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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Is there evidence of selection in the dopamine receptor D4 gene in Australian invasive starling populations?显示文摘 | Lee Ann ROLLINS Michael R. WHITEHEAD Andrew R WOOLNOUGH Ron SINCLAIR William B. SHERWIN | 2015 | Current Zoology2015，61，3： | 2 |
| 3 | Pathogen- induced programmed cell death in tobacco 显示文摘 | Ron M Lee S Eric L | 1997 | Joumal of Ceil Science1997，110，： | 1 |
| 4 | Application of ALARP to the design of the BP Andrew platform against smoke and gas ingress and gas explosion显示文摘 | Vincent Tam Thanos Mores Simon Webb John Allinson Ron Lee Edi Bi1imoria | 1996 | Journal of Loss Prevention in the Process Industries1996，9，5： | 1 |
| 5 | A 31-level cascade inverter for power applications显示文摘 | LEE C K RON Hui HENRY S Y | 2002 | IEEE Transactions on Industrial Electronics2002，49，3： | 1 |
| 6 | Analytical solution of thermal resistance of vapor chamber heat sink with and without pillar显示文摘 | Hsieh Shou Shing Lee Ron Yu | 2007 | Energy Conversion and Management2007，48，： | 1 |
| 7 | Integrating service level agreements with OSS显示文摘 | Ben-Natan Ron | 2002 | Wiley Publishing2002，，： | 1 |
| 8 | Reaction zones in ultrafine TATB显示文摘 | Frank Alan Chau Henry Lee Ron | 2003 | Propellants Explosives Pyrotechnics2003，28，5： | 1 |
| 9 | Hypertrophic cardiomyopathy in a large community-based population: clinical outcome and identification of risk factors for sudden cardiac death and clinical deterioration显示文摘 | Marcel J.M Kofflard Folkert J Ten Cate Chris van der Lee Ron T van Domburg | 2003 | Journal of the American College of Cardiology2003，，6： | 1 |
| 10 | Microsuction of blastocoelic fluid before vitrification increased survival and pregnancy of mouse expanded blastocysts, but pretreatment with the cytoskeletal stabilizer did not increase blastocyst survival 显示文摘 | Shee - Uan Chen Tsung - Hsien Lee Yih - Ron Lien | 2005 | Fertility and Sterility2005，84，2： | 1 |
| 11 | Enterolith Causing Afferent Loop Obstruction: A Case Report and Literature Review显示文摘 | Michael C. Lee James T. Bui M-Grace Knuttinen Ron C. Gaba W. Scott Helton Charles A. Owens | 2009 | CardioVascular and Interventional Radiology2009，，5： | 1 |
| 12 | Growth Emprics:A Panel Data Approach-A comment显示文摘 | Lee Kevin Pesaran M Hashem Smith ron | | 0，，： | 1 |
| 13 | Tetrazolium- Based Cell Bioassay for Neurotoxins Active on Voltage-Sensitive Sodium Channels: Semiautomated Assay for Saxitoxins, Brevetoxins,and Ciguatoxins 显示文摘 | Ron L Manger Linda S Leja Sue Y Lee | 1993 | Analytical Biochemistry1993，214，： | 1 |
| 14 | Growth and convergence in a Multi-country Empirical Stochastic solow Model显示文摘 | Lee Kevin Pesaran M Hashem Smith ron | | 0，，： | 1 |
| 15 | Persistance of micronuclei in lymphocytes of cancer patients after radiotherapy显示文摘 | Lee Tung Kwang Allision Ron R O' Brien Kevin F | 2002 | RadiatRes2002，157，6： | 1 |
| 16 | Circuit-level comparison of STATCOM technologies 显示文摘 | Lee C K Leung J S K Ron Hui S Y | 2003 | IEEE Transactions on Power Electronics2003，18，4： | 1 |
| 17 | Causality assessment of cutaneous adversedrug reactions显示文摘 | Son YM Lee JR Ron JY | 2011 | Ann Dermatol2011，23，4： | 1 |
| 18 | Integrating service level agreements with OSS显示文摘 | LEE JOHN J BEN-NATAN RON | 2002 | Wiley Publishing2002，，： | 1 |
| 19 | Morphometric characterization of calcium sulfate dehydrate(gypsum) scale on reverse osmosis membranes 显示文摘 | Wen - Yi Shih Anditya Rahardianto Ron - Wai Lee | 2005 | J Membr Sci2005，252，： | 1 |
| 20 | Circuit-level comparison of STATCOM technologies显示文摘 | Lee C K Leung J S Ron Hui SY | 2003 | IEEE Trans on Power Electronics2003，18，4： | 1 |
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