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| 1 | Frequency comparative study of coal-fired fly ash acoustic agglomeration显示文摘Particulate pollution is main kind of atmospheric pollution.The fine particles are seriously harmful to human health and environment.Acoustic agglomeration is considered as a promising pretreatment technology for fine particle agglomeration.The mechanisms of acoustic agglomeration are very complex and the agglomeration efficiency is affected by many factors.The most important and controversial factor is frequency.Comparative studies between high-frequency and low-frequency sound source to agglomerate coal- fired fly ash were carried out to investigate the influence of frequency on agglomeration efficiency.Acoustic agglomeration theoretical analysis,experimental particle size distributions (PSDs) and orthogonal design were examined.The results showed that the 20 kHz high-frequency sound source was not suitable to agglomerate coal-fired fly ash.Only within the size ranging from 0.2 to 0.25 μm the particles agglomerated to adhere together,and the agglomerated particles were smaller than 2.5 μm.The application of low-frequency (1000-1800 Hz) sound source was proved as an advisable pretreatment with the highest agglomeration efficiency of 75.3%,and all the number concentrations within the measuring range decreased.Orthogonal design L16 (4) 3 was introduced to determine the optimum frequency and optimize acoustic agglomeration condition.According to the results of orthogonal analysis,frequency was the dominant factor of coal-fired fly ash acoustic agglomeration and the optimum frequency was 1400 Hz. | Jianzhong Liu Jie Wang Guangxue Zhang Junhu Zhou Kefa Cen | 2011 | Journal of Environmental Sciences2011，23，11： | 13 |
| 2 | Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism显示文摘Amycolatopsis mediterranei 被用于 rifamycin 的工业规模生产,它在 antimycobacterial 治疗起一个重要作用。作为类 Amycolatopsis 的首先定序的染色体, 236 715 底配对的包括 10 的紧张 U32 的染色体,最大的原核生物的染色体之一到目前为止曾经被定序。不同于在 streptomycetes 发现的线性拓扑学,这个染色体是圆形的,特别地类似于 Saccharopolyspora erythraea 和奴卡氏菌属 farcinica,在发展史和分类代表他们的靠近的关系。尽管在 A 预言了 9 228 编码蛋白质的基因。mediterranei 染色体 S 与那些分享了 orthologs 的最大的数字。erythraea,它被 Streptomyces coelicolor 而非 N 出人意料地跟随。farcinica,显示不同新陈代谢的特征经由改编演变到多样的生态的壁龛。除类似于那的一个核心区域以外在 streptomycetes 普通,有典型核心特征的一个新奇“伪核心”在非核心区域以内被定义,在 21 从 26 基因为第二等的代谢物生产聚类的总数被定位的地方。位于核心的 rifamycin 生合成基因簇为 rifamycin SV 的变换编码细胞色素 P450 酶必需品到 B,由比作 rifamycin 生产 B 紧张 S699 的高度相应的簇揭示了并且进一步由基因互补证实了。A 的 genomic 信息。mediterranei 表明在看起来复杂的规章的机制的控制下面不仅为各种各样的碳来源和无机的氮混合物的广泛的利用而且为新陈代谢的中介的有效 funneling 安排进第二等的抗菌素合成进程的一个新陈代谢的网络。 | Wei Zhao Yi Zhong Hua Yuan Jin Wang Huajun Zheng Ying Wang Xufeng Cen Feng Xu Jie Bai Xiaobiao Han Gang Lu Yongqiang Zhu Zhihui Shao Han Yan Chen Li Nanqiu Peng Zilong Zhang Yunyi Zhang Wei Lin Yun Fan Zhongjun Qin Yongfei Hu Baoli Zhu Shengyue Wang Xiaoming Ding Guo-Ping Zbao | 2010 | Cell Research2010，20，10： | 10 |
| 3 | Nitridation:A simple way to improve the catalytic performance of hierarchical porous ZSM-5 in benzene alkylation with methanol显示文摘Nitrided hierarchical porous ZSM-5 was synthesized by nitridation of hierarchical porous ZSM-5 with flowing ammonia at elevated temperature.The samples were characterized by XRD,SEM,Nitrogen sorption isotherms,NH3-TPD and Py-IR,and evaluated in alkylation of benzene and methanol.The result indicated that the high specific surface area of parent ZSM-5 was maintained,while the Bronsted acidity was effectively adjusted by nitridation.Moreover,the high suppression of ethylbenzene was observed on nitrided catalyst and this could be attributed to the decrease of Bronsted acidity which suppressed the methanol to olefins reactions. | Jing-Hui Lyu Hua-Lei Hu Jia-Yao Rui Qun-Feng Zhang Jie Cen Wen-Wen Han Qing-Tao Wang Xiao-Kun Chen Zhi-Yan Pan Xiao-Nian Li | 2017 | Chinese Chemical Letters2017，28，2： | 6 |
