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| 1 | Comparison between chemoembolization combined with radiotherapy and chemoembolization alone for large hepatocellular carcinoma显示文摘AIM: To investigate the efficacy of transcatheter arterial chemoembolization (TACE) combined with radiotherapy for unresectable large hepatocellular carcinoma (HCC).METHODS: From June 1994 to June 1999, a total of 76patients with large unresectable HCC were treated with TACE followed by external-beam irradiation. 89 patients with large HCC, who underwent TACE alone during the same period,served as the control group. Clinical features, therapeutic modalities, acute effects and survival rates were analyzed and compared between TACE plus irradiation group and TACE alone group. A multivariate analysis of nine clinical variables and one treatment variable (irradiation) was performed by the Cox proportional hazards model.RESULTS: The clinical features and therapeutic modalities except irradiation between the two groups were comparable (P>0.05). The objective response rate (RR) in TACE plus irradiation group was higher than that in TACE alone group (47.4 % vs28.1%, P<0.05). The overall survival rates in TACE plus irradiation group (64.0 %, 28.6 %, and 19.3 %at 1, 3, 5 years, respectively) were significantly higher than those in TACE alone group (39.9 %, 9.5 %, and 7.2%,respectively, P=0.0001). Cox proportional hazards model analysis showed that tumor extension and Child grade were significant and were independent negative predictors of survival, while irradiation was an independent positive predictor of survival.CONCLUSION: TACE combined with radiotherapy is more effective than TACE alone, and is a promising treatment for unresectable large HCC. | WeiJianGuo Er-XinYu Lu-MingLiu JieLi ZhenChen Jun-HuaLin Zhi-QiangMeng YiFeng | 2003 | World Journal of Gastroenterology2003，9，8： | 36 |
| 2 | Experimental animal models and infl ammatory cellular changes in cerebral ischemic and hemorrhagic stroke显示文摘Stroke,including cerebral ischemia,intracerebral hemorrhage,and subarachnoid hemorrhage,is the leading cause of long-term disability and death worldwide. Animal models have greatly contributed to our understanding of the risk factors and the pathophysiology of stroke,as well as the development of therapeutic strategies for its treatment. Further development and investigation of experimental models,however,are needed to elucidate the pathogenesis of stroke and to enhance and expand novel therapeutic targets. In this article,we provide an overview of the characteristics of commonly-used animal models of stroke and focus on the infl ammatory responses to cerebral stroke,which may provide insights into a framework for developing effective therapies for stroke in humans. | Tao Yan Michael Chopp Jieli Chen | 2015 | Neuroscience Bulletin2015，31，6： | 26 |
| 3 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 4 | Treatment for liver metastases from breast cancer: Results and prognostic factors显示文摘AIM: Liver metastases from breast cancer (BCLM) are associated with poor prognosis. Cytotoxic chemotherapy can result in regression of tumor lesions and a decrease in symptoms. Available data, in the literature, also suggest a subgroup of patients rraay berefit from surgery, but few talked about transcatheter arterial chemoembolization (TACE).We report the results of TACE and systemic chemotherapy for patients with liver metastases from breast cancer and evaluate the prognostic factors. METHODS: Forty-eight patients with liver metastases, from proved breast primary cancer were treated with TACEor systemic chemotherapy between January 1995 and December 2000. Treatment results were assessed according to WHO criteria, along with analysis of prognostic factors for survival using Cox regression model.RESULTS: The median follow-up was 28 mo (1-72 mo). Response rates were calculated for the TACE group and chemotherapy group, being 35.7% and 7.1%,respectively. The difference was significant. The one-, two- and three-year Survival rates for the TACE group were 63.04%, 30.35%, and 13.01%, and those for the systemic chemotherapy group were 33.88%, 11.29%, and 0%. According to univariate analysis, variables