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| 1 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 2 | Sugammadex比新斯的明更快逆转维库溴铵所致神经肌肉阻滞的多中心随机对照研究显示文摘背景Sugammadex是一种具有特异结构的γ-环糊精,能选择性地与肌松药结合快速逆转罗库溴铵所致的神经肌肉阻滞,并较小程度地逆转维库溴铵所致的神经肌肉阻滞。该研究中,我们对比了行择期手术的患者中sugammadex和新斯的明对逆转维库溴铵所致神经肌肉阻滞的作用。方法年龄≥18岁,ASA分级I-Ⅲ级拟行择期手术的患者,在七氟醚/阿片类镇痛药麻醉下给予插管剂量维库溴铵(0.1mg/kg),如有必要,在4个成串刺激(train—of-four,TOF)中第二个颤搐波(T2)恢复时给予的0.02-0.03mg/kg的维持剂量。用加速肌动监测仪(TOF-Watch@SX监测仪,先灵-葆雅,爱尔兰都柏林)监测神经肌肉阻滞。术毕,在最后一次给予维库溴铵后咒恢复时,给患者随机静脉注射sugammadex(2mg/kg)或新斯的明(50μg/kg)加格隆溴铵(10μg/kg)。从注药开始至TOF比值恢复至0.9的时间作为主要有效终点。结果Sugammadex组TOF比值恢复至0.9的时间明显快于新斯的明组(分别为2.7分钟[95%置信区间,CI:2.2—2.3分钟]和17.9分钟[95%CI:13.1—24.3分钟],P〈0.0001)。Sugammadex组TOF恢复至0.8和0.7的平均恢复时间也明显缩短。使用两种药物后均未出现严重不良事件或不可预料的副作用。结论Sugammadex逆转维库溴铵所致神经肌肉阻滞的作用明显快于新斯的明。 | Karin S. Khuenl-Brady, MD Magnus Wattwil, MD Bernard F. Vanacker, MD Jose I. Lora-Tamayo, MD Henk Rietbergen, MSc Jose A. alvarez-Gomez, MD 安博(译) | 2011 | 麻醉与镇痛2011，7，5： | 2 |
| 3 | Suicide prevention strategies, a systematic review 显示文摘 | John Mann MD Alan Apter MD Jose Bertolote MD | 2005 | JAMA2005，294，26： | 1 |
| 4 | Hypertonic saline for cerebral edema and elevated intracranial pressure显示文摘 | Jose I Suarez MD | 2004 | Cleveland Clinic Journal of Medicine Volume 712004，912，： | 1 |
| 5 | Death due to acute pancreatitis显示文摘 | Dr. Ian G. Renner MD FRACP William T. Savage MD Jose L. Pantoja MD V. Jayne Renner PhD | 1985 | Digestive Diseases and Sciences1985，，10： | 1 |
| 6 | Cytomegalovirus encephalitis 显示文摘 | Jose R Gregory A Clifford MD | 1996 | Annals of Internal Med1996，125，7： | 1 |
| 7 | Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation differences in sodium channel inactivation between atria and ventricles and the role of ranolazine显示文摘 | Alexander B Jose MD Luiz B | 2007 | Circulation2007，116，13： | 1 |
| 8 | The Origin of the Spinal Subdural Space:Ultrastructure Findings显示文摘 | Miguel Angel Reina MD Oscar De Leon Casasola MD Andres Lopez MD Jose Antonio De Andres MD Miguel Mora MD and Agustin Fernandez MD | 2002 | Anesth Analg2002，94，4： | 1 |
| 9 | Density functional computational studies on ribose and glycine Maillard reaction : Formation of the Amadori rearrangement products in aqueous solution显示文摘 | Abraham F Jalbout Md Abul Haider Shipar Jose Luis Navarro | 2006 | Food Chemistry2006，，9： | 1 |
| 10 | Predictors of Nonalcoholic Steatohepatitis (NASH) in Obese Patients Undergoing Gastric Bypass显示文摘 | Camilo Boza MD Arnoldo Riquelme MD Luis Iba?ez MD Ignacio Duarte MD Enrique Norero MD Paola Viviani MD Alejandro Soza MD Jose Ignacio Fernandez MD Alejandro Raddatz MD Sergio Guzman MD Marco Arrese MD | 2005 | Obesity Surgery2005，，8： | 1 |
| 11 | Effects of carvedilol on survival and hemodynamics in patients with atrial fibrillation and left ventricular dysfunction:retrospective analysis of the US carvedilol heart failure trials program显示文摘 | Jose A Joglar MD Andre PA | 2001 | Am Heart J2001，142，： | 1 |
| 12 | Macrophage colony-stimulating factor expression and macrophage accumulation in renal allograft rejection显示文摘 | Le Meur Y Jose MD Mu W | 2002 | Transplantation2002，73，8： | 1 |
| 13 | Biliary complications in liver transplant recipients显示文摘 | Jose Franco MD | 2005 | Current Gastroenterology Reports2005，，2： | 1 |
| 14 | Suicide prevention strategies, a systematic review 显示文摘 | John Mann MD Alan Apter MD Jose Bertolote MD | 2005 | JAMA2005，294，26： | 1 |
| 15 | Pharmacogenomics of G proteincoupled receptor signaling: insights from health and disease 显示文摘 | Thompson MD Cole DE Jose PA | 2008 | Methods Mol Biol2008，448，： | 1 |
| 16 | Radiation therapy alone in elderly with early stage non-small cell lung cancer 显示文摘 | San JoseS Amaiz MD Lucas A | 2006 | Lung Cancer2006，52，2： | 1 |
| 17 | Reduced T-Cell and Dendritic Cell Function Is Related to Cyclooxygenase-2 Overexpression and Prostaglandin E2 Secretion in Patients With Breast Cancer显示文摘 | Barbara A. Pockaj MD Gargi D. Basu PhD Latha B. Pathangey MS Richard J. Gray MD Jose L. Hernandez BA Sandra J. Gendler PhD Pinku Mukherjee PhD | 2004 | Annals of Surgical Oncology2004，，3： | 1 |
| 18 | Rectus Flap Reconstruction Decreases Perineal Wound Complications After Pelvic Chemoradiation and Surgery: A Cohort Study显示文摘 | David B. Chessin MD John Hartley MD Alfred M. Cohen MD Madhu Mazumdar PhD Peter Cordeiro MD Joseph Disa MD Babek Mehrara MD Bruce D. Minsky MD Philip Paty MD Martin Weiser MD W. Douglas Wong MD Jose G. Guillem MD MPH | 2005 | Annals of Surgical Oncology2005，，2： | 1 |
| 19 | Triple Therapy with High- Dose Proton-Pump Inhibitor, Amoxicillin, and Doxycycline Is Useless for Helicobacter pylori Eradication: A Proof-of-Concept Study 显示文摘 | Nuno A Jose MR Maria MD | 2014 | Helicobacter2014，19，2： | 1 |
| 20 | Gastric injury induced by ethanol and ischemia-reperfusion in the rat显示文摘 | Gregory S. Smith PhD David W. Mercer MD James M. Cross MD Jose C. Barreto PhD Dr. Thomas A. Miller MD | 1996 | Digestive Diseases and Sciences1996，，6： | 1 |
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