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| 1 | Numerical simulation and experimental verification on downwash air flow of six-rotor agricultural unmanned aerial vehicle in hover显示文摘Recently,multi-rotor unmanned aerial vehicle(UAV)becomes more and more significantly irreplaceable in the field of plant protection against diseases,pests and weeds of crops.The easy takeoff and landing performance,hover function and high spraying efficiency of UAV are urgently required to spray pesticide for crop timely and effectively,especially in dispersed plots and hilly mountains.In such situations,the current researches about UAV spray application mainly focus on studying the influence of the UAV spraying parameters on the droplet deposition,such as operation height,operation velocity and wind velocity.The deposition and distribution of pesticide droplets on crops which depends on installation position of nozzle and airflow distribution characteristics of UAV are directly related to the control effect of pesticide and crop growth in different growth periods.As a preliminary step,this study focuses on the dynamic development law and distribution characteristics of the downwash air flow for the SLK-5 six-rotor agricultural UAV.Based on compressible Reynolds-averaged Navier-Stokes(RANS)equations with an RNG k-εturbulence model and dynamic mesh technology,the efficient three-dimensional computational fluid dynamics(CFD)method was established to analyze the flow field distribution characteristics of UAV in hover.Then the unsteady interaction flow field of the wing was investigated in detail.The downwash wind speed of the marked points for the SLK-5 UAV in hover was also tested by weather tracker.It was found that the maximum velocity value of the downwash flow was close to 10 m/s;the z-direction velocity was the main body of the wind velocity in the downwash airflow,and the comparison of the wind velocity experiment test and simulation showed that the relative error was less than 12%between the experimental and simulated values of the z-direction velocity at the marked points.Then the flow characteristics of the longitudinal and cross section were analyzed in detail,the results obtained can be used as a reference for drift and sedimentation studies for multi-rotor unmanned aerial vehicle. | Yang Fengbo Xue Xinyu Zhang Ling Sun Zhu | 2017 | International Journal of Agricultural and Biological Engineering2017，10，4： | 28 |
| 2 | Community Structure and Seasonal Variation of Soil Arthropods in the Forest-Steppe Ecotone of the Mountainous Region in Northern Hebei,China显示文摘Soil fauna have been receiving more and more attention because they play an important role in nutrient cycling.However,there is a lack of information on soil arthropods in the forest-steppe ecotone in the mountainous region of northern Hebei,which makes it difficult to meet the need of protecting biodiversity in this area.Soil arthropod communities were investigated in the forest-steppe ecotone in northern Hebei province to provide basic information on changes in mountain soil fertility,which could promote the development of soil arthropod communities in mountain ecotones.From the preliminary identification,a total of 7994 individual soil arthropods were collected,which belonged to 25 groups,6 classes and 24 orders.Acarina,Hymenoptera and Collembola were the dominant groups in the ecotone.The number of Acarina was higher than Collembola,and this phenomenon was obviously different from other areas in the same climate zone.The increased abundance of rare groups in the Forest zone with the richer vegetation,higher arthropod abundance and more substantial litter depth,could be interpreted as a reaction to the suitable soil environment and food supply.And these rare groups were sensitive to environmental changes,which could be regarded as biotic indicators for evaluating soil quality.The analysis of community diversity showed that the abundance index (d),the Shannon-Wiener index (H'),the evenness index (J) and the density-group index (DG) were significantly higher in the forest zone,lower in the forest-steppe zone,and lowest in the meadow-steppe zone.Seasonal variations in community composition correlated with changes in average air temperature and precipitation in this ecotone.Groups and individuals of soil arthropod communities in the three zones were present in greater numbers in the middle of the rainy season than in the early or late periods of the rainy season as a whole.At the same time,seasonal changes in soil arthropod communities from different plots were also influenced by habitat condition. | ZHU Xinyu GAO Baojia YUAN Shengliang HU Yunchuan | 2010 | Journal of Mountain Science2010，7，2： | 17 |
