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| 1 | Response gene to complement 32 (RGC-32) expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4显示文摘补充 32 的反应基因(RGC-32 ) 是涉及房间的增长,区别和迁居的一个房间周期管理者并且也在 angiogenesis 被含有。这里,我们证明在巨噬细胞的那 RGC-32 表情被 IL-4 导致并且由 LPS 减少了,显示在 RGC-32 表示和 M2 极化之间的一个连接。我们证明 RGC-32 的增加的表示或者激活的巨噬细胞,这蛋白质在压制支持 inflammatory cytokine IL-6 的生产并且支持反煽动性的调停人 TGF-β 的生产是特征的;。与一致在 vitro,数据, RGC-32 高级的联系肿瘤的巨噬细胞(TAM ) 快车,和这个表达式被导出肿瘤的腹水的液体以一种 M-CSF- 或 IL-4-dependent 方式导致。一起,这些结果为 M2 巨噬细胞极化作为一个标记建立 RGC-32 并且显示这蛋白质是为癌症免疫疗法的一个潜在的目标,指向联系肿瘤的巨噬细胞。 | Peng Zhao Daiqing Gao Qingjie Wang Bingfeng Song Qianqian Shao Jintang Sun Chunyan Ji Xingang Li Peng Li Xun Qu | 2015 | Cellular & Molecular Immunology2015，12，6： | 12 |
| 2 | Holocene aeolian stratigraphic sequences in the eastern portion of the desert belt(sand seas and sandy lands) in northern China and their palaeoenvironmental implications显示文摘This paper presents the environmental history and its responses to palaeoclimatic changes since the start of the Holocene in the eastern portion of the desert belt(sand seas and sandy lands) in northern China by comparing the aeolian sandpalaeosol sequences and their palaeoclimatic proxies. The optically stimulated luminescence(OSL) ages of the aeolian sandpalaeosol sedimentary sequences and a series of palaeoenvironmental proxies show that:(1) The large-scale dune landscape currently in the Kubuqi Sand Sea was formed during the Holocene in general;and the palaeosol was generally developed during the period of 4–2 ka, indicating conditions favorable for vegetation growth, soil development, and organic carbon accumulation due to increased precipitation or effective moisture and weakened aeolian activities;the large-scale expansion of dunes in the recent 2 ka is closely linked to human activities. The variable discharge of the Yellow River with diversions for irrigation may have resulted in a more consistent supply of aeolian particles for dune field expansion.(2) The dune landscape of the Hunshandake Sandy Land was likely formed around 12 ka, and before this, the western part of the Hunshandake Sandy Land would have been covered by a single large lake;it was obviously wetter than today in the sandy land during the period of 9.6–3 ka and the palaeosols were developed at the same time. But the aeolian activities have not been completely dormant in this long-lasting wetter epoch;because the Holocene wetter period was likely time-transgressive across the region.(3) The palaeosol of the Hulunbuir Sandy Land began to develop as early as 14.5 ka, probably continuing until the last 2 ka. The palaeosol development of various dune fields in the eastern portion of the desert belt(sand seas and sandy lands) in northern China is spatially heterogeneous, and even the palaeosol development time in different locations within each sandy land is inconsistent. During the middle Holocene(especially the 7.5–3.5 ka), all the sandy lands were stabilized in general and the intensity of aeolian activities was significantly weakened. The number of palaeoenvironmental records in the eastern portion of the desert belt(sand seas and sandy lands) in northern China has increased rapidly in the past decade, but the amount of published data still does not match the vast extent of the dune fields. It does require much more in-depth palaeoenvironmental studies for a full understanding of the relationship between aeolian activities and climate change in northern China. | Xiaoping YANG Peng LIANG Deguo ZHANG Hongwei LI Patrick RIOUAL Xulong WANG Bing XU Zhibang MA Qianqian LIU Xiaozong REN Fangen HU Yuxin HE Gang RAO Ninghua CHEN | 2019 | Science China Earth Sciences2019，62，8： | 10 |
