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| 1 | Hypoglycemic effect of catalpol on high-fat diet/streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis显示文摘Catalpol, iridoid glycoside,在根值 Rehmanniae 的根存在。一些研究证明了 catalpol 为这效果在导致 streptozotocin 的糖尿病的模型,而是内在的机制有显著血糖过低的效果充分没被阐明。因为 mitochondrial 机能障碍在糖尿病的病理起一个重要作用并且因为改善 mitochondrial 功能可以为糖尿病的处理提供一条新途径,这研究被设计。Catalpol 口头上地予导致的高脂肪的 diet/streptozotocin (HFD/STZ ) 和 metformin 被以为 4 个星期的糖尿病的老鼠日报。身体重量(BW )(IPGTT ) , fasting 血葡萄糖(FBG ) 水平,和葡萄糖处理被测量在期间或在处理以后。结果整个 catalpol 管理的四个连续星期在 BW 没有明显的变化显示出 FBG 水平的剂量依赖者减小。Catalpol 治疗实质地在糖尿病的老鼠减少了浆液总数胆固醇和 triglyceride 层次。另外, catalpol 高效地增加了 mitochondrial ATP 生产并且在骨胳的肌肉织物颠倒了 mitochondrial 膜潜力和 mtDNA 拷贝数字的减少。而且, catalpol (200 mg/kg ) 在骨胳的肌肉救了 mitochondrial 超微结构,与传播电子显微镜学检测了。peroxisome 的相对 mRNA 水平(PGC1 ) 当这效果被 catalpol 颠倒时,激活 proliferator 的受体 gamma 激活剂 1 显著地在糖尿病的老鼠的肌肉组织被减少,导致一条剂量依赖者起来规定。一起拿,我们发现 catalpol 能够经由在 HFD/STZ-induced 糖尿病的老鼠的骨胳的肌肉改进 mitochondrial 功能的阴沉的 FBG 水平。 | Xia Li Zhimeng Xu Zhenzhou Jiang Lixin Sun Jinzi Ji Jingshan Miao Xueji Zhang Xiaojie Li Shan Huang Tao Wang Luyong Zhang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 16 |
| 2 | Mitochondrial fusion/fission process involved in the improvement of catalpol on high glucose- induced hepatic mitochondrial dysfunction显示文摘Catalpol, iridoid glycoside,被显示了由 rescuing mitochondrial 功能,而是详细机制遗体施加血糖过低的效果不清楚还。在这研究,在糖尿病的条件下面的肝的线粒体上的 catalpol 的效果和机制进一步被检验。catalpol 的口头的管理显著地在高脂肪的导致食谱、导致 streptozotocin 的糖尿病的老鼠减少了血葡萄糖, triglyceride,和胆固醇层次。另外, catalpol 在源于糖尿病的肝 mitochondrial ATP 内容稀释了减少。而且,拥有一种长尺寸的线粒体的数字在对待 catalpol 的老鼠被增加。有趣地, mitochondrial 功能的导致 catalpol 的恢复与减少的分裂蛋白质 1 被联系并且 dynamin 相关的蛋白质象增加的 mitofusin 一样的 1 个表达式在肝的 1 个表达式。在 HepG2 房间, catalpol 减轻了 ATP 内容和 mitochondrial 膜潜力的减少,并且反应的氧种类形成的增加由高葡萄糖导致了。当房间与 catalpol 被对待时,线粒体的管状的特征被维持的米托特拉克·格林污点表演。Catalpol 也减少了分裂蛋白质 1 并且 dynamin 相关的蛋白质 1 表情和增加的 mitofusin 在 HepG2 房间的 1 表情。现在的结果建议 catalpol 能改善在一名糖尿病患者下面的肝的 mitochondrial 机能障碍状态,和这可能与它 mitochondrial 的规定有关熔化和分裂事件。 | Zhimeng Xu Luyong Zhang Xiaojie Li Zhenzhou Jiang Lixin Sun Guolin Zhao Guohua Zhou Heran Zhang Jing Shang Tao Wang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 4 |
| 3 | Effective Capacity in Cognitive Radio Networks with Relay and Primary User Emulator显示文摘In this paper,the transmission performances are studied in cognitive radio networks with primary user emulator and relay existence.In the proposed network,the users include primary users,secondary users and primary user emulators.The decreasing access priority of the users are primary users,primary user emulators and secondary users.Different user access to the network results in different transmission effects.We impose interference power constraints on the secondary users to protect the primary users from being interfered.We also adopt the transmission mechanism that transits among more than one secondary transmitters,secondary receivers and relays.The transition models of the transmission states are proposed to describe the transmission mechanism.To investigate the transmission performances,the theory of effective capacity is adopted.The transmission performances in terms of effective capacity are expressed and demonstrated under different transmission policies.The overall effective capacity,as the overall data traffic in the cognitive radio network,is calculated.Besides,the overall effective capacity is demonstrated under different transmission strategies.The results show the greedy transmission strategy outperforms the rest of the transmission 8 policies in the overall effective capacity.For a larger number of the users,the effective capacity converges to a certain value. | Luyong Zhang Yijie Yang Xuan Li Jinhua Chen Yunbing Chi | 2019 | China Communications2019，16，11： | 1 |