| 3 | Drought characteristics of Henan province in 1961-2013 based on Standardized Precipitation Evapotranspiration Index显示文摘干旱是影响农业,水资源,自然生态系统,和社会的最复杂的自然危险之一。干旱的否定社会后果包括严重经济损失,饥荒,流行病,和陆地降级。然而,很少研究分析了干旱特征的复杂性,在多重时间规模并且与在土壤水分蒸发蒸腾损失总量的变化。在这研究,干旱出现用一个新干旱索引被确定,标准化降水土壤水分蒸发蒸腾损失总量索引(SPEI ) 基于从 1961 ~ 2013 的每月吝啬的温度和在河南省省的降水的观察数据,华中。在气象学的干旱的学习,频率和严厉基于每个气象站的 SPEI 价值被计算,并且在一个 53 年的时期上的每月、季节、年度的干旱频率和紧张被分析。空间、时间的进化,紧张,和在河南省的干旱出现的主要原因被揭示。结果证明 SPEI 价值有效地反映了干旱出现的空间、时间的模式。当时间规模减少了, SPEI 的振幅增加了,干旱变得更经常。自从 1961,干旱在年度、季节、每月的规模发生了,并且干旱的出现增加了。然而,地区性的分发是不平的。最高的干旱频率, 35% ,,在 Zhoukou 区域被观察最低价值, ~26% ,在中央、西方的河南省被测量。最严重的干旱发生在春天和夏天,由秋天列在后面。每年,广阔干旱发生在 1966-1968, 1998-2000,和 2011-2013。更高显示出的干旱紧张在它的东方和南方在北方和西方珍视河南省,和更低的价值。最大的干旱紧张价值分别地在 Anyang 被记录,并且最小发生在 Zhumadian,在 22.18% 和 16.60% 点。有对干旱出现的最大的影响的因素正在增加温度,欧亚的大气的发行量模式,和 El Ni ? o 效果。 | SHI Benlin ZHU Xinyu HU Yunchuan YANG Yanyan | 2017 | Journal of Geographical Sciences2017，27，3： | 15 |
| 4 | Changes in China’s lakes: climate and human impacts显示文摘Lakes have played a critical role in providing water and ecosystem services for people and other organisms in China for millennia.However,accelerating climate change and economic boom have resulted in unprecedented changes in these valuable lakes.Using Landsat images covering the entity of the country,we explored the changes in China’s lakes and the associated driving forces over the last 30 years(i.e.mid-1980 s to 2015).We discovered that China’s lakes have changed with divergent regional trends:in the sparsely populated Tibetan Plateau,lakes are abundant and the lake area has increased dramatically from 38596 to46831 km^2(i.e.increased by 8235 km^2,or 21.3%),whereas,in the densely populated northern and eastern regions,lakes are relatively scarce and the lake area has decreased from 36659 to 33657 km^2(i.e.decreased by 3002 km^2,or 8.2%).In particular,severe lake decreases occurred in the Mongolia-Xinjiang Plateau and the Eastern Plain(-2151 km^2).Statistical analyses indicated that climate was the most important factor controlling lake changes in the Tibetan Plateau,the Yun-Gui Plateau and the Northeast Plain.However,the strength of climatic control on lake changes was low in the Eastern Plain and the Mongolia-Xinjiang Plateau,where human activities,e.g.impoldering,irrigation and mining,have caused serious impacts on lakes.Further lake changes will exacerbate regional imbalances between lake resources and population distribution,and thus may increase the risk of water-resource crises in China. | Shengli Tao Jingyun Fang Suhui Ma Qiong Cai Xinyu Xiong Di Tian Xia Zhao Leqi Fang Heng Zhang Jiangling Zhu Shuqing Zhao | 2020 | National Science Review2020，7，1： | 14 |
| 5 | Downwash distribution of single-rotor unmanned agricultural helicopter on hovering state显示文摘The effective coverage and velocity of downwash are directly related to the assemblage of spraying system and spraying effect.The downwash of the unmanned agricultural helicopter(UAH)N-3 was discussed in the paper.The computational fluid dynamics(CFD)methods were used to simulate and analyze the distribution of the downwash,and a wind field measurement device had been designed to test the downwash of UAH N-3.In the tests,the UAH N-3 was raised up to 5.0 m,6.0 m and 7.0 m from the ground,“annular-radial-distribution-point”method was introduced,8 directions separated by an angle of 45°(the radial direction)with the intersection point of the main rotor shaft and the ground plane as the center,0.5 m as the step length for the longitudinal(to 2.5 m)and radial(to 4.0 m)direction to set the sample points,considering the range of the rotor rotating circular area mainly.The 5 m height results of N-3 were fully discussed to describe the downwash distribution with the longitudinal