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| 1 | High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa显示文摘It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection. To investigate the potential route of 2019-n Cov infection on the mucosa of oral cavity, bulk RNA-seq profiles from two public databases including The Cancer Genome Atlas(TCGA) and Functional Annotation of The Mammalian Genome Cap Analysis of Gene Expression(FANTOM5 CAGE) dataset were collected. RNA-seq profiling data of 13 organ types with para-carcinoma normal tissues from TCGA and 14 organ types with normal tissues from FANTOM5 CAGE were analyzed in order to explore and validate the expression of ACE2 on the mucosa of oral cavity. Further, single-cell transcriptomes from an independent data generated in-house were used to identify and confirm the ACE2-expressing cell composition and proportion in oral cavity. The results demonstrated that the ACE2 expressed on the mucosa of oral cavity. Interestingly, this receptor was highly enriched in epithelial cells of tongue. Preliminarily, those findings have explained the basic mechanism that the oral cavity is a potentially high risk for 2019-nCoV infectious susceptibility and provided a piece of evidence for the future prevention strategy in dental clinical practice as well as daily life. | Hao Xu Liang Zhong Jiaxin Deng Jiakuan Peng Hongxia Dan Xin Zeng Taiwen Li Qianming Chen | 2020 | International Journal of Oral Science2020，12，1： | 69 |
| 2 | Evolution Characteristics of Government-Industry-University-Research Cooperative Innovation Network for China's Agriculture and Influ- encing Factors: Illustrated According to Agricultural Patent Case显示文摘Under the special background of China, the cooperative innovation between different government-industry-university-research institutes plays an increasingly important role in the agricultural field. However, the existing literature has paid little attention to it. Considering the cooperation patents, published in the agriculture field stemming from the Full-text Database of China Patents as the study object, the spatial and institutional attribute of the authors as the data source, and by combining the social network and spatial econometrics analysis, this paper analyzes the structure evolution characteristics of cooperative innovation networks of agricultural government-industry-university-research institute in the city level of China in 1985–2014, based on the triple helix theory, with the influence factors discussed. This shows that, 1) since 1985, China's agricultural innovation level has been substantially increased, but the development degree of the cooperative innovation network is low, and the patent cooperation mainly relies on authors in the same unit; 2) enterprises play a leading role in the agricultural cooperative innovation. The effect of the government and hybrid organizations driven by the government is not obvious; 3) the cooperative innovation in the province and city dominates, and a multi-pole pattern has been formed. The cooperative innovation network structure evolves from a single helix empty core and double helix multi core to a double helix hierarchical network; 4) the city's science, education funding and personnel investment are key factors determining the agricultural cooperative innovation, while the agricultural development of the city presents slight negative impacts on it. The spatial mismatch of supply and demand is present in the technical cooperative innovation of China's agriculture. Therefore, the science enhancement and education investment to big agricultural provinces should be promptly implemented. | LI Erling YAO Fei XI Jiaxin GUO Chunyang | 2018 | Chinese Geographical Science2018，28，1： | 13 |
| 3 | In vitro Anthocyanin Induction and Metabolite Analysis in Malus spectabilis Leaves Under Low Nitrogen Conditions显示文摘Anthocyanins are the most widely produced secondary metabolites in plants,and they play an important role in plant growth and reproduction.The nitrogen source is an important factor affecting anthocyanin production,but the nitrogen concentrations on metabolism and the underlying genetic basis remain unclear.In this study,in vitro anthocyanin induction was conducted on Malus spectabilis.The leaf explants were cultivated in media containing different nitrogen concentrations.The results suggested that when the nitrogen contents decreased in limit,the color of leaf explants turned from green to