| 4 | On coherent structures in a three-dimensional transitional plane jet显示文摘Direct numerical simulation of coherent structures in the three-dimensional transitional jet with a moderate Reynolds number of 5000 was conducted. The finite volume method was used to discretize the governing equations in space and the low-storage, three-order Runge-Kutta scheme was used for time integration. The comparisons between the statistical results of the flow field and the related experimental data were performed to validate the reliability of the present numerical schemes. The emphasis was placed on the study of the spatial evolution of the three-dimensional coherent vortex structures as well as their interactions. It is found that the evolution of the spanwise vortex structures in three-dimensional space is similar to that in two-dimensional jet. The spanwise vortex structures are subject to three-dimensional instability and induce the formation of the streamwise and lateral vortex structures. Going with the breakup and mixing of the spanwise vortex structures, the streamwise and transverse vortex tubes also fall to pieces and the mixing arranged small-scale structures are formed in the flow field. Finally, the arrangement relationship among the spanwise, the streamwise and the lateral vortex structures was analyzed and their interactions were also discussed. | Kun Luo Jie Yan JianRen Fan KeFa Cen | 2008 | Science China(Technological Sciences)2008，51，4： | 3 |
| 5 | Differentially Expressed microRNAs as Potential Markers for Vital Reaction of Burned Skin显示文摘The identification of antemortem burns and postmortem burns is essential in forensic practice.In this study,microRNA(miRNA)microarray analysis was conducted to identify differentially expressed miRNAs in the skin of an experimental burn model.Microarray analysis revealed 24 differentially expressed miRNAs in antemortem burned mice skin,with 19 miRNAs significantly upregulated and 5 downregulated.Based on the intersection predicted using three databases(Targetscan,microRNA.org,and PITA),293 potential miRNA targets were identified.These dysregulated miRNAs and their predicted targets were further analyzed using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases.Several functional categories and signaling pathways were enriched,including the“fc epsilon ri signaling pathway,”“endometrial cancer,”and“mTOR signaling pathway.”Expression patterns of 10 differentially expressed miRNAs were verified by reverse transcription‑quantitative polymerase chain reaction in mice skins.The results agreed with the results of microarray analysis.These findings suggest that differentially expressed miRNAs revealed by microarray are potential markers for forensic molecular diagnosis of antemortem burns. | Hao‑Pin Lyu Ming Cheng Jin‑Cen Liu Ming‑Yuan Ye Di Xu Jie‑Tao He Xiao‑Li Xie Qi Wang | 2018 | Journal of Forensic Science and Medicine2018，4，3： | 2 |
| 6 | Duodenal perforation after organophosphorus poisoning: A case report显示文摘BACKGROUND Organophosphorus poisoning(OP)is one of the common critical conditions in emergency departments in China,which is usually caused by suicide by taking oral drugs.Patients with severe OP have disturbance of consciousness,respiratory failure,toxic shock,gastrointestinal dysfunction,and so on.As far as we know,the perforation of the duodenum caused by OP has not been reported yet.CASE SUMMARY A 33-year-old male patient suffered from acute severe OP,associated with abdominal pain.Multiple computed tomography scans of the upper abdomen showed no evidence of intestinal perforation.However,retrograde digital