altitude increased and the radial distance increased.The standard deviations of five test altitudes for eight directions were comparatively analyzed,the results showed that the total standard deviation was not greater than 0.6 m/s.The overall relative maximum margin of error calculated from the simulation and measurement data was between 0.6 and 0.7,which verified the credibility of the simulation data.High-order polynomials were used to fitting the simulation and measurement data,the fitting results showed that the polynomial coefficient of determination R^(2) met or exceeded 0.75 when the altitudes were more than 1 m,indicating the fit equation having the reference values.When the altitudes equal or less than 0.5 m,the polynomial coefficient of determination R^(2) was smaller,ranging during 0.3 to 0.7.The study would provide some foundations for the optimization of the assemblage of spraying system on the single-rotor UAH,which would promote China aviation plant protection. | Zhang Songchao Xue Xinyu Sun Zhu Zhou Lixin Jin Yongkui | 2017 | International Journal of Agricultural and Biological Engineering2017，10，5： | 13 |
| 6 | Astronomical tuning and magnetostratigraphy of Neogene biogenic reefs in Xisha Islands, South China Sea显示文摘Biogenic reefs are one of two major depositional types in the South China Sea, and are constructed by coral, algae and bryozoa. The West Pacific is a major area of biogenic reef development and plays a critical role in the global carbon cycle. However, the lack of geochronological studies in previous works inhibits our understanding of their contributions. Herein, we conduct a cyclostratigraphic and magnetostratigraphic study on Neogene biogenic reefs using the XK–1 core that was drilled at the Shidao Island,Xisha(Paracel) Islands. The main findings of this study are:(1) the establishment of reliable magentostratigraphy for Ledong, Huangliu, Meishan and Sanya Formations;(2) the magnetic susceptibility variation can be inferred as growth index and tuned to the 405–ka long eccentricity cycle;(3) the astronomical geochronology suggests that the bottom ages for Ledong, Yinggehai, Huangliu, Meishan,and Sanya Formations are 2.2 Ma, 5.7 Ma, 10.4 Ma, 16.6 Ma, and 24.3 Ma, respectively; and (4) Earth's eccentricity and obliquity played predominant roles in biogenic reef establishment on orbital to tectonic timescales. Thus, the reported geochronology offers an opportunity to test the contributions of various factors and hypothesize their roles in the global carbon cycle in future. | Liang Yi Zhimin Jian Xinyu Liu Youhua Zhu Daojun Zhang Zhenfeng Wang Chenglong Deng | 2018 | Science Bulletin2018，63，9： | 12 |
| 7 | Evidence and modeling study of droughts in China during 4―2 ka BP显示文摘Four periods with predominated droughts are identified in 4―2 ka BP according to documentary data, namely 3.6―3.5, 3.1―3.0, 2.8―2.7, and 2.45―2.35 ka BP. Palaeo-environmental data indicated that droughts were predominated in 4―2 ka BP in the south of Northeast China, Inner-Mongolia, east of Qinghai-Tibetan Plateau, and South China. Modeling study shows that precession may be responsible for the occurrence of droughts in 4―2 ka BP, integrating the GCM with forcing of insolation. | WANG ShaoWu HUANG JianBin WEN XinYu ZHU JinHong | 2008 | Chinese Science Bulletin2008，53，14： | 10 |
| 8 | Immobilization of functional nano-objects in living engineered bacterial biofilms for catalytic applications显示文摘Nanoscale objects feature very large surface-area-to-volume ratios and are now understood as powerful tools for catalysis,but their nature as nanomaterials brings challenges including toxicity and nanomaterial pollution.Immobilization is considered a feasible strategy for addressing these limitations.Here,as a proof-of-concept for the immobilization of nanoscale catalysts in the extracellular matrix of bacterial biofilms,we genetically engineered amyloid monomers of the Escherichia coli curli nanofiber system that are secreted and can self-assemble and anchor nano-objects in a spatially precise manner.We demonstrated three scalable,tunable and reusable catalysis systems:biofilm-anchored gold nanoparticles to reduce nitro aromatic compounds such as the pollutant p-nitrophenol,biofilm-anchored