red,and increased anthocyanin accumulation led to a change in phenotype.Furthermore,the content of other flavonoids,such as dihydroquercetin,epicatechin,and catechin,increased under low nitrogen conditions.The transcription levels of the general flavonoid pathway genes,from phenylalanine ammonia lyase(PAL)to anthocyanidin synthase(ANS),were associated with the concentration of corresponding flavonoid compounds and phenotype changes.In particular,the expression level of ANS increased substantially under a low nitrogen treatment,which was significantly and positively correlated with the anthocyanin levels(R2=0.72,P<0.05).The increased expression patterns of anthocyanin pathway genes were similar to that of the transcription factor MYB10.We further verified MYB10 played an important role in the anthocyanin pathway in leaves of Malus spectabilis.These results suggested that we can improve the desirable ornamental plant phenotypes by controlling nitrogen content.This process may offer clues to further development of new agricultural practices. | Jiaxin Meng Yan Gao Meiling Han Pengyuan Liu Chen Yang Ting Shen Houhua Li | 2020 | Horticultural Plant Journal2020，6，5： | 13 |
| 4 | Effect of hydrophilic silica nanoparticles on hydrate formation: Insight from the experimental study显示文摘Invasion of drilling fluid into natural gas hydrate deposits during drilling might damage the reservoir,induce hydrate dissociation and then cause wellbore instability and distortion of the data from well logging. Adding nanoparticles into drilling fluid is an effective method in reducing the invasion of drilling fluid and enhancing borehole stability. However, the addition of nanoparticles might also introduce hydrate formation risk in borehole because they can act as the 'seeds' for hydrate nucleation. This paper presents an experimental study of the effect of hydrophilic silica nanoparticle on gas hydrate formation in a dynamic methane/liquid-water system. In the experiment, the ultrapure water with and without1.0 wt%–6.0 wt% concentrations of silica nanoparticles, grain sizes of 20 and 50 nm, were pressurized by methane gas under varied conditions of temperature and pressure. The induction time, the gas consumption, and the average rate of gas consumption in the system were measured and compared to those in ultrapure water. The results show that a concentration of 4.0 wt% hydrophilic SiO_2 particles with a grain size of 50 nm has a relatively strong inhibition effect on hydrate formation when the initial experimental condition is 5.0 °C and 5.0 MPa. Compared to ultrapure water, the hydrophilic nano-SiO_2 fluid increases the induction time for hydrate formation by 194% and decreases the amount and average rate of hydrate formation by 10% and 17%, respectively. This inhibition effect may be attributed to the hydrophilicity,amount and aggregation of silica nanoparticle according to the results of water activity and zeta potential measurements. Our work also elucidates hydrophilic, instead of hydrophobic, nanoparticles can be added to the drilling fluid to maintain wellbore stability and to protect the hydrate reservoir from drilling mud damage, because they exhibit certain degree of hydrate inhibition which can reduce the risk of hydrate reformation and aggregation during gas hydrate or deep water drilling if their concentration can be controlled properly. | Ren Wang Tianle Liu Fulong Ning Wenjia Ou Ling Zhang Zhen Wang Li Peng Jiaxin Sun Zhichao Liu Tianshu Li Huicui Sun Guosheng Jiang | 2019 | Journal of Energy Chemistry2019，28，3： | 12 |
| 5 | Rice functional genomics:decades'efforts and roads ahead显示文摘Rice(Oryza sativa L.)is one of the most important crops in the world.Since the completion of rice reference genome sequences,tremendous progress has been achieved in understanding the molecular mechanisms on various rice traits and dissecting the underlying regulatory networks.In this review,we summarize the research progress of rice biology over past decades,including omics,genome-wide association study,phytohormone action,nutrient use,biotic and abiotic responses,photoperiodic flowering,and reproductive development(fertility and sterility).For the roads ahead,cutting-edge technologies such as new genomics methods,high-throughput phenotyping platforms,precise genome-editing tools,environmental microbiome optimization,and synthetic methods will further extend our understanding of unsolved molecular biology questions in rice,and facilitate integrations of the knowledge for agricultural applications. | Rongzhi Chen Yiwen Deng Yanglin Ding Jingxin Guo Jie Qiu Bing Wang Changsheng Wang Yongyao Xie Zhihua Zhang Jiaxin Chen Letian Chen Chengcai Chu Guangcun He Zuhua He Xuehui Huang Yongzhong Xing Shuhua Yang Daoxin Xie Yaoguang Liu Jiayang Li | 2022 | Science China(Life Sciences)2022，65，1： | 12 |
