|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction显示文摘It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics. Genome-wide association studies(GWAS) were conducted on a discovery panel of Uyghurs. Six significant loci were identified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prospective model was also developed to predict 3D faces based on top GWAS signals and tested in hypothetic forensic scenarios. | Lu Qiao Yajun Yang Pengcheng Fu Sile Hu Hang Zhou Shouneng Peng Jingze Tan Yan Lu Haiyi Lou Dongsheng Lu Sijie Wu Jing Guo Li Jin Yaqun Guan Sijia Wang Shuhua Xu Kun Tang | 2018 | Journal of Genetics and Genomics2018，45，8： | 7 |
| 2 | Changes of gut microbiome and metabolome in the AOM/DSS mouse model of colorectal cancer with FLASH radiation显示文摘Objective:To investigate the differences in small intestinal toxicity and taxonomic composition,diversity,and functional pathways of gut microbiome and metabolome after different radiotherapies in mouse colorectal cancer(CRC)model.Methods:Azoxymethane/dextran sodium sulfate(AOM/DSS)-induced mouse CRC model was treated with single pulse FLASH-RT(dose rate 100 Gy/s)or CONV-RT(dose rate 2 Gy/min)at whole abdomen.At 12 d after radiotherapy,sections of small intestinal tract tissue were dissected for hematoxylin and eosin(HE)staining and the fresh feces were collected for 16S ribosomal RNA(rRNA)microbiome sequencing and liquid chromatography and mass spectrometry(LC-MS)metabolomics sequencing to assess changes in the gut microbiota and metabolites.Microbial high-throughput 16S rRNA data was analyzed with QIIME2 and LEfSe softwares.ProteoWizard,XCMS and Ropls softwares were used for LC-MS analysis.Results:HE staining showed that FLASH-RT maintained small intestinal integrity and reduced the radiotherapyinduced injury.Sequencing analysis of gut fecal microbiome showed that phylum Bacteroidetes and genera Prevotella and Lactobacillus of microbial community were increased after FLASH-RT.Metabolomics sequencing analysis revealed that the metabolites after FLASH-RT were enriched in amino acid metabolism,while cholesterol metabolism was top enriched after CONV-RT.Conclusions:FLASH-RT significantly mitigates the small intestine tissue damage compared with CONV-RT.FLASHRT and CONV-RT have different impact on gut microbiota and its metabolites.Our results provide a theoretical basis for the early evaluation,prediction and individualized treatment of the irradiation effect after novel FLASHRT on tumors through the evaluation of intestinal microbiota and metabolites. | Mengmeng Xu Xinyu Qiu Qiu Chen Tianyu Yang Jingze Xu Liang Chen Lixiong Shuai Zhiming Xu Xinyang Cheng Yongsheng Zhang Zhifei Cao | 2023 | Radiation Medicine and Protection2023，4，1： | 2 |
| 3 | The HuaBiao project:whole-exome sequencing of 5000 Han Chinese individuals显示文摘Next-generation sequencing technologies have significantly accelerated the identification of disease-causing mutations and facilitated the emergence of personalized medicine(Genomes Project Consortium et al.,2015;Goodwin et al.,2016;Sirugo et al.,2019).In comparison with whole-genome sequencing,whole-exome sequencing(WES),which covers the coding regions of the genome,offers a cost-efficacy balance.WES provides deeper sequencing depth(>100)and allows the more accurate detection of rare variants that are tailored for clinical applications(Lek et al.,2016). | Meng Hao Weilin Pu Yi Li Shaoqing Wen Chang Sun Yanyun Ma Hongxiang Zheng Xingdong Chen Jingze Tan Guoqing Zhang Menghan Zhang Shuhua Xu Yi Wang Hui Li Jiucun Wang Li Jin | 2021 | Journal of Genetics and Genomics2021，48，11： | 2 |
