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| 1 | Sugar Input, Metabolism, and Signaling Mediated by Invertase: Roles in Development, Yield Potential, and Response to Drought and Heat显示文摘转化酶(INV ) 水解蔗糖进在主要新陈代谢和植物开发的葡萄糖和果糖的、从而玩的关键角色。基于他们的 pH optima 和亚 cellular 地点, INV 被分成房间墙,细胞质,并且 vacuolar 亚群,分别地作为 CWIN, CIN,和 VIN 缩短了。在植物开发和庄稼生产率的 INV 的宽广重要性和含意吸引了庞大的兴趣从多重观点检验 INV 功能和规定。这里,我们考察在最后二十年在这个区域使进展激动的一些,集中于( 1 )在在translational以后的植物开发和规定的 INV 的新或新兴的角色通过和禁止者的相互作用铺平,( 2 )在 调停INV 的糖发信号之间的串音和开发的神经质的控制,并且( 3 )对种子和水果上的干旱和热压力和他们的影响的调停糖、 调停INV 的回答设定。最后,我们讨论为解开从这新进步和轮廓未来方向产生的主要问题在植物生物工学和农业位于调停 INV 的植物开发和他们的潜在的应用下面的机制。 | Yong-Ling Ruan Ye Jin Yue-Jian Yang Guo-Jing Li John S. Boyer | 2010 | Molecular Plant2010，3，6： | 98 |
| 2 | 藏北高原地壳及上地幔导电性结构——超宽频带大地电磁测深研究结果显示文摘为了研究西藏中、北部壳、幔导电性结构,讨论高原中、北部岩石圈热状态,1998年和1999年(INDEPTH(Ⅲ)-MT)在西藏中、北部完成了德庆—龙尾错(500线)和那曲—格尔木(600线)超宽频带大地电磁深探测剖面的研究.研究结果表明,西藏中、北部以昆仑山断裂为界,其南北壳、幔电性结构有很大差异.昆仑山断裂以北地壳和上地幔为高阻区.而昆仑山以南,地壳和上地幔的导电性有明显的分层结构:地壳上部以不连续的高阻体为主,夹有局部低阻异常体,沿南北方向上地壳的电性结构复杂,具有不连续、分块的特点;但中、下地壳为大范围的高导异常区,区内发育有大规模、不相连续、产状各异的高导体,其电阻率均小于4Ωm;在班公—怒江和金沙江缝合带之下,壳内高导体都具有向上地幔延伸的趋势,存在连通壳、幔的低阻通道.根据西藏高原中、北部壳、幔电性结构的研究推断:如同藏南一样,这里也普遍存在部分熔融体和热流体,它们的成因主要与班公—怒江和金沙江缝合带的壳-幔热交换、热活动有关,这是两期形成的壳-幔热交换通道.其中,班公—怒江缝合带的壳-幔热交换通道形成时间比金沙江缝合带早.因此,研究区壳、幔的热活动是从南边和西边开始,向北、向东扩展,导致现今西藏中、北部地壳和上地幔的热流分布由西向东、由南向北增大. | 魏文博 金胜 叶高峰 邓明 谭捍东 Martyn Unsworth Alan G. Jones John Booker Shenghui Li | 2006 | 地球物理学报2006，49，4： | 71 |
| 3 | Calcineurin-B-Like Protein CBL9 Interacts with Target Kinase CIPK3 in the Regulation of ABA Response in Seed Germination显示文摘钙在植物在许多发信号的小径作为第二个送信人起一个重要作用。calcineurin 象 B 一样蛋白质(CBL ) 代表在钙由与他们的交往的蛋白质 kinases (CIPK ) 交往发信号工作的植物钙绑定蛋白质的一个家庭。在我们的以前的学习,我们在骆驼毛的织物发信号为 CBL (CBL9 ) 之一和 CIPK (CIPK3 ) 之一报导了一个角色。这里,我们证明了 CBL9 和 CIPK3 身体上并且机能上地在调整骆驼毛的织物回答与对方一起交往。CBL9 和 CIPK3 蛋白质在酵母与对方一起交往了二混血儿的系统并且当在植物房间表示了时。双变异的 cbl9cipk3 显示出类似的过分敏感的反应到在单个异种(cbl9 或 cipk3 ) 观察了的骆驼毛的织物。CIPK3 的组成地活跃的形式遗传上补充了 cbl9 异种,显示 CIPK3 CBL9 下游地工作。把调查结果基于这些,我们为调整骆驼毛的织物回答在一样的小径一起结束那 CBL9 和 CIPK3 幕。 | Girdhar K. Pandey John J. Grant Yong Hwa Cheong Beom-Gi Kim Le Gong Li Sheng Luan | 2008 | Molecular Plant2008，1，2： | 44 |
| 4 | Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers显示文摘Gastric cancer and liver cancer are among the most common malignancies and the leading causes of death worldwide,due to late detection and high recurrence rates.Today,these cancers have a heavy socioeconomic burden,for which a full understanding of their pathophysiological features is warranted to search for promising biomarkers and therapeutic targets.Osteopontin (OPN) is overexpressed in most patients with gastric and liver cancers.Over the past decade,emerging evidence has revealed a correlation of OPN level and clinicopathological features and prognosis in gastric and liver cancers,indicating its potential as an independent prognostic indicator in such patients.Functional