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| 1 | Tumor targeted mesoporous silica-coated gold nanorods facilitate detection of pancreatic tumors using Multispectral optoacoustic tomography显示文摘Multispectral optoacoustic 断层摄影术(MSOT ) 是在传统的形式上提供几个优点的一种新兴的成像技术,特别地处于它解决在显微镜的规模上的深度的光对比的能力。当潜在的应用包括临床的阀值由当前的技术设置了的下面的肿瘤的早察觉时,肿瘤特定的对比代理人的缺乏限制 MSOT 成像的使用。因此,我们与 polyacrylic 酸(泛美航空公司) 或 aminefunctionalized mesoporous 硅石(MS ) 由涂层金牌 nanorods (GNR ) 构造了高度稳定的 nano 对比代理人。Syndecan-1,被显示了指向像胰岛素的生长因素 1 受体(IGF1-R )( 在胰腺的肿瘤的 upregulated ) ,在泛美航空公司涂的 GNR (PAA-GNRs ) 或 MS 涂的 GNR (MS-GNRs ) 的表面上被结合创造指向肿瘤的 nanoparticles。在 vitro, nanoparticles 指向的肿瘤与流动 cytometry 被估计。在 S2VP10L 房间(为 IGF1-R 积极) , syndecan-1 MS-GNRs (Syndecan-MS-GNRs ) 在 OA 信号表明了增加, 10x,与 syndecan-1 PAAGNR (Syndecan-PAA-GNRs ) 相比。最小的绑定在 MiaPaca-2 房间被观察(为 IGF1-R 否定) 。在 vivo,肿瘤 Syndecan-MS-GNRs 的特定的指向用鼠科的 orthotopic 被评估胰腺的癌症模型。Syndecan- MS-GNRs 比在象肝那样的离开目标机关在胰腺的肿瘤以内表明了显著地更大的累积。与 IGF1-R 否定 MiaPaca-2 房间植入的老鼠没表明指向的特定的肿瘤。在摘要,我们报导指向的 nano 对比代理人(Syndecan-MS-GNRs ) 能成功地检测 orthotopic 有在用 MSOT 的 vivo 有约束力的最小的离开目标的胰腺的肿瘤。 | Anil Khanal Christopher Ullum Charles W Kimbrough Nichola C. Garbett Joseph A. Burlison Molly W. McNally Phillip Chuong Ayman S. EI-Baz Jacek B. Jasinski Lacey R. McNally | 2015 | Nano Research2015，8，12： | 2 |
| 2 | Correlation of periodontal inflamed surface area with glycemic status in controlled and uncontrolled type 2 diabetes mellitus显示文摘BACKGROUND The bidirectional link between periodontitis and diabetes mellitus(DM)has been established.Periodontitis causes systemic inflammatory burden through inflammatory mediators.The currently utilized tools[clinical attachment loss(CAL)and probing pocket depth(PPD)]are linear measurements,that do not exactly quantify the inflammatory burden of periodontitis.Periodontal inflamed surface area(PISA)quantifies the surface area of bleeding pocket epithelium and estimates the inflammatory burden.Studies relating to the periodontal status of diabetic patients with and without microvascular complications are scarce.This study assessed the proportion of periodontitis and correlation of PISA with glycemic status in controlled,uncontrolled type 2 DM(T2DM)with and without microvascular complications.AIM To assess the proportion of periodontitis and correlation of PISA with glycemic status in controlled,and uncontrolled T2DM with and without microvascular complications.METHODS This study comprised 180 T2DM patients.Based on glycated hemoglobin(HbA1c)levels,they were grouped into:(1)Controlled T2DMgroup:(HbA1c≤7%);(2)Uncontrolled T2DM group:(HbA1c>7%)without microvascular complications;and(3)Uncontrolled T2DM group:(HbA1c>7%)with microvascular complications.Each group comprised 60 patients.All patients were assessed for periodontal parameters(Bleeding on Probing,PPD,CAL,Oral hygiene index simplified and PISA),and systemic parameters(HbA1c,fasting plasma glucose and post prandial plasma glucose).RESULTS The proportion of periodontitis among controlled T2DM group,uncontrolled T2DM group without microvascular complications,uncontrolled T2DM group with micro-vascular complications was 75%,93.4%and 96.6%respectively.Extent and severity of periodontitis were high in the