hybrid Cd0.9Zn0.1S quantum dots and gold nanoparticles to degrade organic dyes and biofilm-anchored CdSeS@ZnS quantum dots in a semi-artificial photosynthesis system for hydrogen production.Our work demonstrates how the ability of biofilms to grow in scalable and complex spatial arrangements can be exploited for catalytic applications and clearly illustrates the design utility of segregating high-energy nano-objects from injury-prone cellular components by engineering anchoring points in an extracellular matrix. | Xinyu Wang Jiahua Pu Yi Liu Fang Ba Mengkui Cui Ke Li Yu Xie Yan Nie Qixi Mi Tao Li Lingli Liu Manzhou Zhu Chao Zhong | 2019 | National Science Review2019，6，5： | 9 |
| 9 | Influence of Sputtered Nanocrystalline Coating on Oxidation and Hot Corrosion of a Nickel-based Superalloy M951显示文摘The isothermal and cyclic oxidation behaviors in air and hot corrosion behaviors in Na2SO4t 25 wt%K2SO4salt of M951 cast superalloy and a sputtered nanocrystalline coating of the same material were studied.Scanning electron microscopy,energy dispersive X-ray spectroscope,X-ray diffraction,and transmission electron microscopy were employed to examine the morphologies and phase composition of the M951 alloy and nanocrystalline coating before and after oxidation and hot corrosion.The as-sputtered nanocrystalline layer has a homogeneous g phase structure of very fine grain size(30e200 nm)with the preferential growth texture of(111)parallel to the interface.Adherent Al2O3rich oxide scale formed on the cast M951 alloy and its sputtered coating after isothermal oxidation at 900 and 1000 C.However,when being isothermal oxidized at 1100 C and cyclic oxidized at 1000 C,the oxide scale formed on the cast alloy was a mixture of NiO,NiAl2O4,Al2O3and Nb2O5and spalled seriously,while that formed on the sputtered coating mainly consisted of Al2O3and was very adherent.Nanocrystallization promoted rapid formation of Al2O3scale during the early stage of oxidation and enhanced the adhesion of the oxide scale,thus improved the oxidation resistance of the substrate alloy.Serious corrosion occurred for the cast alloy.The sputtered nanocrystalline coating apparently improved the hot corrosion resistance of the cast alloy in the mixed sulfate by the formation of a continuous Al2O3and Cr2O3mixed oxide layer on the surface of the coating,and the preoxidation treatment of the coating led to an even better effect. | Xinyue Wang Li Xin Fuhui Wang Shenglong Zhu Hua Wei Xiaolan Wang | 2014 | Journal of Materials Science & Technology2014，30，9： | 9 |
| 10 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 11 | Medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 2002-2011显示文摘Objective: Colorectal cancer(CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in China.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. For each eligible CRC patient diagnosed from 2002 to 2011, clinical information and expenditure data were extracted using a uniform questionnaire. All expenditure data were reported in Chinese Yuan(CNY)using 2011 values.Results: Of the 14,536 CRC patients included, the average age at diagnosis was 58.2 years and 15.8% were stageI cases. The average medical expenditure per patient was estimated at 37,902 CNY [95 % confidence interval(95%CI): 37,282-38,522], and the annual average increase rate was 9.2% from 2002 to 2011(P for trend <0.001), with a cumulative increase of 2.4 times(from 23,275 CNY to 56,010 CNY). The expenditure per patient in stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 31,698 CNY, 37,067 CNY, 38,918 CNY and 42,614 CNY, respectively(P<0.001). Expenditure significantly differed within various subgroups. Expenses for drugs contributed the largest proportion(52.6%).Conclusions: These conservative estimates illustrated that medical expenditures for CRC diagnosis and treatment in tertiary hospitals in China were substantial and increased rapidly over the 10 years, with drugs continually being the main expense by 2011. Relatively, medical expenditures are lower for CRC in the earlier stages. These findings will facilitate the economic evaluation of CRC prevention and control in China. | Jufang Shi Guoxiang Liu Hong Wang Ayan Mao Chengcheng Liu Lanwei Guo Huiyao Huang Jiansong Ren Xianzhen Liao Yana Bai Xiaojie Sun Xinyu Zhu Jialin Wang Bingbing Song Jinyi Zhou Lin Zhu Haike Lei Yuqin Liu Yunyong Liu Lingbin Du Yutong He Kai Zhang Ni Li Wanqing Chen Min Dai Jie He | 2019 | Chinese Journal of Cancer Research2019，31，5： | 8 |
