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| 1 | Apoptosis and DNA damage in human spermatozoa显示文摘DNA 损坏经常在 subfertile 男性的精子被遇到并且包括损害授精与不利临床的结果的一个范围被相关,破坏 preimplantation 胚胎的开发,流产的增加的率和在子孙的疾病的提高的风险。在人的精子的 DNA 破碎的病原学密切与氧化的底的外观被相关使内收并且损害精子形式的证据。我们假设那个氧化压力阻碍精子形式,与糟糕改变的染色质导致精子的产生。这些有缺点的房间有一个趋势默认到线粒体与活动性损失, caspase 激活, phosphatidylserine exteriorization 和免费激进的产生的激活联系的一条 apoptotic 小径。后者导致类脂化合物 peroxidation 和氧化 DNA 损坏,它然后导致 DNA 破碎和房间死亡。精子的物理体系结构阻止从获得存取到原子 DNA 并且导致它的破碎由于这 apoptotic 进程激活的任何核酸酶。是为这个原因在人的精子遇到的 DNA 损坏的一个多数似乎氧化。给氧化应力似乎在 DNA 损坏的病原学有的重要角色,应该为在这个条件的处理的抗氧化剂有一个重要角色。如果在精子的氧化 DNA 损坏正在提供全身的氧化应力的敏感读出,这些调查结果的含意能在我们试着作为一篇序言在精子最小化 DNA 损坏到帮助概念治疗的立即的目标以外拉长。 | R John Aitken Adam J Koppers | 2011 | Asian Journal of Andrology2011，13，1： | 46 |
| 2 | 缺血性卒中的一级预防——美国心脏协会/美国卒中协会卒中委员会指南 动脉粥样硬化性周围血管病跨学科工作组、心血管护理委员会、临床心脏病学委员会、营养、体力活动和代谢委员会以及医疗质量和转归研究跨学科工作组共同倡导显示文摘背景和目的本指南提供有关各种确定和潜在的卒中危险因素证据的概述,并提供降低卒中风险的推荐。方法写作组成员由委员会主席根据每位作者先前在相关课题领域中的工作提名,并经美国心脏协会(AHA)卒中委员会科学声明监督委员会批准。写作组采用系统文献回顾(涵盖时间段为2001年最后一次回顾发表到2005年1月),参考先前已发表的指南、个人文件和专家意见来概括现有的证据,指明现有知识的差距;如果合适,则根据标准的AHA标准做出简明的推荐。写作组全体成员在撰写过程中均有很多机会对推荐进行评论并认可这份声明的最终版本。在AHA科学咨询与协调委员会批准之前,本指南已进行过广泛的同行评议。结果对评价个体首次卒中风险的流程图进行评估。根据干预的可能性(不可干预、可干预或潜在可干预)和证据的强度(证据充分或证据不太充分),对首次卒中的危险因素或风险标记物进行分类。不可干预的危险因素包括年龄、性别、出生体重低、人种/种族和遗传因素。证据充分的可干预危险因素包括高血压、主动或被动吸烟、糖尿病、心房颤动和某些其他心脏病、血脂异常、颈动脉狭窄、镰状细胞病、绝经后激素治疗、不良饮食习惯、缺乏体力活动、肥胖和体脂分布。证据不太充分或潜在的可干预危险因素包括代谢综合征、酗酒、药物滥用、口服避孕药、睡眠呼吸障碍、偏头痛、高同型半胱氨酸血症、脂蛋白(a)升高、脂蛋白相关的磷脂酶升高、高凝状态、炎症和感染。对应用阿司匹林进行卒中一级预防的资料进行回顾。结论有大量证据可以用于确定增加首次卒中风险的各种特殊因素和提供降低这种风险的策略。 | Larry B. Goldstein Robert Adams Mark J. Alberts Lawrence J. Appel Lawrence M. Brass Cheryl D. Bushnell Antonio Culebras Thomas J. DeGraba Philip B. Gorelick John R. Guyton Robert G. Hart George Howard Margaret Kelly-Hayes J.V. (Ian) Nixon Ralph L. Sacco 苏克江 高宗恩 | 2006 | 国际脑血管病杂志2006，14，8： | 28 |
| 3 | Potential Toxicological and Cardiopulmonary Effects of PM2,5 Exposure and Related Mortality:Findings of Recent Studies Published during 2003-2013显示文摘INTRODUCTION Air pollution has become a serious environmental issue owing to its diverse harmful effects on the physical and biological environment.According to the Environmental Protection Agency(EPA)and the World Health Organization(WHO)[1-2],air pollution affects millions of people worldwide.Hundreds of thousands of deaths each year and a range of diseases, | Mohammed O.A.Mohammed SONG Wei Wei MA Wan Li LI Wen Long LI Yi Fan Afed Ullah Khan Mohammed A.E.M.Ibrahim Osman Adam Maarouf Alshebli A Ahmed John J.Ambuchi | 2016 | Biomedical and Environmental Sciences2016，29，1： | 16 |
| 4 | Proteomic changes in mammalian spermatozoa during epididymal maturation显示文摘附睾成熟与 cAMP-inducedtyrosine 磷酸化串联的激活被联系,它最终与表达式被联系 ofcapacitation 依赖的精子工作,例如亢奋的激活的运动和 acrosomal exocytosis。通过附睾的 Asspermatozoa 进步他们首先在主要的片上在目标上获得能力到 phosphorylatetyrosine,由中间的片列在后面。等到这些房间 haver eached 附睾尾他们装 phosphorylate 从颈的全部尾巴到结束片。磷酸化的 Thisparticular 模式与能够使肥沃的充分功能的精子的个体发生被联系卵母细胞。这改变的 Proteomic 分析 indicate 与几 mitochondrial 蛋白质的磷酸化被联系, amitochondrial 膜电位的创造和 mitochondrial 自由基产生的激活。至少在啮齿类动物种类,精子线粒体的激活看起来是特别地重要的部分 ofepididymal 成熟。 | R. John Aitken Brett Nixon Minjie Lin Adam J. Koppers Yun H. Lee Mark A. Baker | 2007 | Asian Journal of Andrology2007，9，4： | 14 |