subtraction angiography,performed via an abdominal drainage tube,revealed duodenal perforation.After conservative treatment,the symptoms eased and the patient was discharged from hospital.CONCLUSION Clinicians should pay close attention to gastrointestinal dysfunction and abdominal signs in patients with severe OP.If clinical manifestation and vital signs cannot be explained by common complications,stress duodenal ulcer or perforation should be highly suspected. | Yuan-Lan Lu Jie Hu Lu-Ying Zhang Xiang-Yin Cen Deng-Hui Yang An-Yong Yu | 2021 | World Journal of Clinical Cases2021，9，27： | 2 |
| 7 | Therapeutic potential of menstrual blood stem cells in treating acute liver failure显示文摘BACKGROUND Acute liver failure(ALF)is a significant and complex hepatic insult that may rapidly progress to life-threatening conditions.Recently,menstrual blood stem cells(MenSCs)have been identified as a group of easily accessible mesenchymal stem cells with the advantages of non-invasive acquisition,low immunogenicity,a greater capacity of self-renewal and multi-lineage differentiation,making them promising candidates for stem cell-based therapy to revolutionize the treatment strategies for liver failure.AIM To investigate the therapeutic potential of MenSCs for treating ALF in pigs and to dynamically trace the biodistribution of transplanted cells.METHODS MenSCs were labeled in vitro with PKH26,a lipophilic fluorescent dye.The treatment group received immediate transplantation of PKH26-labelled MenSCs(2.5×106/kg)via the portal vein after D-galactosamine injection,and the control group underwent sham operation.The survival time,liver function,and hepatic pathological changes were compared between the two groups.Three major organs(liver,lungs and spleen)were extracted from animals and imaged directly with the In vivo Imaging System(IVIS)at the predetermined time points.The regions of interest were drawn to quantify the cell uptake in different organs.RESULTS The labelling procedure did not affect the morphology,viability or multipotential differentiation of MenSCs.Biochemical analysis showed that the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)and prothrombin time(PT)measured at selected time points 24 h after transplantation were significantly decreased in the treatment group(P<0.05).The survival time of ALF animals was prolonged in the treatment group compared with the control group(75.75±5.11 h vs 53.75±2.37 h,log rank,P<0.001).The liver pathological tissue in the MenSC treatment group showed obviously increased numbers of remaining hepatocytes and a comparatively slight necrotic degree and area.In addition,the IVIS imaging revealed that PKH26-positive MenSCs were clearly retained in the liver initially and then diffused through the systemic circulation.Interestingly,the signal intensity in the liver increased obviously at 36 h,which corresponded to the biochemical result that liver function deteriorated most rapidly at 24-36 h.CONCLUSION Our study demonstrates the therapeutic efficacy and homing ability of transplanted MenSCs in a large animal model of ALF and suggests that MenSC transplantation could be a promising strategy for treating ALF. | Pan-Pan Cen Lin-Xiao Fan Jie Wang Jia-Jia Chen Lan-Juan Li | 2019 | World Journal of Gastroenterology2019，25，41： | 2 |
