|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | In situ simultaneous determination of trace elements,U-Pb and Lu-Hf isotopes in zircon and baddeleyite显示文摘This paper describes a combined method of simultaneously measuring U-Pb and Lu-Hf isotopes as well as trace elements in Phalaborwa baddeleyite and 91500, GJ-1, TEMORA-1 and SK10-2 zircons by means of Neptune MC-ICPMS and Agilent Q-ICPMS connected to a 193 nm excimer laser ablation system. Material ablated by laser was carried in different proportions into Q-ICPMS for U-Pb isotopic and trace elemental and MC-ICPMS for Lu-Hf isotopic compositions. Experiments indicate that different proportions of ablated material for the Q-ICPMS and MC-ICPMS (6:4, 5:5 and 4:6 respectively) do not show any bias for the zircon/baddeleyite U-Pb age, Lu-Hf isotope and trace elemental compositions within ana-lytical errors. Using 40―60 μm spot size, the obtained U-Pb ages of Phalaborwa baddeleyite, 91500, GJ-1, TEMORA and SK10-2 zircons are 2065±15 (2σ, n=20), 1063±6 (2σ, n=19), 613±6 (2σ, n=20), 416±5 (2σ, n=20) and 32.6±0.5 (2σ, n=20) Ma, respectively. The 176Hf/177Hf ratios are 0.281231±24 (2SD, n=20), 0.282310±35 (2SD, n=19), 0.282028±34 (2SD, n=20), 0.282687±34 (2SD, n=20) and 0.282752±53 (2SD, n=20), respectively. The obtained trace elemental compositions are identical to the reference values. Therefore, this kind of technique makes it possible to simultaneously obtain the U-Pb age, Lu-Hf iso-topes and trace elemental compositions of zircon and baddeleyite, which could be an important tool in solving problems in earth sciences. | XIE LieWen ZHANG YanBin ZHANG HuiHuang SUN JingFeng WU FuYuan | 2008 | Chinese Science Bulletin2008，53，10： | 97 |
| 2 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 3 | A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2显示文摘The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying asymptomatic and presymptomatic carriers of the virus,and thus highlights a strong motivation for diagnostics with high sensitivity that can be rapidly deployed.On the other hand,several concerning SARS-CoV-2 variants,including Omicron,are required to be identified as soon as the samples are identified as‘positive’.Unfortunately,a traditional PCR test does not allow their specific identification.Herein,for the first time,we have developed MOPCS(Methodologies of Photonic CRISPR Sensing),which combines an optical sensing technology-surface plasmon resonance(SPR)with the‘gene scissors’clustered regularly interspaced short palindromic repeat(CRISPR)technique to achieve both high sensitivity and specificity when it comes to measurement of viral variants.MOPCS is a low-cost,CRISPR/Cas12a-systemempowered SPR gene-detecting platform that can analyze viral RNA,without the need for amplification,within 38 min from sample input to results output,and achieve a limit of detection of 15 fM.MOPCS achieves a highly sensitive analysis of SARS-CoV-2,and mutations appear in variants B.1.617.2(Delta),B.1.1.529(Omicron)and BA.1(a subtype of Omicron).This platform was also used to analyze some recently collected patient samples from a local outbreak in China,identified by the Centers for Disease Control and Prevention.This innovative CRISPR-empowered SPR platform will further contribute to the fast,sensitive and accurate detection of target nucleic acid sequences with single-base mutations. | Zhi Chen Jingfeng Li Tianzhong Li Taojian Fan Changle Meng Chaozhou Li Jianlong Kang Luxiao Chai Yabin Hao Yuxuan Tang Omar AAl-Hartomy Swelm Wageh Abdullah GAl-Sehemi Zhiguang Luo Jiangtian Yu Yonghong Shao Defa Li Shuai Feng William J.Liu Yaqing He Xiaopeng Ma Zhongjian Xie Han Zhang | 2022 | National Science Review2022，9，8： | 3 |