| 6 | A nano-cocrystal strategy to improve the dissolution rate and oral bioavailability of baicalein显示文摘Baicalein(BE) is one of the main active flavonoids representing the variety of pharmacological effects including anticancer, anti-inflammatory and cardiovascular protective activities, but it's very low solubility, dissolution rate and poor oral absorption limit the therapeutic applications. In this work, a nano-cocrystal strategy was successfully applied to improve the dissolution rate and bioavailability of BE. Baicalein-nicotinamide(BE-NCT) nanococrystals were prepared by high pressure homogenization and evaluated both in vitro and in vivo. Physical characterization results including scanning electron microscopy, dynamic light scattering, powder X-ray diffraction and differential scanning calorimetry demonstrated that BE-NCT nano-cocrystals were changed into amorphous state with mean particle size of 251.53 nm. In the dissolution test, the BE-NCT nano-cocrystals performed 2.17-fold and 2.54-fold enhancement than BE coarse powder in FaSSIF-V2 and FaSSGF. Upon oral administration, the integrated AUC0-t of BE-NCT nano-cocrystals(6.02-fold) was significantly higher than BE coarse powder(1-fold), BE-NCT cocrystals(2.87-fold) and BE nanocrystals(3.32-fold). Compared with BE coarse powder, BE-NCT cocrystals and BE nanocrystals, BENCT nano-cocrystals possessed excellent performance both in vitro and in vivo evaluations.Thus, it can be seen that nano-cocrystal is an appropriate novel strategy for improving dissolution rate and bioavailability of poor soluble natural products such as BE. | Jiaxin Pi Shuya Wang Wen Li Dereje Kebebe Ying Zhang Bing Zhang Dongli Qi Pan Guo Nan Li Zhidong Liu | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 12 |
| 7 | Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway显示文摘Glioblastoma 是最好攻击的大脑肿瘤,并且它的预后仍然保持差。因此,新奇治疗学的策略为 glioma 治疗被需要。Polyphyllin 我(PPI ) ,从巴黎 polyphylla 提取的 bioactive 成分,被报导有反肿瘤活动。然而,为这项活动的详细机制仍然保持不清楚。这里,我们在 vitro 在 glioma 房间和它的机制上调查了 PPI 的禁止的效果。U251 房间为 24 ~ 72 h 与 PPI (2-9 M ) 的各种各样的集中被对待。由 PPI 的 U251 房间增长的抑制被 MTT 试金估计。房间周期和 apoptosis 上的效果被流动 cytometry 与 PI 和 annexin V-FITC/PI 检验双染色,并且房间 mitochondrial 膜潜力水平被荧光显微镜学评估, JC-1 染色。apoptosis 相关的蛋白质和 JNK 信号小径蛋白质的表达式层次被西方的污点分析评估。结果证明 PPI 显著地以一种集中依赖者方式禁止了 U251 房间的增长。PPI 导致了 G 2/M 阶段拘捕和 apoptosis,并且它 upregulated Bax,细胞色素 c,和 p-JNK 的表情,而是 downregulated 在 U251 房间的 anti-apoptotic 蛋白质 Bcl-2 的表示。而且, PPI 挑起了 mitochondrial 膜潜力的去极。另外, PPI 导致的 apoptosis 被 JNK 禁止者 SP600125 显著地压制。我们的数据提供 PPI 禁止增长并且在 U251 房间导致 apoptotic 房间死亡的证据。这效果可以与 JNK 小径被联系。这些结果建议 PPI 是与潜在的 anti-glioma 效果表明小径的 JNK 的使活跃之物。 | Jiaxin Liu Yueting Zhang Li Chen Fei Yu Xiaojin Li Dan Tao Jianhua Zhao Shuai Zhou | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 11 |
| 8 | Statistical Characteristics of Suction Pressure Signals for a Centrifugal Pumpunder Cavitating Conditions显示文摘Centrifugal pumps are often used in operating conditions where they can be susceptible to premature failure. The cavitation phenomenon is a common fault in centrifugal pumps and is associated with undesired effects. Among the numerous cavitation detection methods, the measurement of suction pressure fluctuation is one of the most used methods to detect or diagnose the degree of cavitation in a centrifugal pump. In this paper, a closed loop was established to investigate the pump cavitation phenomenon, the statistical parameters for PDF(Probability Density Function), Variance and RMS(Root Mean Square) were used to analyze the relationship between the cavitation performance and the suction pressure signals during the development of cavitation. It is found that the statistical parameters used in this research are able to capture critical cavitation condition and cavitation breakdown condition, whereas difficult for the detection of incipient cavitation in the pump. At part-load conditions, the pressure fluctuations at the impeller inlet show more complexity than the best efficiency point(BEP). Amplitude of PDF values of suction pressure increased steeply when the flow rate dropped to 40 m^3/h(the design flow rate was 60 m^3/h). One possible reason is that the flow structure in the impeller channel promotes an increase of the cavitation intensity when the flow rate is reduced to a certain degree. This shows that it is necessary to find the relationship between the cavitation instabilities and flow instabilities when centrifugal pumps operate under part-load flow rates. | LI Xiaojun YU Benxu JI Yucheng LU Jiaxin YUAN Shouqi | 2017 | Journal of Thermal Science2017，26，1： | 11 |
