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| 1 | Management of entecavir-resistant chronic hepatitis B with adefovir-based combination therapies显示文摘AIM: To evaluate the long-term efficacy adefovir(ADV)-based combination therapies in entecavir(ETV)-resistant chronic hepatitis B(CHB) patients. METHODS: F i fty CHB pat ient s wi t h genotypic resistance to ETV at 13 medical centers in South Korea were included for the analysis. All the patients received rescue therapy with the combination of ADV plus ETV(ADV/ETV,n = 23) or ADV plus lamivudine(LMV)(ADV/LMV,n = 27) for more than 12 mo. Patients were monitored at least every 3-4 mo during ADV-based combination therapy by clinical examination as well as biochemical and virological assessments. Hepatitis B virus(HBV) DNA levels were measured by realtime PCR and logarithmically transformed for analysis. Cumulative rates of virologic response(VR; HBV DNA < 20 IU/m L) were calculated using the Kaplan-Meier method,and the difference was determined by a logrank test. Multivariate logistic regression and Cox proportional hazards models were used to identify independent risk factors significantly associated with short-term and long-term VR,respectively.RESULTS: Baseline median HBV DNA levels were 5.53(2.81-7.63) log10 IU/m L. The most commonly observed ETV genotypic mutation sites were rt184 and rt202. Patients were treated for a median of 27(12-45) mo. Overall,cumulative VR rates at 6,12,24,and 36 mo were 26%,36%,45%,and 68%,respectively. Patients treated with the ADV/ETV combination showed higher cumulative VR rates(35%,43%,65%,and 76%,respectively) than those with the ADV/LAM combination(18%,30%,30%,and 62%,respectively; P = 0.048). In the multivariate analysis,low baseline HBV DNA levels(< 5.2 log10 IU/m L) and initial virologic response at 3 mo(IVR-3; HBV DNA < 3.3 log10 IU/m L after 3 mo) were independent predictive factors for VR. Patients with favorable predictors achieved cumulative VR rates up to 90% at 36 mo. During the same period,the cumulative incidence of virologic breakthrough was as low as 6% in patients with the both favorable predictors.CONCLUSION: If tenofovir is not available,ADV/ETV combination could be considered in ETV-resistant patients with low HBV DNA titers,and may becontinued if IVR-3 is achieved. | Hyoung Su Kim Hyung Joon Yim Myoung Kuk Jang Ji Won Park Sang Jun Suh Yeon Seok Seo Ji Hoon Kim Bo Hyun Kim Sang Jong Park Sae Hwan Lee Sang Gyune Kim Young Seok Kim Jung Il Lee Jin-Woo Lee In Hee Kim Tae Yeob Kim Jin-Wook Kim Sook-Hyang Jeong Young Kul Jung Hana Park Seong Gyu Hwang | 2015 | World Journal of Gastroenterology2015，21，38： | 13 |
| 2 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 3 | Efficacy of Pegylated Interferon Monotherapy versus Sequential Therapy of Entecavir and Pegylated Interferon in Hepatitis B e Antigen-Positive Hepatitis B Patients: A Randomized, Multicenter, Phase IIIb Open-Label Study (POTENT Study)显示文摘 | Dae Won Jun Sang Bong Ahn Tae Yeob Kim Joo Hyun Sohn Sang Gyune Kim Se Whan Lee Byung Ho Kim Dong Joon Kim Ja Kyung Kim Hyoung Su Kim Seong Gyu Hwang Won Choong Choi Won Young Tak Heon Ju Lee Ki Tae Yoon Byung Cheol Yun Sung Wook Lee Soon Koo Baik Seung Ha Park Ji Won Park Sol Ji Park Ji Sung Lee | 2018 | Chinese Medical Journal2018，，14： | 5 |