| 5 | 中英两国珠宝首饰消费特点研究显示文摘英国作为全球主要的珠宝首饰消费大国之一,近年来由于其珠宝首饰需求高于供给的差距急剧扩大,使其在整体上出现了供给赤字。中国是一个珠宝生产大国,应抓住这种时机扩大对英国的出口。通过研究中英两国珠宝首饰消费特点发现,英国从2001年到2005年人均珠宝首饰消费额占个人可支配年收入的0.68%逐年增长到0.77%;其珠宝首饰需求-收入弹性均大于1(平均为2.262),珠宝首饰消费会随着消费者收入的增长而更快地增加。分析认为,中国具有竞争优势的出口珠宝首饰产品为项链、耳饰和珍珠戒指,玉雕产品的题材应以西方文化为主。预计英国2007年的珠宝首饰消费额为130亿美元,到2010年可达到160亿美元,为中国的珠宝首饰出口英国提供有益的参考。 | 尹作为 Maktoba Omar John Adams 曾凯 | 2008 | 宝石和宝石学杂志2008，10，1： | 9 |
| 6 | Simultaneous removal of ammonia and N-nitrosamine precursors from high ammonia water by zeolite and powdered activated carbon显示文摘When adding sufficient chlorine to achieve breakpoint chlorination to source water containing high concentration of ammonia during drinking water treatment, high concentrations of disinfection by-products(DBPs) may form. If N-nitrosamine precursors are present, highly toxic N-nitrosamines, primarily N-nitrosodimethylamine(NDMA), may also form. Removing their precursors before disinfection should be a more effective way to minimize these DBPs formation. In this study, zeolites and activated carbon were examined for ammonia and N-nitrosamine precursor removal when incorporated into drinking water treatment processes.The test results indicate that Mordenite zeolite can remove ammonia and five of seven N-nitrosamine precursors efficiently by single step adsorption test. The practical applicability was evaluated by simulation of typical drinking water treatment processes using six-gang stirring system. The Mordenite zeolite was applied at the steps of lime softening, alum coagulation, and alum coagulation with powdered activated carbon(PAC) sorption. While the lime softening process resulted in poor zeolite performance, alum coagulation did not impact ammonia and N-nitrosamine precursor removal. During alum coagulation, more than67% ammonia and 70%–100% N-nitrosamine precursors were removed by Mordenite zeolite(except 3-(dimethylaminomethyl)indole(DMAI) and 4-dimethylaminoantipyrine(DMAP)). PAC effectively removed DMAI and DMAP when added during alum coagulation. A combination of the zeolite and PAC selected efficiently removed ammonia and all tested seven N-nitrosamine precursors(dimethylamine(DMA), ethylmethylamine(EMA), diethylamine(DEA), dipropylamine(DPA), trimethylamine(TMA), DMAP, and DMAI) during the alum coagulation process. | Runmiao Xue Ariel Donovan Haiting Zhang Yinfa Ma Craig Adams John Yang Bin Hua Enos Inniss Todd Eichholz Honglan Shi | 2018 | Journal of Environmental Sciences2018，30，2： | 7 |
| 7 | Evolution of indications and results of liver transplantation in Europe. A report from the European Liver Transplant Registry (ELTR)显示文摘 | René Adam Vincent Karam Valérie Delvart John O’Grady Darius Mirza Jurgen Klempnauer Denis Castaing Peter Neuhaus Neville Jamieson Mauro Salizzoni Stephen Pollard Jan Lerut Andreas Paul Juan Carlos Garcia-Valdecasas Fernando San Juan Rodríguez Andrew Burro | 2012 | Journal of Hepatology2012，，3： | 6 |
