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| 1 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 2 | Metformin in patients with non-alcoholic fatty liver disease: A randomized, controlled trial显示文摘 | John Willy Haukeland Zbigniew Konopski Heidi Beate Eggesb? Hilde L?land von Volkmann Gabriele Raschpichler Kristian Bj?ro Terese Haaland Else Marit L?berg K?re Birkeland | 2009 | Scandinavian Journal of Gastroenterology2009，，7： | 3 |
| 3 | Degradation of sterols and terrigenous organic matter in waters of the Mackenzie Shelf, Canadian Arctic显示文摘 | Jean-Fran?ois Rontani Bruno Charrière Richard Sempéré David Doxaran Frédéric Vaultier Jorien E. Vonk John K. Volkman | 2014 | Organic Geochemistry2014，，： | 1 |
| 4 | Impaired endothelial function in arterial hypertension and hypercholesterolemia: potential mechanisms and differences显示文摘 | John S Schmieder RE | 2000 | J Hypertens2000，18，： | 1 |
| 5 | Macromolecular crowding: an important but neglected aspect of the intracellular environment 显示文摘 | John RE | 2001 | Structural Biology2001，11，1： | 1 |
| 6 | Application and comparison of classification algorithms for recognition of Alzheimer's disease in electrical brain activity (EEG)显示文摘 | Lehmann C Koenig T Jelic V Prichep L John RE Wahlund LO Dodge Y Dierks T | | 0，，： | 1 |
| 7 | Theodore nicholas, fatigue crack nucleation and growth rate behavior of laser shock peened titanium显示文摘 | Ruschau J J John Re Ji Thompson S R | 1999 | International Journal of Fatigue1999，21，： | 1 |
| 8 | The effect of strabismus on a young child' s selection of a playmate显示文摘 | Johns HA Manny RE Fern KD Hu YS | 2005 | Ophthalmic Physiol Opt2005，25，5： | 1 |
| 9 | Impaired endothelial function in arterial hypertension and hypercholesterolemia: potential mechanisms and differences显示文摘 | John S Schmieder RE | 2000 | J Hypertens2000，18，4： | 1 |
| 10 | Phase Ⅰ and pharmacokinetic study of GI147211,a water-soluble camptothecin analogue,administered for five consecutive days every three weeks显示文摘 | Eckhardt SG Sharyn DB John RE | 1998 | Clinical Cancer Research1998，4，： | 1 |
| 11 | Chromatin accessibility pre-determines glucocorticoid receptor binding patterns显示文摘 | John S Sabo PJ Thurman RE | 2011 | Nature Genet2011，43，3： | 1 |
| 12 | Recent Developments in Myofibroblast Biology显示文摘 | Boris Hinz Sem H. Phan Victor J. Thannickal Marco Prunotto Alexis Desmoulière John Varga Olivier De Wever Marc Mareel Giulio Gabbiani | 2012 | The American Journal of Pathology2012，，4： | 1 |
| 13 | Corneal development,limbal stem cell function,and corneal epithelial cell migration in the Pax6(+/-) mouse显示文摘 | Collinson JM Chanas SA Hill RE John DW | 2004 | Invest Ophthalmol Vis Sci2004，45，4： | 1 |
| 14 | Angiotensin converting enzyme inhibition and angiotemin II AT1-receptor blockade reduce the levels of asymmetrical N^G, N^G-dimethylarginine in human essential hypertension显示文摘 | Delles C Schneider MP John S Gekle M Schmieder RE | 2002 | Am J Hypertens2002，15，71： | 1 |
| 15 | Posterior reversible encephalopathy syndrome presenting with global cerebral edema and herniation显示文摘 | Lee VH Temes RE John S | 2013 | Neurocrit Care2013，18，1： | 1 |
| 16 | Multiphasic Approach for the Identification of the Different Classification Levels Of Pseudomonas savastanoi Pv. Phaseolicola显示文摘 | Abi S. dos A. Marques Roselyne Corbière Louis Gardan Catherine Tourte Charles Manceau John D. Taylor Régine Samson | 2000 | European Journal of Plant Pathology2000，，： | 1 |
| 17 | Recent Developments in Myofibroblast Biology显示文摘 | Boris Hinz Sem H. Phan Victor J. Thannickal Marco Prunotto Alexis Desmoulière John Varga Olivier De Wever Marc Mareel Giulio Gabbiani | 2012 | The American Journal of Pathology2012，，4： | 1 |
| 18 | Airways protection by the laryngeal mask显示文摘 | Hill S Hughes TJ | 1991 | Anesthesia1991，46，： | 1 |
| 19 | Potential mechanisms of impaired endothelial function in arterial hypertension and hypercholesterolemia显示文摘 | John S Schmeider RE | 2003 | Curr Hypertens Rep2003，5，3： | 1 |
| 20 | Potential mechanisms of impaired endothelial function in arterial hypertension and hyperchalesterolemia显示文摘 | JOHN S SCHMIEDER RE | 2003 | Curr Hypertens Rep2003，5，3： | 1 |
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