| 12 | Visualization Feature and CNN Based Homology Classification of Malicious Code显示文摘The malicious code brings a serious security threat.Researchers have found that many new types of malicious code are variants of the existing one.The homology classification of the unknown malicious code can find its corresponding family in which all the code share inherent similarities from the database,so that the defenders can make rapid response and processing.We use the algorithm of malicious code visualization to translate the homology classification problem into the image classifica tion problem.A convol ution neural net work for malicious code image is cons true ted.We t rain it to complete the malicious code homology classification on two different datasets.The results show that our work out performs mos t of existing work with the accuracy of 98.60%. | CHU Qianfeng LIU Gongshen ZHU Xinyu | 2020 | Chinese Journal of Electronics2020，29，1： | 6 |
| 13 | Atmospheric oscillations over the last millennium显示文摘The variations of global atmospheric oscillations over the last millennium, including the North Atlantic Oscillation (NAO), the North Pacific Oscillation (NPO) highly associated with the Pacific Decadal Oscillation (PDO), the Southern Oscillation (SO) and the Antarctic Oscillation (AAO), are studied and compared in this paper based on observations and reconstructed data. The cross correlation analysis of AAO, NAO and NPO shows that there is no significant relationship on interannual variation among them. However, the consistency on decadal variability is prominent. During A.D.1920–1940 and A.D.1980–2000, the positive (strong) phase was dominant and the negative (weak) one noticeable during A.D.1940–1980. In addition, the reconstructed atmospheric oscillations series demonstrate that the positive phase existed in the early of the last millennium for NAO and in the late of the last millennium for AAO, respectively; while it occurred in the mid-late of the last millennium for PDO and ENSO. | HUANG JianBin WANG ShaoWu GONG DaoYi ZHOU TianJun WEN XinYu ZHANG ZiYin ZHU JinHong | 2010 | Chinese Science Bulletin2010，55，22： | 6 |
| 14 | Bifunctional 3D n-doped porous carbon materials derived from paper towel for oxygen reduction reaction and supercapacitor显示文摘Designing and fabricating cheap and active bifunctional materials is crucial for the development of renewable energy technologies.In this article,three-dimensional nitrogen-doped porous carbon materials(NDPC-X,in which X represents the pyrolysis temperature) were fabricated by simultaneous carbonization and activation of polypyrrole-coated paper towel protected by a silica layer followed by acid etching.The material had a high specific surface area(1,123.40 m^2/g).The as-obtained NDPC-900 displayed outstanding activity as a catalyst for the oxygen reduction reaction(ORR) as well as an electrode with a high specific capacitance in a supercapacitor in an alkaline medium.The NDPC-900 catalyst for the ORR exhibited a more positive reduction peak potential of à0.068 V(vs.Hg|HgCl^2) than that of Pt/C(-0.121 V),as well as better cycling stability and stronger methanol tolerance.Moreover,the NDPC-900 had a high specific capacitance of 379.50 F/g at a current density of 1 A/g,with a retention rate of 94.5% after 10,000 cycles in 6 mol/L KOH electrolyte when used as an electrode in a supercapacitor.All these results were attributed to the effect of a large surface area,which provided electrochemically active sites.This work introduces an effective way to use biomass-derived materials for the synthesis of promising bifunctional carbon material for electrochemical energy conversion and storage devices. | Xinyu Gao Xueyan Li Zhuang Kong Guozheng Xiao Ying Zhu | 2018 | Science Bulletin2018，63，10： | 6 |