| 8 | Normalised intrinsic mortality risk in liver transplantation: European Liver Transplant Registry study显示文摘 | René Adam Valérie Cailliez Pietro Majno Vincent Karam Paul McMaster Roy Y Calne John O’Grady Rudolf Pichlmayr Peter Neuhaus Jean-Bernard Otte Krister Hoeckerstedt Henri Bismuth | 2000 | The Lancet . 2000 (9230)2000，，9230： | 3 |
| 9 | Early Wound Complications of Operative Treatment of Calcaneus Fractures: Analysis of 190 Fractures显示文摘 | Jason W. Folk Adam J. Starr John S. Early | 1999 | Journal of Orthopaedic Trauma1999，，5： | 3 |
| 10 | Heart Disease and Stroke Statistics—2006 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Thomas Thom Nancy Haase Wayne Rosamond Virginia J. Howard John Rumsfeld Teri Manolio Zhi-Jie Zheng Katherine Flegal Christopher O’Donnell Steven Kittner Donald Lloyd-Jones David C. Goff Yuling Hong Robert Adams Gary Friday Karen Furie Philip Gorelick Bret | 2006 | Circulation2006，，6： | 3 |
| 11 | Measurements of Acute Cerebral Infarction: A Clinical Examination Scale显示文摘 | Thomas Brott Harold P. Adams Charles P. Olinger John R. Marler William G. Barsan José Biller Judith Spilker Renee Holleran Robert Eberle Vicki Hertzberg Marvin Rorick Charles J. Moomaw Michael Walker | 1989 | Stroke1989，，7： | 2 |
| 12 | YAP1对颗粒细胞的重编程可导致具间质谱系和浆液性特征的高级别卵巢癌显示文摘高级别浆液性卵巢癌(HGSC)是临床中最常见、且恶性程度最高的卵巢癌.深入了解高级别浆液性卵巢癌的起源细胞可对该亚型卵巢癌进行有效预防和早期诊断.最近TCGA和AOCS通过分子分型研究发现了一种具有间充质特征的高级别浆液性卵巢癌亚型,并且表明该亚型是所有新发现的亚型中预后最差的一种,而且目前大家对于这种卵巢癌新亚型的起源细胞一无所知.在研究Hippo信号通路在卵巢颗粒细胞生理和病理中的作用时,意外地发现Hippo信号传导途径的主要效应分子YAP1的高度激活可以诱导具有间质谱系和高可塑性的卵巢颗粒细胞的去分化与重编程,最终导致具有浆液性特征的高级别卵巢癌的发生.本文的研究结果揭示了具间质特征的高级别浆液性卵巢癌的一种潜在起源细胞. | 吕向民 何春波 黄聪 滑国华 陈骍程 Barbara K.Timm Victoria M.Maclin Abigail A.Haggerty Shelly K.Aust Denae M.Golden Bhavana J.Dave Yun-An Tseng 陈利 王洪波 陈培超 David L.Klinkebiel Adam R.Karpf Jixin Dong Ronny I.Drapkin Bo R.Rueda John S.Davis 王诚 | 2020 | Science Bulletin2020，65，15： | 2 |
| 13 | Evolution of liver transplantation in Europe: Report of the European Liver Transplant Registry显示文摘 | René Adam Paul McMaster John G. O’Grady Denis Castaing Jurgen L. Klempnauer Neville Jamieson Peter Neuhaus Jan Lerut Mauro Salizzoni Stephen Pollard Ferdinand Muhlbacher Xavier Rogiers Juan Carlos Garcia Valdecasas Joaquin Berenguer Daniel Jaeck Enrique M | 2003 | Liver Transplantation2003，，12： | 2 |
| 14 | The Role of Synthetic Biology in Atmospheric Greenhouse Gas Reduction: Prospects and Challenges显示文摘The long atmospheric residence time of CO2 creates an urgent need to add atmospheric carbon drawdown to CO2 regulatory strategies.Synthetic and systems biology(SSB),which enables manipulation of cellular phenotypes,offers a powerful approach to amplifying and adding new possibilities to current land management practices aimed at reducing atmospheric carbon.The participants(in attendance:Christina Agapakis,George Annas,Adam