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| 1 | High rate of Helicobacter pylori reinfection in Lithuanianpeptic ulcer patients显示文摘AIM: To evaluate the frequency of Helicobacter pylori(H. pylori) reinfection in peptic ulcer patients during 9 years after H. pylori eradication.METHODS: We invited 117 peptic ulcer patients in whom eradication of H. pylori was confirmed 1 year after eradication treatment both by histology and by rapid urease test. In total, 57 patients were available for the study procedures: 34(59.6%) male, 23(40.4%) female; mean age 52.3 ± 13.0 years. There were 45(78.9%) patients with duodenal ulcer and 12(21.1%) with gastric ulcer. H. pylori was diagnosed by a rapid urease test and histology if endoscopy was performed. If endoscopy was refused, H. pylori was diagnosed by the C14-urea breath test and serology. H. pylori was established if at least one of the tests was positive.RESULTS: The mean follow-up was 8.9 ± 1.0 years(range, 6-12). H. pylori was established in 15 patients. In 2 H. pylori-negative patients, H. pylori was established during the follow-up period and eradicated. Therefore, we consider that reinfection occurred in 17 patients. In the per protocol analysis, reinfection was established in 17 of 57(29.8%; 95%CI: 19.2-42.2) patients during the follow-up period. The annual rate of infection was 3.36%. If all non-responders were considered H. pylori-negative, reinfection would be 14.5%(17/117), the annual ratebeing 1.63%. The mean age of patients with reinfection was 51.8 ± 14.0 years, and without reinfection was 52.5 ± 13.0 years, P > 0.05; the mean body mass index of patients with reinfection was 27.2 ± 4.1 kg/m2, and without reinfection was 25.7 ± 4.2 kg/m2, P > 0.05. There were no differences in the reinfection rates according the location of the peptic ulcer, the eradication regimen used, and smoking status.CONCLUSION: The reinfection rate of H. pylori is relatively high in Lithuania and probably related to the high prevalence of H. pylori, what may reflect differences in the socioeconomic status between Western and Eastern European countries. | laimas jonaitis gediminas kiudelis paulius slepavicius limas kupcinskas | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 7 |
| 2 | Plexiform angiomyxoid myofibroblastic tumor of stomach:A rare case显示文摘Plexiform angiomyxoid myofibroblastic tumor(PAMT) is a rare benign mesenchymal tumor of stomach. Rarity of this kind of tumors and scarce review articles may cause underrecognition of this entity and pose a real diagnostic challenge to gastroenterologists, pathologists and surgeons when encountering such patients and differentiating PAMT from other gastric intramural tumors. We report a case of 28-year-old woman, who presented with epigastric pain after meals, iron-deficiency anaemia and weight loss. Upper gastrointestinal endoscopy revealed submucosal tumorlike elevated lesion in the anterior wall of the antrum with intact overlying mucosa. Endoscopic ultrasound showed a 3-cm hypoechoic homogenous mass, originating from the third layer of the gastric wall. Endoscopic ultrasound-guided fine needle aspiration was not informative. Endoscopic buttonhole biopsy was performed to obtain specimens. Following this, the unexpected prolapse of the tumor occurred into the lumen of the stomach, causing gastric outlet obstruction- the biopsy was obtained. Pathomorphological features suggested the diagnosis of PAMT. Gastric resection of the Billroth I type was performed. Diagnosis was confirmed by histological analysis of the surgical specimen. | Laimas Jonaitis Mindaugas Kiudelis Paulius Slepavicius Lina Poskiene Limas Kupcinskas | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，18： | 2 |
| 3 | Polymorphisms of micro RNA target genes IL12B, INSR, CCND1 and IL10 in gastric cancer显示文摘AIM To evaluate associations between mi RNA target genes IL12B,INSR,CCND1 and IL10 polymorphisms and gastric cancer(GC)in European population.METHODS Gene polymorphisms were analyzed in 508 controls and474 GC patients from 3 tertiary centers in Germany,Lithuania and Latvia.Controls were patients from the out-patient departments,who were referred for upper endoscopy because of dyspeptic symptoms and had no history of previous malignancy.Gastric cancer(GC)patients had histopathological verification of gastric adenocarcinoma.Genomic DNA was extracted using salting out method from peripheral blood mononuclear cells.IL12B T>G(rs1368439),INSR T>C(rs1051690),CCND1 A>C(rs7177)and IL10 T>C(rs3024498)SNPs were genotyped by the real-time polymerase chain reaction.Associations between gene polymorphism and GC were evaluated using multiple logistic regression analysis with adjustment for sex,age and country of birth.RESULTS We observed similar distribution of genotypes and allelic frequencies of all polymorphisms between GC patients and controls except of INSR rs1051690.The frequency of the T allele of INSR gene was significantly higher in GC patients than in controls(23.26%and 19.19%respectively,P=0.028).CT genotype was also more prevalent in patients compared to control group(38.48%and 