uncontrolled T2DM group.A significant positive correlation was found between PISA and HbA1c among all patients(r=0.393,P<0.001).The dose–response relationship between PISA and HbA1c was observed.An increase of PISA with 168 mm^(2) was associated with a 1.0%increase of HbA1c.CONCLUSION High proportion and severity of periodontitis,and increased inflamed surface area in uncontrolled T2DM may have contributed to the poor glycemic control and microvascular complications. | Krishna Anil Rosamma Joseph Vadakkekuttical Chandni Radhakrishnan Fairoz Cheriyalingal Parambath | 2021 | World Journal of Clinical Cases2021，9，36： | 2 |
| 3 | Short-term outcome of critically ill patients with severe acute respiratory syndrome显示文摘 | Charles D. Gomersall Gavin M. Joynt Philip Lam Thomas Li Florence Yap Doris Lam Thomas A. Buckley Joseph J. Y. Sung David S. Hui Gregory E. Antonio Anil T. Ahuja Patricia Leung | 2004 | Intensive Care Medicine2004，，3： | 1 |
| 4 | Kidney Transplantation Alone in ESRD Patients With Hepatitis C Cirrhosis显示文摘 | Anil S. Paramesh John Y. Davis Chaitanya Mallikarjun Rubin Zhang Robert Cannon Nathan Shores Mary T. Killackey Jennifer McGee Bob H. Saggi Douglas P. Slakey Luis Balart Joseph F. Buell | 2012 | Transplantation Journal2012，，3： | 1 |
| 5 | Attention and psychomotor functioning in bipolar depression显示文摘 | Katherine E. Burdick Nisali Gunawardane Joseph F. Goldberg Jeffrey M. Halperin Jessica L. Garno Anil K. Malhotra | 2008 | Psychiatry Research2008，，2： | 1 |
| 6 | Chitosan Effects on Blackmold Rot and Pathogentic Factors Produced by Altemaria alternuta in Posharvest Tomatoes显示文摘 | M V Bhaskara Reddy Panl Angers Fracois Castaigre Joseph Anil | 2000 | Journal of the American society for horticaltural Science2000，125，6： | 1 |
| 7 | Critical role of Wnt/~ catenin signa- ling in driving epithelial ovarian cancer platinum resistance 显示文摘 | ANIL BELUR NAGARAJ PERONNE JOSEPH OLGA KOVALENKO | 2015 | Oncotarget2015，26，23： | 1 |
| 8 | Effect of Intensive Versus Standard Blood Pressure Lowering on Diastolic Function in Patients With Uncontrolled Hypertension and Diastolic Dysfunction显示文摘 | Scott D. Solomon Anil Verma Akshay Desai Amira Hassanein Joseph Izzo Suzanne Oparil Yves Lacourciere Joleen Lee Yodit Seifu Robert J. Hilkert Ricardo Rocha Bertram Pitt | 2010 | Hypertension2010，，2： | 1 |
| 9 | Low 25-Hydroxyvitamin D Levels and Mortality in Non–Dialysis-Dependent CKD显示文摘 | Sankar D. Navaneethan Jesse D. Schold Susana Arrigain Stacey E. Jolly Anil Jain Martin J. Schreiber James F. Simon Titte R. Srinivas Joseph V. Nally | 2011 | American Journal of Kidney Diseases2011，，4： | 1 |
| 10 | Portal vein thrombosis in liver transplantation: radiologic evaluation, risk factors, and occult diagnosis显示文摘Aim:Portal vein thrombosis(PVT)in the liver transplant recipient poses many challenges.Unfortunately,the risk factors and effects on outcomes of PVT are not well-defined.Methods:This study analyzed the experience with PVT in liver transplant program from 2007 to 2013.This included the effectiveness of PVT diagnostics and its risk factors using logistical regression.The primary endpoints were Kaplan-Meir patient and graft survival.The secondary endpoints were the length