| 4 | Large-scale genome-wide scans do not support petaloid toenail as a Mendelian trait显示文摘Petaloid toenail,or accessory nail of the fifth toe,is a physical trait characterized by the presence of an additional tiny toenail on the small toe.Since it can occasionally cause disfigurement and tenderness while wearing tight shoes or walking,standard surgical matricectomy is often carried out to repair the petaloid toenail(Chi and Wang,2004).Chinese legends recorded petaloid | Manfei Zhang Sijie Wu Juan Zhang Yajun Yang Jingze Tan Haijuan Guan Yu Liu Kun Tang Jean Krutmann Shuhua Xu Li Jin Yaqun Guan Hui Li Sijia Wang | 2016 | Journal of Genetics and Genomics2016，43，12： | 2 |
| 5 | hTAC internalizes via both clathrin-dependent and clathrin-independent endocytosis in mammalian cells显示文摘 | Xinyu Zhu Min Li Xiaojun Xu Rui Zhang Xiaofei Zhang Zhuo Ma Jingze Lu Tao Xu Junjie Hou Eli Song | 2018 | Protein & Cell2018，9，10： | 2 |
| 6 | HID-1 is a peripheral membrane protein primarily associated with the medial-and transGolgi apparatus显示文摘Caenorhabditis elegans hid-1 gene was first identified in a screen for mutants with a high-temperature-induced dauer formation(Hid)phenotype.Despite the fact that the hid-1 gene encodes a novel protein(HID-1)which is highly conserved from Caenorhabditis elegans to mammals,the domain structure,subcellular localization,and exact function of HID-1 remain unknown.Previous studies and various bioinformatic softwares predicted that HID-1 contained many transmembrane domains but no known functional domain.In this study,we revealed that mammalian HID-1 localized to the medial-and transGolgi apparatus as well as the cytosol,and the localization was sensitive to brefeldin A treatment.Next,we demonstrated that HID-1 was a peripheral membrane protein and dynamically shuttled between the Golgi apparatus and the cytosol.Finally,we verified that a conserved N-terminal myristoylation site was required for HID-1 binding to the Golgi apparatus.We propose that HID-1 is probably involved in the intracellular trafficking within the Golgi region. | Lifen Wang Yi Zhan Eli Song Yong Yu Yaming Jiu Wen Du Jingze Lu Pingsheng Liu Pingyong Xu Tao Xu | 2011 | Protein & Cell2011，2，1： | 1 |
| 7 | A genome-wide association study of facial morphology identifies novel genetic loci in Han Chinese显示文摘The human face is a heritable surface with many complex sensory organs.In recent years,many genetic loci associated with facial features have been reported in different populations,yet there is a lack of studies on the Han Chinese population.Here,we report a genome-wide association study of 3D normal human faces of 2,659 Han Chinese with autosegment phenotypes of facial morphology.We identify singlenucleotide polymorphisms(SNPs)encompassing four genomic regions showing significant associations with different facial regions,including SNPs in DENND1 B associated with the chin,SNPs among PISRT1 associated with eyes,SNPs between DCHS2 and SFRP2 associated with the nose,and SNPs in VPS13 B associated with the nose.We replicate 24 SNPs from previously reported genetic loci in different populations,whose candidate genes are DCHS2,SUPT3 H,HOXD1,SOX9,PAX3,and EDAR.These results provide a more comprehensive understanding of the genetic basis of variation in human facial morphology. | Yin Huang Dan Li Lu Qiao Yu Liu Qianqian Peng Sijie Wu Manfei Zhang Yajun Yang Jingze Tan Shuhua Xu Li Jin Sijia Wang Kun Tang Stefan Grunewald | 2021 | Journal of Genetics and Genomics2021，48，3： | 1 |
| 8 | Histopathological studies of sclerotia of Rhizoctonia solani parasitized by the EGFP transformant of Trichoderma virens显示文摘 | Liu Luning Zhang Jingze Xu Tong | 2009 | Lett Appl Microbiol2009，49，6： | 1 |