30.12%respectively,P<0.021).Logistic regression analysis revealed that only one polymorphism(rs1051690 in INSR gene)was associated with increased risk of GC.Carriers of CT genotype had higher odds of GC when compared to CC genotype(OR=1.45,95%PI:1.08-1.95,P=0.01).Similar association was observed in a dominant model for INSR gene,where comparison of TT+CT vs CC genotypes showed an increased risk of GC(OR=1.44,95%PI:1.08-1.90,P=0.01).Other analyzed SNPs were not associated with the presence of GC.CONCLUSION INSR rs1051690 SNP is associated with increased risk of GC,while polymorphisms in IL12B,CCND1 and IL10genes are not linked with the presence of GC. | Vytenis Petkevicius Violeta Salteniene Simonas Juzenas Thomas Wex Alexander Link Marcis Leja Ruta Steponaitiene Jurgita Skieceviciene Limas Kupcinskas Laimas Jonaitis Gediminas Kiudelis Peter Malfertheiner Juozas Kupcinskas | 2017 | World Journal of Gastroenterology2017，23，19： | 2 |
| 4 | Experimental Research of Hollow Concrete Block Masonry Stress Deformations显示文摘 | Bronius Jonaitis Robertas Zavalis | 2013 | Procedia Engineering2013，，： | 1 |
| 5 | Analysis of deflection of com posite slabs with profiled sheeting up to the ultimate moment显示文摘 | MARCIUKAITIS G JONAITIS B VALIVONIS J | 2006 | Constructional Steel Research2006，62，： | 1 |
| 6 | A 1 year follow-up study of the consequences of helicobacter pylori eradication in duodenal ulcer patients:unchanged frequency of erosive oesophagitis and decreased prevalence of non-erosive gastro-oesophageal reflux disease显示文摘 | Kupcinskas L Jonaitis L Kiudelis G | 2004 | Eur J Gastroenterol Hepatol2004，16，： | 1 |
| 7 | Typical and atypical symptoms of laryngopharyngeal reflux disease 显示文摘 | Pribuisiene R Uloza V Jonaitis L | 2002 | Medicina(Kaunas)2002，38，7： | 1 |
| 8 | Laryngeal examination is superior to endoscopy in the diagnosis of the laryngopharyngeal form of gastroesophageal reflux disease 显示文摘 | Jonaitis L Pribuisiene R Kupcinskas L | 2006 | Scand J Gastroenterol2006，41，2： | 1 |
| 9 | Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms are not associated with premalignant gastric conditions: a combined haplotype analysis显示文摘 | Limas Kupcinskas Thomas Wex Juozas Kupcinskas Marcis Leja Audrius Ivanauskas Laimas Virgilijus Jonaitis Dainius Janciauskas Gediminas Kiudelis Konrads Funka Agnese Sudraba Han-Mo Chiu Jaw-Town Lin Peter Malfertheiner | 2010 | European Journal of Gastroenterology & Hepatology2010，，10： | 1 |
| 10 | Evolution of H elicobacter pylori susceptibility to antibiotics during a 10‐year period in L ithuania显示文摘 | Limas Kupcinskas Lone Rasmussen Laimas Jonaitis Gediminas Kiudelis Marianne J?rgensen Neringa Urbonaviciene Vytas Tamosiunas Juozas Kupcinskas Jolanta Miciuleviciene Edmundas Kadusevicius Douglas Berg Leif P. Andersen | 2012 | APMIS2012，，5： | 1 |
| 11 | CpG island methylation of the MLH1, MGMT, DAPK, and CASP8 genes in cancerous and adjacent noncancerous stomach tissues 显示文摘 | Kupcinskaite-Noreikiene R Skieceviciene J Jonaitis L | 2013 | Medicina (Kaunas)2013，49，8： | 1 |
| 12 | Laryngeal ex- amination is superior to endoscopy in the diagnosis of the la- ryngopharyngeal form of gastroesophageal reflux disease显示文摘 | Jonaitis L Pribuisiene R Kupcinskas L | 2006 | Seand J Gastroenterol2006，41，： | 1 |
| 13 | An appraisal of the pub- lished literature on the safety and toxicity of food-related nanomate- rials 显示文摘 | Card JW Jonaitis TS Tafazoli S | 2011 | Crit Rev Toxieol2011，41，1： | 1 |
| 14 | Charaeteristics of patients willl erosive and nonerosive GERD in high-helicobacter-pylori preva- lence regien 显示文摘 | Jonaitis LV Kiudelis G Kupcinskas L | 2004 | Dis Esophagus2004，17，3： | 1 |
| 15 | Distinct TPEF/ HPP1 gene methylation patterns in gastric cancer indicate a field effect in gastric carcinogenesis 显示文摘 | Ivanauskas A Hoffmann J Jonaitis LV | 2008 | Dig Liver Dis2008，40，12： | 1 |
| 16 | De novo erosive esophagi- tis in duodenal ulcer patients related to pre - existing reflux symptoms, smoking, and patient age, but not to Helicobacter pylori eradication : a one - year follow - up study 显示文摘 | Jonaitis L Kupcinskas J Kiudelis G | 2010 | Medicina ( Kaunas)2010，46，7： | 1 |
| 17 | Interfem α-2bin combination with ribavirin for the treatment of chonic hepatitis C:assessment of virological,biochemical and histological treatment response显示文摘 | Vitalija Petrenkiene Inga Gudinaviciene Laimas Jonaitis | 2004 | Medicina (Kaunas)2004，40，6： | 1 |
| 18 | Helicobacter pylori genotypes in Lithuanian patients with chronic gastritis and duodenal ulcer显示文摘 | Miciuleviciene J Calkauskas H Jonaitis L | 2008 | Medicina (Kaunas)2008，44，6： | 1 |
| 19 | Precancer ous gastric conditions in high Helicobaeter pylori prevalence areas: comparison between Eastern European (Lithuanian, Latvian ) and Asian (Taiwanese) patients显示文摘 | Jonaitis L Ivanauskas A Janciauskas D | 2007 | Medicina (Kaunas)2007，43，8： | 1 |
| 20 | Gastroesophageal reflux disease after Helicobacter pylori eradication in gastric ulcer patients:a one-year follow-up study显示文摘 | Jonaitis L Kiudelis G Kupcinskas L | 2008 | Medicina(Kaunas)2008，44，3： | 1 |
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