|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hypoglycemic effect of catalpol on high-fat diet/streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis显示文摘Catalpol, iridoid glycoside,在根值 Rehmanniae 的根存在。一些研究证明了 catalpol 为这效果在导致 streptozotocin 的糖尿病的模型,而是内在的机制有显著血糖过低的效果充分没被阐明。因为 mitochondrial 机能障碍在糖尿病的病理起一个重要作用并且因为改善 mitochondrial 功能可以为糖尿病的处理提供一条新途径,这研究被设计。Catalpol 口头上地予导致的高脂肪的 diet/streptozotocin (HFD/STZ ) 和 metformin 被以为 4 个星期的糖尿病的老鼠日报。身体重量(BW )(IPGTT ) , fasting 血葡萄糖(FBG ) 水平,和葡萄糖处理被测量在期间或在处理以后。结果整个 catalpol 管理的四个连续星期在 BW 没有明显的变化显示出 FBG 水平的剂量依赖者减小。Catalpol 治疗实质地在糖尿病的老鼠减少了浆液总数胆固醇和 triglyceride 层次。另外, catalpol 高效地增加了 mitochondrial ATP 生产并且在骨胳的肌肉织物颠倒了 mitochondrial 膜潜力和 mtDNA 拷贝数字的减少。而且, catalpol (200 mg/kg ) 在骨胳的肌肉救了 mitochondrial 超微结构,与传播电子显微镜学检测了。peroxisome 的相对 mRNA 水平(PGC1 ) 当这效果被 catalpol 颠倒时,激活 proliferator 的受体 gamma 激活剂 1 显著地在糖尿病的老鼠的肌肉组织被减少,导致一条剂量依赖者起来规定。一起拿,我们发现 catalpol 能够经由在 HFD/STZ-induced 糖尿病的老鼠的骨胳的肌肉改进 mitochondrial 功能的阴沉的 FBG 水平。 | Xia Li Zhimeng Xu Zhenzhou Jiang Lixin Sun Jinzi Ji Jingshan Miao Xueji Zhang Xiaojie Li Shan Huang Tao Wang Luyong Zhang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 16 |
| 2 | Mitochondrial protein sulfenation during aging in the rat brain显示文摘There is accumulating evidence that cysteine sulfenation (cys-SOH) in proteins plays an important rolein cellular response to oxidative stress. The purpose of the present study was to identify mitochondrialproteins that undergo changes in cys-SOH during aging. Studies were conducted in rats when they were5 or 30 months of age. Following blocking of free protein thiols with N-ethylmaleimide, protein sulfenicacids were reduced by arsenite to free thiol groups that were subsequently labeled with biotin-maleimide. Samples were then comparatively analyzed by two-dimensional Western blots, and proteinsshowing changes in sulfenation were selectively identified by mass spectrometry peptide sequencing.As a result, five proteins were identified. Proteins showing an age-related decrease in sulfenationinclude pyruvate carboxylase and pyruvate dehydrogenase; while those showing an age-relatedincrease in sulfenation include aconitase, mitofilin, and tubulin (α-1). Results of the present studyprovide a general picture of mitochondrial protein sulfenation in brain oxidative stress and implicatethe involvement of protein sulfenation in overall decline of mitochondrial function during brain aging. | Xiaorong Yang Jinzi Wu Siqun ling Michael J. Forster Liang-Jun Yan | 2018 | Biophysics Reports2018，4，2： | 3 |
| 3 | Analysis of influ- ential factors of preschool children's inteRigence level in nine regions of the eotmtry Chinese 显示文摘 | Xue Yong Zhao Ai Wang Jinzi Shao Xianglong Zhang Yumei | 2015 | food and nutrition2015，03，： | 1 |
| 4 | Heat-activated thermosensitive liposomal cisplatin (HTLC) results ineffective growth delay of cervical carcinoma in mice显示文摘 | Yannan ND Jinzi Z Warren DF | 2014 | J Control Release2014，178，： | 1 |
| 5 | Cloud Computing: IT as a Service 显示文摘 | LIN Geng FU David ZHU Jinzy | 2009 | IT Professional2009，11，2： | 1 |
| 6 | Existence of solutions of nonlinear two-point boundary value problems for third order nonlinear differential equations显示文摘 | Wang Jinzi | 1991 | Northeast Math J1991，7，2： | 1 |
| 7 | MXene quantum dot within natural 3D watermelon peel matrix for biocompatible flexible sensing platform显示文摘Environmentally friendly biomimetic materials with good deformability,high pressure-sensitive performance,and excellent biocompatibility are highly attractive for health monitoring,but to simultaneously meet these requirements is a formidable challenge.In this study,biocompatible MXene quantum dot(MQD)/watermelon peel(WMP)aerogels were obtained by immersing freeze-dried fresh watermelon peel into the quantum dot dispersion.The resulting bio-aerogels with a three-dimensional(3D)porous network structure exhibited a low in elasticity modulus(0.03 MPa)and limit of detection(0.4 Pa)and it showed biocompatibility.With a maximum pressure-sensitive response of 323 kPa^(-1),the 3D porous MQD/WMP aerogels exhibited good stability.In addition,the sensing signals could be displayed on mobile phones through a Bluetooth module to monitor human motion(pulse,sound,and walking)in real time.More importantly,the MQD/WMP aerogels exhibited excellent biocompatibility in a cytotoxicity test,thus decreasing the safety risk when they are applied to human skin.The finding in this study will facilitate the fabrication of high-performance biomimetic MXene active matrices,which are derived from natural biological materials,for flexible electronics. | Jinzi Sun Hui Du Zhaojun Chen Lili Wang Guozhen Shen | 2022 | Nano Research2022，15，4： | 1 |