| 4 | CRISPR-Cas12a-Empowered Electrochemical Biosensor for Rapid and Ultrasensitive Detection of SARS-CoV-2 Delta Variant显示文摘Coronavirus disease 2019(COVID-19)is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The gold standard method for the diagnosis of SARS-CoV-2 depends on quantitative reverse transcription-polymerase chain reaction till now,which is time-consuming and requires expensive instrumentation,and the confirmation of variants relies on further sequencing techniques.Herein,we first proposed a robust technique-methodology of electrochemical CRISPR sensing with the advantages of rapid,highly sensitivity and specificity for the detection of SARS-CoV-2 variant.To enhance the sensing capability,gold electrodes are uniformly decorated with electro-deposited gold nanoparticles.Using DNA template identical to SARS-CoV-2 Delta spike gene sequence as model,our biosensor exhibits excellent analytical detection limit(50 fM)and high linearity(R2=0.987)over six orders of magnitude dynamic range from 100 fM to 10 nM without any nucleic-acid-amplification assays.The detection can be completed within 1 h with high stability and specificity which benefits from the CRISPR-Cas system.Furthermore,based on the wireless micro-electrochemical platform,the proposed biosensor reveals promising application ability in point-of-care testing. | Chenshuo Wu Zhi Chen Chaozhou Li Yabin Hao Yuxuan Tang Yuxuan Yuan Luxiao Chai Taojian Fan Jiangtian Yu Xiaopeng Ma Omar AAl-Hartomy SWageh Abdullah GAl-Sehemi Zhiguang Luo Yaqing He Jingfeng Li Zhongjian Xie Han Zhang | 2022 | Nano-Micro Letters2022，14，10： | 2 |
| 5 | A critical review of vanadium-based electrode materials for rechargeable magnesium batteries显示文摘Rechargeable magnesium batteries(RMBs)are one of the most promising next-generation energy storage devices due to their high safety and low cost.With a large family and versatile advantageous structures,vanadium-based compounds are highly competitive as electrode materials of RMBs.This review summa-rizes the structural characteristics,electrochemical performance,and refinement methods of vanadium-based materials,including vanadium oxides,vanadium sulfides,vanadates,vanadium phosphates,and vanadium spinel compounds,as RMB cathodes.Although relatively less,vanadium-based materials as RMB anodes are also introduced.According to the application requirements of RMBs,present common strategies are concluded to improve the electrochemical performance of vanadium-based materials;the probably promising development directions are also proposed,which are not limited only to the elec-trode materials,but also the compatible electrolytes and separator materials.In the near future,RMBs are expected from their large-scale application,standing at the forefront of the energy storage era. | Xiu-Fen Ma Hong-Yi Li Weiwei Ren Daibo Gao Fuyu Chen Jiang Diao Bing Xie Guangsheng Huang Jingfeng Wang Fusheng Pan | 2023 | Journal of Materials Science & Technology2023，，22： | 0 |
| 6 | Expert consensus on organizing the multidisciplinary team(MDT) diagnosis and treatment of hepato-pancreato-biliary diseases in China显示文摘Multidisciplinary team(MDT) discussion has been well established in some European countries and widely carried out in various clinical professional fields(Festen et al.,2021;Fleissig et al.,2006).Many studies have reported the benefits of MDT,including improving survival and quality of cancer care(Munro et al.,2015;Nixon et al.,2021;Tsai et al.,2020). | Binhao Zhang Jian Zhou Weifen Xie Kaishan Tao Shichun Lu Xianglin Yuan Lianxin Liu Weilin Wang Yilei Mao Ping Bie Jingfeng Liu Xinyu Bi Zhiwei Zhang Changhong Liang Jianqiang Cai Zhixiang Jian Yi Lv Peng Zhu Wei Zhang Hongqiang Yang Weiping Zhou Bixiang Zhang Xiaoping Chen | 2022 | Science China(Life Sciences)2022，65，5： | 0 |
| 7 | Identifying Qingkailing(清开灵)ingredients-dependent mesenchymal-epithelial transition factor-axiation“π”structuring module with angiogenesis and neurogenesis effects显示文摘OBJECTIVE:To explore the functional role of the drugdependent mesenchymal-epithelial transition(Met)-axiation'π'structural module of neurogenesis after processing by three components of Qingkailing injection in neurogenesis and angiogenesis in cerebral ischemia.METHODS:We used a Glutathione S-transferase(GST)-pull down assay,isothermal titration calorimetry assay,and other related methods to identify the relationships among Met,inositol polyphosphate phosphatase like 1(Inppl1),and death associated protein kinase 3(Dapk3)in this allosteric module.The biological effects of the modules of neurons generation composed of Met,Inppl1,and Dapk3 were measured through Western blot,apoptosis analysis,and