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| 1 | The effects of vegetation restoration strategies and seasons on soil enzyme activities in the Karst landscapes of Yunnan, southwest China显示文摘Soil enzymes play a vital role in biogeochemical cycling and ecosystem functions.In this study,we examined the response of six soil enzymes to changes in physicochemical properties resulting from changes in season and vegetation and geological conditions.Catalase,urease,acid phosphatase,invertase,amylase,and cellulase not only promote carbon,nitrogen,and phosphorus cycling,but also participate in the decomposition of harmful substances.Thirty-six soil samples were collected from karst and non-karst areas in two different seasons and from three different types of vegetation in Yunnan province,southwest China.Both vegetation types and season had significant effects on soil physicochemical properties and enzyme activities.In the same plot,soil water content,electrical conductivity,organic carbon,total nitrogen,and total phosphorus increased in the rainy season,indicating enhanced microbial metabolic activity.With the exception of urease activity,the remaining five enzymes showed higher activity in the rainy season.Changes in activities between the two seasons were significant in all samples.In the same season,activity levels of soil enzymes were higher in karst areas than in non-karst areas,and higher in natural forest than in artificial forests.The transformative abilities of soil elements are higher in karst areas than in non-karst areas,and higher in natural forests than in artificial forests.Correlation analysis showed that the activities of the six enzymes correlated significantly;however,soil physical and chemical indices,such as organic matter,pH,and moisture,which are essential for enzyme activity,differed by season.Redundancy analysis also revealed that the main factors influencing enzyme activity differed between the two seasons.The results from this study provide a theoretical basis for further research on the restoration of natural ecological systems in karst landscapes. | Zhouzhou Fan Shuyu Lu Shuang Liu Zhaorong Li Jiaxin Hong Jinxing Zhou Xiawei Peng | 2020 | Journal of Forestry Research2020，31，5： | 5 |
| 2 | Relationship between nitrogen deposition and LUCC and its impact on terrestrial ecosystem carbon budgets in China显示文摘Increased nitrogen(N) deposition and land-use and land-cover change(LUCC) have influenced the terrestrial ecosystem carbon budget in China over the past few decades.However,the coupling effects of N deposition and LUCC on the carbon cycle remain unclear.This study first evaluated the effects of LUCC on N deposition based on estimated N deposition data from NO_2 column remote sensing data and the GlobeLand30 LUCC dataset,and then assessed the coupling effects of N deposition and LUCC on carbon budgets in China based on a terrestrial ecosystem process-based model.The results showed that the average rate of increase in N deposition in China was 0.35 Tg N yr^(-1)(Tg = 10^(12) g),which caused net primary production(NPP) and net ecosystem production(NEP) to rise by 92.2 Tg C yr^(-1) and 46.9 Tg C yr^(-1),respectively.The effects of LUCC reduced N deposition by 0.21 GgNyr^(-1)(Gg= 10~9g).The land changed from forest to cropland had the greatest rate of increase in N deposition among all types of land-cover change.Changes from cropland to forest slowed the rate of N deposition increase the most.Generally,the change in N deposition resulting from LUCC reduced NPP and NEP by 0.7 and 0.4 Gg C yr^(-1),respectively.Compared with the total effects of N deposition on NPP and NEP,N deposition changes caused by LUCC had a limited aggregate effect on the C budget. | LU XueHe JIANG Hong ZHANG XiuYing JIN JiaXin | 2016 | Science China(Information Sciences)2016，59，12： | 4 |
| 3 | Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles显示文摘The spread of coronavirus disease 2019(COVID-19)throughout the world has resulted in stressful healthcare burdens and global health crises.Developing an effective measure to protect people from infection is an urgent need.The blockage of interaction between angiotensin-converting enzyme 2(ACE2)and S protein is considered an essential target for anti-severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)drugs.A full-length ACE2 protein could be a potential drug to block early entry of SARS-Co V-2 into host cells.In this study,a therapeutic strategy was developed by using extracellular vesicles(EVs)with decoy receptor ACE2 for neutralization of SARS-Co V-2.The EVs embedded with