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| 1 | Experimental Study on Preparation of Natural Gas Hydrate by Crystallization显示文摘In this paper, the saturated solution crystallization method is proposed to promote the formation of hydrate by means of the known similarities between the hydrate formation process and the crystallization process. In this method,adding the second phase crystals was used to replace the spontaneous formation of hydrate crystal nuclei to form hydrate.The effects of saturated Na_2SO_4, MgSO_4, NH_4HCO_3 and CuSO_4 solutions on the formation rates of natural gas hydrate and gas storage capacity were investigated. The results showed that the saturated solution had an influence on the hydrate formation process. Under the given experimental conditions, the saturated Na_2SO_4 solution showed a highest increase in the hydrate formation rate, and the average hydrate formation rate in its presence was 11.8 times higher than that obtained in the deionized water. Moreover, the largest formation rate of gas hydrates observed in the saturated Na_2SO_4 solution was 386 times bigger than that in the deionized water, and the gas storage capacity increased by 10 times. In addition, the average hydrate formation rate in the saturated Mg SO_4 solution was faster than that in water by 20 times. The largest formation rate of gas hydrates in the saturated MgSO_4 solution was 165 times faster than that obtained in the deionized water, and the gas storage capacity increased by 6.2 times. The saturated NH_4HCO_3 and saturated CuSO_4 solutions also influenced the formation process of hydrate. Therefore, the crystallization method of saturated solution can be used to achieve a highefficiency preparation of natural gas hydrates, which provides theoretical guidance for the storage of natural gas in the form of hydrate. | Ma Shihui Pan Zhen Li Ping Wu Yuguo Li Bingfan Kang Jinke Zhang Zhien | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，1： | 7 |
| 2 | Over-expression of small ubiquitin-like modifier proteases 1 predicts chemo-sensitivity and poor survival in non-small cell lung cancer显示文摘 | Mu Juwei Zuo Yong Yang Wenjing Chen Zhaoli Liu Ziyuan Tu Jun Li Yan Yuan Zuyang Cheng Jinke He Jie | 2014 | Chinese Medical Journal2014，，23： | 7 |
| 3 | Asymmetric distribution of cytokinins determines root hydrotropism in Arabidopsis thaliana显示文摘The phenomenon of plant root tips sensing moisture gradient in soil and growing towards higher water potential is designated as root hydrotropism,which is critical for plants to survive when water is a limited factor.Molecular mechanisms regulating such a fundamental process,however,are largely unknown.Here we report our identification that cytokinins are key signaling molecules directing root growth orientation in a hydrostimulation(moisture gradient)condition.Lower water potential side of the root tip shows more cytokinin response relative to the higher water potential side.Consequently,two cytokinin downstream type-A response regulators,ARR16 and ARR17,were found to be up-regulated at the lower water potential side,causing increased cell division in the meristem zone,which allows the root to bend towards higher water potential side.Genetic analyses indicated that various cytokinin biosynthesis and signaling mutants,including the arr16 arr17 double mutant,are significantly less responsive to hydrostimulation.Consistently,treatments with chemical inhibitors interfering with either cytokinin biosynthesis or cell division completely abolished root hydrotropic response.Asymmetrically induced expression of ARR16 or ARR17 effectively led to root bending in both wild-type and miz1,a previously known hydrotropism-defective mutant.These data demonstrate that asymmetric cytokinin distribution is a primary determinant governing root hydrotropism. | Jinke Chang Xiaopeng Li Weihao Fu Jiawen Wang Yueyuan Yong Hongyong Shi Zhaojun Ding Hong Kui Xiaoping Gou Kai He Jia Li | 2019 | Cell Research2019，29，12： | 4 |