double immunofluorescence labeling.RESULTS:The GST-pull down assay revealed that proline-serine-threonine rich domain of Met binds to the Src homology domain of Inppl1 to form a protein-protein complex;Dapk3 with a C-terminal domain interacts weakly with the protein kinase C domain of Met in the intracellular region.Thus,we obtained a“π”structuring module considered a neural regeneration module.The biological effects of angiogenesis and neurogenesis modules composed of Met,Inppl1,and Dapk3 were also verified.CONCLUSION:The study suggested that understanding the functional modules that contribute to pharmaceutics might provide novel signatures that can be used as endpoints to define disease processes under stroke or cerebral ischemia conditions. | CHENG Kunming YUAN Jianan LIU Jun ZHANG Shengpeng XU Qixiang XIE Yong ZHAO Jingfeng ZHANG Xiaoxu TANG Xudong ZHENG Yongqiu WANG Zhong | 2024 | Journal of Traditional Chinese Medicine2024，44，1： | 0 |
| 8 | Cooling Rate Dependence of Structural Order and Energy Landscape in Zr_(55)Cu_(35)Al_(10) Glass显示文摘Classical molecular dynamics simulation has been widely used to study the rapid cooling process of preparing amorphous alloys.However,the simulated cooling rate is several orders of magnitude higher than the experimental cooling rate.In this paper,Zr_(55)Cu_(35)Al_(10)alloy was taken as an example.It is found that adding isothermal annealing at a temperature slightly lower than Tand prolonging isothermal annealing time could effectively reduce the cooling rate.The glassy sample prepared in this way demonstrates significant energetic stability and well-developed short-range and medium-range order. | Jingfeng Zhao Xiangxu Xie Feng Chen Kailong Di Xuefeng Zhou | 2022 | Journal of Harbin Institute of Technology(New Series)2022，29，5： | 0 |
| 9 | Parameter study on lateral moments of banked wings in ground effect显示文摘Ground effect dramatically improves the performance of the Wing-in-Ground(WIG)vehicles near the ground.However,making coordinate turnings in ground effect zone may raise complexity in flight control.The Angle of Attack(AOA)and height are believed to be important factors.To find the impact of these factors,three straight rectangular wings with different aspect ratios are simulated via CFD approach.The results show that in normal situations,the rolling moment tends to level the wing but less effective with the decreasing AOA and changes its direction when the AOA is less than a height dependent value.The yaw moment exhibits complex behavior because two different effects generate oppose moments.The rolling moment coefficient is more influenced by the ground if a wing has larger Aspect Ratio(AR)and works at low to medium AOA.The yawing coefficient is always more influenced if the wing has larger AR regardless AOAs.These findings can provide basic guidance for the design of control system and enable aircraft designers to reshape the crafts to avoid or utilize this effect. | Jingfeng XIE Lei SONG Jun HUANG Jingcheng FU | 2022 | Chinese Journal of Aeronautics2022，35，3： | 0 |
| 10 | Structural Properties and Energy Analysis of Zr_(x)Cu_(90-x)Al_(10)Ternary Metallic Glasses显示文摘Classical molecular dynamics(MD)were conducted to study the structure and energy distribution of Zr_(x)Cu_(90-x)Al_(10)(x=20,30,40,50,60,70)ternary alloys.When the Zr composition is 30%,the glass transition temperature reaches the maximum value and the Zr_(30)Cu_(60)Al_(10)owns high glass forming ability(GFA).Analysis of the short⁃range structure shows that there are more low⁃energy Zr⁃centered polyhedron with high coordination number(CN)and Cu and Al⁃centered coordination polyhedron with CN=12 in Zr_(30)Cu_(60_Al_(10)alloy.As the medium⁃range structure is concerned,Zr_(30)Cu_(60_Al_(10)alloy has the largest number of coordination polyhedron connection sharing three atoms and connection in this way presenting the lowest energy.These low⁃energy and stable short and medium⁃range structures contribute to the high GFA of Zr_(30)Cu_(60_Al_(10). | Jingfeng Zhao Xiangxu Xie Feng Chen Kailong Di Xuefeng Zhou | 2023 | Journal of Harbin Institute of Technology(New Series)2023，30，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员