| 9 | Decontamination of heavy metal complexes by advanced oxidation processes:A review显示文摘Heavy metal complexes with high mobility are widely distributed in wastewater from modern industries,which are mo re stable and refracto ry than free heavy metal ions.Their re movals from wastewater draw increasing attentions and various technologies have been developed,among which advanced oxidation processes(AOPs)are more effectively and promising.Progresses on five representative types of AOPs,including Fenton(like)oxidation,electrochemical oxidation,photocatalytic oxidation,ozonation and discharge plasma oxidation for heavy metal complexe s degradation are summarized in this review.Their rationales,advantages,applications,challenges and prospects are introduced independently.Combinations among these AOPs,such as electrochemical Fenton oxidation and photoelectrocatalytic oxidation,are also comprehensively highlighted.Future efforts should be made to reduce acid requirement and scale up for practical applications of AOPs for heavy metal complex degradation efficiently and cost-effectively. | Junqun Du Baogang Zhang Jiaxin Li Bo Lai | 2020 | Chinese Chemical Letters2020，31，10： | 10 |
| 10 | FKF1 F-box protein promotes flowering in part by negatively regulating DELLA protein stability under long-day photoperiod in Arabidopsis^FA显示文摘FLAVIN-BINDING KELCH REPEAT F-BOX 1(FKF1)encodes an F-box protein that regulates photoperiod flowering in Arabidopsis under long-day conditions(LDs).Gibberellin(GA)is also important for regulating flowering under LDs.However,how FKF1 and the GA pathway work in concert in regulating flowering is not fully understood.Here,we showed that the mutation of FKF1 could cause accumulation of DELLA proteins,which are crucial repressors in GA signaling pathway,thereby reducing plant sensitivity to GA in flowering.Both in vitro and in vivo biochemical analyses demonstrated that FKF1 directly interacted with DELLA proteins.Furthermore,we showed that FKF1 promoted ubiquitination and degradation of DELLA proteins.Analysis of genetic data revealed that FKF1 acted partially through DELLAs to regulate flowering under LDs.In addition,DELLAs exerted a negative feedback on FKF1 expression.Collectively,these findings demonstrate that FKF1 promotes flowering partially by negatively regulating DELLA protein stability under LDs,and suggesting a potential mechanism linking the FKF1 to the GA signaling DELLA proteins. | Jindong Yan Xinmei Li Bingjie Zeng Ming Zhong Jiaxin Yang Piao Yang Xin Li Chongsheng He Jianzhong Lin Xuanming Liu Xiaoying Zhao | 2020 | Journal of Integrative Plant Biology2020，62，11： | 8 |
| 11 | 无人船的法律地位研究显示文摘随着无人技术的兴起,无人船在各个领域所发挥的作用愈加重要,进而引发了对其国际法律地位的探讨,即无人船是否构成国际法意义上的'船舶'。本文将结合与'船舶'相关度较高的国际公约如《联合国海洋法公约》《国际海上人命安全公约》《国际海上避碰规则》及《海员培训、发证和值班标准国际公约》等进行分析,并对无人船可能面临的法律障碍进行讨论。 | 李瑞 LI Jiaxin ZENG Yan | 2019 | 中华海洋法学评论2019，15，4： | 8 |
| 12 | Numerical study on the fracturing mechanism of shock wave interactions between two adjacent blast holes in deep rock blasting显示文摘With the application of electronic detonators, millisecond blasting is regarded as a signifi cant promising approach to improve the rock fragmentation in deep rock blasting. Thus, it is necessary to investigate the fracturing mechanisms of short-delay blasting. In this work, a rectangle model with two circle boreholes is modeled as a particles assembly based on the discrete element method to simulate the shock wave interactions induced by millisecond blasting. The rectangle model has a size of 12 × 6 m (L × W) and two blast holes have the same diameter of 12 cm. The shock waves are simplifi ed as time-varying forces applied at the particles of walls of the two boreholes. Among a series of numerical tests in this study, the spacing between two adjacent boreholes and delay time of millisecond blasting are considered as two primary variables, and the decoupling charge with a coeffi cient of 1.5 is taken into account in each case. The results show that stress superposition is not a key factor for improving rock fragmentation (tensile stress interactions rather than compressive stress superposition could aff ect the generation of cracks), whereas collision actions from isolated particles or particles with weakened constraints play a crucial role in creating the fracture network. The delay time has an infl uence on causing cracks in rock blasting, however, whether it works heavily depends on the distance between the two holes. | Yuan Wei Liu Shangge Wang Wei Su Xuebin Li Zonghong Li Jiaxin Wen Lei Chang Jiangfang Sun Xiaoyun | 2019 | Earthquake Engineering and Engineering Vibration2019，18，4： | 7 |