significantly associated with survival were the lymph node status of the primary cancer, the clinical stage of liver metastases, the Child-Pugh grade, loss of weight. Other factors such as age, the intervals between the primary to the metastases, the maximal diameter of the liver metastases, the number of liver metastases, extrahepatic metastasis showed no prognostic significances. These factors mentioned above such as the lymph node status of the primary cancer, the clinical stage of liver metastases, the Child-Pugh grade, loss of weight were also independent factors in multivariate analysis.CONCLUSION: TACE treatment of liver metastases from breast cancer may prolong survival in certain patients. This approach offers new promise for the curative treatment of the patients with metastatic breast cancer. | Xiao-PingLi Zhi-QiangMeng Wei-JianGuo JieLi | 2005 | World Journal of Gastroenterology2005，11，24： | 8 |
| 5 | Patients with SARS-CoV-2 and HBV coinfection are at risk of greater liver injury显示文摘To date,it remains unclear if severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)co-infection exacerbates liver injury in patients with chronic hepatitis B virus(HBV)infection.In this study,we present a retrospective study of 133 hospitalized confirmed mild coronavirus disease 2019(COVID-19)cases,including 116 patients with COVID-19 with negative serum hepatitis B antigen and 17 HBV inactive carriers with COVID-19.We found that there were no significant differences for the discharge rate or duration of hospitalization be-tween the two groups.However,inactive HBV carriers with SARS-CoV-2 co-infection are at a higher risk of abnormal liver function tests.The enhanced liver injury induced by SARS-CoV-2 and HBV co-infection was identified as the hepatocyte type rather than the cholangiocyte type.Moreover,the inflammatory response,including abnormal lactate dehydrogenase,D-dimer and interleukin-6 production,may contribute to this injury following SARS-CoV-2 co-infection.Collectively,SARS-CoV-2 and HBV co-infection exacerbates liver function of the pa-tients with COVID-19. | Yong Lin Jun Yuan Quanxin Long Jieli Hu Haijun Deng Zhenyu Zhao Juan Chen Mengji Lu Ailong Huang | 2021 | Genes & Diseases2021，8，4： | 5 |
| 6 | Clinical outcomes of elderly South-East Asian patients in primary percutaneous coronary intervention for ST- elevation myocardial infarction显示文摘评估临床的特征和经历主要经皮的冠的干预(PPCI ) 的老东南亚洲病人的在里面医院结果 .MethodsFrom 2009 年 1 月到 2012 年 12 月, 1268 个病人(86.4% 男性, 58.4 楴 的吝啬的年龄? | Jieli Tong Wen Wei Xiang An Shing Ang Wen Jun Sim Kien Hong Quah David Foo Paul Jau Lueng Ong Hee Hwa Ho | 2016 | Journal of Geriatric Cardiology2016，13，10： | 4 |
| 7 | Selective oxidation of methane to formaldehyde by oxygen over silica-supported iron catalysts显示文摘FeOx-SiO2 catalysts prepared by a sol-gel method were studied for the selective oxidation of methane by oxygen.A single-pass formaldehyde yield of 2.0% was obtained over the FeOx-SiO2 with an iron content of 0.5 wt% at 898 K.This 0.5 wt% FeOx-SiO2 catalyst demonstrated significantly higher catalytic performances than the 0.5 wt% FeOx/SiO2 prepared by an impregnation method.The correlation between the catalytic performances and the characterizations with UV-Vis and H2-TPR suggested that the higher dispersion of iron species in the catalyst prepared by the sol-gel method was responsible for its higher catalytic activity for formaldehyde formation.The modification of the FeOx-SiO2 by phosphorus enhanced the formaldehyde selectivity,and a single-pass formaldehyde yield of 2.4% could be attained over a P-FeOx-SiO2 catalyst(P/Fe = 0.5) at 898 K.Raman spectroscopic measurements indicated the formation of FePO4 nanoclusters in this catalyst,which were more selective toward formaldehyde formation. | Jieli He Yang Li Dongli An Qinghong Zhang Ye Wang | 2009 | Journal of Natural Gas Chemistry2009，18，3： | 3 |
| 8 | 人rab13基因克隆和表达显示文摘以人的胚胎cDNA为模板 ,用PCR方法筛选获得rab13基因 ,并克隆到真核表达载体pcDNA3和原核表达载体pGEX、pET 15b和 pMAL c2中 .把rab13基因转染入牛肾上腺毛细血管内皮细胞 (BCE细胞 )中 ,免疫荧光染色显示Rab13定位于BCE细胞胞质内膜性细胞器上 .在大肠杆菌DH5a或BL2 1:DE3中表达的原核质粒表达系统均显示rab13基因的高表达 . | 李希 徐根兴 王建军 李侠 沈海雁 JinpingMa JieLi MindongRen | 2000 | 南京大学学报(自然科学版)2000，36，5： | 3 |