| 3 | Dry deposition velocity of total suspended particles and meteorological influence in four locations in Guangzhou,China显示文摘Dry deposition velocity of total suspended particles(TSP) is an effective parameter that describes the speed of atmospheric particulate matter deposit to the natural surface.It is also an important indicator to the capacity of atmosphere self-depuration.However,the spatial and temporal variations in dry deposition velocity of TSP at different urban landscapes and the relationship between dry deposition velocity and the meteorological parameters are subject to large uncertainties.We concurrently investigated this relationship at four different landscapes of Guangzhou,from October to December of 2009.The result of the average dry deposition velocity is(1.49 ± 0.77),(1.44 ± 0.77),(1.13 ± 0.53) and(1.82 ± 0.82) cm/sec for urban commercial landscape,urban forest landscape,urban residential landscape and country landscape,respectively.This spatial variation can be explained by the difference of both particle size composition of TSP and meteorological parameters of sampling sites.Dry deposition velocity of TSP has a positive correlation with wind speed,and a negative correlation with temperature and relative humidity.Wind speed is the strongest factor that affects the magnitude of TSP dry deposition velocity,and the temperature is another considerable strong meteorological factor.We also find out that the relative humidity brings less impact,especially during the dry season.It is thus implied that the current global warming and urban heat island effect may lead to correlative changes in TSP dry deposition velocity,especially in the urban areas. | Leifu Chen Shaolin Peng Jingang Liu Qianqian Hou | 2012 | Journal of Environmental Sciences2012，24，4： | 10 |
| 4 | Estimation and Projection of the HIV Epidemic Trend among the Migrant Population in China显示文摘Objective The migrant population is a vulnerable group for HIV infection in China.Understanding potential epidemic trends among migrants is critical for developing HIV preventative measures in this population.Methods The Estimation and Projection Package (EPP) model was used to process prefecture and county-level surveillance data to generate HIV prevalence and epidemic trends for migrant populations in China.Results The prevalence of HIV among migrants in 2009 was estimated at 0.075% (95% CI:0.042%,0.108%) in China.The HIV epidemic among migrants is likely to increase over the next 5 years,with the prevalence expected to reach 0.110% (95% CI:0.070%,0.150%) by 2015.Conclusion Although the 2009 estimates for the HIV/AIDS epidemic in China indicate a slower rate of increase compared with the national HIV/AIDS epidemic,it is estimated to persistently increase among migrants over the next 5 years.Migrants will have a strong impact on the overall future of the HIV epidemic trend in China and evidence-based prevention and monitoring efforts should be expanded for this vulnerable population. | MENGXiaoJun WANG Lu Susan CHAN Kathleen Heather REILLY PENG ZhiHang GUO Wei DING GuoWei DING ZhengWei QIN QianQian | 2011 | Biomedical and Environmental Sciences2011，24，4： | 8 |
| 5 | Near-surface Geothermal Gradient Observation and Geothermal Analyses in the Xianshuihe Fault Zone,Eastern Tibetan Plateau显示文摘The Xianshuihe fault(XSHF) zone, characterized by intense tectonic activity, is located at the southwest boundary of the Bayan Har block, where several major earthquakes have occurred, including the 2008 Wenchuan and the 2013 Lushan earthquakes. This study analysed underground temperature sequence data for four years at seven measuring points at different depths(maximum depth: 18.9 m) in the southeastern section of the XSHF zone. High-frequency atmospheric noise was removed from the temperature sequences to obtain relatively stable temperature fields and heat fluxes near the measurement points. Our measurements show that the surrounding bedrock at(the seven stations distributed in the fault zone) had heat flux values range from-41.0 to 206 m W/m^2, with a median value of 54.3 m W/m^2. The results indicate a low heat flux in the northern section of DaofuKangting and a relatively high heat flux in the southern section of Kangting, which is consistent with the temperature distributions of the hot springs near the fault. Furthermore, our results suggest that the heat transfer in this field results primarily from stable underground heat conduction. In addition, the underground hydrothermal activity is also an obvious factor controlling the geothermal gradient. | LIU Qianqian SHI Yanan WEI Dongping HAN Peng CHEN Shunyun LIU Peixun LIU Liqiang | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 8 |