| 13 | Microbubble resonators combined with a digital optical frequency comb for high-precision air-coupled ultrasound detectors显示文摘Fast and sensitive air-coupled ultrasound detection is essential for many applications such as radar,ultrasound imaging,and defect detection.Here we present a novel approach based on a digital optical frequency comb(DOFC)technique combined with high-Q optical microbubble resonators(MBRs).DOFC enables precise spectroscopy on resonators that can trace the ultrasound pressure with its resonant frequency shift with femtometer resolution and sub-microsecond response time.The noise equivalent pressure of air-coupled ultrasound as low as 4.4 m Pa∕pHz is achieved by combining a high-Q(~3×10~7)MBR with the DOFC method.Moreover,it can observe multi-resonance peaks from multiple MBRs to directly monitor the precise spatial location of the ultrasonic source.This approach has a potential to be applied in 3 D air-coupled photoacoustic and ultrasonic imaging. | JINGSHUN PAN BIN ZHANG ZHENGYONG LIU JIAXIN ZHAO YUANHUA FENG LEI WAN ZHAOHUI LI | 2020 | Photonics Research2020，8，3： | 6 |
| 14 | Modulating the photoelectrons of g-C3N4 via coupling MgTi2O5 as appropriate platform for visible-light-driven photocatalytic solar energy conversion显示文摘Graphitic carbon nitride (g-C3N4) has become an attractive visible-light-responsive photocatalyst because of its semiconductor polymer compositions and easy-modulated band structure. However, the bulk g-C3N4 photocatalyst has the low separation efficiency of photogenerated carriers and unsatisfied surface catalytic performance, which leads to poor photocatalytic performance. As for this, MgTi2O5 with high chemical stability, wide band gap and negative conduction band was used as a suitable platform for coupling with g-C3N4 to enhance charge separation and promoted the photoactivity. Different from common approaches, here, we propose an innovative method to construct g-C3N4/MgTi2O5 nanocomposites featuring “0 + 1 >1' magnification effect to improve g-C3N4 photocatalytic performance under visible light irradiation. Additionally, compositing metal oxides of MgTi2O5 with g-C3N4 has proven to be a proper strategy to accelerate surface catalytic reactions in g-C3N4, and the photoinduced carriers were modulated to maintain thermodynamic equilibrium, which convincingly promotes the photocatalytic activity. The photocatalytic performance of the nanocomposites was measured by hydrogen production and CO2 reduction under visible light. The developed g-C3N4/MgTi2O5 nanocomposites with a 5 wt.% MgTi2O5 exhibits the highest H2 and CO yield under visible light and excellent stability compare to the other MgTi2O5 contents in composites. According to surface photo-voltage spectra, electrochemical CO2 reduction, photoluminescence, etc. The superior performance can be related to an enhanced electron lifetime, the promoted charge transfer and the increased electronic separation property of g-C3N4. Our work provides an approach to overcome the defect of pure g-C3N4, which accesses to composite with the second component matched well. | Jiaxin Shen Yanzhen Li Haoying Zhao Kai Pan Xue Li Yang Qu Guofeng Wang Dingsheng Wang | 2019 | Nano Research2019，12，8： | 6 |
| 15 | Clinical Characteristics of Hospitalized Patients with SARS-CoV-2 and Hepatitis B Virus Co-infection显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a global pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2).SARS-Co V-2 infection was first detected in Wuhan,China in late December 2019.The virus was spreading rapidly to other cities of China and accumulating cases had been reported(Li et al.2020). | Xiaoping Chen Qunqun Jiang Zhiyong Ma Jiaxin Ling Wenjia Hu Qian Cao Pingzheng Mo Lei Yao Rongrong Yang Shicheng Gao Xien Gui Wei Hou Yong Xiong Jinlin Li Yongxi Zhang | 2020 | Virologica Sinica2020，35，6： | 6 |