Arkin,George Church,Robert Cook-Deegan,Charles DeLisi,Dan Drell,Sheldon Glashow,Steve Hamburg,Henry Jacoby,Henry Kelly,Mark Kon,Todd Kuiken,Mary Lidstrom,Mike MacCracken,June Medford,Jerry Melillo,Ron Milo,Pilar Ossorio,Ari Patrinos,Keith Paustian,Kristala Jones Prather,Kent Redford,David Resnik,John Reilly,Richard J.Roberts,Daniel Segre,Susan Solomon,Elizabeth Strychalski,Chris Voigt,Dominic Woolf,Stan Wullschleger,and Xiaohan Yang)identified a range of possibilities by which SSB might help reduce greenhouse gas concentrations and which might also contribute to environmental sustainability and adaptation.These include,among other possibilities,engineering plants to convert CO2 produced by respiration into a stable carbonate,designing plants with an increased root-to-shoot ratio,and creating plants with the ability to self-fertilize.A number of serious ecological and societal challenges must,however,be confronted and resolved before any such application can be fully assessed,realized,and deployed. | Charles DeLisi Aristides Patrinos Michael MacCracken Dan Drell George Annas Adam Arkin George Church Robert Cook-Deegan Henry Jacoby Mary Lidstrom Jerry Melillo Ron Milo Keith Paustian John Reilly Richard J.Roberts Daniel Segrè Susan Solomon Dominic Woolf Stan D.Wullschleger Xiaohan Yang | 2020 | BioDesign Research2020，，1： | 2 |
| 15 | Evolution of liver transplantation in Europe: Report of the European Liver Transplant Registry显示文摘 | René Adam Paul McMaster John G. O’Grady Denis Castaing Jurgen L. Klempnauer Neville Jamieson Peter Neuhaus Jan Lerut Mauro Salizzoni Stephen Pollard Ferdinand Muhlbacher Xavier Rogiers Juan Carlos Garcia Valdecasas Joaquin Berenguer Daniel Jaeck Enrique M | 2003 | Liver Transplantation2003，，12： | 2 |
| 16 | Antenna design for a massive multiple input environmental sensor network显示文摘 | J. Craig Prather Michael Bolt Haley Harrell John Manobianco Mark L. Adams | 2016 | Digital Communications and Networks2016，2，4： | 2 |
| 17 | The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts显示文摘Heterogeneous nuclear ribonucleoprotein(hnRNP) C plays a key role in RNA processing but also exerts a dominant negative effect on responses to 1,25-dihydroxyvitamin D(1,25(OH)2D) by functioning as a vitamin D response element-binding protein(VDRE-BP). hnRNPC acts a tetramer of hnRNPC1(huC1) and hnRNPC2(huC2), and organization of these subunits is critical to in vivo nucleic acid-binding. Overexpression of either huC1 or huC2 in human osteoblasts is sufficient to confer VDRE-BP suppression of 1,25(OH)2D-mediated transcription. However, huC1 or huC2 alone did not suppress 1,25(OH)2D-induced transcription in mouse osteoblastic cells. By contrast, overexpression of huC1 and huC2 in combination or transfection with a bone-specific polycistronic vector using a ‘‘self-cleaving'' 2A peptide to co-express huC1/C2 suppressed1,25D-mediated induction of osteoblast target gene expression. Structural diversity of hnRNPC between human/NWPs