| 4 | Dietary fat-associated osteoarthritic chondrocytes gain resistance to lipotoxicity through PKCK2/STAMP2/FSP27显示文摘Free fatty acids(FFAs), which are elevated with metabolic syndrome, are considered the principal offender exerting lipotoxicity. Few previous studies have reported a causal relationship between FFAs and osteoarthritis pathogenesis. However, the molecular mechanism by which FFAs exert lipotoxicity and induce osteoarthritis remains largely unknown. We here observed that oleate at the usual clinical range does not exert lipotoxicity while oleate at high pathological ranges exerted lipotoxicity through apoptosis in articular chondrocytes. By investigating the differential effect of oleate at toxic and nontoxic concentrations, we revealed that lipid droplet(LD) accumulation confers articular chondrocytes, the resistance to lipotoxicity. Using high fat diet-induced osteoarthritis models and articular chondrocytes treated with oleate alone or oleate plus palmitate, we demonstrated that articular chondrocytes gain resistance to lipotoxicity through protein kinase casein kinase 2(PKCK2)—six-transmembrane protein of prostate 2(STAMP2)—and fat-specific protein 27(FSP27)-mediated LD accumulation. We further observed that the exertion of FFAs-induced lipotoxicity was correlated with the increased concentration of cellular FFAs freed from LDs, whether FFAs are saturated or not. In conclusion, PKCK2/STAMP2/FSP27-mediated sequestration of FFAs in LD rescues osteoarthritic chondrocytes. PKCK2/STAMP2/FSP27 should be considered for interventions against metabolic OA. | Sung Won Lee Jee Hyun Rho Sang Yeob Lee Won Tae Chung Yoo Jin Oh Jung Ha Kim Seung Hee Yoo Woo Young Kwon Ju Yong Bae Su Young Seo Hokeun Sun Hye Young Kim Young Hyun Yoo | 2018 | Bone Research2018，6，3： | 3 |
| 5 | Risk Factors Associated with Complication Following Laparoscopy-Assisted Gastrectomy for Gastric Cancer: A Large-Scale Korean Multicenter Study显示文摘 | Min Chan Kim MD Wook Kim MD Hyung Ho Kim MD Seung Wan Ryu MD Seong Yeob Ryu MD Kyo Young Song MD Hyuk Joon Lee MD Gyu Seok Cho MD Sang Uk Han MD Woo Jin Hyung MD | 2008 | Annals of Surgical Oncology2008，，10： | 2 |
| 6 | Ostreae Testa prevent ovariectomy-induced bone loss in mice by osteoblast activations 显示文摘 | Sang Yeob Hana Jong Rok Lee Young Kyu Kwon | 2007 | Journal of Ethnopharmacology2007，114，： | 1 |
| 7 | Synthesis and curing of liquid crystalline epoxy resins based on 4, 4'-biphenol 显示文摘 | Jun Yeob Lee Jyongsik Jang Seung Sang Hwang etal | 1998 | Polymer1998，24，39： | 1 |
| 8 | Synthesis and curing of liquid crystalline epoxy resins based on 4,4' -biphenol显示文摘 | Jun Yeob Lee Jyongsik Jang Seung Sang Hwang Soon Man Hong Kwang Ung Kim | 1998 | Polymer1998，39，24： | 1 |
| 9 | Sol-gel transition behavior of biodegradable three-arm and four-arm star-shaped PLGA-PEG block copolymer aqueous solution显示文摘 | Su Jeong Lee Bo Ryeong Han Sang Yeob Park | 2006 | J Polym Sci Part A:Polym Chem2006，44，： | 1 |
| 10 | High Power Efficiency in Simplified Two Layer Blue Phosphorescent Organic Light-emitting Diodes显示文摘 | Jang Sang Eok Yook Kyoung Soo Lee Jun Yeob | | 0，，： | 1 |
| 11 | High power efficiency in simplified two layer blue phosphorescent organic light-emitting diodes 显示文摘 | Jang Sang Eok Yook Kyoung Soo Lee Jun Yeob | 2010 | Organic Electronics2010，11，： | 1 |
