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| 1 | Diagnostic performance of contrast-enhanced ultrasound and enhanced magnetic resonance for breast nodules显示文摘In the current study, we sought to evaluate the diagnostic efficacies of conventional ultrasound(US), contrastenhanced US(CEUS), combined US and CEUS and magnetic resonance imaging(MRI) in detecting focal solid breast lesions. Totally 117 patients with 120 BI-RADS category 4A-5 breast lesions were evaluated by conventional US and CEUS, and MRI, respectively. SonoVue was used as contrast agent in CEUS and injected as an intravenous bolus; nodule scan was performed 4 minutes after bolus injection. A specific sonographic quantification software was used to obtain color-coded maps of perfusion parameters for the investigated lesion, namely the time-intensity curve.The pattern of contrast enhancement and related indexes regarding the time-intensity curve were used to describe the lesions, comparatively with pathological results. Histopathologic examination revealed 46 benign and 74 malignant lesions. Sensitivity, specificity, and accuracy of US in detecting malignant breast lesions were 90.14%, 95.92%, and 92.52%, respectively. Meanwhile, CE-MRI showed sensitivity, specificity, and accuracy of 88.73%, 95.92%, and91.67%, respectively. The area under the ROC curve for combined US and CEUS in discriminating benign from malignant breast lesions was 0.936, while that of MRI was 0.923, with no significant difference between them, as well as among groups. The time-intensity curve of malignant hypervascular fibroadenoma and papillary lesions mostly showed a fast-in/fast-out pattern, with no good correlation between them(kappa <0.20). In conclusion, the combined use of conventional US and CEUS displays good agreement with MRI in differentiating benign from malignant breast lesions. | Cuiying Li Haiyan Gong Lijun Ling Liwen Du Tong Su Shui Wang Jie Wang | 2018 | The Journal of Biomedical Research2018，32，3： | 27 |
| 2 | Triptolide Inhibits Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression in Human Colon Cancer and Leukemia Cells显示文摘Triptolide ( TP ),繁体中文药,被报导了在在几人的肿瘤 celllines.This 研究的肿瘤的活动调查的自体免疫的疾病和施加的反的治疗有效在人的结肠癌房间( SW114 )的 TP 的反肿瘤效果 andmyelocytic 白血病( K562 ),并且阐明可能的分子的机制 involved.SW114 和 K562cells 与 TP ( 0,5,10,20 ,或 50 ng/ml )的不同剂量被对待。房间生存能力被 3- 估计[4,5-dimethylthiazol-2-yl ]-2,5-diphenyltetrazolium 溴化物(MTT ) 。结果证明 TP 以一种剂量依赖者方式禁止了两根肿瘤房间线的增长。为了推进,调查它的机制,产品前列腺素 E2 (PGE2 ) 和氮的氧化物(没有) 被连接酶的免疫吸着剂试金(ELISA ) 测量。我们的数据证明 TP 强烈禁止了生产没有并且有这些的 PGE2.Consistent 结果,表示可诱导合酶(i NOS ) 和 cyclooxygenase-2 (COX-2 ) 都不在 mRNA 水平和蛋白质表示水平两个都是起来调整的由即时 RT-PCR 并且西方的弄污出现。这些结果显示煽动性的因素 COX-2 和 i NOS 活动的抑制能涉及 TP 的 antitumormechanisms。 | Xiangmin TONG~# Shui’er ZHENG~# Jie JIN Lifen ZHU Yinjun LOU and Hangping YAO Institute of Hematologic Disease,Department of Hematology,First Affiliated Hospital,Medical School,Zhejiang University,Hangzhou 310003,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，2： | 12 |
| 3 | Seismites in the Dasheng Group: New evidence of strong tectonic and earthquake activities of the Tanlu Fault Zone显示文摘More than 80 layers of seismites were recognized from the Early Cretaceous Dasheng Group in the Mazhan and Tancheng graben basins in the Tanlu Fault Zone, eastern China. The responsible seismic events took place about 110–100 Ma in the Early Cretaceous. The fault zone was affected at the time by strong tectonics, due to tension-related stretching and scattered squeezing by strike-slip faults. These tectonic activities induced a series of strong earthquakes with Richter magnitudes(M) of 5–8.5. The earthquakes affected saturated or semi-consolidated flood and lake sediments, and