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| 1 | Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism显示文摘Amycolatopsis mediterranei 被用于 rifamycin 的工业规模生产,它在 antimycobacterial 治疗起一个重要作用。作为类 Amycolatopsis 的首先定序的染色体, 236 715 底配对的包括 10 的紧张 U32 的染色体,最大的原核生物的染色体之一到目前为止曾经被定序。不同于在 streptomycetes 发现的线性拓扑学,这个染色体是圆形的,特别地类似于 Saccharopolyspora erythraea 和奴卡氏菌属 farcinica,在发展史和分类代表他们的靠近的关系。尽管在 A 预言了 9 228 编码蛋白质的基因。mediterranei 染色体 S 与那些分享了 orthologs 的最大的数字。erythraea,它被 Streptomyces coelicolor 而非 N 出人意料地跟随。farcinica,显示不同新陈代谢的特征经由改编演变到多样的生态的壁龛。除类似于那的一个核心区域以外在 streptomycetes 普通,有典型核心特征的一个新奇“伪核心”在非核心区域以内被定义,在 21 从 26 基因为第二等的代谢物生产聚类的总数被定位的地方。位于核心的 rifamycin 生合成基因簇为 rifamycin SV 的变换编码细胞色素 P450 酶必需品到 B,由比作 rifamycin 生产 B 紧张 S699 的高度相应的簇揭示了并且进一步由基因互补证实了。A 的 genomic 信息。mediterranei 表明在看起来复杂的规章的机制的控制下面不仅为各种各样的碳来源和无机的氮混合物的广泛的利用而且为新陈代谢的中介的有效 funneling 安排进第二等的抗菌素合成进程的一个新陈代谢的网络。 | Wei Zhao Yi Zhong Hua Yuan Jin Wang Huajun Zheng Ying Wang Xufeng Cen Feng Xu Jie Bai Xiaobiao Han Gang Lu Yongqiang Zhu Zhihui Shao Han Yan Chen Li Nanqiu Peng Zilong Zhang Yunyi Zhang Wei Lin Yun Fan Zhongjun Qin Yongfei Hu Baoli Zhu Shengyue Wang Xiaoming Ding Guo-Ping Zbao | 2010 | Cell Research2010，20，10： | 10 |
| 2 | Palladium-Catalyzed Asymmetric [4+3]-Cyclization Reaction of Fused 1-Azadienes with Amino-trimethylenemethanes: Highly Stereoselective Construction of Chiral Fused Azepines显示文摘Summary of main observation and conclusion A Pd-catalyzed asymmetric aromative[4+3]-cyclization reaction of amino-trimethylenemethanes(TMM,1d,ip3-oles)with fused 1-azadienes has been developed.This method enables access to the synthetically importance and biologically active benzofuran fused azepines and indeno-azepines in excellent efficiency and stereoselectivity(up to 95%yield,99%ee,>19:1 dr). | Prathibha Kumari Weiwei Liu Cheng-Jie Wang Jun Dai Mei-Xin Wang Qi-Qiong Yang Yu-Hua Deng Zhihui Shao | 2020 | Chinese Journal of Chemistry2020，38，2： | 5 |
| 3 | Modulating effects of RAMPs on signaling profiles of the glucagon receptor family显示文摘Receptor activity-modulating proteins(RAMPs)are accessory molecules that form complexes with specific G protein-coupled receptors(GPCRs)and modulate their functions.It is established that RAMP interacts with the glucagon receptor family of GPCRs but the underlying mechanism is poorly understood.In this study,we used a bioluminescence resonance energy transfer(BRET)approach to comprehensively investigate such interactions.In conjunction with c AMP accumulation,Gaqactivation andβ-arrestin1/2 recruitment assays,we not only verified the GPCR-RAMP pairs previously reported,but also identified new patterns of GPCR-RAMP interaction.While RAMP1 was able to modify the three signaling events elicited by both glucagon receptor(GCGR)and glucagon-like peptide-1 receptor(GLP-1 R),and RAMP2 mainly affectedβ-arrestin1/2 recruitment by GCGR,GLP-1 R and glucagon-like peptide-2 receptor,RAMP3 showed a widespread negative impact on all the family members except for growth hormone-releasing hormone receptor covering the three pathways.Our results suggest that RAMP modulates both G protein dependent and independent signal transduction among the glucagon receptor family members in a receptor-specific manner.Mapping such interactions provides new insights into the role of RAMP in ligand recognition and receptor activation. | Lijun Shao Yan Chen Shikai Zhang Zhihui Zhang Yongbing Cao Dehua Yang Ming-Wei Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 4 | Two-dimensional local graph embedding discriminant analysis (2DLGEDA) with its application to face and palm biometrics 显示文摘 | WAN Minghua LAI Zhihui SHAO Jie | 2009 | Neurocomputing(S0925-2312)2009，73，1： | 1 |
| 5 | General and Phosphine-Free Cobalt-Catalyzed Hydrogenation of Esters to Alcohols显示文摘Background and Originality Content Reduction of esters to alcohols is a fundamental transformation in organic chemistry,and is important for the production of a wide range of bulk and fine chemicals.Compared with traditional approaches using stoichiometric amounts of metal hydride reagents,catalytic hydrogenation represents an environmentally benign and atom economic alternative. | Zhihui Shao Rui Zhong Raffaella Ferraccioli Yibiao Li Qiang Liu | 2019 | Chinese Journal of Chemistry2019，37，11： | 1 |
| 6 | Using Methanol as a Formaldehyde Surrogate for Sustainable Synthesis of N-Heterocycles via Manganese-Catalyzed Dehydrogenative Cyclization显示文摘The development of an efficient and sustainable synthetic route for formaldehyde production from renewable feedstock,especially in combination with a subsequent transformation to straightforwardly construct valuable chemicals,is highly desirable.Herein,we report a novel manganese-catalyzed dehydrogenative cyclization of methanol as a formaldehyde surrogate with a variety of dinucleophiles for facile synthesis of N-heterocycles.The in situ generated formaldehyde via catalytic methanol dehydrogenation can be selectively trapped by diverse dinucleophiles to avoid several possible side reactions.The utilty of this transformation is further highlighted by its successful appliation to the synthesis of 13C-labeled N-heterocycles using 13CH_(3)OH as a readily accessible 13C-isotope reagent. | Zhihui Shao Shanshan Yuan Yibiao Li Qiang Liu | 2022 | Chinese Journal of Chemistry2022，40，10： | 1 |
