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| 1 | Geology and hydrocarbon accumulations in the deepwater of the northwestern South China Sea——with focus on natural gas显示文摘The deepwater of the northwestern South China Sea is located in the central to southern parts of the Qiongdongnan Basin(QDN Basin),which is a key site for hydrocarbon exploration in recent years.In this study,the authors did a comprehensive analysis of gravity-magnetic data,extensive 3D seismic survey,cores and cuttings,paleontology and geochemical indexes,proposed the mechanism of natural gas origin,identified different oil and gas systems,and established the model of hydrocarbon accumulations in the deep-water region.Our basin tectonic simulation indicates that the evolution of QDN Basin was controlled by multiple-phased tectonic movements,such as Indochina-Eurasian Plate collision,Tibetan Uplift,Red River faulting and the expansion of the South China Sea which is characterized by Paleogene rifting,Neogene depression,and Eocene intensive faulting and lacustrine deposits.The drilling results show that this region is dominated by marineterrestrial transitional and neritic-bathyal facies from the early Oligocene.The Yacheng Formation of the early Oligocene is rich in organic matter and a main gas-source rock.According to the geological-geochemical data from the latest drilling wells,Lingshui,Baodao,Changchang Sags have good hydrocarbon-generating potentials,where two plays from the Paleogene and Neogene reservoirs were developed.Those reservoirs occur in central canyon structural-lithologic trap zone,Changchang marginal trap zone and southern fault terrace of Baodao Sag.Among them,the central canyon trap zone has a great potential for exploration because the various reservoirforming elements are well developed,i.e.,good coal-measure source rocks,sufficient reservoirs from the Neogene turbidity sandstone and submarine fan,faults connecting source rock and reservoirs,effective vertical migration,late stage aggregation and favorable structural–lithological composite trapping.These study results provide an important scientific basis for hydrocarbon exploration in this region,evidenced by the recent discovery of the significant commercial LS-A gas field in the central canyon of the Lingshui Sag. | WANG Zhenfeng SUN Zhipeng ZHANG Daojun ZHU Jitian LI Xushen HUANG Baojia GUO Minggang JIANG Rufeng | 2015 | Acta Oceanologica Sinica2015，34，10： | 9 |
| 2 | Synergistic effect of N- and F-codoping on the structure and photocatalytic performance of TiO_2显示文摘Three types of Ti O2 nanostructures were synthesized via a facile hydrolysis method at195 °C. Effects of the preparation method and doping with N and F on the crystal structure and photocatalytic performance of Ti O2 were investigated. The nanomaterials were characterized by X-ray diffraction, transmission electron microscopy, X-ray photoelectron spectroscopy, Brunauer–Emmett–Teller porosimetry, ultraviolet–visible diffuse reflectance spectroscopy and fluorescent emission spectra. Their photo-catalytic activity was examined by the photodegradation of methylene blue in aqueous solution under both ultra-violet and visible light irradiation. The results show that nitrogen and fluorine co-doped anatase Ti O2 had the characteristics of a smaller crystalline size, broader light absorption spectrum and lower charge recombination than pure Ti O2. Most importantly, more efficient photocatalytic activity under both ultra-violet and visible light was observed. The obtained N–F-Ti O2 nanomaterial shows considerable potential for water treatment under sunlight irradiation. | Jiemei Yu Zongming Liu Haitao Zhang Taizhong Huang Jitian Han Yihe Zhang Daohuang Chong | 2015 | Journal of Environmental Sciences2015，27，2： | 7 |
| 3 | Experimental study on freezing of liquids under static magnetic field显示文摘Freezing processes of several liquids under static magnetic field(SMF) less than 50 mT were investigated. Central temperature of liquid samples held in glass test tubes immersed in a liquid bath was measured and collected. Nucleation temperature and phase transition time were obtained from freezing curves. Normality tests were performed for nucleation temperature of these liquids with/without magnetic field and normality distributions were justified. Analysis of variances was carried out for nucleation temperature of these liquids with magnetic field flux density as the influencing factor. Results showed that no significant difference was found for deionized water with or without SMF. However, differences exist in 0.9% NaCl solution and 5% ethylene glycol solution with and without SMF. Nucleation temperature of 0.9% NaCl with SMF is lower than that without SMF, while its phase transition time is shorter than that without SMF. Nucleation temperature of 5% ethylene glycol with SMF is higher than that without SMF, while its phase transition time is not modified with SMF. | Hongxia Zhao Feng Zhang Hanqing Hu Sheng Liu Jitian Han | 2017 | Chinese Journal of Chemical Engineering2017，25，9： | 4 |
