2： | 1 |
| 19 | Numerical and experi- mental study on heat pump water heater with PCM for thermal storage 显示文摘 | Long Jianyou Zhu Dongsheng | 2008 | Energy and Buildings2008，40，4： | 1 |
| 20 | Removal of low concentrations of hardness ions from aqueous solutions using electrodeionizaiton proeess显示文摘 | Fu Lin Wang Jianyou Su Yulong | 2009 | Separation and Purification Technology2009，68，： | 1 |
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