and mouse/rat/rabbit/dog was investigated by analysis of sequence variations within the hnRNP CLZ domain. The predicted loss of distal helical function in hnRNPC from lower species provides an explanation for the altered interaction between huC1/C2 and their mouse counterparts. These data provide new evidence of a role for hnRNPC1/C2 in 1,25(OH)2D-driven gene expression, and further suggest that species-specific tetramerization is a crucial determinant of its actions as a regulator of VDR-directed transactivation. | Thomas S Lisse Kanagasabai Vadivel S Paul Bajaj Rui Zhou Rene F Chun Martin Hewison John S Adams | 2014 | Bone Research2014，2，2： | 2 |
| 18 | The effect of endoscopic sphincterotomy on acute and chronic complications of biliary endoprostheses显示文摘 | Craig Margulies Eduardo Sampaio Siqueira William Bruce Silverman Xue Sen Lin John Anthony Martin Mordechai Rabinovitz Adam Slivka | 1999 | Gastrointestinal Endoscopy1999，，6： | 2 |
| 19 | Formulation development and characterization of cellulose acetate nitrate based propellants for improved insensitive munitions properties显示文摘Cellulose acetate nitrate(CAN) was used as an insensitive energetic binder to improve the insensitive munitions(IM) properties of gun propellants to replace the M1 propellant used in 105 mm artillery charges.CAN contains the energetic nitro groups found in nitrocellulose(NC),but also acetyl functionalities,which lowered the polymer's sensitivity to heat and shock,and therefore improved its IM properties relative to NC.The formulation,development and small-scale characterization testing of several CAN-based propellants were done.The formulations,using insensitive energetic solid fillers and high-nitrogen modifiers in place of nitramine were completed.The small scale characterization testing,such as closed bomb testing,small scale sensitivity,thermal stability,and chemical compatibility were done.The mechanical response of the propellants under high-rate uni-axial compression at,hot,cold,and ambient temperatures were also completed.Critical diameter testing,hot fragment conductive ignition(HFCI) tests were done to evaluate the propellants' responses to thermal and shock stimuli.Utilizing the propellant chemical composition,theoretical predictions of erosivity were completed.All the small scale test results were utilized to down-select the promising CAN based formulations for large scale demonstration testing such as the ballistic performance and fragment impact testing in the105 mm M67 artillery charge configurations.The test results completed in the small and large scale testing are discussed. | Thelma MANNING Jeffrey WYCKOFF Carlton ADAM Eugene ROZUMOV Kenneth KLINGAMAN Viral PANCHAL Joseph LAQUIDARA Mike FAIR John BOLOGNINI Keith LUHMANN Steve VELARDE Christine KNOTT Stephanie M.PIRAINO Kevin BOYD | 2014 | Defence Technology(防务技术)2014，10，2： | 2 |
| 20 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
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