| 8 | Circ_0049447 acts as a tumor suppressor in gastric cancer through reducing proliferation, migration, invasion, and epithelial-mesenchymal transition显示文摘Background:Although increasing abnormal expression of circular RNAs(circRNAs)has been revealed in various cancers,there were a small number of studies about circRNAs in gastric cancer(GC).Here,we explored the expression and function of a novel circRNA,circ_0049447,in GC.Methods:A total of 80 GC tissues and non-tumorous tissues were collected from the First Affiliated Hospital of China Medical University.And all cells were cultured with 10%fetal bovine serum and incubated at 37°C and 5%CO2.The expression of circ_0049447 was quantified by real-time polymerase chain reaction.The biological function of circ_0049447 on proliferation,migration,invasion,and epithelial-mesenchymal transition(EMT)was evaluated by cell counting kit-8(CCK-8),colony formation assay,transwell migration and invasion assay,and Western blotting.Luciferase report assay was used to verify the direct binding between circ_0049447 and predicted microRNA(miRNA).Furthermore,a xenograft mouse model was used to validate the function of circ_0049447 in vivo.Results:We demonstrated that circ_0049447 was downregulated in GC(P<0.001).The area under the receiver operating characteristic curve reached 0.838,while sensitivity was 82.3%and specificity was 77.2%.CCK-8 and colony formation assay showed that overexpression of circ_0049447 could inhibit the proliferation(P<0.05).Transwell migration and invasion assay showed upregulated circ_0049447 could impede migration in GC cells(P<0.05).In addition,overexpression of circ_0049447 could impede GC cell EMT.Upregulation of miR-324-5p in GC specimens and direct binding between miR-324-5p with circ_0049447 proven by luciferase reporter assay indicated that circ_0049447 may inhibit GC by sponging certain miRNA.Conclusion:Circ_0049447 acts as a tumor suppressor in GC through reducing proliferation,migration,invasion,and EMT,and it is a promising biomarker for diagnosis. | Kai-Wen Tang Zhe-Xu Guo Zhong-Hua Wu Cen Zhou Jie Sun Xin Wang Yong-Xi Song Zhen-Ning Wang | 2021 | Chinese Medical Journal2021，，11： | 2 |
| 9 | A molecular roadmap for induced multi-lineage transdifferentiation of fibroblasts by chemical combinations显示文摘 | Xiaoping Han Hao Yu Daosheng Huang Yang Xu Assieh Saadatpour Xia Li Lengmei Wang Jie Yu Luca Pinello Shujing Lai Mengmeng Jiang Xueying Tian Fen Zhang Yanhong Cen Yuko Fujiwara Wei Zhu Bin Zhou Tianhua Zhou Hongwei Ouyang Jianan Wang Guo-Cheng Yuan Shumin Duan Smart H Orkin Guoji Guo | 2017 | Cell Research2017，27，3： | 2 |
| 10 | A preliminary study onthe manufactured techniques of Tibetan ‘ Xuegang ’ copper coin显示文摘 | LIU Jie LI Xiao - cen YANG Jun | 2015 | J Guangxi Univ Nat ( Nat Sci Ed)2015，，1： | 1 |
| 11 | A common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression显示文摘 | Xing-dong Xiong Miook Cho Xiu-ping Cai Jie Cheng Xia Jing Jin-ming Cen Xinguang Liu Xi-li Yang Yousin Suh | 2014 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2014，，： | 1 |
| 12 | mTOR regulates cocaine-induced behavioural sensitization through the SynDIG1–GluA2 interaction in the nucleus accumbens显示文摘Behavioral sensitization is a progressive increase in locomotor or stereotypic behaviours in response to drugs. It is believed to contribute to the reinforcing properties of drugs and to play an important role in relapse after cessation of drug abuse. However, the mechanism underlying this behaviour remains poorly understood. In this study, we showed that mTOR signaling was activated during the expression of behavioral sensitization to cocaine and that intraperitoneal or intra-nucleus accumbens (NAc) treatment with rapamycin, a specific mTOR inhibitor, attenuated cocaine-induced behavioural sensitization. Cocaine significantly modified brain lipid profiles in the NAc of cocaine-sensitized mice and markedly elevated the levels of phosphatidylinositol-4-monophosphates (PIPs), including PIP, PIP2, and PIP3. The behavioural effect of cocaine was attenuated by intra-NAc administration of LY294002, an AKT-specific inhibitor, suggesting that PIPs may contribute