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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | 直立性低血压显示文摘 | John G.Bradley M.D. Kathy A.Davis R.N. 金世红 | 2005 | 中国实用乡村医生杂志2005，12，3： | 6 |
| 3 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 4 | Endoscopic Ultrasound–Guided Fine-Needle Aspiration of Ascites显示文摘 | John DeWitt Julia LeBlanc Lee McHenry Kathy McGreevy Stuart Sherman | 2007 | Clinical Gastroenterology and Hepatology2007，，5： | 2 |
| 5 | CFOs and CEOs: Who have the most influence on earnings management?显示文摘 | John (Xuefeng) Jiang Kathy R. Petroni Isabel Yanyan Wang | 2010 | Journal of Financial Economics2010，，3： | 2 |
| 6 | 叶绿酸对肝癌高发区黄曲霉毒素暴露人群的干预研究显示文摘[目的]评估叶绿酸能否降低肝癌高危人群尿中黄曲霉毒素(AFT)鄄N7鄄鸟嘌呤的水平。[方法]采用随机双盲、以安慰剂为对照的预防干预试验。将180名健康成人随机分成叶绿酸干预组(服用100mg叶绿酸)和安慰剂对照组。采用顺序免疫亲和色谱法和液相色谱法结合电子喷射质谱法测定尿中AFT鄄N7鄄鸟嘌呤的变化。[结果]在169份尿样中,105份检出AFT鄄N7鄄鸟嘌呤。叶绿酸组尿中AFT鄄N7鄄鸟嘌呤比安慰剂组下降了55%(P=0.036)。未见副作用。[结论]应用叶绿酸或富含叶绿素的食物进行预防干预是可能阻断肝癌的有效手段。 | 王金兵 Patricia A.Egner 朱源荣 张宝初 吴燕 张启南 钱耕荪 旷双远 Stephen J.Gange Lisa P.Jacobson Kathy J.Helzlsoure George S.Bailey John D.Groopman Thomas W.Kensler | 2004 | 中国肿瘤2004，13，5： | 2 |
| 7 | Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a T H 2-skewed immune response显示文摘 | Stephanie T. Yerkovich Marjut Roponen Miranda E. Smith Kathy McKenna Anthony Bosco Lily S. Subrata Emilie Mamessier Matthew E. Wikstr?m Peter Le Souef Peter D. Sly Patrick G. Holt John W. Upham | 2009 | The Journal of Allergy and Clinical Immunology2009，，1： | 1 |
| 8 | Pilot study of F 18 -Fluorodeoxyglucose Positron Emission Tomography/computerised tomography in Wilms’ tumour: Correlation with conventional imaging, pathology and immunohistochemistry显示文摘 | Joanna Begent Neil J. Sebire Gill Levitt Penelope Brock Kathy Pritchard Jones Peter Ell Isky Gordon John Anderson | 2010 | European Journal of Cancer2010，，3： | 1 |
| 9 | Upregulation of prostate-specific membrane antigen after androgen-deprivation therapy显示文摘 | George L. Wright B. Mayer Grob Cara Haley Katie Grossman Kathy Newhall Daniel Petrylak John Troyer Alice Konchuba Paul F. Schellhammer Richard Moriarty | 1996 | Urology1996，，2： | 1 |
| 10 | Investigation of a novel algorithm for synchronized left-ventricular pacing and ambulatory optimization of cardiac resynchronization therapy: Results of the adaptive CRT trial显示文摘 | David O. Martin Bernd Lemke David Birnie Henry Krum Kathy Lai-Fun Lee Kazutaka Aonuma Maurizio Gasparini Randall C. Starling Goran Milasinovic Tyson Rogers Alex Sambelashvili John Gorcsan Mahmoud Houmsse | 2012 | Heart Rhythm2012，，11： | 1 |
| 11 | Endoscopic Ultrasound–Guided Fine-Needle Aspiration of Ascites显示文摘 | John DeWitt Julia LeBlanc Lee McHenry Kathy McGreevy Stuart Sherman | 2007 | Clinical Gastroenterology and Hepatology2007，，5： | 1 |
| 12 | Partners for child passenger safety: a unique child-specific crash surveillance system显示文摘 | Dennis R. Durbin Esha Bhatia John H. Holmes Kathy N. Shaw John V. Werner Wayne Sorenson Flaura K. Winston | 2001 | Accident Analysis and Prevention2001，，3： | 1 |
| 13 | Thermoplastic modification of monomeric and partially polymerized Bisphenol A dicyanate ester 显示文摘 | John N Suman John Kathi Shekharam Tammishetti | 2005 | European Polymer Journal2005，41，： | 1 |
| 14 | Avoidance of ven- tricular pacing in cardiac resynchronization therapy im- proves right ventricular hemodynamics in heart failure patients显示文摘 | Kathy L John E Thomas J | 2007 | J Cardiovasc Electrophysiol2007，18，： | 1 |
| 15 | Long-term effects of maximally intensive statin therapy on changes in coronary atheroma composition: insights from SATURN显示文摘 | Rishi Puri Peter Libby Steven E. Nissen Kathy Wolski Christie M. Ballantyne Phillip J. Barter M. John Chapman Raimund Erbel Joel S. Raichlen Kiyoko Uno Yu Kataoka E. Murat Tuzcu Stephen J. Nicholls | 2014 | European Heart Journal – Cardiovascular Imaging2014，，： | 1 |
| 16 | A Comparison of Fatigue Properties of Austempered Versus Quenched and Tempered 4340 Steel显示文摘 | John Tartaglia Kathy Hayrynen | 2012 | Journal of Materials Engineering and Performance2012，，6： | 1 |
| 17 | Healthy brain aging: A meeting report from the Sylvan M. Cohen Annual Retreat of the University of Pennsylvania Institute on Aging显示文摘 | Lisa J. Bain Kathy Jedrziewski Marcelle Morrison-Bogorad Marilyn Albert Carl Cotman Hugh Hendrie John Q. Trojanowski | 2008 | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association2008，，6： | 1 |
| 18 | Thermoplastic modification of monomeric and partially polymerized bisphenol a dicyanate ester显示文摘 | Dinakaran K John Kathi Shekharam | 2005 | European Polymer Journal2005，41，6： | 1 |
| 19 | Thermoplastic modification of monomeric and partially polymerized bisphenol a dicyanate ester显示文摘 | John N Suman John Kathi Shekharam Tammishetti | 2005 | Eur Polym J2005，41，12： | 1 |
| 20 | A multicenter comparison of intraaortic balloon pump utilization in isolated coronary artery bypass graft surgery显示文摘 | Roger J.F Baskett Gerald T O’Connor Gregory M Hirsch William A Ghali Kathy Sabadosa Jeremy R Morton Cathy S Ross Felix Hernandez William C Nugent Stephen J Lahey Donato A Sisto Lawrence J Dacey John D Klemperer Robert E Helm Andrew Maitland | 2003 | The Annals of Thoracic Surgery2003，，6： | 1 |
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