| 15 | Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal crohn's disease显示文摘AIM To examine the relationship between elevated granulocyte-macrophage colony-stimulating factor(GMCSF) auto-antibodies(Ab) level and time to surgical recurrence after initial surgery for Crohn's disease(CD). METHODS We reviewed 412 charts from a clinical database at tertiary academic hospital. Patients included in the study had ileal or ileocolonic CD and surgical resection of small bowel or ileocecal region for management of disease. Serum samples were analyzed for serological assays including GM-CSF cytokine, GM-CSF Ab, ASCA Ig G and Ig A, and genetic markers including SNPs rs2066843, rs2066844, rs2066845, rs2076756 and rs2066847 in NOD2, rs2241880 in ATG16 L1, and rs13361189 in IRGM. Cox proportional-hazards models were used to assess the predictors of surgical recurrence.RESULTS Ninety six percent of patients underwent initial ileocecal resection(ICR) or ileal resection(IR) and subsequently 40% of patients required a second ICR/IR for CD. GMCSF Ab level was elevated at a median of 3.81 mcg/mL. Factors predicting faster time to a second surgery included elevated GM-CSF Ab [hazard ratio(HR) 3.52, 95%CI: 1.45-8.53, P = 0.005] and elevated GM-CSF cytokine(HR = 2.48, 95%CI: 1.31-4.70, P = 0.005). Factors predicting longer duration between first and second surgery included use of Immunomodulators(HR = 0.49, 95%CI: 0.31-0.77, P = 0.002), the interaction effect of low GM-CSF Ab levels and smoking(HR = 0.60, 95%CI: 0.45-0.81, P = 0.001) and the interaction effect of low GM-CSF cytokine levels and ATG16 L1(HR = 0.65, 95%CI: 0.49-0.88, P = 0.006).CONCLUSION GM-CSF bioavailability plays a critical role in maintaining intestinal homeostasis. Decreased bioavailability coupled with the genetic risk markers and/or smoking results in aggressive CD behavior. | Grace Gathungu Yuanhao Zhang Xinyu Tian Erin Bonkowski Leahana Rowehl Julia Krumsiek Billy Nix Claudia Chalk Bruce Trapnell Wei Zhu Rodney Newberry Lee Denson Ellen Li | 2018 | World Journal of Gastroenterology2018，24，5： | 5 |
| 16 | Molecular and serological surveillance of Getah virus in the Xinjiang Uygur Autonomous Region,China,2017–2020显示文摘The Getah virus(GETV),a mosquito-borne RNA virus,is widely distributed in Oceania and Asia.GETV is not the only pathogenic to horses,pigs,cattle,foxes and boars,but it can also cause fever in humans.Since its first reported case in Chinese mainland in 2017,the number of GETV-affected provinces has increased to seventeen till now.Therefore,we performed an epidemiologic investigation of GETV in the Xinjiang region,located in northwestern China,during the period of 2017-2020.ELISA was used to analyze 3299 serum samples collected from thoroughbred horse,local horse,sheep,goat,cattle,and pigs,with thoroughbred horse(74.8%),local horse(67.3%),goat(11.7%),sheep(10.0%),cattle(25.1%)and pigs(51.1%)being positive for anti-GETV antibodies.Interestingly,the neutralizing antibody titer in horses was much higher than in other species.Four samples from horses and pigs were positive for GETV according to RT-PCR.Furthermore,from the serum of a local horse,we isolated GETV which was designated as strain XJ-2019-07,and determined its complete genome sequence.From the phylogenetic relationships,it belongs to the Group III lineage.This is the first evidence of GETV associated to domestic animals in Xinjiang.Overall,GETV is prevalent in Xinjiang and probably has been for several years.Since no vaccine against GETV is available in China,detection and monitoring strategies should be improved in horses and pigs,especially imported and farmed,in order to prevent economic losses. | Ning Shi Xiangshu Qiu Xinyu Cao Zhanhai Mai Xiangyu Zhu Nan Li He Zhang Jinyong Zhang Zhuoxin Li Nuerlan Shaya Huijun Lu Ningyi Jin | 2022 | Virologica Sinica2022，37，2： | 5 |