| 4 | Optimization of hypocrellin B derivative amphiphilicity and biological activity显示文摘To satisfy the dual requirements of the fluent transportation in blood and the affinity to the target tissues of vascular diseases, hypocrellin derivatives with optimized amphiphilicity are expected. In this work, 3-amino-1-propanesulfonic acid and 4-amino-1-butanesulfonic acid substituted hypocrellin B, named compounds 1 and 2, were designed, synthesized in high yields and characterized. Besides greatly strengthened red absorption, the maximum solubility of compound 2 in phosphate buffered saline (PBS) is 4.2 mg/mL which is just enough to prepare an aqueous solution for intravenous injection in clinically acceptable concentration, while the partition coefficient between n-octanol and PBS, 5.6, benefits the cell-uptake and biological activity as well. Furthermore, EPR measurements reveal that the photosensitization activities of the two compounds to generate semiquinone anion radicals, superoxide anion radicals and singlet oxygen are a little bit higher than those of taurine substituted hypocrellin B (THB), but the photodynamic activities to human lung cancer A549 cells are several times that of THB, mainly due to increases in lipophilicity and cell-uptake. | LIU Xin XIE Jie ZHANG LuYong CHEN HongXia GUYing ZHAO JingQuan | 2009 | Chinese Science Bulletin2009，54，12： | 1 |
| 5 | Tolerance of neurite outgrowth to Rho kinase inhibitors decreased by cyclooxygenase-2 inhibitor显示文摘In this study, PC12 Adh cells and Neuro-2a cells were treated with Rho-associated kinase inhibitors (Y27632 and Fasudil), a cyclooxygenase-1 selective inhibitor (SC560), and a cyclooxygenase-2 inhibitor (NS398). We found that these cells became tolerant to Rho-associated kinase inhibitors, as neurite outgrowth induced by these inhibitors diminished following more than 3 days of exposure in either cell line. The proteins cyclooxygenase-2 and cytosolic prostaglandin E synthetase were upregulated at day 3. NS398 decreased the tolerance to neurite outgrowth induction in both cell lines, whereas SC560 had almost no effect. These findings indicate that cells become tolerant to neurite outgrowth induced by Rho-associated kinase inhibitors, this is at least partly associated with upregulation of proteins involved in the cyclooxygenase-2 pathway, and cyclooxygenases-2 inhibition prevents this tolerance. | Weigang Duan Ling Que Xiaoman Lv Qifeng Li Hua Yin Luyong Zhang | 2012 | Neural Regeneration Research2012，7，34： | 1 |
| 6 | Anti-inflammatory and analgestic effect of two extracts isolated from Illicium显示文摘 | ZHAO Chuan HE Ling ZHANG Luyong | 2009 | Chin J Nat Med2009，7，4： | 1 |
| 7 | Intrinsic gemcitabine resistance in a novel pancreatic cancer cell lineis associated with cancer stem cell-like phenotype显示文摘 | Gang Hu Fu Li Kedong Ouyang Fubo Xie Xuzhen Tang Ke Wang Sufang Han Zhenzhou Jiang Minghua Zhu Danyi Wen Xiaoran Qin Luyong Zhang | 2012 | International Journal of Oncology2012，，3： | 1 |
| 8 | Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase显示文摘 | Jun Chen Jun Liu Luyong Zhang Guanzhong Wu Weiyi Hua Xiaoming Wu Hongbin Sun | 2006 | Bioorganic & Medicinal Chemistry Letters2006，，11： | 1 |
| 9 | Interworking ofWimax and 3GPP Networks based on IMS显示文摘 | Fangmin Xu Luyong Zhang Zheng Zhou | 2007 | IEEE Communications Mag- azine2007，，3： | 1 |
| 10 | A novel hypocrellin B derivative designed and synthesized by taking consideration to both drug delivery and biological photodynamic activity显示文摘 | Xin Liu Jie Xie Luyong Zhang | 2009 | Journal of Photochemistry and Photobiology B:Biology2009，94，： | 1 |
| 11 | Interworking of WiMAX and 3GPP networks based on IMS显示文摘 | Fangmin Xu Luyong Zhang Zheng Zhou | 2007 | IEEE Communications Magazine2007，7，3： | 1 |
| 12 | Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells显示文摘 | Ji Li Liang Zhang Zhenzhou Jiang Bin Shu Fu Li Qingli Bao Luyong Zhang | | Toxicology in Vitro0，，： | 1 |
| 13 | Transactivation of the human NME5 gene by Sp1 in pancreatic cancer cells显示文摘 | Fu Li Zhenzhou Jiang Ke Wang Jingjing Guo Gang Hu Lixin Sun Tao Wang Xuzhen Tang Ling He Jincheng Yao Danyi Wen Xiaoran Qin Luyong Zhang | 2012 | Gene2012，，2： | 1 |