| 4 | Cancer-associated histone mutation H2BG53D disrupts DNA–histone octamer interaction and promotes oncogenic phenotypes显示文摘Dear Editor,Recent studies from us and others have deciphered the clinical relevance of a variety of oncohistones1 in different diseases.The H3K27M and H3K36M mutant histones exert dominant-negative effects on methylation levels of histone H3K27 and H3K36 on wildtype histone protein in pediatric brain cancers2–4 and chondroblastoma,5,6 respectively.In contrast to H3K27M and H3K36M that act in trans to cause global reduction of methylation at the respective residues,the H3G34 mutations,including H3G34V/R and H3G34W/L found in pediatric high-grade glioma and giant cell tumor of the bone,affect the H3K36 methylation in cis and alter the H3K36 methylation on the nucleosome containing the H3G34 mutation(s). | Yi Ching Esther Wan Tsz Chui Sophia Leung Dongbo Ding Xulun Sun Jiaxian Liu Lina Zhu Tze Zhen Evangeline Kang Du Yang Yuchen Zhang Jitian Zhang Chengmin Qian Michael Shing Yan Huen Qing Li Maggie Zi Ying Chow Zongli Zheng Junhong Han Ajay Goel Xin Wang Toyotaka Ishibashi Kui Ming Chan | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 5 | A compact and reconfigurable low noise amplifier employing combinational active inductors and composite resistors feedback techniques显示文摘A compact and reconfigurable low noise amplifier(LNA)is proposed by combining an input transistor,composite transistors with Darlington configuration as the amplification and output transistor,T-type structure composite resistors instead of a simplex structure resistor,a shunt inductor feedback realized by a tunable active inductor(AI),a shunt inductor peaking technique realized by another tunable AI.The division and collaboration among different resistances in the T-type structure composite resistor realize simultaneously input impedance matching,output impedance matching and good noise performance;the shunt feedback and peaking technique using two tunable AIs not only extend frequency bandwidth and improve gain flatness,but also make the gain and frequency band can be tuned simultaneously by the external bias of tunable AIs;the Darlington configuration of composite transistors provides high gain;furthermore,the adoption of the small size AIs instead of large size passive spiral inductor,and the use of composite resistors make the LNA have a small size.The LNA is fabricated and verified by GaAs/InGaP hetero-junction bipolar transistor(HBT)process.The results show that at the frequency of 7 GHz,the gain S_(21)is maximum and up to 19 dB;the S_(21)can be tuned from 17 dB to 19 dB by tuning external bias of tunable AIs,that is,the tunable amount of S_(21)is 2 dB,and similarly at 8 GHz;the tunable range of 3 dB bandwidth is 1 GHz.In addition,the gain S_(21)flatness is better than 0.4 dB under frequency from 3.1 GHz to 10.6 GHz;the size of the LNA only has 760μm×1260μm(including PADs).Therefore,the proposed strategies in the paper provide a new solution to the design of small size and reconfigurable ultra-wideband(UWB)LNA and can be used further to adjust the variations of gain and bandwidth of radio frequency integrated circuits(RFICs)due to package,parasitic and the variation of fabrication process and temperature. | 张正 Zhang Yanhua Yang Ruizhe Shen Pei Ding Chunbao Liu Yaze Huang Xin Chen Jitian | 2021 | High Technology Letters2021，27，1： | 0 |
| 6 | miR-126 mitigates the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting the ERK1/2 and Bcl-2 pathways显示文摘Human bone marrow mesenchymal stem cells(hBMMSCs)are a promising cell source for bone engineering owing to their high potential to differentiate into osteoblasts.The objective of the present study is to assess microRNA-126(miR-126)and examine its effects on the osteogenic differentiation of hBMMSCs.In this study,we investigate the role of miR-126 in the progression of osteogenic differentiation(OD)as well as the apoptosis and inflammation of hBMMSCs during OD induction.OD is induced in hBMMSCs,and matrix mineralization along with other ODassociated markers are evaluated by Alizarin Red S(AR)staining and quantitative PCR(qPCR).Gain-and loss-offunction studies are performed to demonstrate the role of miR-126 in the OD of hBMMSCs.Flow cytometry and qPCR-based cytokine expression studies are performed to investigate the effect of miR-126 on the apoptosis and inflammation of hBMMSCs.The results indicate that miR-126 expression is downregulated during the OD of hBMMSCs.Gain-and loss-of function assays reveal that miR-126 upregulation inhibits the differentiation of hBMMSCs into osteoblasts,whereas the downregulation of miR-126 promotes hBMMSC differentiation,as assessed by the determination of osteogenic genes and alkaline phosphatase activity.Furthermore,the miR-126 level is positively correlated with the production of inflammatory cytokines and apoptotic cell death.Additionally,our results suggest that miR-126 negatively regulates not only B-cell lymphoma 2(Bcl-2)expression but also the phosphorylation of extracellular signal-regulated protein kinase(ERK)1/2.Moreover,restoring ERK1/2 activity and upregulating Bcl-2 expression counteract the miR-126-mediated suppression of OD in hBMMSCs by promoting inflammation and apoptosis,respectively.Overall,our findings suggest a novel molecular mechanism relevant to the differentiation of hBMMSCs into osteoblasts,which can potentially facilitate bone formation by counteracting miR-126-mediated suppression of ERK1/2 activity and Bcl-2 expression. | Ying Zhang Yiping Dong Qiushi Wei Zhikun Zhuang Youwen Liu Qiang Yuan Wei He Zhenhao Jing Jitian Li Peifeng Li Leilei Zhang Zhinan Hong Ning Zhang Haibin Wang Wuyin Li | 2023 | Acta Biochimica et Biophysica Sinica2023，55，3： | 0 |
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