| 17 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 18 | Biogenic carbonate formation and sedimentation in the Xisha Islands: evidences from living Halimeda显示文摘A recent island survey reveals that the Xuande Atoll and the Yongle Atoll in the Xisha Islands can be classified into one of two systems: the depleted atoll system and growth atoll system; the survey also indicates that the decreased area of several shoals is an unbearable burden for the Xisha Islands, of which the largest island area is 2.13 km2 and the minimum elevation is 1.4 m. According to a survey on the ecological characteristics of Halimeda in the Laolongtou breaker zone of Shidao Island in the Xisha Islands, the green and white living Halimeda are collected,the isotopic ages of 14 C contained in the Halimeda are shown to be 27 years and 55 years, respectively, and carbonate mainly occurs in five types, i.e., luster, segment, sand, sand grain, and marl in the formation. The Halimeda segments mainly provide the carbonate sediments of long-term biogenic deposits in the reef environment and the annual productivity per area is 60–100 g/m2; the characteristics of the microstructure of the Halimeda are analyzed, the aragonite raphide carbonate is deposited and enriched in the cortexes, medullas and cysts, and the Halimeda generally contain major elements such as C, O, Ca, Cl, Mg, K, Na, S and Al, and are rich in trace elements such as tellurium(Te), rhodium(Rh) and strontium. It is believed that the Halimeda grow slowly,including the biotic community of reef corals in the reef areas, thus they possess an environmental remediation capacity, but it takes much time to remedy the environment, and it is necessary to make the law to protect the diversity and vulnerability of the Xisha marine ecology, the ecology of the reef community and the island environment in a scientific way. As indicated in the survey, under the background of global warming and sea-level rise, the discovery of large amounts of Halimeda in the Laolongtou sea area is significant for the natural increase of the depleted atoll system of the Xuande Atoll, while the Halimeda segments represent the primary form of the fossil Halimeda, of which the species can be identified and preserved in great numbers under geological conditions. The Miocene was discovered in large amounts in the Xichen-1 well, therefore the study on the characteristics and mechanism of Halimeda carbonate sediments plays a pivotal role in the formation and construction of organic reefs in the South China Sea as well as oil and gas exploration. | XU Hong ZHAO Xinwei EBERLI G.P. LIU Xinyu ZHU Yurui CAI Ying LUO Wei YAN Guijing ZHANG Bolin WEI Kai SHI Jian | 2015 | Acta Oceanologica Sinica2015，34，4： | 4 |
| 19 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 20 | Highly sensitive flexible capacitive pressure sensor with a broad linear response range and finite element analysis of micro-array electrode显示文摘With the continuous development of wearable electronics,health care and smart terminals,highly performance flexible pressure sensors present a huge application prospect.In this study,by introducing the micro-array structured electrodes and dielectric layers with high dielectric constant,capacitive pressure sensor fabricated with a brand new preparation strategy and highly sensitive is proposed.The prepared micro-array structure is the basis for sensors with high sensitivity.Besides,the contact area between the two electrodes changes from linear to planar with the increased loading,which result in a wider linear responding range.In addition,by introducing ceramic dielectric material-barium titanate(BT)fillers into the dielectric layer to increase it’s the dielectric constant,the sensitivity of the sensor shows two-fold increase.Moreover,the sensitivity gradients can be tuned by changing the loading contents of BT particles.Hence,compared with parallel board capacitive sensors with ordinary dielectric layer,these sensors exhibit excellent performance as follow,high sensitivity(up to 4.9 kPa^(-1))under low pressure range(0-2500 Pa),low detection limit(<1.7 Pa),short response time(<50 ms),a stable response over 5000 loading-unloading cycles,bending stability and an adjustable sensitivity.Further,the flexible pressure sensor can detect the pressure of the water droplets and monitor human movement behavior.With the facile design and excellent comprehensive properties,the flexible pressure sensor provides a new approach to improve the sensitivity and shows a broad application prospects in the wearable electronics,health care and smart terminals. | Longquan Ma Xuecheng Yu Yuanyuan Yang Yougen Hu Xinyu Zhang Huayuan Li Xing Ouyang Pengli Zhu Rong Sun Ching-ping Wong | 2020 | Journal of Materiomics2020，6，2： | 4 |
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