| 14 | A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis显示文摘Ischemic stroke is the second leading cause of death worldwide with limited medications and neuroinflammation was recognized as a critical player in the progression of stroke,but how to control the overactive neuroinflammation is still a long-standing challenge.Here,we designed a novel SIRT6 activator MDL-811 which remarkably inhibited inflammatory response in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and primary mouse microglia,which were abolished by silencing SIRT6.RNA-seq screening identified the forkhead box C1 (Foxc1) is a key gene evoked by MDL-811stimulation and is required for the anti-inflammatory effects of MDL-811.We found MDL-811-activated SIRT6 directly interacted with enhancer of zeste homolog 2 (EZH2) and promoted deacetylation of EZH2 which could bind to the promoter of Foxc1 and upregulate its expression to modulate inflammation.Moreover,our data demonstrated that MDL-811 not only ameliorated sickness behaviors in neuroinflammatory mice induced by LPS,but also markedly reduced the brain injury in ischemic stroke mice in addition to promoting long-term functional recovery.Importantly,MDL-811 also exhibited strong anti-inflammatory effects in human monocytes isolated from ischemic stroke patients,underlying an interesting translational perspective.Taken together,MDL-811 could be an alternative therapeutic candidate for ischemic stroke and other brain disorders associated with neuroinflammation. | Tailin He Jialin Shang Chenglong Gao Xin Guan Yingyi Chen Liwen Zhu Luyong Zhang Cunjin Zhang Jian Zhang Tao Pang | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 1 |
| 15 | Gene expression profiling reveals potential key pathways involved in pyrazinamide‐mediated hepatotoxicity in Wistar rats显示文摘 | Yun Zhang Zhenzhou Jiang Yijing Su Mi Chen Fu Li Li Liu Lixin Sun Yun Wang Shuang Zhang Luyong Zhang | 2013 | J Appl Toxicol2013，，8： | 1 |
| 16 | Recent progress in aptamer-based microfluidics for the detection of circulating tumor cells and extracellular vesicles显示文摘Liquid biopsy is a technology that exhibits potential to detect cancer early,monitor therapies,and predict cancer prognosis due to its unique characteristics,including noninvasive sampling and real-time analysis.Circulating tumor cells(CTCs)and extracellular vesicles(EVs)are two important components of circulating targets,carrying substantial disease-related molecular information and playing a key role in liquid biopsy.Aptamers are single-stranded oligonucleotides with superior affinity and specificity,and they can bind to targets by folding into unique tertiary structures.Aptamer-based microfluidic platforms offer new ways to enhance the purity and capture efficiency of CTCs and EVs by combining the advantages of microfluidic chips as isolation platforms and aptamers as recognition tools.In this review,we first briefly introduce some new strategies for aptamer discovery based on traditional and aptamer-based microfluidic approaches.Then,we subsequently summarize the progress of aptamer-based microfluidics for CTC and EV detection.Finally,we offer an outlook on the future directional challenges of aptamer-based microfluidics for circulating targets in clinical applications. | Duanping Sun Ying Ma Maoqiang Wu Zuanguang Chen Luyong Zhang Jing Lu | 2023 | Journal of Pharmaceutical Analysis2023，13，4： | 0 |
| 17 | Controlled manipulation of conductive ferroelectric domain walls and nanoscale domains in BiFeO_(3) thin films显示文摘Recently,there is a surge of research interest in configurable ferroelectric conductive domain walls which have been considered as possible fundamental building blocks for future electronic devices.In this work,by using piezoresponse force microscopy and conductive atomic force microscopy,we demonstrated the controlled manipulation of various conductive domain walls in epitaxial BiFeO_(3) thin films,e.g.neutral domain walls(NDW)and charged domain walls(CDWs).More interestingly,a specific type of nanoscale domains was also identified,which are surrounded by highly conductive