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| 1 | Development of "Purple Endosperm Rice" by Engineering Anthocyanin Biosynthesis in the Endosperm with a High-Efficiency Transgene Stacking System显示文摘Anthocyanins 在主食庄稼的 anthocyanin 生合成的高抗氧化剂活动,和工程例如米饭(Oryza sativa L.) ,能为改进人的健康提供支持健康的食物。然而,为 biofortification 设计新陈代谢的小径仍然保持困难,并且因为它的 biosynthetic 小径的复杂基因规章的网络,在米饭内乳设计 anthocyanin 生产的以前的尝试失败了。在这研究,我们为叠的 transgene 开发了一个高效率的向量系统并且使用了它在米饭内乳设计 anthocyanin 生合成。我们做了包含内乳特定的倡导者驾驶的八 anthocyanin 相关的基因(从从薄荷科植物的玉米和六结构的基因 ?的二规章的基因) 的构造,加为标记切除的一个可选的标记和基因。有这构造的米饭的转变产生了新奇 biofortified germplasm 紫色内乳瑞斯(用汉语的叫的 Zijingmi ) ,它在内乳有高 anthocyanin 内容和抗氧化剂活动。这 anthocyanin 生产源于 transgenes 和产生激活的表示(或改进) 13 内长的 anthocyanin 生合成基因的表示,那是 silenced 或在野类型的米饭内乳在底层表示。这研究为叠的 transgene 提供一个有效、万用的工具箱并且为一条复杂生物小径的成功的工程表明它的使用,建议为在工厂的农学的特点的合成生物学和改进的这个工具箱的潜在的用途。 | Qinlong Zhu Suize Yu Dongchang Zeng Hongmei Liu Huicong Wang Zhongtang Yang Xianrong Xie Rongxin Shen Jiantao Tan Heying Li Xiucai Zhao Qunyu Zhang Yuanling Chen Jingxing Guo Letian Chen Yao-Guang Liu | 2017 | Molecular Plant2017，10，7： | 47 |
| 2 | Cognitive improvement following transvenous adipose-derived mesenchymal stem cell transplantation in a rat model of traumatic brain injury显示文摘The effects of adipose-derived mesenchymal stem cell (ADMSC) transplantation for the repair of traumatic brain injury remain poorly understood. The present study observed neurological functional changes in a rat model of traumatic brain injury following ADMSC transplantation via the tail vein. Cell transplants were observed in injured cerebral cortex, and expression of brain-derived nerve growth factor was significantly increased in the injured hippocampus following transplantation. Results demonstrated that transvenous ADMSC transplants migrated to the injured cerebral cortex and significantly improved cognitive function. | Dongfei Li Chun Yang Rongmei Qu Huiying Yang Meichun Yu Hui Tao Jingxing Dai Lin Yuan | 2011 | Neural Regeneration Research2011，6，10： | 7 |
| 3 | Lipid rafts participate in aberrant degradative autophagic-lysosomal pathway of amyloid-beta peptide in Alzheimer's disease显示文摘Amyloid-beta peptide is the main component of amyloid plaques,which are found in Alzheimer’s disease.The generation and deposition of amyloid-beta is one of the crucial factors for the onset and progression of Alzheimer’s disease.Lipid rafts are glycolipid-rich liquid domains of the plasma membrane,where certain types of protein tend to aggregate and intercalate.Lipid rafts are involved in the generation of amyloid-beta oligomers and the formation of amyloid-beta peptides.In this paper,we review the mechanism by which lipid rafts disturb the aberrant degradative autophagic-lysosomal pathway of amyloid-beta,which plays an important role in the pathological process of Alzheimer’s disease.Moreover,we describe this mechanism from the view of the Two-system Theory of fasciology and thus,suggest that lipid rafts may be a new target of Alzheimer’s disease treatment. | Xin Zhou Chun Yang Yufeng Liu Peng Li Huiying Yang Jingxing Dai Rongmei Qu Lin Yuan | 2014 | Neural Regeneration Research2014，9，1： | 4 |
| 4 | Three abrupt climatic events since the Late Pleistocene in the North China Plain显示文摘Based on the data from 121 boreholes(9552 samples) and the distribution pattern analysis of foraminifera,ostracods,pollen,spores,wooly rhinoceros,elephants,water buffalo and beachrocks in time and space,three abrupt climate change events since the Late Pleistocene are recognized in the North China Plain.These climatic events caused three very warm periods and two severely cold periods.During the two warmest periods,the mean temperature was about 7℃ higher than at present,and during the two extreme cold periods,the mean temperature was some 6℃ lower than today.Moreover,the last warm period was in the Middle Holocene;its mean temperature was 3℃ higher than now in the region. | Lin Jingxing Chen Lei Yang Mei Qu Ming | 2013 | Journal of Palaeogeography2013，2，4： | 2 |