| 6 | Performance and microbial diversity of an expanded granular sludge bed reactor for high sulfate and nitrate waste brine treatment显示文摘The disposal of waste brines has become a major challenge that hinders the wide application of ionexchange resins in the water industry in recent decades. In this study, high sulfate removal efficiency(80%–90%) was achieved at the influent sulfate concentration of 3600 mg/L and 3% NaCl after 145 days in an expanded granular sludge bed(EGSB) reactor. Furthermore, the feasibility of treating synthetic waste brine containing high levels of sulfate and nitrate was investigated in a single EGSB reactor during an operation period of 261 days. The highest nitrate and sulfate loading rate reached 6.38 and 5.78 kg/(m3·day) at SO2-4-S/NO-3-N mass ratio of 4/3, and the corresponding removal efficiency was 99.97% and 82.26% at 3% NaCl, respectively. Meanwhile, 454-pyrosequencing technology was used to analyze the bacterial diversity of the sludge on the 240th day for stable operation of phase X. Results showed that a total of 9194 sequences were obtained, which could be affiliated to 14 phyla, including Proteobacteria, Firmicutes, Chlorobi, Bacteroidetes, Synergistetes and so on. Proteobacteria(77.66%) was the dominant microbial population, followed by Firmicutes(12.23%) and Chlorobi(2.71%). | Runhua Liao Yan Li Xuemin Yu Peng Shi Zhu Wang Ke Shen Qianqian Shi Yu Miao Wentao Li Aimin Li | 2014 | Journal of Environmental Sciences2014，26，4： | 7 |
| 7 | Chromosome-level genome of Himalayan yew provides insights into the origin and evolution of the paclitaxel biosynthetic pathway显示文摘Taxus,commonly known as yew,is a well-known gymnosperm with great ornamental and medicinal value.In this study,by assembling a chromosome-level genome of the Himalayan yew(Taxus wallichiana)with 10.9 Gb in 12 chromosomes,we revealed that tandem duplication acts as the driving force of gene family evolution in the yew genome,resulting in the main genes for paclitaxel biosynthesis,i.e.those encoding the taxadiene synthase,P450s,and transferases,being clustered on the same chromosome.The tandem duplication may also provide genetic resources for the nature to sculpt the core structure of taxoids at different positions and subsequently establish the complex pathway of paclitaxel by neofunctionalization.Furthermore,we confirmed that there are two genes in the cluster encoding isoenzymes of a known enzyme in the paclitaxel biosynthetic pathway.The reference genome of the Himalayan yew will serve as a platform for decoding the complete biosynthetic pathway of paclitaxel and understanding the chemodi-versity of taxoids in gymnosperms. | Jian Cheng Xiao Wang Xiaonan Liu Xiaoxi Zhu Zihe Li Huanyu Chu Qian Wang QianQian Lou Bijun Cai Yiqun Yang Xiaoyun Lu Kai Peng Dingyu Liu Yuwan Liu Lina Lu Huan Liu Ting Yang Qijin Ge Chengcheng Shi Guichun Liu Zhiwei Dong Xun Xu Wen Wang Huifeng Jiang Yanhe Ma | 2021 | Molecular Plant2021，14，7： | 6 |
| 8 | In-situ structural evolution analysis of Zr-doped Na_(3)V_(2)(PO_(4))_(2)F_(3) coated by N-doped carbon layer as high-performance cathode for sodium-ion batteries显示文摘With great superiorities in energy density,rate capability and structural stability,Na_(3)V_(2)(PO_(4))_(2) F_(3)(NVPF)has attracted much attentions as cathode of sodium ion battery(SIB),but it also faces challenges on its poor intrinsic electronic conductivity and the controversial de/sodiation mechanism.Herein,a series of Zr-doped NVPF coated by N-doped carbon layer(~5 nm in thickness,homogenously)materials are fabricated by a sol-gel method,and the optimized heteroatom-doping amounts of Zr and N doping improve intrinsic properties on enlarging lattice distance and enhancing electronic conductivity,respectively.Specifically,among all samples of Na_(3) V_(2-x)Zr_(x)(PO_(4))_(2) F_(3)/NC(NVPF-Zr-x/NC,x=0,0.01,0.02,0.05,and 0.1),the optimized electrode of NVPF-Zr-0.02/NC