circular CWDs.Similar nano-scale domains can also be controlled created and erasured by applying local field via conductive probe,which allow nondestructive current readout of different domain states with a large on/off resistance ratio up to 102.The results indicate the potential to design and develop high-density non-volatile ferroelectric memories by utilizing these programable conductive nanoscale domain walls. | Dongfeng Zheng Guo Tian Yadong Wang Wenda Yang Luyong Zhang Zoufei Chen Zhen Fan Deyang Chen Zhipeng Hou Xingsen Gao Qiliang Li Jun-Ming Liu | 2022 | Journal of Materiomics2022，8，2： | 0 |
| 18 | Patterning of large area nanoscale domains in as-grown epitaxial ferroelectric PbTiO_(3)films显示文摘Effective tuning of nanoscale domain structures provides fundamental basis for controlling and engineering of various functionalities in ferroelectric materials.In this work,we demonstrate the precise patterning of nanoscopic domain structures in as-grown epitaxial PbTiO_(3)(PTO)films by merely introducing an ultrathin pre-patterned doping layer(e.g.,Fe-doped PTO).The doping layer can effectively reverse the interfacial built-in bias,consequent to a reversed initial polarization reorientation in the as-grown film,which makes it possible to transfer the nano-patterns in the doping layer into the domain structure of ferroelectric films.For instance,we have successfully fabricated large area ordered array of nanoscale cylindrical domains(downward polarization)embedded in the matrix domain with opposite polarization(upward polarization)in PTO film.These nanoscale cylinder domains also allow deterministic and reversible erasure and creation induced by biased tip scanning.The results provide an effective pathway for on-demand patterning of large area nanoscale domains in the as-grown films,which may find applications in a wide range of nanoelectronic devices. | Luyong Zhang Guo Tian Wenda Yang Dongfeng Zheng Chuanjie Lin Jianbiao Xian Yihang Guo Xingchen Zhang Xiuqin Qiu Lanping Zhang Zhen Fan Deyang Chen Zhipeng Hou Minghui Qin Jun-Ming Liu Xingsen Gao | 2023 | Journal of Materiomics2023，9，1： | 0 |
| 19 | Total glucosides of Rhizoma Smilacis Glabrae:a therapeutic approach for psoriasis by regulating Th17/Treg balance显示文摘Total glucosides of Rhizoma Smilacis Glabrae(RSG)are selective immunosuppressants that exhibit primary efficacy in the treatment of rheumatoid arthritis through targeted inhibition of activated T cells.In this study,we aimed to investigate the potential application of RSG in the treatment of psoriasis and elucidate its mechanism of action and material basis.Our findings revealed significant improvements upon administration of RSG in an imiquimod(IMQ)-induced psoriasis model.These improvements were characterized by a remarkable increase in the number of tail scales in mice and a substantial amelioration of skin erythema,ulceration,and flaking.By transcriptome sequencing and T-cell flow sorting assay,we identified notable effects of RSG on the modulation of various cellular processes.Specifically,RSG prominently down-regulated the Th17/Treg ratio in damaged skin tissues and reduced the proportion of G2 phase cells.Furthermore,RSG exhibited a stimulatory effect on the proliferation and differentiation of epithelial cells.Of particular interest,we discovered thatβ-sitosterol,sitostenone,stigmasterol,smiglanin,and cinchonain Ib displayed potent inhibitory effects on the IL-17-mediated inflammatory response in HaCaT cells.In summary,our study highlights the therapeutic potential of RSG in the treatment of psoriasis,attributed to its ability to regulate the Th17/Treg balance.These findings contribute to the development of new indications for RSG and provide a solid theoretical foundation for further exploration in this field. | TANG Yingzhan YU Jingyi ZHAO Wen LIU Juyan PENG Hongying ZHANG Haoran JIANG Zhenzhou YU Qinwei ZHANG Luyong | 2023 | Chinese Journal of Natural Medicines2023，21，8： | 0 |
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