| 8 | Cloud Computing: IT as a Service显示文摘 | Lin Geng Fu David Zhu Jinzy Dasmalchi Glenn | 2009 | IT Professional Magazine2009，，2： | 1 |
| 9 | Biochemical and biophysical characterization of the transmissible gastroenteritis coronavirus fusion core显示文摘 | Guangpeng Ma Youjun Feng Feng Gao Jinzi Wang Cheng Liu Yijing Li | 2005 | Biochemical and Biophysical Research Communications2005，，4： | 1 |
| 10 | Cloud Computing:IT as a Service显示文摘 | Geng Lin David Fu Jinzy Zhu Glenn Dasmalchi | 2009 | IEEE Computer Society2009，，： | 1 |
| 11 | Ribosome biogenesis protein Urb1 acts downstream of mTOR complex 1 to modulate digestive organ development in zebrafish显示文摘Ribosome biogenesis is essential for the cell growth and division. Disruptions in ribosome biogenesis result in developmental defects and a group of diseases, known as ribosomopathies. Here, we report a mutation in zebrafish urb1, which encodes an essential ribosome biogenesis protein. The urb1 cq31 mutant exhibits hypoplastic digestive organs, which is caused by impaired cell proliferation with the differentiation of digestive organ progenitors unaffected. Knockdown of mtor or raptor leads to similar hypoplastic phenotypes and reduced expression of urb1 in the digestive organs. Overexpression of Urb1 results in overgrowth of digestive organs, and can efficiently rescue the hypoplastic liver and pancreas in the mtor and raptor morphants. Reduced syntheses of free ribosomal subunits and impaired assembly of polysomes are observed in the urb1 mutant as well as in the mtor and raptor morphants, which can be rescued by the Urb1 overexpression. These data demonstrate that Urb1 plays an important role in governing ribosome biogenesis and protein synthesis downstream of mammalian/mechanistic target of rapamycin complex 1(mTORC1), thus regulating the development of digestive organs. Our study indicates the requirement of hyperactive protein synthesis for the digestive organ development. | Jia He Yun Yang Junren Zhang Jinzi Chen Xiangyong Wei Jianbo He Lingfei Luo | 2017 | Journal of Genetics and Genomics2017，44，12： | 1 |
| 12 | Cloud Computing: IT as a Service显示文摘 | Geng Lin David Fu Jinzy Zhu Glenn Dasmalchi | 2009 | IEEE Computer Society2009，，： | 1 |
| 13 | Gene expression profiling and pathway analysis of hepatotoxicity induced by triptol- ide in Wistar rats显示文摘 | Wang Jiaying Jiang Zhenzhou Ji Jinzi | 2013 | Food and Chemical Toxicology2013，58，： | 1 |
| 14 | IBM cloud computing powering a smarter planet 显示文摘 | JINZY Z XING F ZHE G | 2009 | Lecture Notes in Computer Science2009，，5931： | 1 |
| 15 | APN/CD13-targeting as a strategy to alter the tumor accumulation of liposomes 显示文摘 | Michael D Jinzi Z Joshua R | 2011 | J Control Release2011，158，1： | 1 |
| 16 | The Jinsha River Groundwater Observation Network and Discussion about Its Earthquake Precursor Monitoring Capability显示文摘A groundwater observational network for monitoring seismic precursors has been established at the reservoirs on the lower reaches of the Jinsha River in southwestern China, where a series of hydropower stations are under construction. It is the second network in China that is operated by enterprises with the purpose to observe and study earthquake precursors in reservoir areas. This paper presents the layout and technical constitution of the network, features of its observational wells and aquifers and the preliminary result of its experimental operation. Its capability to monitor seismic precursor is evaluated based on an analysis of the well-aquifer system as well as the multiple-monthly, monthly, daily and hourly variations of water levels and water temperatures observed by this network. | Li Wanming Che Yongtai Liu Chenglong Yu Jinzi He Anhua | 2012 | Earthquake Research in China2012，26，2： | 0 |