| 16 | Visible Kerr comb generation in a high-Q silica microdisk resonator with a large wedge angle显示文摘This paper describes the specially designed geometry of a dry-etched large-wedge-angle silica microdisk resonator that enables anomalous dispersion in the 780 nm wavelength regime. This anomalous dispersion occurs naturally without the use of a mode-hybridization technique to control the geometrical dispersion. By fabricating a1-μm-thick silica microdisk with a wedge angle as large as 56° and an optical Q-factor larger than 107, we achieve a visible Kerr comb that covers the wavelength interval of 700–897 nm. The wide optical frequency range and the closeness to the clock transition at 698 nm of 87 Sr atoms make our visible comb a potentially useful tool in optical atomic clock applications. | Jiyang Ma Longfu Xiao Jiaxin Gu Hao Li Xinyu Cheng Guangqiang He Xiaoshun Jiang Min Xiao | 2019 | Photonics Research2019，7，5： | 5 |
| 17 | Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular Drug Delivery for Osteoarthritis Therapy显示文摘Osteoarthritis is the most prevalent chronic and debilitating joint disease,resulting in huge medical and socioeconomic burdens.Intra-articular administration of agents is clinically used for pain management.However,the effectiveness is inapparent caused by the rapid clearance of agents.To overcome this issue,nanoparticles as delivery systems hold considerable promise for local control of the pharmacokinetics of therapeutic agents.Given the therapeutic programs are inseparable from pathological progress of osteoarthritis,an ideal delivery system should allow the release of therapeutic agents upon specific features of disorders.In this review,we firstly introduce the pathological features of osteoarthritis and the design concept for accurate localization within cartilage for sustained drug release.Then,we review the interactions of nanoparticles with cartilage microenvironment and the rational design.Furthermore,we highlight advances in the therapeutic schemes according to the pathology signals.Finally,armed with an updated understanding of the pathological mechanisms,we place an emphasis on the development of“smart”bioresponsive and multiple modality nanoparticles on the near horizon to interact with the pathological signals.We anticipate that the exploration of nanoparticles by balancing the efficacy,safety,and complexity will lay down a solid foundation tangible for clinical translation. | Xu Li Bingyang Dai Jiaxin Guo Lizhen Zheng Quanyi Guo Jiang Peng Jiankun Xu Ling Qin | 2021 | Nano-Micro Letters2021，13，10： | 5 |
| 18 | Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis显示文摘Silicosis is a leading cause of occupational disease-related morbidity and mortality worldwide,but the molecular basis underlying its development remains unclear.An accumulating body of evidence supports gasdermin D(GSDMD)-mediated pyroptosis as a key component in the development of various pulmonary diseases.However,there is little experimental evidence connecting silicosis and GSDMD-driven pyroptosis.In this work,we investigated the role of GSDMD-mediated pyroptosis in silicosis.Single-cell RNA sequencing of healthy and silicosis human and murine lung tissues indicated that GSDMD-induced pyroptosis in macrophages was relevant to silicosis progression.Through microscopy we then observed morphological alterations of pyroptosis in macrophages treated with silica.Measurement of interleukin-1βrelease,lactic dehydrogenase activity,and real-time propidium iodide staining further revealed that silica induced pyroptosis of macrophages.Additionally,we verified that both canonical(caspase-1-mediated)and non-canonical(caspase-4/5/11-mediated)signaling pathways mediated silica-induced pyroptosis activation,in vivo and in vitro.Notably,Gsdmd knockout mice exhibited dramatically alleviated silicosis phenotypes,which highlighted the pivotal role of pyroptosis in this disease.Taken together,our results demonstrated that macrophages underwent GSDMD-dependent pyroptosis in silicosis and inhibition of this process could serve as a viable clinical strategy for mitigating silicosis. | Meiyue Song Jiaxin Wang Youliang Sun Junling Pang Xiaona Li Yuan Liu Yitian Zhou Peiran Yang Tianhui Fan Ying Liu Zhaoguo Li Xianmei Qi Baicun Li Xinri Zhang Jing Wang Chen Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 5 |