studies have verified the potential of OPN knockdown as a therapeutic approach in vitro and in vivo .Furthermore,OPN mediates multifaceted roles in the interaction between cancer cells and the tumor microenvironment,in which many details need further exploration.OPN signaling results in various functions,including prevention of apoptosis,modulation of angiogenesis,malfunction of tumor-associated macrophages,degradation of extracellular matrix,activation of phosphoinositide 3-kinase-Akt and nuclear factor-κB pathways,which lead to tumor formation and progression,particularly in gastric and liver cancers.This editorial aims to review recent findings on alteration in OPN expression and its clinicopathological associations with tumor progression,its potential as a therapeutic target,and putative mechanisms in gastric and liver cancers.Better understanding of the implications of OPN in tumorigenesis might facilitate development of therapeutic regimens to benefit patients with these deadly malignancies. | Dong-Xing Cao Zhi-Jie Li Xiao-Ou Jiang Yick Liang Lum Ester Khin Nikki P Lee Guo-Hao Wu John M Luk | 2012 | World Journal of Gastroenterology2012，18，30： | 29 |
| 5 | Acupuncture's Role in Solving the Opioid Epidemic: Evidence, Cost-Effectiveness, and Care Availability for Acupuncture as a Primary, Non-Pharmacologic Method for Pain Relief and Management-White Paper 2017显示文摘The United States(U.S.) is facing a national opioid epidemic, and medical systems are in need of nonpharmacologic strategies that can be employed to decrease the public's opioid dependence. Acupuncture has emerged as a powerful, evidence-based, safe, cost-effective, and available treatment modality suitable to meeting this need. Acupuncture has been shown to be effective for the management of numerous types of pain conditions, and mechanisms of action for acupuncture have been described and are understandable from biomedical, physiologic perspectives. Further, acupuncture's cost-effectiveness can dramatically decrease health care expenditures, both from the standpoint of treating acute pain and through avoiding addiction to opioids that requires costly care, destroys quality of life, and can lead to fatal overdose. Numerous federal regulatory agencies have advised or mandated that healthcare systems and providers offer non-pharmacologic treatment options for pain. Acupuncture stands out as the most evidence-based, immediately available choice to fulfil these calls. Acupuncture can safely, easily, and cost-effectively be incorporated into hospital settings as diverse as the emergency department, labor and delivery suites, andneonatal intensive care units to treat a variety of commonly seen pain conditions. Acupuncture is already being successful y and meaningfully utilized by the Veterans Administration and various branches of the U.S. Military, in some studies demonstrably decreasing the volume of opioids prescribed when included in care. | arthur yin fan david w.miller bonnie bolash matthew bauer john mcdonald sarah faggert hongjian he yong ming li amy matecki lindy camardella mel hopper koppelman jennifer a.m.stone lindsay meade john pang | 2017 | Journal of Integrative Medicine2017，15，6： | 29 |