| 17 | Effects of oxygen vacancy on bond ionicity,lattice energy,and microwave dielectric properties of CeO_(2) ceramics with Yb^(3+)substitution显示文摘Novel Yb_(x)Ce_(1-x)O_(2-0.5x)(x=0-0.8)ceramics,designed by replacing Ce^(4+)with Yb^(3+)ions were prepared by conventional oxide reaction,and the structural stability of the cubic fluorite structure was assessed using lattice energy and ionic properties of Ce/Yb-O bonds.The oxygen vacancy caused by unequal substitution,which played a decisive role in bond ionicity and lattice energy,was analyzed experimentally by XPS and also theoretically by first principles.The Yb_(x)Ce_(1-x)O_(2-0.5x) ceramics maintain a stable cubic fluorite structure when x≤0.47,corresponding to the minimum lattice energy of 4142 kJ/mol with the lowest ionicity as ƒ_(i)=87.57%.For microwave dielectric properties,when the Yb_(x)Ce_(1-x)O_(2-0.5x)(x=0-0.4)ceramics are pure phase,the porosity-corrected permittivity is dependent on the bond ionicity.The Q׃ values are related to the lattice energy and grain distribution.The temperature coefficient of resonance frequency has been analyzed using bond valence.When the Yb_(x)Ce_(1-x)O_(2-0.5x)(x=0.5-0.8)ceramics are multiple phases,the microwave dielectric properties are associated with the phase composition and grain growth. | Mingan Shi Shuyang Ma Wangsuo Xia Ying Wang Jinzi Yu Haitao Wu | 2024 | Journal of Advanced Ceramics2024，13，2： | 0 |
| 18 | Design of Fixed-Time Neural Controller for Uncertain Nonstrict-Feedback Systems with Smooth Switching Functions显示文摘The tracking problem of uncertain nonstrict-feedback nonlinear systems(UNFNS)is examined to develop a novel adaptive neural control scheme to ensure fixed-time convergence.In particular,the challenge associated with the unknown nonlinear function can be overcome through neural network(NN)based estimation.Therefore,an NN-based adaptive fixed-time control scheme is established with only one parameter,using the property of the basis function vector to address the algebraic loop problem.Furthermore,the singularity problem can be solved by incorporating a smooth switching function.A rigorous theoretical analysis is performed to demonstrate that the output signal can track the reference signal within a fixed time and that the signals in the control systems are bounded.Finally,numerical simulations are performed to validate the feasibility of the proposed methodology. | YANG Jinzi LI Yuanxin TONG Shaocheng | 2023 | Journal of Systems Science & Complexity2023，36，6： | 0 |
| 19 | The First Record of Co-seismic Effect of Mercury Vapor in China显示文摘Using the ATG-6138 mercury detector recently developed by the Hangzhou Aadtech Co.Ltd.,a record of the co-seismic effect of mercury(Hg)vapor accompanying the 2015 Nepal M_S8.1 earthquake was obtained in the Mile monitoring well,Yunnan Province.This is the first record of co-seismic effect obtained by mercury vapor observation in China.Such a fact implies that it would be possible to record more information about crustal dynamic effects,such as solid tide,co-seismic effect,etc.,by further improving observation instrument precision and increasing the sampling frequency of the chemical quantity of subsurface fluids.This may help us to raise the capability of earthquake precursor monitoring and forecasting in the future. | Che Yongtai Yang Li He Lan Yu Jinzi | 2017 | Earthquake Research in China2017，31，1： | 0 |
| 20 | Fine Measurements and Analysis of Temperature Gradients in the Wells of the Jinsha River Groundwater Observational Network显示文摘Fine measurements have been conducted to temperatures and their gradients of six wells of the Jinsha River Groundwater Observational Network.The results show that the influence depths of sun radiation heat are 50m to 125m,average temperature gradients in the wells range from 0.11 to 2.81℃/hm and most are 1~2℃/hm,and the temperature gradients on varied depth sections of one well are highly changeable.Lithology of strata and their integrity,particularly high-angle crashed fault zones,have imposed major effects on the influence depths of sun radiation heat and temperature gradients of the wells.The micro dynamic characteristics of water temperature,such as coseismic effects,tidal effects and anomalies of the wells prior to earthquakes,probably depend,to a large degree,on the temperature gradients of the depths at which the water temperature sensors are settled. | Che Yongtai He Anhua Yu Jinzi Liu Chenglong Li Wanming | 2012 | Earthquake Research in China2012，26，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员