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| 1 | Role of CD56-expressing immature biliary epithelial cells in biliary atresia显示文摘AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.RESULTS: Differences in some clinical laboratoryparameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients(74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage(81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. | Rui-Zhong Zhang Jia-Kang Yu Jiao Peng Feng-Hua Wang Hai-Ying Liu Vincent CH Lui John M Nicholls Paul KH Tam Jonathan R Lamb Yan Chen Hui-Min Xia | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 2 | Mutations around interferon sensitivity-determining region:A pilot resistance report of hepatitis C virus 1b in a Hong Kong population显示文摘AIM: To explore mutations around the interferon sensitivity-determining region (ISDR) which are associated with the resistance of hepatitis C virus 1b (HCV-1b) to interferon-α treatment. METHODS: Thirty-seven HCV-1b samples were ob- tained from Hong Kong patients who had completed the combined interferon-α/ribavirin treatment for more than one year with available response data. Nineteen of them were sustained virological responders, while 18 were non-responders. The amino acid sequences of the extended ISDR (eISDR) covering 64 amino acids upstream and 67 amino acids downstream from the previously reported ISDR were analyzed. RESULTS: One amino acid variation (I2268V, P = 0.023) was significantly correlated with treatment outcomein this pilot study with a limited number of patients, while two amino acid variations (R2260H, P = 0.05 and S2278T, P = 0.05) were weakly associated with treatment outcome. The extent of amino acid variations within the ISDR or eISDR was not correlated with treatment outcome as previously reported. CONCLUSION: Three amino acid mutations near but outside of ISDR may associate with interferon treatment resistance of HCV-1b patients in Hong Kong. | Xiao-Ming Zhou Paul KS Chan John S Tam | 2011 | World Journal of Gastroenterology2011，17，48： | 3 |
| 3 | 荧光定量聚合酶链反应与分支链DNA信号扩增法检测血清HBV DNA的比较显示文摘目的 了解荧光定量聚合酶链反应 (PCR)法与分支链DNA信号扩增 (bDNA)法在检测血清中HBVDNA含量上的优缺点。方法 分别用这两种方法平行检测 44份乙型肝炎患者的血清标本 ,并与定性PCR检测结果比较。同时用荧光定量PCR法观察 15例乙肝患者干扰素治疗期间HBVDNA含量变化。结果 ①荧光定量PCR法和bDNA法比较 ,○a前者测出的HBVDNA含量均值为 ( 3 5 0× 10 5± 3 3 6)copies/μl ;后者为 ( 3 0 7× 10 5± 12 9)copies/μl ,两者比较差异无显著性 (P >0 0 5 )。○b前者的HBVDNA阳性率 79 5 % ;后者及常规PCR定性法均为 5 9 1%。荧光定量PCR法的阳性检出率显著高于bDNA法及常规定性PCR法 (P <0 0 5 )。② 15例中 5例获完全应答的乙型肝炎患者其血清HBVDNA含量在治疗 16周内均逐渐下降至完全转阴。结论 荧光定量PCR法与bDNA法在检测血清HBVDNA含量上 ,结果大多一致 ,且敏感性强 ,检验也较简便、价廉 ,并能较好评价和检测乙肝患者抗病毒疗效 ,宜于临床推广。 | 袁静 马为民 周伯平 徐六妹 王火生 John S Tam | 2000 | 广东医学2000，21，10： | 3 |
| 4 | Applicability of Intraoperative Parathyroid Hormone Assay During Thyroidectomy显示文摘 | Chung Yau Lo John M. Luk Sidney C. Tam | 2002 | Annals of Surgery2002，，5： | 1 |
| 5 | Viral genotype and hepatitis B virus DNA levels are correlated with histological liver damage in HBeAg-negative chronic hepatitis B virus infection显示文摘 | Henry Lik-Yuen Chan Steven Woon-Choi Tsang Chook-Tiew Liew Chi-Hang Tse May-Ling Wong Jessica Yuet-Ling Ching Nancy Wai-Yee Leung John Siu-Lun Tam Joseph Jao-Yiu Sung | 2002 | The American Journal of Gastroenterology2002，，2： | 1 |
| 6 | Application of ALARP to the design of the BP Andrew platform against smoke and gas ingress and gas explosion显示文摘 | Vincent Tam Thanos Mores Simon Webb John Allinson Ron Lee Edi Bi1imoria | 1996 | Journal of Loss Prevention in the Process Industries1996，9，5： | 1 |
| 7 | P2 purinoceptors:Renal pathophysiology and therapeutic potential显示文摘 | John W Booth Frederick W Tam Robert J Unwin | 2012 | C|in Nephrol2012，78，2： | 1 |