| 12 | Predictor of Severe Gastroduodenal Toxicity After Stereotactic Body Radiotherapy for Abdominopelvic Malignancies显示文摘 | Sun Hyun Bae Mi-Sook Kim Chul Koo Cho Jin-Kyu Kang Sang Yeob Lee Kyung-Nam Lee Dong Han Lee Chul Ju Han Ki Young Yang Sang Bum Kim | 2012 | International Journal of Radiation Oncology Biology Physics2012，，4： | 1 |
| 13 | Synthesis and curing of liquid crystalline epoxy resins based on 4,4'-biphenol显示文摘 | Jun Yeob Lee Jyongsik Jang Seung Sang Hwang Soon Man Hong and Kwang Ung Kim | 1998 | Polymer1998，39，24： | 1 |
| 14 | Risk Factors Associated with Complication Following Laparoscopy-Assisted Gastrectomy for Gastric Cancer: A Large-Scale Korean Multicenter Study显示文摘 | Min Chan Kim MD Wook Kim MD Hyung Ho Kim MD Seung Wan Ryu MD Seong Yeob Ryu MD Kyo Young Song MD Hyuk Joon Lee MD Gyu Seok Cho MD Sang Uk Han MD Woo Jin Hyung MD | 2008 | Annals of Surgical Oncology2008，，10： | 1 |
| 15 | High quantum efficiency in simple blue phosphorescent organic light-emitting diodes without any electron injection layer显示文摘 | Sang Eok Jang Chul Woong Joo Jun Yeob Lee | 2010 | Thin Solid Films2010，，2： | 1 |
| 16 | CpG Methylation of Transcription Factor 4 in Gastric Carcinoma显示文摘 | Jae Kyoon Joo Sang Hyun Kim Ho Gun Kim Dong Yi Kim Seong Yeob Ryu Kyung Hwa Lee Jae Hyuk Lee | 2010 | Annals of Surgical Oncology2010，，12： | 1 |
| 17 | Pentoxifylline versus corticosteroid to treat severe alcoholic hepatitis: A randomised, noninferiority, open trial显示文摘 | Seung Ha Park Dong Joon Kim Young Seok Kim Hyung Joon Yim Won Young Tak Heon Ju Lee Joo Hyun Sohn Ki Tae Yoon In Hee Kim Hyoung Su Kim Soon Ho Um Soon Koo Baik June Sung Lee Ki Tae Suk Sang Gyune Kim Sang Jun Suh Soo Young Park Tae Yeob Kim Jae Young Jang | 2014 | Journal of Hepatology2014，，： | 1 |
| 18 | Synthesis and curing of liquid crystalline epoxy resins based on 4,4′-biphenol显示文摘 | Jun Yeob Lee Jyongsik Jang Seung Sang Hwang Soon Man Hong Kwang Ung Kim | 1998 | Polymer1998，，24： | 1 |
| 19 | Application of automated cone penetrometer for railway investigation using correlations with DCPI and deflection modulus显示文摘Portable in-situ devices have been used for characterizing low accessible field,such as the railway subgrade.In this study,the automated cone penetrometer(ACP)was designed for the application on the railway subgrade.ACP is composed of the cone tip,driving rod,and hydraulic hammer system.The hydraulic motor lifts and drops the 294.3 N hammer from a height of 200 mm such that the potential energy of 58.9 N m impacts the driving rod.The N-value(NACP)from the ACP test was compared with the dynamic cone penetration index(DCPI)from the dynamic cone penetrometer(DCP)test.The test results show that the NACP and DCPI profiles show opposite trend owing to the inverse concept of the unit.From the correlation of DCPI and NACP,the limitation of DCPI reveals owing the minimum manually measured value of 1 mm/blow.Additionally,the evaluation of the deflection modulus(EFWD)using NACP is more efficient than that using DCPI.Based on the result of this study,we suggest that ACP can be used for strength and stiffness evaluation of railway subgrade rapidly and reliably. | Sang Yeob Kim Won-Taek Hong Jong-Sub Lee | 2022 | Research in Cold and Arid Regions2022，14，4： | 0 |
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