| 9 | Spatiotemporal dynamics of the urban sprawl in a typical urban agglomeration: a case study on Southern Jiangsu, China (1983-2007)显示文摘 | Yongxue LIU Jieli CHEN Wangyu CHENG Chao SUN Saishuai ZHAO Yingxia PU | 2014 | Frontiers of Earth Science2014，8，4： | 3 |
| 10 | Geochemical Evidence for Coal and Carbonaceous Mudstone as the Possible Major Oil Source Rock in the Jurassic Turpan Basin, Northwest China显示文摘Petroleum geologists have debated whether the hydrocarbons from Jurassic coal measures are derived from the coals, carbonaceous mudstones or coal-measure mudstones in the Turpan Basin. Based on the geochemistry analysis of the 20 crude oils and 40 source rocks from the Turpan Basin, some data have been obtained as follows: carbon preference index and methylphenanthrene index of the Jurassic oils are 1.16-1.45 and 0.28-0.80, and the ααα C 29 sterane 20S/(20S+20R) and C 29 sterane ββ/(ββ+αα) are 0.44-0.51 and 0.4-0.54 respectively, which show the normal maturity of oils; the vitrinite reflectance of the source rocks from the Xishanyao to Badaowan Formations range from 0.47% to 0.97%, which indicate immature to mature thermal evolutionary stage and sufficient conditions for generating mass mature oil. The effect of hydrocarbon expulsion should be considered when studying the source of coal-derived oil by using Biomarkers. Biomarkers in the Jurassic oils from the basin are similar to those in the coals and carbonaceous mudstones, with a strong predominant content of pristane, relatively high ratio of C 15 /C 16 sesquiterpenoids (>1), a relatively high content of low carbon number tricyclic terpanes and C 24 tetracyclic terpane, little gammacerane and C 29 Ts detected, an absolute predominant content of C 29 sterane and a relatively high content of diasterane. However, the opposite characteristics are shown in mudstones, with an approximately equal content of pristane and phytane, relatively low ratio of C15 /C16 sesquiterpenoids (<1), a relatively high content of high carbon number tricyclic terpanes and a low content of C 24 tetracyclic terpane, peaks of gammacerane and C29 Ts detected obviously and an increasing C27 sterane content. All of these characteristics identify the coals and carbonaceous mudstones as the possible major oil source rocks in this area, and they were formed in the stronger oxidizing environment with shallower water than mudstones. | MENG Jianghui ZHANG Min ZHAO Hongjing LIU Luofu WANG Zhiyong ZHOU Jieli WANG Ying | 2012 | Acta Geologica Sinica(English Edition)2012，86，5： | 3 |
| 11 | Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective cohort study显示文摘The association between serum uric acid and the risk of incident diabetes in Chinese adults remains unknown.This study aimed to investigate this association in a community-dwelling population aged≥40 years in Shanghai,China.Oral glucose tole3rance test was conducted during baseline and follow-up visits.Relative risk regression was utilized to examine the associations between baseline gender-specific serum uric acid levels and incident diabetes risk.A total of 613(10.3%)incident diabetes cases were identified during the follow-up visit after 4.5 years.Fasting plasma glucose,postload glucose,and glycated hemoglobin A1c during the follow-up visit progressively increased across the sex-specific quartiles of serum uric acid(all Ps<0.05).The incidence rate of diabetes increased across the quartiles of serum uric acid(7.43%,8.77%,11.47%,and 13.43%).Multivariate adjusted regression analysis revealed that individuals in the highest quartile had 1.36-fold increased risk of diabetes compared with those in the lowest quartile of serum uric acid(odds ratio(95%confidence interval)=1.36(1.06−1.73)).Stratified analysis indicated that the association was only observed in women.Accordingly,serum uric acid was associated with the increased risk of incident diabetes among middle-aged and elderly Chinese women. | Di Cheng Chunyan Hu Rui Du Hongyan Qi Lin Lin Xueyan Wu Lina Ma Kui Peng Mian Li Min Xu Yu Xu Yufang Bi Weiqing Wang Yuhong Chen Jieli Lu | 2020 | Frontiers of Medicine2020，14，6： | 3 |