| 6 | CIPK9: a calcium sensor-interacting protein kinase required for low-potassium tolerance in Arabidopsis显示文摘钾是为在植物的很多个细胞的过程的主要宏营养素必需品之一。在土壤的低钾水平为庄稼生产代表一个限制因子。最近的研究识别了涉及钾获得的钾运输 ers,并且他们中的一些为在低钾条件下面的钾营养是批评的。然而,很少在涉及低钾发信号和回答的分子的部件上被理解。我们这里在 Arabidopsis 作为低钾反应的一个批评管理者报导 calcineurin 象 B 一样交往蛋白质的 proteinkinase (CIPK9 ) 的鉴定。CIPK9 基因对不能生活的压力条件应答,并且它的抄本由钾剥夺在根和射击是可诱导的。CIPK9 功能的混乱使变异的植物变为过分敏感到低钾媒介。进一步的分析显示那 K (+) 举起和内容没在变异的植物被影响,暗示在钾利用的规定的 CIPK9 或察觉到过程。 | Girdhar K Pandey Yong Hwa Cheongx Beom-Gi Kim John J Grant Legong Li Sheng Luan | 2007 | Cell Research2007，17，5： | 23 |
| 7 | Cold adaptation in pigs depends on UCP3 in beige adipocytes显示文摘 | Jun Lin Chunwei Cao Cong Tao Rongcai Ye Meng Dong Qiantao Zheng Chao Wang Xiaoxiao Jiang Guosong Qin Changguo Yan Kui Li John R. Speakman Yanfang Wang Wanzhu Jin Jianguo Zhao | 2017 | Journal of Molecular Cell Biology2017，9，5： | 20 |
| 8 | 西藏高原中、北部断裂构造特征:INDEPTH(Ⅲ)-MT观测提供的依据显示文摘根据1998年和1999年INDEPTH(Ⅲ)MT在西藏中、北部所完成的德庆-龙尾错(500线)和那曲-格尔木(600线)超宽频带大地电磁深探测剖面数据研究西藏高原中北部断裂构造特征,有助于推进印度板块与亚洲板块碰撞、俯冲构造模式的研究.研究结果表明,区内发育有F1~F10一系列深断裂.其中,F2向北倾斜是早期的主断裂,F1则是后期主逆冲断裂,它们共同构成空间结构复杂的嘉黎深断裂带.班公-怒江缝合带的主断裂系由略微向南陡倾的F3、F4和F5三组超壳深断裂构成;由于受后期构造运动强烈的改造,缝合带内发育多条延深不大的上地壳断层.唐古拉断裂带由F6、F7两组主断裂和一系列次级断裂构成;主断裂产状上陡、下缓,总体向南倾斜,向下延深达下地壳.而金沙江缝合带是由F8(金沙江断裂)和F9(可可西里断裂),以及它们之间存在的一系列上地壳次级断层共同组成的,是一组很宽的地块碰撞缝合带.F10即昆中断裂是产状陡立的超壳深断裂,是昆仑山断裂带的主体构造,它构成松潘-甘孜-可可西里地块的北部边界.从剖面电性结构特征分析,昆中断裂以南属于西藏高原主体;而以北地区是否还归属西藏高原?这有待更深入的讨论.值得特别关注的事实是,研究区内2组缝合带之下都存在向上地幔延伸的壳内高导体,它们可能反映区内壳幔热交换过程的痕迹. | 魏文博 金胜 叶高峰 邓明 谭捍东 Martyn Unsworth John Booker Alan G. Jones LI Sheng-hui | 2006 | 地球科学(中国地质大学学报)2006，31，2： | 19 |
| 9 | A Review of the Functional and Anatomical Default Mode Network in Schizophrenia显示文摘Schizophrenia is a severe mental disorder characterized by impaired perception,delusions,thought disorder,abnormal emotion regulation,altered motor function,and impaired drive. The default mode network(DMN),since it was first proposed in 2001,has become a central research theme in neuropsychiatric disorders,including schizophrenia. In this review,first we define the DMN and describe its functional activity,functional and anatomical connectivity,heritability,and inverse correlation with the task positive network. Second,we review empirical studies of the anatomical and functional DMN,and anti-correlation between DMN and the task positive network in schizophrenia. Finally,we review preliminary evidence about the relationship between antipsychotic medications and regulation of the DMN,review the role of DMN as a treatment biomarker for this disease,and consider the DMN effects of individualized therapies for schizophrenia. | Mao-Lin Hu Xiao-Fen Zong J. John Mann Jun-Jie Zheng Yan-Hui Liao Zong-Chang Li Ying He Xiao-Gang Chen Jin-Song Tang | 2017 | Neuroscience Bulletin2017，33，1： | 19 |