delivers high reversible capacities(119.2 mAh g^(-1) at0.5 C),superior rate capability(98.1 mA h g^(-1) at 20 C)and excellent cycling performance.The structural evolution of NVPF-Zr-0.02/NC electrode,in-situ monitored by X-ray diffractometer,follows a step-wise Na-extraction/intercalation mechanism with reversible multi-phase changes,not just a solid-solutionreaction one.Full cells of NVPF-Zr-0.02/NC//hard carbon demonstrate high capacity(99.8 mA h g^(-1) at 0.5 C),high out-put voltage(3.5 V)and good cycling stability.This work is favorable to accelerate the development of high-performance cathode materials and explore possible redox reaction mechanisms of SIBs. | Chuan Guo Jianwei Yang Zhiyuan Cui Shuo Qi Qianqian Peng Weiwei Sun Li-Ping Lv Yi Xu Yong Wang Shuangqiang Chen | 2022 | Journal of Energy Chemistry2022，31，2： | 5 |
| 9 | Rice metabolic regulatory network spanning the entire life cycle显示文摘As one of the most important crops in the world,rice(Oryza sativa)is a model plant for metabolome research.Although many studies have focused on the analysis of specific tissues,the changes in metab-olite abundance across the entire life cycle have not yet been determined.In this study,combining both tar-geted and nontargeted metabolite profiling methods,a total of 825 annotated metabolites were quantified in rice samples from different tissues covering the entire life cycle.The contents of metabolites in different tissues of rice were significantly different,with various metabolites accumulating in the plumule and radicle during seed germination.Combining these data with transcriptome data obtained from the same time period,we constructed the Rice Metabolic Regulation Network.The metabolites and co-expressed genes were further divided into 12 clusters according to their accumulation patterns,with members within each cluster displaying a uniform and clear pattern of abundance across development.Using this dataset,we established a comprehensive metabolic profile of the rice life cycle and used two independent strategies to identify novel transcription factors-namely the use of known regulatory genes as bait to screen for new networks underlying lignin metabolism and the unbiased identification of new glycerophospholipid metabolism regulators on the basis of tissue specificity.This study thus demonstrates how guilt-by-association analysis of metabolome and transcriptome data spanning the entire life cycle in cereal crops provides novel resources and tools to aid in understanding the mechanisms underlying important agro-nomic traits. | Chenkun Yang Shuangqian Shen Shen Zhou Yufei Li Yuyuan Mao Junjie Zhou Yuheng Shi Longxu An Qianqian Zhou Wenju Peng Yuanyuan Lyu Xuemei Liu Wei Chen Shouchuang Wang Lianghuan Qu Xianqing Liu Alisdair R.Fernie Jie Luo | 2022 | Molecular Plant2022，15，2： | 3 |
| 10 | The impact of fluorination on both donor polymer and non-fullerene acceptor:The more fluorine,the merrier显示文摘Fluorination of the donor polymer or non-fullerene acceptor (NFA) in an organic photovoltaic device is an effective method to improve device efficiency.Although there have been many studies on donor polymer fluorination,blends containing both a fluorinated donor and fluorinated NFA have rarely been reported.In this study,we use two donor polymers (4'-FT-HTAZ and 4'-FT-FTAZ) and two NFAs (ITIC-Th and ITIC-Th1) with different amounts of fluorine (from 2F to 6F) to investigate how the degree of fluorination in a blend impacts device performance.We find that fluorinating the NFA leads to a higher short-circuit current density (Jsc) and fill factor (FF),however,the open-circuit voltage (Voc) is decreased due to a depressed lowest unoccupied molecular orbital (LUMO) level.Adding additional fluorine to the donor polymer does not have a large effect on the Jsc or FF,but it does lead to an improved Voc.By fluorinating the NFA and having more fluorine on the donor polymer,we obtain both a high Jsc and Voc simultaneously,leading to a power conversion efficiency over 10% in the case of 4'-FT-FTAZ:ITIC-Th1,which has the most amount of fluorine (6F). | Nicole Bauer Qianqian Zhang Jeromy James Rech Shuixing Dai Zhengxing Peng Harald Ade Jiayu Wang Xiaowei Zhan Wei You | 2019 | Nano Research2019，12，9： | 3 |