| 12 | Anemia in patients on combined androgen block therapy for prostate cancer显示文摘Aim: To study the effect of combined androgen block therapy on hemoglobin and hematocrit values in patients with prostate cancer. Methods: One hundred and thirty-six patients with adenocarcinoma of prostate were treated with combined androgen block (orchiectomy and flutamide 250 mg, tid). Complete blood counts were determined before and after 1,2,3,6,9 and 12 months of therapy. Results: The hemoglobin and hematocrit levels declined significantly in all patients and at all the time points after treatment (P<0.05). Conclusion: Prostate cancer patients treated with combined androgen block would develop obvious anemia. Recombinant human erythropoietin can be used to treat patients with severe anemia. (Asian J Androl 2004 Dec;6: 383-384) | Li-XinQian Li-XinHua Hong-FeiWu Yuan-GengSui Shuang-GuanCheng WeiZhang,JieLi Xin-RuWang | 2004 | Asian Journal of Andrology2004，6，4： | 3 |
| 13 | The prevalence of thyroid nodules and its relationship with metabolic parameters in a Chinese community-based population aged over 40 years显示文摘 | Hongwei Guo Min Sun Wei He Huanhuan Chen Wen Li Jinmei Tang Wei Tang Jieli Lu Yufang Bi Guang Ning Tao Yang Yu Duan | 2014 | Endocrine2014，，： | 2 |
| 14 | Atorvastatin Decreases C‐Reactive Protein‐Induced Inflammatory Response in Pulmonary Artery Smooth Muscle Cells by Inhibiting Nuclear Factor‐κB Pathway显示文摘 | JieLi Jian‐JunLi Jian‐GuoHe Jing‐longNan Yuan‐linGuo Chang‐mingXiong | 2010 | Cardiovascular Therapeutics2010，，1： | 2 |
| 15 | Enhanced osteoarthritis therapy by nanoengineered mesenchymal stem cells using biomimetic CuS nanoparticles loaded with plasmid DNA encoding TGF-β1显示文摘Mesenchymal stem cells(MSCs)therapy shows the potential benefits to relieve clinical symptoms of osteoarthritis(OA),but it is uncertain if it can repair articular cartilage lesions-the main pathology of OA.Here,we prepared biomimetic cupper sulfide@phosphatidylcholine(CuS@PC)nanoparticles(NPs)loaded with plasmid DNA(pDNA)encoding transforming growth factor-beta 1(TGF-β1)to engineer MSCs for enhanced OA therapy via cartilage regeneration.We found that the NPs not only promoted cell proliferation and migration,but also presented a higher pDNA transfection efficiency relative to commercial transfection reagent lipofectamine 3000.The resultant CuS/TGF-β1@PC NP-engineered MSCs(termed CTP-MSCs)were better than pure MSCs in terms of chondrogenic gene expression,glycosaminoglycan deposition and type II collagen formation,favoring cartilage repair.Further,CTP-MSCs inhibited extracellular matrix degradation in interleukin-1β-induced chondrocytes.Consequently,intraarticular administration of CTP-MSCs significantly enhanced the repair of damaged cartilage,whereas pure MSCs exhibited very limited effects on cartilage regeneration in destabilization of the medial meniscus(DMM)surgical instability mice.Hence,this work provides a new strategy to overcome the limitation of current stem cell therapy in OA treatment through developing more effective nanoengineered MSCs. | Yu Cai Cuixi Wu Qianhua Ou Muhui Zeng Song Xue Jieli Chen Yao Lu Changhai Ding | 2023 | Bioactive Materials2023，，1： | 2 |
| 16 | Therapeutic Benefit of Intravenous Administration of Bone Marrow Stromal Cells After Cerebral Ischemia in Rats显示文摘 | Jieli Chen Yi Li Lei Wang Zhenggang Zhang Dunyue Lu Mei Lu Michael Chopp | 2001 | Stroke: Journal of the American Heart Association2001，，4： | 2 |
| 17 | Revisiting Asian monsoon formation and change associated with Tibetan Plateau forcing: II. Change显示文摘 | Yimin Liu Guoxiong Wu Jieli Hong Buwen Dong Anmin Duan Qing Bao Linjiong Zhou | 2012 | Climate Dynamics2012，，5： | 2 |
| 18 | Therapeutic benefit of intravenous transplantation of bone marrow stromal cells after cerebral ischemia in rats显示文摘 | Chen Jieli LI Yi Wang Lei | 2001 | Jourrnal of the Neurological sciences2001，189，： | 1 |
| 19 | Microwave-assisted synthesis of SrFe 12 O 19 hexaferrites显示文摘 | Wang Zhanyong Zhong Liuming Lv Jieli Qian Huichun Zheng Yuli Fang Yongzheng Jin Minglin Xu Jiayue | 2010 | Journal of Magnetism and Magnetic Materials2010，，18： | 1 |
| 20 | Recipe determination and scheduling of gasoline blending operations显示文摘 | JieLi I. A.Karimi RajagopalanSrinivasan | 2010 | AIChE J2010，，2： | 1 |
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