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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Acute compartment syndrome of the thigh following hip replacement by anterior approach in a patient using oral anticoagulants显示文摘Acute compartment syndrome(ACS) of the thigh following primary total hip arthroplasty(THA) is a highly uncommon complication and has not yet been reported before with regards to the anterior approach through the anterior supine interval. We present a case of a 69-year-old male patient with a history of stroke, who developed ACS of the thigh after elective THA while using therapeutic low molecular weight heparin as bridging for regular oral anticoagulation. ACS pathogenesis, diagnostic tools, treatment and relevant literature are discussed. The patient's ACS was recognized in time and treated by operative decompression with fasciotomy of the anterior compartment. Follow-up did not show any neurological deficit or soft-tissue damage. | Dirk Pieter Hogerzeil Imraan Muradin Eline W Zwitser Joris A Jansen | 2017 | World Journal of Orthopedics2017，8，12： | 8 |
| 3 | Neuroanatomy of lower gastrointestinal pain disorders显示文摘Chronic abdominal pain accompanying intestinal inflammation emerges from the hyperresponsiveness of neuronal,immune and endocrine signaling pathways within the intestines,the peripheral and the central nervous system.In this article we review how the sensory nerve information from the healthy and the hypersensitive bowel is encoded and conveyed to the brain.The gut milieu is continuously monitored by intrinsic enteric afferents,and an extrinsic nervous network comprising vagal,pelvic and splanchnic afferents.The extrinsic afferents convey gut stimuli to second order neurons within the superficial spinal cord layers.These neurons cross the white commissure and ascend in the anterolateral quadrant and in the ipsilateral dorsal column of the dorsal horn to higher brain centers,mostly subserving regulatory functions.Within the supraspinal regions and the brainstem,pathways descend to modulate the sensory input.Because of this multiple level control,only a small proportion of gut signals actually reaches the level of consciousness to induce sensation or pain.In inflammatory bowel disease(IBD)and irritable bowel syndrome(IBS)patients,however,long-term neuroplastic changes have occurred in the brain-gut axis which results in chronic abdominal pain.This sensitization may be driven on the one hand by peripheral mechanisms within the intestinal wall which encompasses an interplay between immunocytes,enterochromaffin cells,resident macrophages,neurons and smooth muscles.On the other hand,neuronal synaptic changes along with increased neurotransmitter release in the spinal cord and brain leads to a state of central wind-up.Also life factors such as but not limited to inflammation and stress contribute to hypersensitivity.All together,the degree to which each of these mechanisms contribute to hypersensitivity in IBD and IBS might be diseaseand even patient-dependent.Mapping of sensitization throughout animal and human studies may significantly improve our understanding of sensitization in IBD and IBS.On the long run,this knowledge can be put forward in potential therapeutic targets for abdominal pain in these conditions. | Wim Vermeulen Joris G De Man Paul A Pelckmans Benedicte Y De Winter | 2014 | World Journal of Gastroenterology2014，20，4： | 7 |
| 4 | Predominant mucosal expression of 5-HT_(4(+h)) receptor splice variants in pig stomach and colon显示文摘AIM: To investigate cellular 5-HT4(-h/+h) receptor distribution, particularly in the epithelial layer, by laser mi-crodissection and polymerase chain reaction (PCR) in porcine gastrointestinal (GI) tissues. METHODS: A stepwise approach was used to evaluate RNA quality and to study cell-specific 5-HT4 receptor mRNA expression in the porcine gastric fundus and colon descendens. After freezing, staining and laser microdissection and pressure catapulting (LMPC), RNA quality was evaluated by the Experion automated electrophoresis system. 5-HT4 receptor and glyceral-dehyde-3-phosphate dehydrogenase (GAPDH) expressions were examined by endpoint reverse transcription (RT)-PCR in mucosal and muscle-myenteric plexus (MMP) tissue fractions, in mucosal and MMP parts of hematoxylin and eosin (HE) stained tissue sections andin microdissected patches of the epithelial and circular smooth muscle cell layer in these sections. Pig gastric fundus tissue sections were also stained immunohisto-chemically (IHC) for enterochromaffin cells (EC cells; MAB352); these cells were isolated by LMPC and examined by endpoint RT-PCR. RESULTS: After HE staining, the epithelial and circular smooth muscle cell layer of pig colon descendens and the epithelial cell layer of gastric fundus were identified morphologically and isolated by LMPC. EC cells of pig gastric fundus were successfully stained by IHC and isolated by LMPC. Freezing, HE and IHC staining, and LMPC had no influence on RNA quality. 