| 11 | Investigation on Reduction of Pressure Fluctuation for a Double-Suction Centrifugal Pump显示文摘Double-suction centrifugal pumps have been applied extensively in many areas,and the significance of pressure fluctuations inside these pumps with large power is becoming increasingly important.In this study,a double-suction centrifugal pump with a high-demand for vibration and noise was redesigned by increasing the flow uniformity at the impeller discharge,implemented by combinations of more than two parameters.First,increasing the number of the impeller blades was intended to enhance the bounding effect that the blades imposed on the fluid.Subsequently,increasing the radial gap between the impeller and volute was applied to reduce the rotor-stator interaction.Finally,the staggered arrangement was optimized to weaken the efficacy of the interference superposition.Based on numerical simulation,the steady and unsteady characteristics of the pump models were calculated.From the fluctuation analysis in the frequency domain,the dimensionless pressure fluctuation amplitude at the blade passing frequency and its harmonics,located on the monitoring points in the redesigned pumps(both with larger radial gap),are reduced a lot.Further,in the volute of the model with new impellers staggered at 12°,the average value for the dimensionless pressure fluctuation amplitude decreases to 6%of that in prototype pump.The dimensionless rootmean-square pressure contour on the mid-span of the impeller tends to be more uniform in the redesigned models(both with larger radial gap);similarly,the pressure contour on the mid-section of the volute presents good uniformity in these models,which in turn demonstrating a reduction in the pressure fluctuation intensity.The results reveal the mechanism of pressure fluctuation reduction in a double-suction centrifugal pump,and the results of this study could provide a reference for pressure fluctuation reduction and vibration performance reinforcement of doublesuction centrifugal pumps and other pumps. | Qianqian Li Shiyang Li Peng Wu Bin Huang Dazhuan Wu | 2021 | Chinese Journal of Mechanical Engineering2021，34，1： | 2 |
| 12 | New perylene diimide derivatives: stable red emission, adjustable property from ACQ to AIE, and good device performance with an EQE value of 4.93%显示文摘Perylene diimide(PDI) derivatives, due to their special opto-electronic property, have been successfully utilized in organic field-effect transistor(OFET), solar cells, and as non-fullerene acceptor and others,while few cases in organic light-emitting diodes(OLEDs). In this work, six perylene bisimide-based red emitters, N,N''-bis(2-decyltetradecyl)-1-([1,1':3',1''-terphenyl]-5'-yl)perylene-3,4,9,10-diimide(STPH),N,N'-bis(2-decyltetradecyl)-1,7-bis([1,1':3',1''-terphenyl]-5'-yl)perylene-3,4,9,10-diimide(DTPH), N,N''-bis(2-decyltetradecyl)-1-(5'-phenyl-[1,1':3',1''-terphenyl]-4-yl)perylene-3,4,9,10-diimide(STRPH), N,N0-bis(2-decyltetradecyl)-1,7-bis(5'-phenyl-[1,1':3',1''-terphenyl]-4-yl)perylene-3,4,9,10-diimide(DTRPH),N,N0-bis(2-decyltetradecyl)-1-(4-(2,2-diphenylvinyl)phenyl)perylene-3,4,9,10-diimide(STTPE) and N,N'-bis(2-decyltetradecyl)-1,7-bis(4-(2,2-diphenylvinyl)phenyl)perylene-3,4,9,10-diimide(DTTPE), with the excellent chemical, thermal and photo-chemical stability, are synthesized through the convenient Suzuki coupling reaction, in which, the fluorescent properties can be modified easily from ACQ to AIE by just simply changing the bulky volume of the introduced aromatic substituents. After being fabricated into organic light-emitting diodes, STRPH exhibits the best performance with the maximum luminescence, power efficiency, current efficiency and external quantum efficiency of 1,948 cd m^(-2), 2.04 lm W^(-1), 5.85 cd A^(-1), 4.93% at Commission Internationale de L'Eclairage(CIE) coordinates of(0.56, 0.34),as the result of the high efficient energy transfer and good energy match achieved in the device. | Luyi Zong Yanbin Gong Yun Yu Yujun Xie Guohua Xie Qian Peng Qianqian Li Zhen Li | 2018 | Science Bulletin2018，63，2： | 2 |