| 10 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 11 | 铸造压力对ADC12Z压铸件孔洞和力学性能的影响显示文摘测定了不同铸造压力下ADC12Z压铸件密度、孔洞面积百分比、孔洞平均直径及力学性能,研究了铸造压力对ADC12Z压铸件孔洞和力学性能影响。结果表明,随着铸造压力增大,压铸件孔洞面积百分比和平均粒径逐渐减小,密度逐渐增大;同时,铸造压力增大可以细化α-Al和黑色针片状共晶Si,使压铸件力学性能明显改善。但当铸造压力增加到一定程度,压力的增加对密度、孔洞及性能影响幅度变小。 | 闫焉服 熊守美 柳百成 Mei Li John Allison | 2007 | 铸造2007，56，11： | 17 |
| 12 | 应用两相流模型模拟压铸充型过程的卷气现象显示文摘通过对压铸充型过程中卷气缺陷形成机理的分析,认为型腔中空气的流动以及与金属液之间的相互作用是形成卷气现象的主要原因.为了考虑型腔中空气的流动,采用了一种不可压缩两相流数学模型来模拟压铸充型过程的卷气现象.通过计算流体力学中的两个基准算例,较为全面地验证了该模型的准确性和可靠性.在此基础上,设计了专门针对压铸充型过程的高速水模拟实验,通过对可视化实验结果与两相流模拟结果的比较,证实二者吻合较好,说明了该模型能够较好地模拟液体的充填行为和卷入其中的气泡. | 李帅君 熊守美 Mei Li John Allison | 2009 | 金属学报2009，45，10： | 16 |
| 13 | 压铸充型过程中卷气现象的数值模拟研究显示文摘采用一种液-气两相耦合模型模拟了压铸充型过程中的卷气现象,对卷入金属液中的每个气泡均单独计算其压力变化的趋势,通过压力传递将液-气两相联系在一起.为了验证模型的可靠性和准确性,开展了专门针对压铸的高速水模拟实验,并采用液-气两相耦合模型以及单相流模型分别进行了模拟,通过比较可以证实两相耦合模型在模拟卷气方面比单相流模型具有更高的精确度. | 李帅君 熊守美 Mei Li John Allison | 2010 | 金属学报2010，46，5： | 16 |
| 14 | An update: the role of Nephrin inside and outside the kidney显示文摘Nephrin is a key molecule in podocytes to maintain normal slit diaphragm structure. Nephin interacts with many other podocyte and slit diaphragm protein and also mediates important cell signaling pathways in podocytes. Loss of nephrin during the development leads to the congenital nephrotic syndrome in children. Reduction of nephrin expression is often observed in adult kidney diseases including diabetic nephropathy and HIV-associated nephropathy. The critical role of nephrin has been confirmed by different animal models with nephrin knockout and knockdown. Recent studies demonstrate that knockdown of nephrin expression in adult mice aggravates the progression of unilateral nephrectomy and Adriamycin-induced kidney disease. In addition to its critical role in maintaining normal glomerular filtration unit in the kidney, nephrin is also expressed in other organs. However, the exact role of nephrin in kidney and extra-renal organs has not been well characterized. Future studies are required to determine whether nephrin could be developed as a drug target to treat patients with kidney disease. | LI XueZhu HE John Cijiang | 2015 | Science China(Life Sciences)2015，58，7： | 16 |