5-HT4 recep-tor and GAPDH mRNA expressions were detected in mucosa and MMP tissue fractions, and in mucosal and MMP parts of HE stained tissue sections of pig colon descendens and gastric fundus. In the mucosa tissue fractions of both GI regions, the expression of h-exon containing receptor [5-HT4(+h) receptor] mRNA was significantly higher (P<0.01) compared to 5-HT4(-h) re-ceptor expression, and a similar trend was obtained in the mucosal part of HE stained tissue sections. Large microdissected patches of the epithelial and circular smooth muscle cell layer of pig colon descendens and of the epithelial cell layer of pig gastric fundus, also showed 5-HT4 receptor and GAPDH mRNA expression. No 5-HT4 receptor mRNA expression was detected in gastric LMPC-isolated EC cells from IHC stained tissues, which cells were positive for GAPDH. CONCLUSION: Porcine GI mucosa predominantly expresses 5-HT4(+h) receptor splice variants, suggesting their contribution to the 5-HT4 receptor-mediated mu-cosal effects of 5-HT. | Evelien KV Priem Joris H De Maeyer Mado Vandewoestyne Dieter Deforce Romain A Lefebvre | 2013 | World Journal of Gastroenterology2013，19，24： | 2 |
| 5 | Spinal mechanisms contribute to analgesia prodused by epidural sufentanil clmbined with bupivacaine far postoperative analgesia显示文摘 | Joris J L Jacob E A Sessler D I | 2003 | Anesth Analg2003，97，： | 1 |
| 6 | Evidence for biotype-specific effectsof bovine viral diarrhea virus on biological responses in acutely infected calves显示文摘 | Joris E Douart A | 1998 | Journal of General Virology1998，79，： | 1 |
| 7 | Characterizzation of the immune response of cattle against non-cytopathic and cytopathic biotype of bovin viral diarrhea显示文摘 | Douart A Joris E | 1997 | Gen Virol1997，78，： | 1 |
| 8 | In-vitro matured metaphase-I oocytes have a lower fertilization rate but similar embryo quality as mature metaphase-II oocytes after intracytoplasmic sperm injection显示文摘 | DeVos A Van de Velde H Joris H | 1999 | Hum Reprod1999，14，7： | 1 |
| 9 | Early application of CPAP in newborns with gestational age below 34 weeks lower sintubation rate and shortens oxygen therapy without altering mortality and morbidity显示文摘 | Joris H Sudre P Moessinger A | | 0，，49： | 1 |
| 10 | Molecular pathways involved in neural in vitro differentiation of marrow stromal stem cells 显示文摘 | Jori FP Napolitano MA Melone MA Cipollaro M Cascino A Altucci L | 2005 | J Cell Biochem2005，94，4： | 1 |
| 11 | Subjective and Objective Knowledge as Determinants of Organic Vegetables Consumption 显示文摘 | Zuzanna P Joris A Wim V | 2010 | Food Quality and Preference2010，21，6： | 1 |
| 12 | Early application of CPAP in newborns with gestational age below 34 weeks lowers intubation rate and shortens oxygen therapy without altering mortality and morbidity显示文摘 | Joris N Sudre P Moessinger A | | 0，，49： | 1 |
| 13 | Molecular path- ways involved in neural in vitro differentiation of marrow stromal stem cells显示文摘 | Jori F P Napolitano M A Melone M A | 2005 | J Cell Biochem2005，94，4： | 1 |
| 14 | Comparison of the results of human embryo biopsy and outcome of PGS after zona drilling using acid tyrode medium or laser显示文摘 | Joris H De Vos A Janssens R | 2003 | Hum Reprod2003，18，9： | 1 |
| 15 | Ecotoxicological profile of pyridine 显示文摘 | Jori A Calamari D Cattabeni F | 1983 | Ecotoxicology and Environmental Safety1983，7，： | 1 |
| 16 | Modelling soil - sweep inter- action with discrete element method 显示文摘 | Tamas K Jori I J Mouazen A M | 2013 | Soil and Tillage Re-search2013，134，： | 1 |
| 17 | Early application of CPAP in newboors with gestational age below 34 weeks lowers intubation rate and shortens oxygen therapy without altering mortality and morbidity显示文摘 | Joris H Sudre P Moessinger A | 2000 | Schweiz Med Wochenschr2000，130，49： | 1 |
| 18 | In-vitro ,natured metaphase-I oocytes have a lower fertilization rate but similar embryo quality as mature metaphase-II oocytes after intracytoplasmic sperm injection显示文摘 | DE VOS A VAN DE VELDE H JORIS H | 1999 | Hum Reprod1999，14，： | 1 |
| 19 | Method for estimation of low outer membrane permeability to β-lactam antibiotics 显示文摘 | Lakaye B Dubus A Joris B | 2002 | Antimicrob Agents Chemother2002，46，9： | 1 |
| 20 | De novomutations in human genetic disease显示文摘 | Joris A Veltman & Han G Brunne | 2012 | Nature2012，13，： | 1 |
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