| 7 | Pd-catalyzed functionalization of 1,3-enynes via alkylene-π-allylpalladium intermediates显示文摘In recent years,the concept of transition metal-catalyzed functionalization of unsaturated hydrocarbons has emerged as a promising strategy for developing new and valuable reactions,and has attracted considerable attention because it is efficient and atomic economical.In this critical review,we describe recent advances that have been made in the development of transition metal-catalyzed functionalization of 1,3-enynes via alkyleneπ-allylpalladium intermediates. | Long Li Shan Wang Ajay Jakhar Zhihui Shao | 2023 | Green Synthesis and Catalysis2023，4，2： | 0 |
| 8 | GInR positive transcriptional regulation of the phosphate-specific transport system pstSCAB in Amycolatopsis mediterranei U32显示文摘 | Yuhui Zhang Yixuan Zhang Peng Li Ying Wang Jin Wang Zhihui Shao Guoping Zhao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 0 |
| 9 | Facile preparation and efficient MnxCoy porous nanosheets for the sustainable catalytic process of soot显示文摘The pursuit of high-performance is worth considerable effort in catalysis for energy efficiency and environmental sustainability. To develop redox catalysts with superior performance for soot combustion, a series of Mn_(x)Co_(y) oxides were synthesized using MgO template substitution.This method greatly improves the preparation and catalytic efficiency and is more in line with the current theme of green catalysts and sustainable development. The resulting Mn_(1)Co_(2.3) has a strong activation capability of gaseous oxygen due to a high concentration of Co^(3+) and Mn^(3+). The Mn doping enhanced the intrinsic activity by prompting oxygen vacancy formation and gaseous oxygen adsorption. The nanosheet morphology with abundant mesoporous significantly increased the solid–solid contact efficiency and improved the adsorption capability of gaseous reactants. The novel design of Mn_(1)Co_(2.3)oxide enhanced its catalytic performance through a synergistic effect of Mn doping and the porous nanosheet morphology, showing significant potential for the preparation of high-performance soot combustion catalysts. | Miaomiao Hu Kun Zhou Tingyi Zhao Zheng Li Xianhai Zeng Di Yu Xuehua Yu Mingqin Zhao Zhihui Shao Qixiang Xu Bing Cui | 2024 | Green Energy & Environment2024，9，3： | 0 |
| 10 | Optimization of PCR system in EST-SSR analysis of Pinus massoniana Lamb显示文摘All factors affecting the PCR system in Pinus massoniana Lamb were investigated one by one.The results show that the optimum PCR system of EST-SSR were:2μL 10×Buffer(Mg2+ Free), 30 ng template DNA,0.187 5 mmol/L dNTPs, 3.75 mmol/L Mg2+,8 pmol primer pair,1.0 U Taq DNA poly-merase in total 20μL reaction system. Finally,a total of 11 isolates of P.massoniana was used for testing the stability of the PCR amplification.The results prove that the optimum PCR system was stable,reliable,highly repetitive. | Shao Junpei Li Zhihui Yang Mohua Huang Liqun Hong Yonghui Huang Yifa | 2012 | Chinese Forestry Science and Technology2012，11，3： | 0 |
| 11 | Vascular bundle connection between seed stalk and seed coat of Caragana arborescens显示文摘The purpose of this study was to investigate the morphology, transmission route of photosynthetic products in the seed stalk of Caragana arborescens Lam. at various stages after flowering and evaluate the role of the seed stalk in seed maturation using scanning electron microscopy. We found that the mature seed stalk mainly consisted of vessels,sclerenchymatous cells and parenchymatous cells. Elongated cells formed a ring at the junction between the seed stalk and seed, and a large hollow was produced by two layers of sclerenchymatous cells in the interior seed, which functions to sustain seed growth. The opening in the center of the ring was closed during an early stage of seed development, and the opening enlarged as the seed matured.There were two routes for material transport, which started from the seed stalk: one from the seed coat to the embryo,and another directly entering the embryo. Vessels, which are abundant in the seed stalk, are the pathway for absorption of nutrients by the seeds. The vessels were densely packed in the seed stalk, and secondary thickening of the cell wall of the vessels was characterized by net thread thickening, while the secondary thickening of the cell wall of the vessels within the seed was characterized by screw thread thickening. The morphological characteristics of the vessels were adaptive to its functions. | Zhihui Luan Daowei Zhou Diankun Shao | 2018 | Journal of Forestry Research2018，29，1： | 0 |
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