engineered ACE2(EVs-ACE2)were prepared;the EVs-ACE2 were derived from an engineered cell line with stable ACE2 expression.The potential effect of the EVs-ACE2 on anti-SARS-Co V-2 was demonstrated by both in vitro and in vivo neutralization experiments using the pseudovirus with the S protein(S-pseudovirus).EVs-ACE2 can inhibit the infection of S-pseudovirus in various cells,and importantly,the mice treated with intranasal administration of EVs-ACE2 can suppress the entry of S-pseudovirus into the mucosal epithelium.Therefore,the intranasal EVs-ACE2 could be a preventive medicine to protect from SARS-Co V-2 infection.This EVs-based strategy offers a potential route to COVID-19 drug development. | Canhao Wu Qin Xu Huiyuan Wang Bin Tu Jiaxin Zeng Pengfei Zhao Mingjie Shi Hong Qiu Yongzhuo Huang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 2 |
| 4 | Improvement of ecological geographic regionalization based on remote sensing and canonical correspondence analysis: A case study in China显示文摘Ecological geographic regions, also called eco-regions, can be used to divide a remotely sensed image, which is helpful for reducing the complexity of land cover types within eco-regions and for improving the classification accuracy of land cover. In this case study in China, we improved a method of ecological geographic regionalization that is more suitable for remote sensing mapping of regional land cover, and we obtained new eco-regions. The canonical correspondence analysis(CCA) and k-means clustering were adopted in the ecological geographic regionalization using both seasonal remotely-sensed vegetation information and environmental data including climate, elevation and soil features. Our results show that the combination of seasonal vegetation information and the CCA performed well in the selection of the dominant environmental factor of the biogeographic pattern, and it can be used as regionalization indicators of eco-regions. We found that thermal factors are the most important driving forces of the biogeographic pattern in China, which followed by moisture factors. Two global land cover products(MODIS MCD12C1 and Glob Cover) were used to assess our eco-regions. The results show that our eco-regions performed better than that of a previous study regarding the complexity of land cover types, such as in the number of types and the proportional area of the major/secondary type. These results indicate that the method of ecological geographic regionalization, which is based on environmental factors associated with seasonal vegetation features, is effective for reducing the regional complexity of land cover. | JIN JiaXin WANG Ying JIANG Hong KONG Yan LU XueHe ZHANG XiuYing | 2016 | Science China Earth Sciences2016，59，9： | 2 |
| 5 | CmBES1 is a regulator of boundary formation in chrysanthemum ray florets显示文摘Chrysanthemum(Chrysanthemum morifolium)is an ideal model species for studying petal morphogenesis because of the diversity in the flower form across varieties;however,the molecular mechanisms underlying petal development are poorly understood.Here,we show that the brassinosteroid transcription factor BRI1-EMS-SUPPRESSOR 1(CmBES1)in chrysanthemum(C.morifolium cv.Jinba)is important for organ boundary formation because it represses organ boundary identity genes.Chrysanthemum plants overexpressing CmBES1 displayed increased fusion of the outermost ray florets due to the loss of differentiation of the two dorsal petals,which developed simultaneously with the ventral petals.RNA-seq analysis of the overexpression lines revealed potential genes and pathways involved in petal development,such as CUP-SHAPED COTYLEDON(CUC2),CYCLOIDEA 4(CYC4),genes encoding MADS-box transcription factors and homeodomain-leucine zippers(HD-Zips)and auxin pathway-related genes.This study characterizes the role of CmBES1 in ray floret development by its modulation of flower development and boundary identity genes in chrysanthemum. | Peilei Cheng Yanan Liu Yiman Yang Hong Chen Hua Cheng Qian Hu Zixin Zhang Jiaojiao Gao Jiaxin Zhang Lian Ding Weimin Fang Sumei Chen Fadi Chen Jiafu Jiang | 2020 | Horticulture Research2020，7，1： | 2 |
| 6 | On the Reform of Mathematics Teaching in Colleges and Universities under the Background of Big Data显示文摘 | Li Yin Haiyue Jin Yicheng Hong Jiaxin Su Yingyue Li | 2017 | 教育研究前沿(中英文版)2017，7，4： | 1 |
| 7 | High performance silicene nanoribbon field effect transistors with current saturation显示文摘 | Hong Li Lu Wang Qihang Liu Jiaxin Zheng Wai-Ning Mei Zhengxiang Gao Junjie Shi Jing Lu | 2012 | The European Physical Journal B2012，，： | 1 |