| 5 | Human iPS Cells Loaded with MnO2-Based Nanoprobes for Photodynamic and Simultaneous Enhanced Immunotherapy Against Cancer显示文摘How to trigger strong anti-tumor immune responses has become a focus for tumor therapy.Here,we report the human-induced pluripotent stem cells(iPSs)to deliver MnO2@Ce6 nanoprobes into tumors for simultaneous photodynamic therapy(PDT)and enhanced immunotherapy.Ce6 photosensitizer was attached on manganese dioxide(MnO2)nanoparticles,and resultant MnO2@Ce6 nanoprobes were delivered into mitomycin-treated iPSs to form iPS-MnO2@Ce6 nanoprobes.The iPS-MnO2@Ce6 actively targeted in vivo tumors,the acidic microenvironment triggered interaction between MnO2 and H2O2,released large quantities of oxygen,alleviated hypoxia in tumor.Upon PDT,singlet oxygen formed,broken iPSs released tumor-shared antigens,which evoked an intensive innate and adaptive immune response against the tumor,improving dendritic cells matured,effector T cells,and natural killer cells were activated.Meanwhile,regulatory T cells were reduced,and then the immune response induced by iPS-MnO2@Ce6 was markedly stronger than the immune reaction induced by MnO2@Ce6(P<0.05).The iPS-MnO2@Ce6 markedly inhibited tumor growth and metastasis and reduced mortality in mice models with tumor.Human iPS s loaded with MnO2-based nanoprobes are a promising strategy for simultaneous PDT and enhanced immunotherapy against tumor and own clinical translational prospect. | Yanlei Liu Jingxing Yang Bin Liu Wen Cao Jingpu Zhang Yuming Yang Lijun Ma Jesus Martinez de la Fuente Jie Song Jian Ni Chunfu Zhang Daxiang Cui | 2020 | Nano-Micro Letters2020，12，10： | 2 |
| 6 | Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase显示文摘Current DNA base editors contain nuclease and DNA deaminase that enables deamination of cytosine(C)or adenine(A),but no method for guanine(G)or thymine(T)editing is available at present.Here we developed a deaminase-free glycosylase-based guanine base editor(gGBE)with G editing ability,by fusing Cas9 nickase with engineered N-methylpurine DNA glycosylase protein(MPG).By several rounds of MPG mutagenesis via unbiased and rational screening using an intron-split EGFP reporter,we demonstrated that gGBE with engineered MPG could increase G editing efficiency by more than 1500 fold.Furthermore,this gGBE exhibited high base editing efficiency(up to 81.2%)and high G-to-T or G-to-C(i.e.G-to-Y)conversion ratio(up to 0.95)in both cultured human cells and mouse embryos.Thus,we have provided a proof-of-concept of a new base editing approach by endowing the engineered DNA glycosylase the capability to selectively excise a new type of substrate. | Huawei Tong Nana Liu Yinghui Wei Yingsi Zhou Yun Li Danni Wu Ming Jin Shuna Cui Hengbin Li Guoling Li Jingxing Zhou Yuan Yuan Hainan Zhang Linyu Shi Xuan Yao Hui Yang | 2023 | National Science Review2023，10，8： | 1 |
| 7 | Preliminary notes on Holecene transgression in the southeast coast of Liaodong Peninsula显示文摘 | Yang Wencai Lin Jingxing | | 0，，： | 1 |
| 8 | Transplanted adipose-derived stem cells delay D-galactose-induced aging in rats显示文摘To investigate the effects of allogeneically transplanted, adipose-derived stem cells in aging rats, in the present study, we established a rat model of subacute aging using continuous subcutaneous injections of D-galactose. Two weeks after the adipose-derived stem cells transplantations, serum superoxide dismutase activity was significantly increased, malondialdehyde content was significantly reduced, hippocampal neuronal degeneration was ameliorated, the apoptotic index of hippocampal neurons was decreased, and learning and memory function was significantly improved in the aging rats. These results indicate that allogeneic transplantation of adipose-derived stem cells may effectively delay D-galactose-induced aging. | Chun Yang Dongfei Li Zhongqiu Wen Huiying Yang Meichun Yu Hui Tao Rongmei Qu Yikuan Du Yong Huang Ou Sha Jingxing Dai Lin Yuan | 2011 | Neural Regeneration Research2011，6，34： | 1 |