| 13 | Ofloxacin induces apoptosis in microencapsulated juvenile rabbit chondrocytes by caspase-8-dependent mitochondrial pathway显示文摘 | Zhiguo Sheng Xiaojuan Cao Shuangqing Peng Changyong Wang Qianqian Li Yimei Wang Mifeng Liu | 2007 | Toxicology and Applied Pharmacology2007，，2： | 2 |
| 14 | Characteristics of dental morphology in the Xinjiang Uyghurs and correlation with the EDARV370A variant显示文摘Teeth are one of the most important materials for anthropological studies because they are likely to be preserved in ancient remains.While the frequencies of dental characteristics can provide clues to the phylogeny of populations,genetic studies at the individual level can further reveal the biological mechanisms and evolutionary context of dental characteristics.In this study,by analyzing 38 dental characteristics of 242 Xinjiang Uyghur individuals,we found that(i)the dental characteristics of the Uyghurs showed evidence of admixture between European and East Asian populations.The admixture proportions were in line with those previously reported in population genetic studies;(ii)the Xinjiang Uyghur dental characteristics formed three clusters in pairwise correlation analysis.One of the main clusters consisted of characteristics including incisor shoveling,double shoveling and mesial ridge;and(iii)all the characteristics in this cluster were significantly correlated with the genetic variant EDARV370A.The extracted composite phenotypic factor was also significantly associated with EDARV370A,which explained 18%of the total phenotypic variance.This indicated a pleiotropic effect,i.e.,the same genetic factor affects a number of dental characteristics at the same time.Our results confirmed that EDARV370A,a genetic variant that first originated in East Asia about 30000 years ago,played an important role in incisor shoveling in East Asia.This finding suggested that incisor shoveling in modern humans in East Asia is likely to have appeared after the late Pleistocene. | TAN JingZe PENG QianQian LI JinXi GUAN YaQun ZHANG LiPing JIAO Yi YANG YaJun WANG SiJia JIN Li | 2014 | Science China(Life Sciences)2014，57，5： | 2 |
| 15 | Design and Operation of the Printing and Dyeing Wastewater Treatment Project by Combination of Coagulation Sedimentation - Hydrolytic Acidification with Aeration Tank - Biological Aerated Filter - Active Sand Filter显示文摘In order to protect quality of Baiyangdian surface water and Gaoyang groundwater,the project is applied to process printing and dyeing wastewater that contains complicated compositions,high concentrations of organics and SS,and lots of pollutants difficult to degrade by microorganism. The process and operating parameters of project are optimized and debugged,and its economic and environmental benefits are analyzed.The results show that the process of coagulation sedimentation-hydrolytic acidification with aeration tank-biological aerated filter-active sand filter is applied in Gaoyang Sewage Treatment Plant. The design scale of sewage treatment plant is 120000 m^3/d. The influent is as following: COD is 669mg/L; SS is 424mg/L; NH_3-N is 8.83mg/L; TP is 6.03mg/L. After the process,the best removal rates of COD,SS,NH_3-N and TP are 93. 5%,98. 8%,97. 1% and 96. 2%,respectively. The various indexes of effluent water complied with standard A of the first order in Pollutants Emission Standard of Urban Wastewater Treatment Plant( GB 18918-2002). The processing cost is only 0. 807 yuan/m^3. As a result,the project construction and operation not only improve the environment,but also promote regional economic development. Process design and operating parameters provide an important reference value for the printing and dyeing wastewater treatment industry. | Dong Qianqian He Qianmei Yang Jingyuan Peng Yadong Bian Lipo | 2017 | Meteorological and Environmental Research2017，8，4： | 2 |
| 16 | Starter culture fermentation of Chinese sauerkraut: Growth, acidification and metabolic analyses显示文摘 | Tao Xiong Xiao Li Qianqian Guan Fei Peng Mingyong Xie | 2014 | Food Control2014，，： | 2 |