| 8 | 肝肠循环因子FGF15/19调节胆汁酸代谢从而控制肝脏尺寸大小与肝癌发生显示文摘文章简介肝脏是人体的一个重要代谢器官,它的大小相对于整个个体大小始终维持在一个合适的比例。肝脏如何感知生长起始和停止是肝脏发育、再生以及癌症生物学中一个有待解决的基本科学问题。近年来研究发现,Hippo信号通路在从果蝇到哺乳动物个体的器官发育及大小调控中都起着至关重要的作用。然而具体何种外部因子在调控Hippo信号通路来维持肝脏大小稳态及抑制癌症发生,一直是领域内未解决的问题。 | 姬素渊 刘清许 张世浩 陈青花 王聪 Weiji Zhang Chen Xiao Yuxi Li Cheng Nian Jiaxin Li Junhong Li Jing Geng Lixin Hong Changchuan Xie Ying He Xing Chen Xun Li Zhen-Yu Yin Han You Kwang-Huei Lin Qiao Wu Chundong Yu Randy L.Johnson Li Wang Lanfen Chen Fen Wang 周大旺 | 2020 | 科学新闻2020，，2： | 1 |
| 9 | Purification and Characterization of a Novel Hydrolase That Can Specifically Degrade the Polysaccharide Isolated from Green Seaweed Ulva prolifera显示文摘The extracellular polysaccharide hydrolase-producing strain EP-1 was isolated from seawater and identified as Paenibacillus pabuli. Furthermore, a homogeneous extracellular polysaccharide hydrolase from Paenibacillus pabuli EP-1 was purified by combining ion-exchange chromatography and size exclusion chromatography with a purification fold of 90.69 and recovery of 16.23%. Characterization of the purified polysaccharide hydrolase revealed a molecular mass of 38 k Da and optimum activity at 45℃ and pH 6.0. The polysaccharide hydrolase maintained its stability within a wide range of pH(3.0–12.0) and thermal stability when the temperature was below 50℃. The presence of Hg^(2+), Fe^(2+), Mn^(2+), Co^(2+) and SDS notably decreased hydrolase activity, and organic solvents such as formaldehyde, acetone, DMF and acetonitrile completely inhibited hydrolase activity. The purified hydrolase had no activity on agar, carrageenan, gellan gum, sodium alginate, or starch, but effectively hydrolyzed the polysaccharide from Ulva prolifera. The Km and Vmax values of this hydrolase were 43.84 mg m L^(-1) and 4.33 mg m L^(-1) min^(-1), respectively. The sequence analysis with quantitative time-of-flight mass spectrometry indicated that the hydrolase was an endoglucanase. | LI Jiaxin ZHANG Pei HONG Liang LIU Chenguang | 2019 | Journal of Ocean University of China2019，18，1： | 1 |
| 10 | Author correction to'Neutralization of SARSCoV-2 pseudovirus using ACE2-engineered extracellular vesicles'[Acta Pharmaceutica Sinica B 12(2022)1523-1533]显示文摘The authors regret in the initially published version of this article,there is a misapplied image in Fig.3C.The corrected Fig.3 is provided below. | Canhao Wu Qin Xua Huiyuan Wang Bin Tu Jiaxin Zeng Pengtei Zhao Mingjie Shi Hong Qiu Yongzhuo Huang | 2023 | Acta Pharmaceutica Sinica B2023，13，11： | 0 |
| 11 | Assessing the contribution of global wildfire biomass burning to BaP contamination in the Arctic显示文摘Polycyclic aromatic hydrocarbons(PAHs)have become cause for growing concern in the Arctic ecosystems,partly due to their stable levels despite global emission reduction.Wildfire is considered one of the primary sources that influence PAH levels and trends in the Arctic,but quantitative investigations of this influence are still lacking.This study estimates the global emissions of benzo[a]pyrene(BaP),a congener of PAHs with high carcinogenicity,from forest and grassland fires from 2001 to 2020 and simulates the contributions of wildfire-induced BaP emissions from different source regions to BaP contamination in the Arctic.We find that global wildfires contributed 29.3%to annual averaging BaP concentrations in the Arctic from 2001 to 2020.Additionally,we show that wildfires contributed significantly to BaP concentrations in the Arctic after 2011,enhancing it from 10.1%in 2011 to 83.9%in 2020.Our results reveal that wildfires accounted for 94.2%and 50.8%of BaP levels in the Asian Arctic during boreal summer and autumn,respectively,and 74.2%and 14.5%in the North American Arctic for the same seasons.The source-tagging approach identified that local wildfire biomass emissions were the largest source of BaP in the Arctic,accounting for 65.7%of its concentration,followed by those of Northern Asia(17.8%)and Northern North America(13.7%).Our findings anticipate wildfires to play a larger role in Arctic PAH contaminations alongside continually decreasing anthropogenic emissions and climate warming in the future. | Shijie Song Boqi Chen Tao Huang Shuxin Ma Luqian Liu Jinmu Luo Huizhong Shen Jiaxin Wang Liang Guo Min Wu Xiaoxuan Mao Yuan Zhao Hong Gao Jianmin Ma | 2023 | Environmental Science and Ecotechnology2023，，2： | 0 |