| 4 | RGF1-RGI1,a Peptide-Receptor Complex,Regulates Arabidopsis Root Meristem Development via a MAPK Signaling Cascade显示文摘Root growth is maintained by the continuous division of cells in the apical meristem.ROOT MERISTEM GROWTH FACTOR 1(RGF1)is a critical peptide hormone regulating root stem cell niche maintenance.Previous studies discovered that five closely related leucine-rich repeat receptor-like protein kinases(LRRRLKs),named RGF1 INSENSITIVES(RGIs)or RGF1 RECEPTORS(RGFRs),are able to perceive the RGF1 signal and redundantly control root stem cell niche maintenance.RGF1 regulates root meristem activity mainly via two downstream transcription factors,PLETHORA 1(PLT1)and PLT2.Regulatory proteins connecting cell surface RGF1-RGI1 and nuclear PLTs,however,were not identified.Here,we report that the mitogen-activated protein(MAP)kinase kinase 4(MKK4)and MAP kinase 3(MPK3)were coimmunoprecipitated with RGI1-FLAG after Arabidopsis seedlings were treated with RGF1.Genetic and biochemical assays confirmed that MKK4 and MKK5,and their downstream targets MPK3 and MPK6,are essential RG卜dependent regulators of root meristem development.In addition,we found that the MKK4/MKK5-MPK3/MPK6 module functions downstream of YDA,a MAPKKK.Our results demonstrate that RGF1-RGI1 regulate the expression of PLT1/PLT2 via a YDA-MKK4/MKK5-MPK3/MPK6 signaling cascade. | Xiaoting Lu Hongyong Shi Yang Ou Yanwei Cui Jinke Chang Liang Peng Xiaoping Gou Kai He Jia Li | 2020 | Molecular Plant2020，13，11： | 3 |
| 5 | Traditional Chinese medicines and their active ingredients sensitize cancer cells to TRAIL-induced apoptosis显示文摘The rapidly developing resistance of cancers to chemotherapy agents and the severe cytotoxicity of such agents to normal cells are major stumbling blocks in current cancer treatments.Most current chemotherapy agents have significant cytotoxicity,which leads to devastating adverse effects and results in a substandard quality of life,including increased daily morbidity and premature mortality.The death receptor of tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)can sidestep p53-dependent pathways to induce tumor cell apoptosis without damaging most normal cells.However,various cancer cells can develop resistance to TRAIL-induced apoptosis via different pathways.Therefore,it is critical to find an efficient TRAIL sensitizer to reverse the resistance of tumor cells to TRAIL,and to reinforce TRAIL’s ability to induce tumor cell apoptosis.In recent years,traditional Chinese medicines and their active ingredients have shown great potential to trigger apoptotic cell death in TRAIL-resistant cancer cell lines.This review aims to collate information about Chinese medicines that can effectively reverse the resistance of tumor cells to TRAIL and enhance TRAIL’s ability to induce apoptosis.We explore the therapeutic potential of TRAIL and provide new ideas for the development of TRAIL therapy and the generation of new anticancer drugs for human cancer treatment.This study involved an extensive review of studies obtained from literature searches of electronic databases such as Google Scholar and PubMed.'TRAIL sensitize'and'Chinese medicine'were the search keywords.We then isolated newly published studies on the mechanisms of TRAIL-induced apoptosis.The name of each plant was validated using certified databases such as The Plant List.This study indicates that TRAIL can be combined with different Chinese medicine components through intrinsic or extrinsic pathways to promote cancer cell apoptosis.It also demonstrates that the active ingredients of traditional Chinese medicines enhance the sensitivity of cancer cells to TRAIL-mediated apoptosis.This provides useful information regarding traditional Chinese medicine treatment,the development of TRAIL-based therapies,and the treatment of cancer. | Bingyu SUN Yongqiang LIU Danhua HE Jinke LI Jiawei WANG Wulin WENS Ming HONG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，3： | 3 |
| 6 | SENP1 regulates IFN-γ-STAT1 signaling throug STAT3-SOCS3 negative feedback loop显示文摘干扰素 --(IFN-) 由激活发信号的细胞内部的 JAKSTAT1 为发炎反应触发巨噬细胞。表明 1 的 cytokine (SOCS1 ) 和蛋白质酷氨酸磷酸酶的 Suppressor 能否定地调制 IFN- 发信号。这里,我们鉴别一个新奇否定反馈环由 STAT3SOCS3 调停了,它被 SENP1 紧经由蛋白质酷氨酸磷酸酶 1B (PTP1B ) 的 de-SUMOylation 控制,在 IFN- 发信号。SENP1 缺乏的巨噬细胞在 IFN- 发信号和 M1 巨噬细胞激活显示出缺点。在 SENP1 缺乏的巨噬细胞的 PTP1B 高度 SUMOylated,它减少 STAT3 的导致 PTP1B 的 de-phosphorylation。激活的 STAT3 然后经由在 SENP1 缺乏的巨噬细胞感应的 SOCS3 压制 STAT1 激活。因此, SENP1 缺乏的巨噬细胞显示减少的能力抵抗 Listeria monocytogenes 感染。这些结果在巨噬细胞极化揭示控制 SENP1 的 STAT1 和 STAT3 平衡的一个关键角色。 | Tingting Yu Yong Zuo Rong Cai Xian Huang Shuai Wu Chenxi Zhang Y. Eugene Chin Dongdong Li Zhenning Zhang Nansong Xia Qi Wang Hao Shen Xuebiao Yao Zhong-Yin Zhang Song Xue Lei Shen Jinke Cheng | 2017 | Journal of Molecular Cell Biology2017，9，2： | 3 |