of stay(LOS),transfusion rate,and overall morbidity.Independent predictors of survival were identified using a Cox’s proportional hazards model.Results:Two hundred and sixteen consecutive liver transplant recipients were examined,and 30(13.8%)had either a total or partial PVT.Two hundred and five patients had imaging within 1 year of liver transplantation with only 7(23.3%)of the 30 PVTs identified pre-operatively.Calculated sensitivity(4.8-50%)and negative predictive values(10.5-22.2%)were poor.Only,age significantly predicted PVT[P=0.037/hazard ratio(HR)=0.95].Ninety-day-patient and graft survival for PVT was similar at 6 months,although 1-year survival was significantly lower.“Occult”PVT was not associated with inferior survival.Model for end-stage liver disease score>25(P=0.001,HR=0.49/P=0.004,HR=0.52)and age>60 years(P=0.017,HR=0.64/P=0.013,HR=0.67)were significant predictors of patient and graft survival.Although the transfusion rate was significantly greater with PVT,LOS,and morbidity were not.Conclusion:Older recipients had a greater likelihood of PVT.Diagnostic studies were not effective at excluding PVT,and occult diagnosis did not affect the outcome.PVT was not an independent predictor of mortality or graft loss,but was associated with greater blood loss but not increased LOS or morbidity. | Adam Hauch Carl Winkler Eric Katz Peter W.Lundberg Mary Killackey Anil S.Paramesh Luis A.Balart Nathan J.Shores Martin Moehlen Ward Miller Douglas P.Slakey Joseph F.Buell Bob H.Saggi | 2016 | Hepatoma Research2016，2，1： | 1 |
| 11 | Detection of porcine teschovirus and enterovirus type Ⅱ by reverse transcription polymerase chain reaction显示文摘 | JOSEPH M P SHIRIN M ANIL T | 2002 | J Vet Diagn Invest2002，14，6： | 1 |
| 12 | miRNAs as prognostic and therapeutic tools in epithelial ovarian cancer显示文摘 | Anil Belur Nagaraj Peronne Joseph Analisa DiFeo | 2015 | Biomark. Med2015，，： | 1 |
| 13 | Management of the neck after chemoradiotherapy for head and neck cancers in Asia: consensus statement from the Asian Oncology Summit 2009显示文摘 | Joseph T Wee Benjamin O Anderson June Corry Anil D’Cruz Khee C Soo Chao-Nan Qian Daniel T Chua Rodney J Hicks Christopher HK Goh James B Khoo Seng C Ong Arlene A Forastiere Anthony T Chan | 2009 | Lancet Oncology2009，，11： | 1 |
| 14 | Effect of Intensive Versus Standard Blood Pressure Lowering on Diastolic Function in Patients With Uncontrolled Hypertension and Diastolic Dysfunction显示文摘 | Scott D. Solomon Anil Verma Akshay Desai Amira Hassanein Joseph Izzo Suzanne Oparil Yves Lacourciere Joleen Lee Yodit Seifu Robert J. Hilkert Ricardo Rocha Bertram Pitt | 2010 | Hypertension2010，，2： | 1 |
| 15 | Long-term outcome of ketoconazole and tacrolimus coadministration in kidney transplant patients显示文摘AIM:To study the long-term outcome of ketoconazole and tacrolimus combination in kidney transplant recipients.METHODS:From 2006 to 2010,ketoconazole was given in 199 patients and was continued for at least 1year or until graft failure(Group 1),while 149 patients did not receive any ketoconazole(Group 2).A combination of tacrolimus,mycophenolate and steroid was used as maintenance therapy.High risk patients received basiliximab induction.RESULTS:Basic