| 12 | Silicon-based epitaxial ferroelectric memristor for high temperature operation in self-assembled vertically aligned BaTiO_(3)-CeO_(2) films显示文摘Ferroelectric memristors,as one of the most potential non-volatile memory to meet the rapid development of the artificial intelligence era,have the comprehensive function of simulating brain storage and calculation.However,due to the high dielectric loss of traditional ferroelectric materials,the durability of ferroelectric memristors and Si based integration have a great challenge.Here,we report a silicon-based epitaxial ferroelectric memristor based on self-assembled vertically aligned nanocomposites BaTiO_(3)(BTO)-CeO_(2) films.The BTO-CeO_(2) memristors exhibit a stable resistance switching behavior at a high temperature of 100℃ due to higher Curie temperatures of BTO-CeO_(2) films with in-plane compressive strain.And the endurance of the device can reach the order of magnitude of 1×106 times.More importantly,the device has excellent functions for simulating artificial synaptic behavior,including excitatory post-synaptic current,paired-pulse facilitation,paired-pulse depression,spike-time-dependent plasticity,and short and long-term plasticity.Digits recognition ability of the memristor devices is evaluated though a single-layer perceptron model,in which recognition accuracy of digital can reach 86.78%after 20 training iterations.These results provide new way for epitaxial composite ferroelectric films as memristor medium with high temperature intolerance and better durability integrated on silicon. | Xiaobing Yan Hongwei Yan Gongjie Liu Jianhui Zhao Zhen Zhao Hong Wang Haidong He Mengmeng Hao Zhaohua Li Lei Wang Wei Wang Zixuan Jian Jiaxin Li Jingsheng Chen | 2022 | Nano Research2022，15，10： | 0 |
| 13 | Targeting glutamine metabolism enhances responses to platinum-based chemotherapy in triple-negative breast cancers(TNBC)显示文摘Reprogramming of metabolic pathways,a hallmark of human cancer,results from a process in which cancer cells become dependent on specific metabolic pathways such as glutamine catabolism or glutaminolysis for growth and survival.Previous studies have demonstrated that triplenegative breast cancers(TNBC)may use glutamine as an extracellular nutrient source to generate lipids,proteins,and nucleic acids.1 Glutamine catabolism in cancer cells also contributes to the production of the antioxidant,glutathione(GSH),which is critical for redox homeostasis and for protection of cells from oxidative stress elicited by reactive oxygen species(ROS).2 Considering TNBC cell lines are often dependent on glutamine for growth and survival,we sought to determine whether targeting glutaminolysis with a small molecule inhibitor,CB-839,in combination with platinum-based chemotherapy drug,would elicit significant anti-tumor activity. | Jiaxin Hong Yao-An Shen Chih-Yi Hsu Peng Huang Alicja Tomaszewski Edward Gabrielson Ie-Ming Shih Stephanie Gaillard Tian-Li Wang | 2022 | Genes & Diseases2022，9，6： | 0 |
| 14 | Comparison analysis of sampling methods to estimate regional precipitation based on the Kriging interpolation methods: A case of northwestern China显示文摘The accuracy of spatial interpolation of precipitation data is determined by the actual spatial variability of the precipitation, the interpolation method, and the distribution of observatories whose selections are particularly important. In this paper, three spatial sampling programs, including spatial random sampling, spatial stratified sampling, and spatial sandwich sampling, are used to analyze the data from meteorological stations of northwestern China. We compared the accuracy of ordinary Kriging interpolation methods on the basis of the sampling results. The error values of the regional annual precipitation interpolation based on spatial sandwich sampling, including ME(0.1513), RMSE(95.91), ASE(101.84), MSE(-0.0036), and RMSSE(1.0397), were optimal under the premise of abundant prior knowledge. The result of spatial stratified sampling was poor, and spatial random sampling was even worse. Spatial sandwich sampling was the best sampling method, which minimized the error of regional precipitation estimation. It had a higher degree of accuracy compared with the other two methods and a wider scope of application. | JinKui Wu ShiWei Liu LePing Ma Jia Qin JiaXin Zhou Hong Wei | 2016 | Research in Cold and Arid Regions2016，8，6： | 0 |