| 7 | Mobile platform of rocker-type coal mine rescue robot显示文摘After a coal mine disaster,especially a gas and coal dust explosion,the space-restricted and unstructured underground terrain and explosive gas require coal mine rescue robots with good obstacle-surmounting performance and explosion-proof capability. For this type of environment,we designed a mobile platform for a rocker-type coal mine rescue robot with four independent drive wheels.The composition and operational principles of the mobile platform are introduced,we discuss the flameproof design of the rocker assembly,as well as the operational principles and mechanical structure of the bevel gear differential and the main parameters are provided.Motion simulation of the differential function and condition of the robot running on virtual,uneven terrain is carried out with ADAMS.The simulation results show that the differential device can maintain the main body of the robot at an average angle between two rockers.The robot model has good operating performance.Experiments on terrain adaptability and surmounting obstacle performance of the robot prototype have been carried out.The results indicate that the prototype has good terrain adaptability and strong obstacle-surmounting performance. | LI Yunwang GE Shirong ZHU Hua FANG Haifang GAO Jinke | 2010 | Mining Science and Technology2010，20，3： | 3 |
| 8 | c-Jun binding site identification in K562 cells显示文摘决定抄写因素的有约束力的地点为 transcriptional 规定的理解是重要的。抄写因素 c6 月戏在细胞生长,区别和开发的一个重要角色,而是有约束力的地点和目标基因清楚地没在整个人被定义染色体。在这研究,我们执行了一个 ChIP-Seq 实验在人的染色体识别 c6 月绑定地点。48 个有约束力的地点被选择由 dsDNA microarray 试金处理进一步的评估。我们在 K562 房间识别了 283 个 c6 月绑定地点。数据分析证明 48.8% 有约束力的地点在 100 以内定位了 kb 注解基因在上游, 28.6% 有约束力的地点包括了一致 TRE/CRE 主题(5-TGAC/GTCA-3, 5-TGACGTCA-3 ) 并且变体序列。42 从选择了地点被发现在 dsDNA microarray 分析绑 c6 月 homodimer 的 48 绑定。数据分析也证明 1569 基因在 dsDNA microarray 验证的 42 个有约束力的地点的邻居位于 283 个有约束力的地点和 191 基因的邻居。我们在以前的研究请教了 38 c6 月目标基因, 16 也在这研究在这 38 基因之中被检测。在染色体规模的 c6 月绑定地点和潜在的目标基因的鉴定可以在位于与 c6 月有关的抄写规定下面的分子的机制改进我们的基本理解。 | Minli Li Qinyu Ge Wei Wang Jinke Wang Zuhong Lu | 2011 | Journal of Genetics and Genomics2011，38，6： | 2 |
| 9 | Multi-action self-healing coatings with simultaneous recovery of corrosion resistance and adhesion strength显示文摘In this study, a new self-healing strategy that can simultaneously recover the corrosion resistance and the adhesion strength of coatings was introduced. The coating was based on a shape memory epoxy resin containing ethylene vinyl acetate(EVA) microspheres loaded with Ce(NO_(3))_(3)inhibitors, and was cured at a relatively high temperature to facilitate the fusion of adjacent microspheres for a strengthened self-healing effect. The electrochemical impedance spectroscopy(EIS) and scanning electrochemical microscopy(SECM) results demonstrated that the shape memory effect of epoxy matrix, the filling of molten EVA microspheres as well as the release of Ce(NO_(3))_(3)inhibitors contributed synergistically to suppress the corrosion reaction at the coating damage. After healing, the low frequency impedance modulus of the coatings containing Ce(NO_(3))_(3)-EVA microspheres was three orders of magnitude higher than that of the blank epoxy coating. The adhesion strength of the coatings containing Ce(NO_(3))_(3)-EVA microspheres on the metal substrate was also largely repaired thanks to the strong bonding effect of the EVA microspheres. | Chenhao Ren Yao Huang Wenkui Hao Dawei Zhang Xiejing Luo Lingwei Ma Jinke Wang Thee Chowwanonthapunya Chaofang Dong Xiaogang Li | 2022 | Journal of Materials Science & Technology2022，，6： | 2 |
| 10 | Overexpression of cystic fibrosis transmembrane conductance regulator (CFTR) is associated with human cervical cancer malignancy, progression and prognosis显示文摘 | Xue Peng Zhao Wu Lei Yu Jinke Li Wenming Xu Hsiao Chang Chan Yi Zhang Lina Hu | 2012 | Gynecologic Oncology2012，，： | 1 |
| 11 | Constitutive Activation of Nuclear Factor κB Contributes to Cystic Fibrosis Transmembrane Conductance Regulator Expression and Promotes Human Cervical Cancer Progression and Poor Prognosis显示文摘 | Zhao Wu Xue Peng Jinke Li Yi Zhang Lina Hu | 2013 | International Journal of Gynecological Cancer2013，，： | 1 |