| 19 | Salinity Tolerance and Genetic Diversity of the Dinoflagellate Oxyrrhis marina显示文摘To evaluate the relationship between salinity tolerance and genetic diversity of plankton,we collected a wild species of plankton from Taipingjiao,Qingdao.The fragment of ITS1-5.8S rDNA-ITS2 was extracted and sequenced.The results showed that the plankton belongs to Oxyrrhis marina.The salinity tolerance of O.marina ranges from 4 to 60.Seven selected groups were built up to evaluate salinity tolerance and to assess genetic diversity by RAPD.The salinity tolerance comparison revealed considerable differences among groups:the strains of O.marina in group 4 could survive under salinity from 4 to 32,while the strains selected for salinity 60 died under the salinity lower than 16.Analysis of genetic diversity of the seven groups showed that the mean genetic diversity index value was 0.28,but it was only 0.16 in selected group of 4 and was 0.24 for group 60.The result of AMOVA suggested a significantly positive relationship between the salinity tolerance and genetic diversity of O.marina (P<0.01).This study indicates that consideration of intraspecific genetic divergence in O.marina might be indispensable when using it as a model in the study of salinity tolerance of wild plankton. | ZHANG Jingyu LI Yun CHEN Jiaxin | 2010 | Journal of Ocean University of China2010，9，1： | 5 |
| 20 | Characteristics of air pollution events over Hotan Prefecture at the southwestern edge of Taklimakan Desert, China显示文摘Hotan Prefecture is located at the southwestern edge of Taklimakan Desert, the world's largest shifting sand desert, of China. The desert is one of the main sources for frequent sand-dust weather events which strongly affect the air quality of Hotan Prefecture. Although this region is characterized by the highest annual mean PM_(10) concentration values that are routinely recorded by environmental monitoring stations across China, both this phenomenon and its underlying causes have not been adequately addressed in previous researches. Reliable pollutant PM_(10) data are currently retrieved using a tapered element oscillating microbalance(TEOM) 1400 a, a direct real-time monitor, while additional concentration values including for PM_(2.5), sulfur dioxide(SO_2), nitrogen dioxide(NO_2), carbon monoxide(CO) and ozone(O_3) have been collected in recent years by the Hotan Environmental Monitoring Station. Based on these data, this paper presents a comparison of the influences of different kinds of sand-dust weather events on PM10(or PM_(2.5)) as well as the concentrations of other gaseous pollutants in Hotan Prefecture. It is revealed that the highest monthly average PM10 concentrations are observed in the spring because of the frequent occurrence of three distinct kinds of sand-dust weather events at this time, including dust storms, blowing dust and floating dust. The floating dust makes the most significant contribution to PM_(10)(or PM_(2.5)) concentration in this region, a result that differs from eastern Chinese cities where the heaviest PM_(10) pollution occurs usually in winter and air pollution results from the excess emission of local anthropogenic pollutants. It is also shown that PM_(10) concentration varies within typical dust storms. PM_(10) concentrations vary among 20 dust storm events within Hotan Prefecture, and the hourly mean concentrations tend to sharply increase initially then slowly decreasing over time. Data collected from cities in eastern China show the opposite with the hourly mean PM_(10)(or PM_(2.5)) concentration tending to slowly increase then sharply decrease during heavy air pollution due to the excess emission of local anthropogenic pollutants. It is also found that the concentration of gaseous pollutants during sand-dust weather events tends to be lower than those cases under clear sky conditions. This indicates that these dust events effectively remove and rapidly diffuse gaseous pollutants. The analysis also shows that the concentration of SO_2 decreases gradually at the onset of all three kinds of sand-dust weather events because of rapidly increasing wind velocity and the development of favorable atmospheric conditions for diffusion. In contrast, changes in O_3 and NO_2 concentrations conformed to the opposite pattern during all three kinds of sand-dust weather events within this region, implying the inter transformation of these gas species during these events. | LI Jingxin WANG Shigong CHU Jinhua WANG Jiaxin LI Xu YUE Man SHANG Kezheng | 2018 | Journal of Arid Land2018，10，5： | 5 |
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