| 17 | Abundance,Diversity and Functional Potentials of Planktonic Bacteria and Microeukaryotes in the Coral-Reef System of Xisha Islands,China显示文摘Corals influence microorganisms within the surrounding seawater,yet the diversities and functions of seawater bacteria and microeukaryotes in coral-reef systems have not been well addressed.We collected 40 seawater samples in outer coral reef flats and semi-closed inner lagoons from the surface,middle and bottom layers in the pristine coral-reef system of Xisha Islands,South China Sea.We detected the abundance,composition and distribution of bacteria and microeukaryotes using flow cytometry,qPCR and high throughput sequencing techniques,and profiled the potential ecological roles based on the information of 16S and 18S rDNA sequencing.In terms of flow cytometry,Prochlorococcus dominated the autotrophs with cell abundance ranging from 5.8×10^(2)to 5.44×10^(3)cells mL−1 seawater.Based on qPCR,the 16S rDNA copies were much higher in coral reef flats than in lagoons(P=0.003).The bacterial communities held significantly lower diversity in bottom waters compared with surface and middle waters(P<0.05),which were dominated by SAR11,Flavobacteriales,and Synechococcus.Alveolata represented most of the microeukaryotic communities with Dinophyceae and Syndiniales well represented in all samples.Neither bacterial nor microeukaryotic community exhibited distinct layer or niche pattern,however,Haptophyta and Picozoa decreased with depth and SAR 86,MAST-3 and Picozoa were enriched in lagoons(P<0.05).To adapt the nutrient-poor and organic matter-rich environment,bacterial nitrogen fixation and assimilatory/dissimilatory nitrate reduction were active in the system,and mixotrophy was the most important trophic strategy among microeukaryotes.The study highlighted the ecological adaptability of seawater microbes to the unique coral-reef environments. | ZHANG Xiaoli WANG Lei PENG Saijun WUZHONG Qiyue ZHANG Lei DONG Zhijun SUN Tingting LIU Ping ZHANG Qianqian ZHAO Jianmin | 2022 | Journal of Ocean University of China2022，21，3： | 1 |
| 18 | The antigenicity of SARS-CoV-2 Delta variants aggregated 10 high-frequency mutations in RBD has not changed sufficiently to replace the current vaccine strain显示文摘Emerging SARS-CoV-2 variants are the most serious problem for COVID-19 prophylaxis and treatment.To determine whether the SARS-CoV-2 vaccine strain should be updated following variant emergence like seasonal flu vaccine,the changed degree on antigenicity of SARS-CoV-2 variants and H3N2 flu vaccine strains was compared.The neutralization activities of Alpha,Beta and Gamma variants’spike protein-immunized sera were analysed against the eight current epidemic variants and 20 possible variants combining the top 10 prevalent RBD mutations based on the Delta variant,which were constructed using pseudotyped viruses.Meanwhile,the neutralization activities of convalescent sera and current inactivated and recombinant protein vaccine-elicited sera were also examined against all possible Delta variants.Eight HA protein-expressing DNAs elicited-animal sera were also tested against eight pseudotyped viruses of H3N2 flu vaccine strains from 2011–2019.Our results indicate that the antigenicity changes of possible Delta variants were mostly within four folds,whereas the antigenicity changes among different H3N2 vaccine strains were approximately 10–100-fold.Structural analysis of the antigenic characterization of the SARS-CoV-2 and H3N2 mutations supports the neutralization results.This study indicates that the antigenicity changes of the current SARS-CoV-2 may not be sufficient to require replacement of the current vaccine strain. | Jiajing Wu Jianhui Nie Li Zhang Hao Song Yimeng An Ziteng Liang Jing Yang Ruxia Ding Shuo Liu Qianqian Li Tao Li Zhimin Cui Mengyi Zhang Peng He Youchun Wang Xiaowang Qu Zhongyu Hu Qihui Wang Weijin Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 1 |
