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| 1 | Integrative Analysis Reveals Enhanced Regulatory Effects of Human Long Intergenic Non-Coding RNAs in Lung Adenocarcinoma显示文摘Although there is an accumulating appreciation of the key roles that long intergenic non-coding RNAs(linc RNAs) play in diverse cellular processes, our knowledge of how linc RNAs function in cancer remains sparse. Here, we present a comprehensive landscape of RNA-seq transcriptome profiles of lung adenocarcinomas and their paired normal counterparts to unravel gene regulation rules of linc RNAs.Consistent with previous findings of co-expression between neighboring protein-coding genes, linc RNAs were typically co-expressed with their neighboring genes, which was found in both cancerous and normal tissues. By building a mathematical model based on correlated gene expression, we distinguished an additional subset of linc RNAs termed 'regulatory linc RNAs', representing their dominant roles in gene regulation. The number of regulatory linc RNAs was significantly higher in cancerous compared to normal tissues, and most of them positively regulated protein-coding genes in trans. Functional validation, using knockdown, determined that regulatory linc RNA,GAS5, affected its predicted protein-coding targets. Moreover, we discovered hundreds of differentially expressed regulatory linc RNAs with inclusion of some cancer-associated linc RNAs. Our integrated analysis reveals enhanced regulatory effects of linc RNAs and provides a resource for the study of regulatory linc RNAs that play critical roles in lung adenocarcinoma. | You Zhou Kai Wu Jianping Jiang Jinfei Huang Peiwei Zhang Yufei Zhu Guohong Hu Jingyu Lang Yufang Shi Landian Hu Tao Huang Xiangyin Kong | 2015 | Journal of Genetics and Genomics2015，42，8： | 3 |
| 2 | Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma显示文摘Hepatocellular 癌(HCC ) 是世界范围的致命的肝恶意。在这研究,我们报导了那个蛋白质磷酸酶镁依赖者(PPM1D ) 1 高度在 HCC 案例(约 59%) 的多数被表示并且显著地把水平与高浆液 -fetoprotein (法新社) 联系了(P = 0.044 ) 。Kaplan- Meier 和考克斯回归数据显示 PPM1D overexpression 是 HCCspecific 全面幸存的一个独立预言者(HR, 2.799;95% CI, 1.346-5.818, P = 0.006 ) 。, Overexpressing PPM1D 支持了房间生存能力和侵略 RNA 调停干扰 PPM1D 击倒有教养的 HCC 房间的禁止的增长,侵略,和移植。另外,由小介入 RNA 的 PPM1D 抑制减少了在 vivo 的 HCC 房间的 tumorigenicity。总的来说,结果建议 PPM1D 为 HCC 是一个潜在的预示的标记和治疗学的目标。 | Zhi Xu Chunxiang Cao Haiyan Xia Shujing Shi Lingzhi Hong Xiaowei Wei Dongying Gu Jianmin Bian Zijun Liu Wenbin Huang Yixin Zhang Song He Nikki Pui-Yue Lee Jinfei Chen | 2016 | Frontiers of Medicine2016，10，1： | 3 |
| 3 | The studies on the combustion and luminescence of SrAl2O4: Eu2+ 显示文摘 | Song Qingmei Huang Jinfei Wu Maojun | 1991 | Chin J Lumin1991，12，： | 1 |
| 4 | Clinical significance of the expression of DNA methyltransferase proteinsin gastric cancer显示文摘 | Jian Yang Xiaowei Wei Qingxiang Wu Zhi Xu Dongying Gu Yan Jin Yue Shen Huaying Huang Hong Fan Jinfei Chen | 2011 | Molecular Medicine Reports2011，，6： | 1 |
| 5 | Synthesis, Structural Studies and Reactivity of Two cis-Bis(phosphine)bis(silyl) Palladium(ll) Complexes显示文摘 | Lizhong Wang Jinfei Guo Yajuan Li Yanrong Su Jiawei Liu Yonghua Li Shi Wang Shigeru Shimada Wei Huang | 2017 | Chinese Journal of Chemistry2017，35，4： | 1 |
| 6 | Microstructural Evolution of Co_(35)Cr_(25)Fe_(30)Ni_(10) TRIP Complex Concentrated Alloy with the Addition of Minor Cu and Its Effect on Mechanical Properties显示文摘The influences of minor Cu addition(2 and 4 at.%)on the microstructural evolution and room-temperature mechanical property of metastable Co_(35)Cr_(25)Fe_(30)Ni_(10)are systemically investigated in the present study.The results indicate that the thermally induced hexagonal close-packed(HCP)phase is absent when Cu was added,due to the increase in stacking fault energy(SFE).The 2%-Cu-added alloys showed the largest total elongation of 69%among the three alloys.With the addition of Cu content reaching 4 at.