| 15 | Structural basis of phosphorylation-induced activation of the response regulator VbrR显示文摘Two-component systems typically consist of a paired histidine kinase and response regulator and couple environmental changes to adaptive responses.The response regulator VbrR from Vibrio parahaemolyticus,a member of the OmpR/PhoB family,regulates virulence and antibiotic resistance genes.The activation mechanism of VbrR remains unclear.Here,we report the crystal structures of full-length VbrR in complex with DNA in the active conformation and the N-terminal receiver domain(RD)and the C-terminal DNA-binding domain(DBD)in both active and inactive conformations.Structural and biochemical analyses suggest that unphosphorylated VbrR adopts mainly as inactive dimers through the DBD at the autoinhibitory state.The RD undergoes a monomer-todimer transition upon phosphorylation,which further induces the transition of DBD from an autoinhibitory dimer to an active dimer and enables its binding with target DNA.Our study suggests a new model for phosphorylationinduced activation of response regulators and sheds light on the pathogenesis of V.parahaemolyticus. | Sen Hong Jiaxin Guo Xue Zhang Xiaohui Zhou Peng Zhang Fang Yu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，1： | 0 |
| 16 | Responses of water use efficiency to phenology in typical subtropical forest ecosystems——A case study in Zhejiang Province显示文摘Ecosystem-scale water-use efficiency(WUE) is an important indicator for understanding the intimately coupled relationship between carbon and water cycles in ecosystems. Previous studies have suggested that both abiotic and biotic factors have significant effects on WUE in forest ecosystems. However, responses of WUE to phenology in the context of climate change remain poorly understood. In this study, we analyzed the sensitivity and response patterns of seasonal WUE to phenology in Zhejiang Province where typical subtropical forest ecosystems are located, and discussed potential causes of the changes of the sensitivity and response patterns along different climate gradient during 2000–2014. The results of interannual partial correlation analysis showed widespread negative correlations between WUE and the start of growing season(SOS) in spring. This is because the increase in gross primary product(GPP) is larger than that of evapotranspiration(ET), resulting from an advanced SOS. The positive correlation between WUE and SOS was widely observed in summer mainly because of water stress and plant ecological strategy. The autumn WUE enhanced with the delay in the end of growing season(EOS)mainly because of the increase in GPP meanwhile the decrease or steadiness in ET, resulting from a delayed EOS. In space, the sensitivity of spring WUE to SOS significantly decreased along the radiation gradient, which might be related to strong soil evaporation in high radiation area;the sensitivity of WUE to SOS in summer showed a positive correlation with precipitation and a negative correlation with temperature, respectively, which might be attributed to the compensation of GPP to the delayed SOS and water stress caused by high temperature. The sensitivity of WUE to EOS increased significantly along the radiation and precipitation gradients in autumn, which may be because the increase of radiation and precipitation provides more water and energy for photosynthesis. | Fengsheng GUO Jiaxin JIN Bin YONG Ying WANG Hong JIANG | 2020 | Science China Earth Sciences2020，63，1： | 0 |
| 17 | RASGRP1 targeted by H3K27me3 regulates myoblast proliferation and differentiation in mice and pigs显示文摘Skeletal muscle is not only the largest organ in the body that is responsible for locomotion and exercise but also crucial for maintaining the body’s energy metabolism and endocrine secretion.The trimethylation of histone H3 lysine 27(H3K27me3)is one of the most important histone modifications that participates in muscle development regulation by repressing the transcription of genes.Previous studies indicate that the RASGRP1 gene is regulated by H3K27me3 in embryonic muscle development in pigs,but its function and regulatory role in myogenesis are still unclear.In this study,we verify the crucial role of H3K27me3 in RASGRP1 regulation.The gain/loss function of RASGRP1 in myogenesis regulation is performed using mouse myoblast C2C12 cells and primarily isolated porcine skeletal muscle satellite cells(PSCs).The results of qPCR,western blot analysis,EdU staining,CCK-8 assay and immunofluorescence staining show that overexpression ofRASGRP1 promotes cell proliferation and differentiation in both skeletal muscle cell models,while knockdown of RASGRP1 leads to the opposite results.These findings indicate that RASGRP1 plays an important regulatory role in myogenesis in both mice and pigs. | Liyao Xiao Jiaxin Qiao Yiyang Huang Baohua Tan Linjun Hong Zicong Li Gengyuan Cai Zhenfang Wu Enqin Zheng Shanshan Wang Ting Gu | 2024 | Acta Biochimica et Biophysica Sinica2024，56，3： | 0 |
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