| 9 | An engineered xCas12i with high activity,high specificity,and broad PAM range显示文摘Dear Editor,The clustered regularly interspaced short palindromic repeats-Cas(CRISPR-Cas)systems,including type II Cas9 and type V Cas12 systems,which serve in the adaptive immunity of prokaryotes against viruses,have been developed into genome-editing tools(Anzalone et al.,2020;Doudna,2020).Compared with type II systems,the type V systems including V-A to V-K showed more functional diversity(Yan et al.,2019).Amongst them,Cas12i has a relatively smaller size(1,033-1,093 aa),compared to SpCas9 and Cas12a,and has a 5'-TTN protospacer adjacent motif(PAM)preference(Yan et al.,2019). | Hainan Zhang Xiangfeng Kong Mingxing Xue Jing Hu Zikang Wang Yinghui Wei Haoqiang Wang Jingxing Zhou Weihong Zhang Mengqiu Xu Xiaowen Shen Fengcai Yin Zhiyuan Ai Guangyan Huang Junhui Xia Xueqiong Song Hengbin Li Yuan Yuan Jinhui Li Na Zhong Meiling Zhang Yingsi Zhou Hui Yang | 2023 | Protein & Cell2023，14，7： | 0 |
| 10 | Breaking of Large-Scale Filament due to Magnetic Reconnection and Consequent Partial Eruption显示文摘Following our previous work,we studied the partial eruption of a large-scale horse-shoe-like filament that had beenobserved in a decaying active region on the solar disk for more than 4.5 days.The filament became active after itwas broken into two pieces,P1 and P2 seen in Hα,by magnetic reconnection between the magnetic field around itand that of a newly emerging active region nearby.P1 eventually erupted 13 hr after the breaking and escaped fromthe Sun,developing to a fast coronal mass ejection,and P2 stayed.But the mass in P1 falling down to P2 in theeruption suggests that the global magnetic fields over P1 and P2 were still connected to each other prior to theeruption.The reconnection process breaking the filament occurred outside the filament,and P1 and P2 were locatedalmost at the same altitude,so the fashion of the filament partial eruption studied here differs from that of the“double-decker model”and that of reconnection inside the filament.Analyzing the decay indices of thebackground fields above P1 and P2,n_(1)and n_(2),showed that the altitude where n_(1)exceeds the critical value of n_(c)=1.5 for the loss of equilibrium or the torus instability is lower than that where n_(2)>nc,and that n_(1)>n_(2) alwaysholds at all altitudes.Combining this fact with that the eruption occurred 13 hr after filament was broken byreconnection,we conclude that the eruption of P1 was triggered by the loss of equilibrium or the torus instability inthe configuration,and magnetic reconnection breaking the filament helped weaken the confinement of thebackground field on P1,allowing P1 to erupt.Detailed features of the eruption and the corresponding physicalscenario were also discussed. | Kaifeng Kang Yang Guo Yan Li Jingxing Wang Jun Lin | 2023 | Research in Astronomy and Astrophysics2023，23，9： | 0 |
| 11 | Paravertebral fascial massage promotes brain development of neonatal rats via the insulin-like growth factor 1 pathway显示文摘Massage in traditional Chinese medicine can promote body and brain development of premature and normal newborn infants. In the present study, neonatal rats (1 day old) underwent paravertebral fascial massage (15 consecutive days), followed by subcutaneous injection of insulin-like growth factor 1 receptor antagonist, JB1 (9 consecutive days). Paravertebral fascial massage significantly increased insulin-like growth factor 1 expression and cell proliferation in the subventricular zone of the lateral ventricle and dentate gyrus of the hippocampus. However, JB1 inhibited this increase. Results suggest that paravertebral fascial massage can promote brain development of neonatal rats via the insulin-like growth factor 1 pathway. | Zhongqiu Wen Wenqin Zeng Jingxing Dai Xin Zhou Chun Yang Fuhua Duan Yufeng Liu Huiying Yang Lin Yuan | 2012 | Neural Regeneration Research2012，7，15： | 0 |