| 19 | Secondary solar heat gain modelling of spectral-selective glazing based on dynamic solar radiation spectrum显示文摘The secondary solar heat gain,defined as the heat flows from glazing to indoor environment through longwave radiation and convection,grows with the increasing of glazing absorption.With the rapid development and application of spectrally selective glazing,the secondary solar heat gain becomes the main way of glazing heat transfer and biggest proportion,and indicates it should not be simplified calculated conventionally.Therefore,a dynamic secondary solar heat gain model is developed with electrochromic glazing system in this study,taking into account with three key aspects,namely,optical model,heat transfer model,and outdoor radiation spectrum.Compared with the traditional K-Sc model,this new model is verified by on-site experimental measurements with dynamic outdoor spectrum and temperature.The verification results show that the root mean square errors of the interior and exterior glass surface temperature are 3.25°C and 3.33°C,respectively,and the relative error is less than 10.37%.The root mean square error of the secondary heat gain is 13.15 W/m2,and the dynamic maximum relative error is only 13.2%.The simulated and measured results have a good agreement.In addition,the new model is further extended to reveal the variation characteristics of secondary solar heat gain under different application conditions(including orientations,locations,EC film thicknesses and weather conditions).In summary,based on the outdoor spectrum and window spectral characteristics,the new model can accurately calculate the increasing secondary solar heat gain in real time,caused by spectrally selective windows,and will provide a computational basis for the evaluation and development of spectrally selective glazing materials. | Peng Xue Yi Shen Sheng Ye Jinqing Peng Yanyun Zhang Qianqian Zhang Yuying Sun | 2023 | Building Simulation2023，16，12： | 1 |
| 20 | A dynamic risk-based early warning monitoring system for population-based management of cardiovascular disease显示文摘Risk prediction tools are crucial for population-based management of cardiovascular disease(CVD).However,most prediction models are currently used to assess long-term risk instead of the risk of short-term CVD onset.We developed a Dynamic Risk-based Early wAming Monitoring(DREAM)system using large-scale,real-time electronic health record data from 2010 to 2020 from the CHinese Electronic health Records Research in Yinzhou study.The dynamic risk scores were derived from a 1:5 matched nested case-control set comprising 70,470 individuals(11,745 CVD events)and then validated in a cohort of 81,205 individuals(5950 CVD events).The individuals were Chinese adults aged 40-79 years without a history of CVD at baseline.Eleven predictors related to vital signs,laboratory tests,and health service utilization were selected to establish the dynamic scores.The proposed scores were significantly associated with the subsequent CVD onset(adjusted odds ratio,1.21;95%confidence interval,1.20-1.23).The area under the receiver operating characteristic curves(AUCs)was 0.6010(0.5929-0.6092)and 0.6021(0.5937-0.6105)for the long-term 10-year CVD risk<10%and≥10%groups in the derivation set,respectively.In the long-term 10-year CVD risk>10%group in the validation set,the change in AUC in addition to the long-term risk was 0.0235(0.0155-0.0315).By increasing the risk threshold from 7 to 16 points,the proportion of true subsequent CVD cases among those given alerts increased from 40.61%to 85.31%.In terms of management efficiency,the number needed to manage per CVD case ranged from 2.46 to 1.17 using the risk scores.With the increasing popularity and integration of EHR systems with wearable technology,the DREAM scores can be incorporated into an early-warning system and applied in dynamic,real-time,EHR-based,automated management to support healthcare decision making for individuals,general practitioners,and policymakers. | Xiaofei Liu Qianqian Li Weiye Chen Peng Shen Yexiang Sun Qi Chen Jinguo Wu Jingyi Zhang Ping Lu Hongbo Lin Xun Tang Pei Gao | 2021 | Fundamental Research2021，1，5： | 1 |
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