produced intra-layer deformations by several processes, including liquefaction, thixotropy, drop, faulting, cracking, filling and folding, which resulted in the formation of various soft-sediment deformation structures, such as dikes and veins of liquefied sand, liquefied breccias, liquefied homogeneous layers, load structures, flame structures, ball-and-pillow structures, boudinage, diapirs, fissure infillings, a giant conglomerate wedge, and syn-sedimentary faults. The seismites are new evidence of tectonic and seismic activities in the Tanlu Fault Zone during the Early Cretaceous; the series of strong seismic events that can be deduced from them must be considered as a response to the destruction of the North China Craton. | TIAN Hong Shui Antonius Johannes VAN LOON WANG Hua Lin ZHANG Shen He ZHU Jie Wang | 2016 | Science China Earth Sciences2016，59，3： | 10 |
| 4 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 5 | Effect of traditional Chinese medicine compounds on rumen fermentation, methanogenesis and microbial flora in vitro显示文摘This study was conducted to investigate the effects of traditional Chinese medicine compounds(TCMC)on rumen fermentation, methane emission and populations of ruminal microbes using an in vitro gas production technique. Cablin patchouli herb(CPH), Atractylodes rhizome(AR), Amur Cork-tree(AC) and Cypsum were mixed with the weight ratios of 1:1:1:0.5 and 1:1:1:1 to make up TCMC1 and TCMC2,respectively. Both TCMC were added at level of 25 g/kg of substrate dry matter. In vitro gas production was recorded and methane concentration was determined at 12 and 24 h of incubation. After 24 h, the incubation was terminated and the inoculants were measured for pH, ammonia nitrogen, volatile fatty acids(VFA). Total deoxyribonucleic acid of ruminal microbes was extracted from the inocula, and populations were determined by a real-time quantitative polymerase chain reaction. Populations of total rumen methanogens, protozoa, total fungi, Ruminococcus albus, Fibrobacter succinogenes and Ruminococcus flavefaciens were expressed as a proportion of total rumen bacterial 16 S ribosomal deoxyribonucleic acid. Compared with the control, the 2 TCMC decreased(P < 0.05) total VFA concentration,acetate molar proportion, acetate to propionate ratio, gas and methane productions at 12 and 24 h,hydrogen(H) produced and consumed, and methanogens and total fungi populations, while the 2 TCMC increased(P < 0.05) propionate molar proportion. Traditional Chinese medicine compound 1 also decreased(P ≤ 0.05) R. flavefaciens population. From the present study, it is inferred that there is an effect of the TCMC in suppressing methanogenesis, probably mediated via indirect mode by channeling H2 utilized for methanogenesis to synthesis of propionate and direct action against the rumen microbes involved in methane formation. In addition, the relative methane reduction potential(RMRP) of TCMC2 was superior to that of TCMC1. | Shui Ping Wang Wen Juan Wang Zhi Liang Tan Guo Wei Liu Cheng Fu Zhou Meng Jie Yin | 2019 | Animal Nutrition2019，，2： | 4 |
| 6 | Potential transcriptional regulatory regions exist upstream of the human ezrin gene promoter in esophageal carcinoma cells显示文摘我们以前证明这个区域 ? 人的 ezrin 基因(VIL2 ) 的 87/+134 在人的食道的癌 EC109 房间,和一个进一步在上游的区域展出了倡导者活动 ?1324/? 890 断然调整的抄写。在这研究,识别 transcriptional VIL2 倡导者在上游的规章的区域,我们克隆 VIL2 ?1541/? 包含 ? 1324/ 的 706 片断 ? 890,并且调查了它的 transcriptional 经由酶试金在的规章的性质短暂地 transfected 房间。在 EC109 房间,它被发现那 VIL2 ?1541/? 706 项拥有的倡导者和 enhancer 活动。我们也局部性的 transcriptional 由熔化 VIL2 的 5 删除或 3 删除片断的规章的区域 ?1541/? 706 到一个酶记者。我们发现有三积极并且一否定 transcriptional 在 VIL2 以内的规章的区域 ?1541/? 706 在 EC109 房间。当这些区域独立被定位时没有倡导者的酶基因在上游,或定位指导酶基因的 VIL2 倡导者或 SV40 倡导者在上游,仅仅 VIL2 ?1297/? 1186 展出了可观的倡导者和 enhancer 活动,它是比那些低的 ?1541/? 706。另外, Sp1 的短暂表示增加了 ezrin 表示和 VIL2 的 transcriptional 激活 ?1297/? 1186。尽管在删除实验展出显著地积极或否定的 transcriptional 规定,另外的三个区域显示出一条更弱或不在的规定。这些数据建议 VIL2 倡导者在上游的超过一个区域参予了 VIL2 抄写,和 VIL2 ?1297/? 1186,可能作为关键 transcriptional 规章的区域,在有另外的潜在的规章的区域的同伴的调整 VIL2 抄写。 | Shuying Gao Yanpeng Dai Meijun Yin Jing Ye Gang Li Jie Yu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，6： | 4 |