to mTOR activation in response to cocaine. An RNA-sequencing analysis of the downstream effectors of mTOR signalling revealed that cocaine significantly decreased the expression of SynDIG1, a known substrate of mTOR signalling, and decreased the surface expression of GluA2. In contrast, AAV-mediated SynDIG1 overexpression in NAc attenuated intracellular GluA2 internalization by promoting the SynDIG1–GluA2 interaction, thus maintaining GluA2 surface expression and repressing cocaine-induced behaviours. In conclusion, NAc SynDIG1 may play a negative regulatory role in cocaine-induced behavioural sensitization by regulating synaptic surface expression of GluA2. | Hong-chun Li Jia-mei Zhang Rui Xu Yong-hai Wang Wei Xu Rong Chen Xue-mei Wan Hao-luo Zhang Liang Wang Xiao-jie Wang Lin-hong Jiang Bin Liu Ying Zhao Yuan-yuan Chen Yan-ping Dai Min Li Hua-qin Zhang Zhen Yang Lin Bai Jie Zhang Hong-bo Wang Jing-wei Tian Ying-lan Zhao Xiao-bo Cen | 2022 | Acta Pharmacologica Sinica2022，43，2： | 1 |
| 13 | Development of technologies for high phosphorus oolitic hematite utilization 显示文摘 | Wu Jie Wen Zhijun Cen Mingjin | 2011 | Steel Research In- ternational2011，82，5： | 1 |
| 14 | Theoretical Prediction and Experimental Investigation on the Thermal and Mechanical Properties of Bulk β‐ Yb 2 Si 2 O 7显示文摘 | Yan‐Chun Zhou Cen Zhao Feng Wang Yin‐Jie Sun Li‐Ya Zheng Xiao‐Hui Wang | 2013 | J. Am. Ceram. Soc2013，，12： | 1 |
| 15 | Evaluation of specific fecal protein biochips for the diagnosis of colorectal cancer显示文摘AIM: To develop and initially test a potential fecal protein biochip for the screening of colorectal cancer(CRC). METHODS: Fecal protein from 20 colorectal cancer patients and 20 healthy controls were extracted from all of the fecal samples and screened for proteomic differences using a Biotin label-based protein array. Candidate proteins were then verified by ELISA. Finally, we will select out the significant protein and a seven-target multiplex fecal protein biochip was generated and tested for 20 fecal samples to determine the effectiveness of the biochip on identifying CRC. And the value of the protein biochip would be discussed. RESULTS: After tested by protein biochip of the fecal protein from 20 colorectal cancer patients and 20 healthy controls and levels of calprotectin, M2-pyruvatekinase, angiopoietin-2, fibroblast growth factor-23(FGF-23), proteins of the matrix metalloproteinase, thrombopoietin(TPO) and interleukin-13(IL-13) were significantly different between CRC and healthy controls. The sensitivity of all the seven proteins combined was 0.7, specificity was 0.4, and area under the receiver operating characteristics was 0.729. The most promising combinations of test proteins were FGF-23, TPO, and IL-13, reaching a sensitivity of 0.7 and a specificity of 0.7. The combination of FGF-23 and TPO scored highest with sensitivity of 0.7 and specificity of 0.8. Its mean that the combination of FGF-23 and TPO has the highest value for the diagnosis of CRC in our study. CONCLUSION: A protein biochip composed of proteins found to be elevated in the feces of colorectal cancer patients has great potential as a noninvasive diagnostic for colorectal cancer. The addition of new protein biomarkers and technologies, as they are discovered, is an excellent avenue of future research. | Hui-Peng Wang Yang-Yun Wang Jie Pan Rong Cen Yuan-Kun Cai | 2014 | World Journal of Gastroenterology2014，20，5： | 1 |
| 16 | High suppressionof the formation of ethylbenzene in benzene alkylationwith methanol over ZSM-5 catalyst modified byplatinum显示文摘 | Hu Hualei Zhang Qunfeng Cen Jie | 2014 | Catalysis Communications2014，57，： | 1 |