| 8 | Typing and subtyping of influenza viruses and respiratory syncytial viruses by multiplex RT-PCR显示文摘 | Akira Yamada Lap-yee Lam John S Tam | 2004 | Intemational Congress Series2004，1263，： | 1 |
| 9 | Prospective Multicenter Study of Pregnancy Outcomes in Women With Heart Disease显示文摘 | Samuel C. Siu Mathew Sermer Jack M. Colman A. Nanette Alvarez Lise-Andree Mercier Brian C. Morton Catherine M. Kells M. Lynn Bergin Marla C. Kiess Francois Marcotte Dylan A. Taylor Elaine P. Gordon John C. Spears James W. Tam Kofi S. Amankwah Jeffrey F. S | 2001 | Circulation: Journal of the American Heart Association2001，，5： | 1 |
| 10 | Bone mineral density and its correlation with clinical and laboratory factors in chronic peritoneal dialysis patients显示文摘 | Fettah Fevzi Ersoy Stauros Ploumis Passadakis Paul Tam Evaggelos Dimitros Memmos Pericles Konstantinos Katopodis ?etin ?zener Fehmi Ak?i?ek Taner ?amsar? Kenan Ate? Rezzan Ataman John George Vlachojannis Athanasios Nicholas Dombros Cengiz Uta? Tekin Akpol | 2006 | Journal of Bone and Mineral Metabolism2006，，1： | 1 |
| 11 | Survey of Spatio-temporal Database 显示文摘 | TAMS A JOHN F RODDICK F | 1999 | Journal of Geoinformatica1999，3，1： | 1 |
| 12 | The presence of ST-elevation in lead aVR predicts significant left main coronary artery stenosis in cardiogenic shock resulting from myocardial infarction: The Manitoba cardiogenic shock registry显示文摘 | Robin Ducas Vignendra Ariyarajah Roger Philipp John Ducas Jason Elliott Davinder Jassal James Tam Philip Garber Nasir Shaikh Farrukh Hussain | 2013 | International Journal of Cardiology2013，，2： | 1 |
| 13 | Typing and subtyping of influenza viruses and respiratory syncytial viruses by multiplex RT-PCR显示文摘 | Akira Yamada Lap-yee Lam John S Tam | 2004 | International Congress Series2004，1263，： | 1 |
| 14 | Pediatric liver transplantation in Hong Kong—a domain with scarce deceased donors显示文摘 | Kwong Leung Chan Sheung Tat Fan Chung Mau Lo William I. Wei Raymond Wai Man Ng Ho Yu Chung Kelvin Kwok Chai Ng See Ching Chan Kwok Wah Chan Wai Kuen Tso Nai Shun Tsoi Paul Kwong Hang Tam John Wong | 2009 | Journal of Pediatric Surgery2009，，12： | 1 |
| 15 | Influenza A (H5N1) in Hong Kong : an overview 显示文摘 | John S Tam | 2002 | Vaccine2002，20，： | 1 |
| 16 | Someras-transformed cells have increased radiosensitivity and decreased repair of sublethal radiation damage显示文摘 | John F. Harris Ann F. Chambers Andrew S. K. Tam | 1990 | Somatic Cell and Molecular Genetics1990，，1： | 1 |
| 17 | Typing and subtyping of influenza viruses and respiratory syncytial viruses by multiplex RT-PCR显示文摘 | AKIRA Yamada Lap-yee Lam John S Tam | 2004 | International Congress Series2004，，1263： | 1 |
| 18 | Occult HBV infection in cryptogenic liver cirrhosis in an area with high prevalence of HBV infection显示文摘 | Henry Lik-Yuen Chan Steven Woon-Choi Tsang Nancy Wai-Yee Leung Chi-Hang Tse Yui Hui John Siu-Lun Tam Francis Ka-Leung Chan Joseph Jao-Yiu Sung | 2002 | The American Journal of Gastroenterology2002，，5： | 1 |
| 19 | Sensitivity and specificity of Epstein-Barr virus IGA titer in the diagnosis of nasopharyngeal carcinoma:a three-year institutional review显示文摘 | Vlantis Alexander C Ho Ricky W K Tam John S L | 2004 | Head & Neck2004，26，7： | 1 |
| 20 | Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis显示文摘 | Wen Cai Zhang Ng Shyh-Chang He Yang Amit Rai Shivshankar Umashankar Siming Ma Boon Seng Soh Li Li Sun Bee Choo Tai Min En Nga Kishore Kumar Bhakoo Senthil Raja Jayapal Massimo Nichane Qiang Yu Dokeu A. Ahmed Christie Tan Wong Poo Sing John Tam Agasthian T | 2012 | Cell2012，，1： | 1 |
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