| 7 | Metabolomics through the lens of precision cardiovascular medicine显示文摘Metabolomics, which targets at the extensive characterization and quantitation of global metabolites from both endogenous and exogenous sources, has emerged as a novel technological avenue to advance the field of precision medicine principally driven by genomics-oriented approaches. In particular,metabolomics has revealed the cardinal roles that the environment exerts in driving the progression of major diseases threatening public health. Herein, the existent and potential applications of metabolomics in two key areas of precision cardiovascular medicine will be critically discussed: 1) the use of metabolomics in unveiling novel disease biomarkers and pathological pathways; 2) the contribution of metabolomics in cardiovascular drug development. Major issues concerning the statistical handling of big data generated by metabolomics, as well as its interpretation, will be briefly addressed. Finally, the need for integration of various omics branches and adopting a multi-omics approach to precision medicine will be discussed. | Sin Man Lam Yuan Wang Bowen Li Jie Du Guanghou Shui | 2017 | Journal of Genetics and Genomics2017，44，3： | 3 |
| 8 | Aortic rupture during radiofrequency catheter ablation of left ventricular tachycardia显示文摘 | Qi Shuying Yao Yan Sun Jiaan Ma Yanzhuo Li Jie Wang Dongmei | 2014 | Chinese Medical Journal2014，，12： | 3 |
| 9 | Comprehensive lipidomics in apoM^(-/-) mice reveals an overall state of metabolic distress and attenuated hepatic lipid secretion into the circulation显示文摘Apolipoprotein M(apoM) participates in both high-density lipoprotein and cholesterol metabolism. Little is known about how apo M affects lipid composition of the liver and serum. In this study, we systemically investigated the effects of apo M on liver and plasma lipidomes and how apo M participates in lipid cycling, via apo M knockout in mice and the human SMMC-7721 cell line. We used integrated mass spectrometry-based lipidomics approaches to semiquantify more than 600 lipid species from various lipid classes, which include free fatty acids, glycerolipids, phospholipids, sphingolipids, glycosphingolipids, cholesterol, and cholesteryl esters(CEs), in apo M^(-/-)mouse. Hepatic accumulation of neutral lipids, including CEs, triacylglycerols, and diacylglycerols, was observed in apo M^(-/-)mice;while serum lipidomic analyses showed that, in contrast to the liver, the overall levels of CEs and saturated/monounsaturated fatty acids were markedly diminished. Furthermore, the level of Apo B-100 was dramatically increased in the liver, whereas significant reductions in both Apo B-100 and low-density lipoprotein(LDL) cholesterol were observed in the serum of apo M^(-/-)mice, which indicated attenuated hepatic LDL secretion into the circulation. Lipid profiles and proinflammatory cytokine levels indicated that apo M^(-/-)leads to hepatic steatosis and an overall state of metabolic distress. Taken together, these results revealed that apo M knockout leads to hepatic steatosis, impaired lipid secretion, and an overall state of metabolic distress. | Yuanping Shi Sin Man Lam Hong Liu Guanghua Luo Jun Zhang Shuang Yao Jie Li Lu Zheng Ning Xu Xiaoying Zhang Guanghou Shui | 2020 | Journal of Genetics and Genomics2020，47，9： | 2 |