| 15 | Potential Toxicological and Cardiopulmonary Effects of PM2,5 Exposure and Related Mortality:Findings of Recent Studies Published during 2003-2013显示文摘INTRODUCTION Air pollution has become a serious environmental issue owing to its diverse harmful effects on the physical and biological environment.According to the Environmental Protection Agency(EPA)and the World Health Organization(WHO)[1-2],air pollution affects millions of people worldwide.Hundreds of thousands of deaths each year and a range of diseases, | Mohammed O.A.Mohammed SONG Wei Wei MA Wan Li LI Wen Long LI Yi Fan Afed Ullah Khan Mohammed A.E.M.Ibrahim Osman Adam Maarouf Alshebli A Ahmed John J.Ambuchi | 2016 | Biomedical and Environmental Sciences2016，29，1： | 16 |
| 16 | New insight into inter-organ crosstalk contributing to the pathogenesis of non- alcoholic fatty liver disease (NAFLD)显示文摘非酒精的脂肪肝疾病(NAFLD ) 与在在最后十年的流行的实质的上升是长期的肝机能障碍和一个重要全球健康问题的最普通的原因。NALFD 主要是新陈代谢的症候群的肝的表明,正在变得逐渐地清楚不仅,而且包含额外肝的机关和规章的小径。治疗学的选择为 NAFLD 的处理被限制。因此, NAFLD 的致病的更好的理解为获得新卓见进 NAFLD 并且为为 NAFLD 的预防和处理识别新目标的规章的网络是批评的。在这评论,我们在在肝和外部机关之间的内部器官的串音的当前的理解上强调贡献 NAFLD 的致病。 | Xu Zhang Xuetao Ji Qian Wang John Zhong Li | 2018 | Protein & Cell2018，9，2： | 14 |
| 17 | Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma显示文摘瞄准:在整个 Barretts 食管的前进调查 cyclooxygenase-2 (COX-2 ) 和上皮的生长因素受体(EGFR ) 的表示() 。方法:COX-2 和 EGFR 蛋白质表情被使用免疫检测组织化学的方法。详细 cytomorphological 改变的 A 是坚定的。COX-2 和 EGFR 表示的区域被使用计算机成像系统确定。结果:COX-2 和 EGFR 的表情与前进一起增加了从到食管腺癌(EAC ) 。积极关联在 COX-2 表示和 EGFR 表示之间被发现。结论:COX-2 和 EGFR 可能在逐步的前进从是合作的到 EAC,从而导致致癌作用。 | Yan Li John M Wo Mukunda B Ray Whitney Jones Ruifeng R Su Susan Ellis Robert C G Martin | 2006 | World Journal of Gastroenterology2006，12，6： | 14 |
| 18 | Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells显示文摘外长的 dopaminergic 神经原(DA 神经原) 的移植是为治疗 Parkinson 的疾病(PD ) 的一条有希望的途径。然而,主要跌倒块是施主 DA 神经原的可靠来源的缺乏。这里,我们证明五 transcriptional 因素 Mash1, Ngn2, Sox2, Nurr1,和 Pitx3 的联合直接并且有效地装改编人成纤维细胞进 DA 像神经原的房间。为为 DA 神经原的各种各样的标记积极的染色的 reprogrammed 房间。他们也显示出典型 DA 举起和生产性质。而且,他们展出了 DA 神经原特定的 electrophysiological 侧面。最后,他们在一个老鼠 PD 模型提供了征兆的地势。因此,我们的直接 reprogrammed DA 像神经原的房间是为 PD 的房间代替治疗的有希望的来源。 | Xinjian Liu Fang Li Elizabeth A Stubblefield Barbara Blanchard Toni L Richards Gaynor A Larson Yujun He Qian Huang Aik-Choon Tan Dabing Zhang Timothy A Benke John R Sladek Nancy R Zahniser Chuan-Yuan Li | 2012 | Cell Research2012，22，2： | 14 |
| 19 | Distribution and source of microplastics in China's second largest reservoir-Danjiangkou Reservoir显示文摘Fresh water microplastic pollution is of pressing concern globally,but its distribution and sources in reservoirs are poorly documented.Danjiangkou Reservoir is the second largest reservoir in China and is divided into the Han Reservoir and Dan Reservoir.In this work,microplastic abundances and morphological characteristics of the reservoir were investigated.The microplastic abundance of 15 main tributaries of the reservoir was also measured.The vertical distribution(in water column and sediment),horizontal distribution(in Han Reservoir and Dan Reservoir)and source of microplastics were analyzed.Microplastics accumulated in the middle layer of the reservoir,and the size and color of the microplastic particles