%,heterogeneous grain structures composed of coarse grains(~9μm)and fine grains(~4μm)and Cu-rich precipitates near the grain boundary are observed,showing the highest yield strength.Additionally,the segregation state of Cu was quantitatively characterized by electron probe microanalysis(EPMA).And effects of Cu addition on microstructures and tensile properties of(Co_(35)Cr_(25)Fe_(30)Ni_(10))_(100-x) Cu _(x) are also discussed.The findings are beneficial to comprehensively understand the Cu-containing complex concentrated alloys. | Haoyang Yu Wei Fang Jinfei Zhang Jiaxin Huang Jiaohui Yan Xin Zhang Juan Wang Jianhang Feng Fuxing Yin | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，8： | 0 |
| 7 | Influence of nanosized magnesia on the hydration of borehole-sealing cements prepared using different methods显示文摘Gas drainage is an efective technology for gas control in coal mines.A high borehole-sealing quality is the fundamental precondition for efcient gas drainage.The expansibilities of cement pastes used in borehole-sealing processes are critical for the borehole-sealing efect.Nanosized magnesia expansive agents are used to improve the expansibilities of cement pastes and improve the borehole-sealing efect.Nuclear magnetic resonance spectrometry and scanning electron microscopy were adopted to study the efects of nanosized magnesia on the hydration of borehole-sealing cements used with diferent preparation methods.The results showed that an increase in the mass fraction of the nanosized magnesia promoted cement hydration,and the mass fraction was positively correlated with the promotion efect.The use of diferent preparation methods did not change the water-phase distribution in the cement.When using the wet-mixing preparation method,nanosized magnesia promoted the induction,acceleration,and deceleration periods of hydration;when using the dry-mixing preparation method,the nanosized magnesia promoted the induction period of cement hydration,and the promotion efect was less obvious than that seen when using the wet-mixing method.When using the wet-mixing preparation method,the nanosized magnesia was uniformly dispersed,thus enlarging the surface area of the reaction,which provided more nucleation sites for the hydration products of the cement and therefore accelerated the hydration reaction.When using the dry-mixing preparation method,the nanosized magnesia powders were dispersed nonuniformly and aggregated.Under these conditions,only a few nanosized magnesia particles on the surfaces of the aggregated clusters took part in hydration,so only a small number of nucleation sites were provided for the hydration products of cement.This led to inconsistent hydration of cement pastes prepared using the dry-mixing method.The surface porosity of the cement prepared with the wet-mixing preparation method frst decreased and then increased with increases in the mass fraction of the nanosized magnesia.The cement surface exhibited compact hydration products and few pores,and the surface was relatively smooth.In comparison,the surface porosity of the cement prepared using the dry-mixing method fuctuated with increasing mass fraction of the nanosized magnesia,resulting in a rough cement surface and microfractures on some surfaces.The two preparation methods both reduced the surface porosity of the cement.The wet-mixing preparation was more efective and consistent in improving the compactness of the cement than the dry-mixing preparation.These results provide important guidance on the addition of nanosized magnesia in borehole-sealing engineering and the selection of cement preparation methods,and they also lay a solid foundation for realizing safe and efcient gas drainage. | Quanle Zou Jinfei Zhan Xin Wang Zhen Huang | 2023 | International Journal of Coal Science & Technology2023，10，4： | 0 |
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