| 10 | Configuration of nucleolar DNA in situ in nucleolus of Allium cepa cells显示文摘The location and configuration of nucleolar DNA have not been determined for a long time. In this paper, we have observed the nucleolar infrastructure and the character of nucleolar DNA in Allium cepa cells by conventional electron microscopy and the cytochemical NAMA-Ur DNA specific staining method. Furthermore, we have properly improved the NAMA-Ur method so as to analyze the location and configuration of nucleolar DNA in situ. Our results indicated that the nucleolar DNA in Allium cepa cells is mainly located at the border between fibrillar centers and dense fibribllar component, especially distributed in the configuration of encircling the fibrillar centers. | TAO Wei HE Jie JIAO Mingda HE Mengyuan HAO Shui | 2001 | Chinese Science Bulletin2001，46，1： | 1 |
| 11 | Synthesis and characterization of poly(lactic-acid) and aliphatic polycarbonate copolymers显示文摘 | Yu Tao Ren Jie Gu Shuying | 2009 | Polymer International2009，58，9： | 1 |
| 12 | Poly (d,l-lactide)/nano-hydroxyapatite composite scaffolds for bone tissue engineering and biocompatibility evaluation显示文摘 | Jie Ren Peng Zhao Tianbin Ren Shuying Gu Kefeng Pan | 2008 | Journal of Materials Science: Materials in Medicine2008，，3： | 1 |
| 13 | Study on the dyeing of wool fabrics with Phytolacca berry natural dyes显示文摘 | Jie Liu Ping Zhu Chuanjun Zhao Shuying Sui Zhaohong Dong Lin Zhang | 2014 | Fibers and Polymers2014，，8： | 1 |
| 14 | Preparation, Structure and Performances of Cross-Linked Regenerated Cellulose Fibers显示文摘Cross-linked regenerated cellulose fibers(CRCFs) were prepared by wet spinning firstly and then treated by high temperature curing. Cellulose dissolved in ionic liquid together with wrinkle proofing agent and cross-linking agent was employed as spinning solution. The properties and structure of CRCFs were investigated. Fourier transform infrared(FT-IR) spectroscopy and X-ray diffraction(XRD) analysis show that CRCFs were prepared successfully and the crystal form of the fibers remained the same before and after cross-linking. The results indicate that CRCFs prepared in this study possess more excellent wrinkle recovery ability and wash durability than those treated by finishing process. | LIU Jie WANG Huaifang ZHANG Lin SUI Shuying ZHANG Rui DONG Chaohong LIU Yun ZHU Ping | 2019 | Wuhan University Journal of Natural Sciences2019，24，1： | 1 |
| 15 | Structure-rheology responses of polylactide/calcium carbonate composites显示文摘 | Zhou Kai Gu Shuying Ren Jie | 2009 | Journal of Applied Polymer Science2009，114，3： | 1 |
| 16 | Characterization of calixarene/ionic liquid mixture as gas chromatographic sta- tionary phase through thermodynamic parameters显示文摘 | SHI Jie Hua JIA Qian Qian XU Shui Xing | 2012 | Chromatographia2012，75，1314： | 1 |
| 17 | Preparation of nano- sized hard carbon spherule and its electrochemical property 显示文摘 | SHU Jie SHUI Miao XU Dan | 2011 | Journal of Electroanalytical Chemistry2011，，1： | 1 |
| 18 | Chain-Linked Lactic Acid Polymers by Benzene Diisocyanate 显示文摘 | Ren Jie Wang Qinfeng Gu Shuying | 2006 | Journal of Applied Polymer Science2006，，99： | 1 |
| 19 | Rheology ofpoly(propylene)/ clay nanocomposites显示文摘 | Gu Shuying Ren Jie Wang Qinfeng | 2004 | Applied Polymer Science2004，91，4： | 1 |
| 20 | The potential dependent electrochemical impedance spectroscopy and lithium diffusion kinetics of LiFePO 4显示文摘 | Lin Feng Xiaoping Xu Miao Shui Weidong Zheng Jie Shu Lei Hui Linxia Xu Liangliang Chen Yuanlong Ren | 2014 | Solid State Ionics2014，，： | 1 |
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