| 12 | The osteogenic effect of aligned porous poly(ethylene glyol)/silk fibroin/hydroxyapatite scaffold in different stiffness显示文摘The physical factors of the extracellular matrix have a profound influence on the differentiation behavior of mesenchymal stem cells(MSCs).In this study,different proportions of hydroxyapatite(HAp)were mixed into a poly(ethylene glycol)/silk fibroin(PEG/SF)solution to prepare scaffolds with different stiffness for studying the osteogenic effect on rat BMSCs in a biophysical microenvironment in vitro and in vivo.The amount of HAp ranged from 25 mg to 100 mg,which allowed the stiffness increasing from(80.98±17.45)kPa to(190.51±3.02)kPa be controlled suggesting the elastic modulus of the scaffolds increased with increasing HAp. | Yang Yuchao Bi Zhenyu Dai Jingxing Ouyang Jun | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 13 | Facility Cultivation Techniques of ‘Kaorino’ Strawberry显示文摘Strawberry‘Kaorino’is one of the perfect early-maturing strawberry varieties with high quality and high yield due to its anthracnose resistance,early maturity and good quality.The variety has become more and more popular with the promotion over the last few years,but there are great differences from other varieties in cultivation.Based on its varietal characteristics and cultivation performance in production over the last few years,we summarized the seedling cultivation techniques,planting management techniques,main disease control techniques and harvesting and storage techniques,aiming to provide reference for better promotion and application of‘Kaorino’. | Risheng YANG Peng WANG Jingxing YANG Shuwei YAO Defu LI Muxiang JI | 2023 | Agricultural Biotechnology2023，12，5： | 0 |
| 14 | Mechanical sensor PDLIM5 promotes the osteogenesis of human adipose-derived stem cells through microfilament alterations显示文摘Bone regeneration is a multifaceted,abstract,and wellcoordinated physiological progression of bone formation that participates in continuous regeneration and remodeling throughout life.However,when it comes to complex clinical situations requiring extensive bone regeneration,such as massive bone defects caused by injuries,infection,or tumor removal,traditional methods do not often yield good treatment strategies or protocols due to their limitations. | Yuchao Yang Shutong Wu Rongmei Qu Congrong Wang Jinyang Wang Asmat Ullah Khan You Pan Wenqing Liu Jinhui Zhu Muhammad Akram Khan Chujiang Xu Jingxing Dai Jun ouyang | 2024 | Genes & Diseases2024，11，3： | 0 |
| 15 | Improved Properties of Cellulose/Antarctic Krill Protein Composite Fibers with a Multiple Cross‑Linking Network显示文摘In the present work,novel cellulose(C)/Antarctic krill protein(AKP)composite fbers with a multiple cross-linking network were prepared using glutaraldehyde(GA)as cross-linking agent to improve the fber's properties.The structure and properties of fbers were characterized by diferent techniques including FTIR,NMR,XRD,SAXS,SEM and electronic single yarn strength tester,etc.The results indicate that the reaction of GA with C and AKP separately forms a multiple cross-linking network.The C/AKP composite fbers with a multiple cross-linking network has stronger crystallization ability,higher orientation degree and deeper trench than C/AKP composite fbers.The breaking stress and wet strength of composite fbers reaches the maximum of 1.04 cN/dtex and 0.55 cN/dtex at GA content of 0.2 wt%.And the fatigue and tensile properties,hygroscopicity and moisture retention of C/AKP composite fbers has been improved.The development of C/AKP composite fbers with a multiple cross-linking network could be a promising candidate for biomedicine applications. | Qiang Yang Jing Guo Yuanfa Liu Fucheng Guan Jingxing Song Xueyong Gong | 2022 | Advanced Fiber Materials2022，4，2： | 0 |
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