| 9 | Mn-doped perovskite-type oxide LaFeO3 as highly active and durable bifunctional electrocatalysts for oxygen electrode reactions显示文摘Perovskite oxides based on the alkaline earth metal lanthanum for oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)in alkaline electrolytes are promising catalysts,but their catalytic activity and stability remain unsatisfactory.Here,we synthesized a series of LaFe1-xMn2O3(x=0,0.1,0.3,0.5,0.7,0.9 and 1)perovskite oxides by doping Mn into LaFeO3(LF).The results show that the doping amount of Mn has a significant effect on the catalytic performance.When x=0.5,the catalyst LaFeo.sMno.sO3(LFM)exhibits the best performance.The limiting current density in 0.1 mol·L^-1 KOH solution is 7 mA·cm^-2,much larger than that of the commercial Pt/C catalyst(5.5 mA·cm^-2).Meanwhile,the performance of the doped catalyst is also superior to that of commercial Pt/C in terms of the long-term durability.The excellent catalytic performance of LFM may be ascribed to its abundant 0^2-/0^-species and low charge transfer resistance after doping the Mn element. | Jingze ZHANG Sheng ZHU Yulin MIN Qunjie XU | 2020 | Frontiers of Materials Science2020，14，4： | 1 |
| 10 | Bulk-like endocytosis plays an important role in the recycling of insulin granules in pancreatic beta cells显示文摘Although bulk endocytosis has been found in a number of neuronal and endocrine cells,the molecular mechanism and physiological function of bulk endocytosis remain elusive.In pancreatic beta cells,we have observed bulk-like endocytosis evoked both by flash photolysis and trains of depolarization.Bulk-like endocytosis is a clathrin-independent process that is facilitated by enhanced extracellular Ca^(2+) entry and suppressed by the inhibition of dynamin function.Moreover,defects in bulklike endocytosis are accompanied by hyperinsulinemia in primary beta cells dissociated from diabetic KKAy mice,which suggests that bulk-like endocytosis plays an important role in maintaining the exo-endocytosis balance and beta cell secretory capability. | Du Wen Yanhong Xue Kuo Liang Tianyi Yuan Jingze Lu Wei Zhao Tao Xu Liangyi Chen | 2012 | Protein & Cell2012，3，8： | 0 |
| 11 | De Novo Dissecting the Three‑Dimensional Facial Morphology of 2379 Han Chinese Individuals显示文摘Phenotypic diversity,especially that of facial morphology,has not been fully investigated in the Han Chinese,which is the largest ethnic group in the world.In this study,we systematically analyzed a total of 14,838 facial traits representing 15 categories with both a large-scale three-dimensional(3D)manual landmarking database and computer-aided facial segmented phenotyping in 2379 Han Chinese individuals.Our results illustrate that homogeneous and heterogeneous facial morphological traits exist among Han Chinese populations across the three geographical regions:Zhengzhou,Taizhou,and Nanning.We identifed 1560 shared features from extracted phenotypes,which characterized well the basic facial morphology of the Han Chinese.In particular,heterogeneous phenotypes showing population structures corresponded to geographical subpopulations.The greatest facial variation among these geographical populations was the angle of glabella,left subalare,and right cheilion(p=3.4×10^(−161)).Interestingly,we found that Han Chinese populations could be classifed into northern Han,central Han,and southern Han at the phenotypic level,and the facial morphological variation pattern of central Han Chinese was between the typical diferentiation of northern and southern Han Chinese.This result was highly consistent with the results revealed by the genetic data.These fndings provide new insights into the analysis of multidimensional phenotypes as well as a valuable resource for further facial phenotype-genotype association studies in Han Chinese and East Asian populations. | Hui Qiao Jingze Tan Shaoqing Wen Menghan Zhang Shuhua Xu Li Jin | 2024 | Phenomics2024，4，1： | 0 |
| 12 | I-BAR protein IRSp53 regulates clathrin-independent endocytosis in a biphasic manner显示文摘Endocytosis is a fundamental cellular activity that plays crucial roles in a variety of biological processes,including nutrient uptake,signal transduction,immune response,morphogenesis,neurotransmission,cell migration and tissue development[1–3].Endocytosis has been classified into two subtypes:the | Xinyu Zhu Xiaojun Xu Kang Du Jingze Lu Eli Song | 2018 | Science Bulletin2018，63，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员