changed from the surface to the bottom,which implies that surveys of surface water are not enough to determine the microplastic contamination for deep water reservoirs.In the surface water,the microplastic abundance in the Han Reservoir was lower than that in the Dan Reservoir(p<0.05),but microplastic abundance did not differ significantly in the intermediate and bottom water.Tributaries were one of the main sources of microplastics for Han Reservoir but not for Dan Reservoir.Agricultural cultivation in the hydro-fluctuation belt might be an important source of microplastics in the Dan Reservoir,which should be given additional attention.The results of this study can provide valuable information for developing microplastic sampling strategies in deep water reservoirs.Further studies are recommended to investigate the process through which microplastics in the hydro-fluctuation belt enter the reservoir and the sinking behavior of microplastics in the reservoir. | Li Lin Xiong Pan Sheng Zhang Danwen Li Wenliang Zhai Zhen Wang Jingxiang Tao Changqing Mi Qingyun Li John C.Crittenden | 2021 | Journal of Environmental Sciences2021，33，4： | 13 |
| 20 | Cardioprotective mechanism of SGLT2 inhibitor against myocardial infarction is through reduction of autosis显示文摘Sodium-glucose cotransporter 2(SGLT2)inhibitors reduce cardiovascular mortality in patients with diabetes mellitus but the protective mechanism remains elusive.Here we demonstrated that the SGLT2 inhibitor,Empagliflozin(EMPA),suppresses cardiomyocytes autosis(autophagic cell death)to confer cardioprotective effects.Using myocardial infarction(Ml)mouse models with and without diabetes mellitus,EMPA treatment significantly reduced infarct size,and myocardial fibrosis,thereby leading to improved cardiac function and survival.In the context of ischemia and nutritional glucose deprivation where autosis is already highly stimulated,EMPA directly inhibits the activity of the Na^(+)/H^(+)exchanger 1(NHE1)in the cardiomyocytes to regulate excessive autophagy.Knockdown of NHE1 significantly rescued glucose deprivation-induced autosis.In contrast,overexpression of NHE1 aggravated the cardiomyocytes death in response to starvation,which was effectively rescued by EMPA treatment.Furthermore,in vitro and in vivo analysis of NHE1 and Beclin 1 knockout mice validated that EMPA s cardioprotective effects are at least in part through downregulation of autophagic flux.These findings provide new insights for drug development,specifically targeting NHE1 and autosis for ventricular remodeling and heart failure after Ml in both diabetic and non-diabetic patients. | Kai Jiang Yue Xu Dandan Wang Feng Chen Zizhuo Tu Jie Qian Sheng Xu Yixiang Xu John Hwa Jian Li Hongcai Shang Yaozu Xiang | 2022 | Protein & Cell2022，13，5： | 13 |
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