demographic data was similar between the 2 groups.The 5-year cumulative incidence of biopsy-confirmed and clinically-treated acute rejection was significantly higher in Group 1 than in Group 2(34%vs 18%,P=0.01).The 5-year Kaplan-Meier estimated graft survival(74.3%vs 76.4%,P=0.58)and patient survival(87.8%vs 87.5%,P=0.93)were not differentbetween the 2 groups.Multivariable analyses identified ketoconazole usage as an independent risk of acute rejection(HR=2.33,95%CI:1.33-4.07;P=0.003)while tacrolimus dose in the 2nd month was protective(HR=0.89,95%CI:0.75-0.96;P=0.041).CONCLUSION:Co-administration of ketoconazole and tacrolimus is associated with significantly higher incidence of acute rejection in kidney transplant recipients. | Enver Khan Mary Killackey Damodar Kumbala Heather LaGuardia Yong-Jun Liu Huai-Zhen Qin Brent Alper Anil Paramesh Joseph Buell Rubin Zhang | 2014 | World Journal of Nephrology2014，3，3： | 1 |
| 16 | 对WHO严重急性呼吸综合征诊断标准用于门诊 患者的评价:前瞻性观察研究显示文摘目的 研究严重急性呼吸综合征(SARS)患者的临床和影像学特征并评价世界卫生组织(WHO)关于SARS诊断指南的准确性。 试验设计 前瞻性观察研究。 研究地点 香港新界一所教学医院急诊科新建立的SARS鉴别门诊。 研究对象 有SARS患者接触史的556名医院工作人员、患者及曾访问过该门诊的工作人员和患者的亲属。 主要观察指标 SARS患者的确诊人数。 结果 556名研究对象中,收入院141人,其中97人被确诊为SARS。97例确诊患者中,发热、寒战、乏力、肌痛、畏寒、纳差、呕吐、腹泻、颈痛等非呼吸道症状的发生率均显著高于其他患者。WHO关于诊断可疑SARS患者指南的准确性为83%,其阴性预计值为86%(95%可信区间为83%~89%),敏感性为26%(17%~36%),特异性为96%(93%~97%)。 结论 现行WHO关于诊断可疑SARS患者的指南,用于诊断入院前的患者尚不够敏感,而每天随诊、评价非呼吸道和全身的症状以及胸部X线检查可能是更好的鉴别工具。 | Timothy H Rainer Peter A Cameron De Villiers Smit Kim L Ong Alex Ng Wing Huang David Chan Po Nin Anil T Ahuja Lowis Chan Yik Si Joseph J Y Sung 张隽 | 2003 | 英国医学杂志中文版2003，6，4： | 0 |
| 17 | Non-typhoidal salmonella:an unusual cause of spontaneous bacterial peritonitis in decompensated cirrhosis显示文摘Salmonella typhimurium, a non-typhoidal salmonella, is an unusual cause of spontaneous bacterial peritonitis (SBP). It isusually reported in asymptomatic patients with normal or high ascitic fluid protein levels with underlying immunosuppression,as high opsonic activity in the ascitic fluid of these patients protects them from the usual organisms causingspontaneous bacterial peritonitis, unless they are exposed to a particularly virulent organism like salmonella. We report acase of culture-proven non-typhoidal salmonella in a patient with decompensated cirrhosis, with low protein and withoutany underlying immunosuppression, and no other source to explain its origin. | Tony Joseph Prasanth Sobhan Suthanu Bahuleyan Anil John Shanid Abdul Sathar Srijaya Sreesh Kattoor Ramakrishnan Vinayakumar | 2014 | Gastroenterology Report2014，2，3： | 0 |
| 18 | CEDI膜堆结构和性能的改进显示文摘从如下三方面着手改进连续电去离子(CEDI)膜堆的结构:改善膜堆的性能:增加膜堆的可靠性;降低CEDI系统的总费用。从而,CEDI可更好地与传统的混床去离子相竞争。 | Anil D.Jha Li-ShiangLiang Joseph D.Gifford 王方(译) 王明亚(译) | 2005 | 水处理信息报导2005，，5： | 0 |
| 19 | CEDI膜堆结构和性能的改进显示文摘从如下三方面着手改进连续电去离子(CEDI)膜堆的结构:改善膜堆的性能;增加膜堆的可靠性:降低CEDI系统的总费用。从而.CEDI可更好地与传统的混床去离子相竞争。
通过树脂分层最佳化和利用流道串联布置来改善膜堆的性能,通过实现O形环密封和采用圆柱形玻璃纤维增强塑料制外壳来改进膜堆的可靠性,像RO元件一样,通过在线连接成多级膜堆的方式.研制出创新的标准部件,实现系统组装,减少系统的组装费用。本文将介绍膜堆和系统的设计及现有的某些操作数据,并对采用这种CEDI新技术时的费用与采用可再生的混床时的费用作出对比评价。 | 王方(译) 王明亚(译) Anil D.Jha. Li-Shiang Liang Joseph D.Gifford 王方(译) 王明亚(译) | 2005 | 水处理信息报导2005，，6： | 0 |
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