| 17 | High suppression of the formation of ethylbenzene in benzene alkylation with methanol over ZSM-5 catalyst modified by platinum显示文摘 | Hu Hualei Zhang Qunfeng Cen Jie | 2014 | Catal Commun2014，57，： | 1 |
| 18 | Experimental study of acoustic agglomeration of coal-fired fly ash particles at low frequencies显示文摘 | Jianzhong Liu Guangxue Zhang Junhu Zhou Jie Wang Weidong Zhao Kefa Cen | 2009 | Powder Technology2009，，1： | 1 |
| 19 | Serostatus disclosure and associated factors among people living with HIV/AIDS (PLWHA) in Liuzhou City, China显示文摘Introduction HIV serostatus disclosure has become an entry criterion for prevention of sexual partners spread, so we aimed to examine the prevalence of disclosure and associated factors among people living with HIV / AIDS( PLWHA) in Liuzhou City,Guangxi Zhuang Autonomous Region,southern China. Methods The PLWHA with marital or regular sexual relationship were eligible for our study,and a self-designed questionnaire was assigned to all the conveniently sampled participants. Determinants of disclosure were analyzed using chi-square test and binary Logistic regression. Results A total of 425 PLWHA were included in the present study. Two hundred and forty-five( 57. 6%) disclosed their HIV-positive status to their spouses / regular sexual partners,while 180( 42. 4%) did not. Among the 245 informed spouses / regular sexual partners,236( 96. 3%) had received the HIV testing and the positive rate was 50. 4%. While among the non-in-formed spouses / regular sexual partners,63( 35. 0%) had received the HIV testing and the positive rate was 3. 2%. Binary Logistic regression analysis indicated that age,area,monthly income,HIV / AIDS related knowledge and antiretroviral therapy( ART) were independently associated with HIV serostatus disclosure. Conclusions The disclosure rate was low in this study. As to its influencing factors,it is necessary to provide comprehensive disclosure consulting among PLWHA living in urban,the elderly or high monthly income and emphasize the propaganda on HIV / AIDS related knowledge,expand coverage for antiretroviral therapy, so as to provide scientific reference for promoting HIV disclosure and reducing the HIV incidence of spouses / regular sexual partners among PLWHA. | Lin-Feng Hu Yu-Jing Zhang Ming-Qiang Li Xian-Xiang Feng Juan Liu Jing Ni Han Cen Jie Liu Dong-Qing Ye | 2014 | 中华疾病控制杂志2014，18，3： | 1 |
| 20 | Synthesis of Polypeptides with High-Fidelity Terminal Functionalities under NCA Monomer-Starved Conditions显示文摘Controlled polypeptide synthesis viaα-amino acid N-carboxylic anhydride(NCA)polymerization using conventional primary amine initiators encounters two major obstacles:(i)normal amine mechanism(NAM)and activated monomer mechanism(AMM)coexist due to amine basicity and nucleophilicity and(ii)NCA is notoriously sensitive towards moisture and heat and unstable upon storage.We serendipitously discover that N-phenoxycarbonyl-functionalizedα-amino acid(NPCA),a latent NCA precursor,could be polymerized solely based on NAM with high initiating efficiency by using primary amine hydrochloride as an initiator.The polymerization affords well-defined polypeptides with narrow polydispersity and highfidelity terminal functionalities,as revealed by the clean set of MALDI-TOF MS patterns.We further demonstrate successful syntheses of random and block copolypeptides,even under open-vessel conditions.Overall,the integration of moistureinsensitive and air-tolerant NPCA precursors with stable primary amine hydrochloride initiators represents a general strategy for controlled synthesis of high-fidelity polypeptides with sophisticated functions. | Lei Li Jie Cen Wenhao Pan Yuben Zhang Xuanxi Leng Zhengqi Tan Hao Yin Shiyong Liu | 2021 | Research2021，，1： | 1 |
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