| 12 | Conversion of mouse fibroblasts into oligodendrocyte progenitor-like cells through a chemical approach显示文摘Transplantation of oligodendrocyte progenitor cells (OPCs) is a promising way for treating demyelinating diseases. However, generation of scalable and autologous sources of OPCs has proven difficult. We previously established a chemical condition M9 that could specifically initiate neural program in mouse embryonic fibroblasts. Here we found that M9 could induce the formation of colonies that undergo mesenchymal-to-epithelial transition at the early stage of reprogramming. These colonies may represent unstable and neural lineage-restricted intermediates that have not established a neural stem cell identity. By modulating the culture signaling recapitulating the principle of OPC development, these intermediate cells could be reprogrammed towards OPC fate. The chemical-induced OPC-like cells (ciOPLCs) resemble primary neural stem cell-derived OPCs in terms of their morphology, gene expression, and the ability of self-renewal. Upon differentiation, ciOPLCs could produce functional oligodendrocytes and myelinate the neuron axons in vitro, validating their OPC identity molecularly and functionally. Therefore, our study provides a non-integrating approach to OPC reprogramming that may ultimately provide an avenue to patient-specific cell-based or in situ regenerative therapy. | Chang Liu Xu Hu Yawen Li Wenjie Lu Wenlin Li Nan Cao Saiyong Zhu Jinke Cheng Sheng Ding Mingliang Zhang | 2019 | Journal of Molecular Cell Biology2019，11，6： | 1 |
| 13 | Identification of two migratory colon ILC2 populations differentially expressing IL-17A and IL-5/IL-13显示文摘Group 2 innate lymphoid cells(ILC2s)play important tissue resident roles in anti-parasite immunity,allergic immune response,tissue homeostasis,and tumor immunity.ILC2s are considered tissue resident cells with little proliferation at steady state.Recent studies have shown that a subset of small intestinal ILC2s could leave their residing tissues,circulate and migrate to different organs,including lung,liver,mesenteric LN and spleen,upon activation.However,it remains unknown whether other ILC populations with migratory behavior exist.In this study,we find two major colon ILC2 populations with potential to migrate to the lung in response to IL-25 stimulation.One subset expresses IL-17A and resembles inflammatory ILC2s(iILC2s)but lacks CD27 expression,whereas the other expresses CD27 but not IL-17A.In addition,the IL-17A^(+)ILC2s express lower levels of CD127,CD25,and ST2 than CD27^(+)ILC2s,which express higher levels of IL-5 and IL-13.Surprisingly,we found that both colon ILC2 populations still maintained their colonic features of preferential expression of IL-17A and CD27,IL-5/IL-13,respectively.Together,our study identifies two migratory colon ILC2 subsets with unique surface markers and cytokine profiles which are critical in regulating lung and colon immunity and homeostasis. | Hongzhi Liu Liang Li Yanyun Hao Jialu Li Zhaoyuan Liu Jingjing Qi Jingjing Zhang Ningbo Wu Dandan Wu Caixia Gao Lei Chen Lei Shen Jinke Cheng Bing Su | 2023 | Science China(Life Sciences)2023，66，1： | 1 |
| 14 | A note on M-Groups 显示文摘 | Hal Jinke Li Zhengxing | 2011 | March 12011，，： | 1 |
| 15 | Causality relationship between coal consumption and GDP: Difference of major OECD and Non-OECD countries显示文摘 | Li Jinke Song Hualing Geng Dianming | 2008 | Applied Energy2008，85，6： | 1 |
| 16 | Simulation of temperature field-RCC arch dam 显示文摘 | Li Shouyi Ren Jinke Wu Zhongming | 2008 | International Water Power and Dam Construction2008，60，4： | 1 |
| 17 | Sodium and chloride distribution in roots and transport in three poplar genotypes under increasing NaCl stress显示文摘 | CHEN Shaoliang LI Jinke FRITZ E | | 0，，1： | 1 |
| 18 | Effects of NaCl on shoot growth,transpiration,ion compartmentation,and transport in regenerated plants of Populus euphratica and Populus tomentosa显示文摘 | CHEN Shaoliang LI Jinke WANG Shasheng | | 0，，06： | 1 |
| 19 | The normalizer property for integral group rings of finite solvable T-groups显示文摘 | LI Zhengxing HAI Jinke | 2012 | J Group Theory2012，15，2： | 1 |
| 20 | Class-Preserving Coleman Automorphisms of Finite Groups Whose Second Maximal Subgroups Are TI-Subgroups显示文摘Recall that a subgroup H of a finite group G is called a TI-subgroup if H ∩ H^g= 1 or H for each g ∈ G.Suppose that G is a finite group whose second maximal subgroups are TI-subgroups.It is shown that every class-preserving Coleman automorphism of G is an inner automorphism.As an immediate consequence of this result,we obtain that the normalizer property holds for G. | Zhengxing LI Jinke HAI | 2013 | Journal of Mathematical Research with Applications2013，33，2： | 1 |
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