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| 1 | The Level of Expression of Thioredoxin is Linked to Fundamental Properties and Applications of Wheat Seeds显示文摘有谷物(大麦和小麦) 和荚(Medicago truncatula ) 的工作作为种子的中央规章的蛋白质建立了 thioredoxin h (Trx h ) 。Trx h 由减少二硫化物(SS ) 扮演一些多样的种子蛋白质(存储蛋白质,酶,和酶禁止者) ,从而便于萌芽。早,在 vitro,蛋白质研究与有在内乳的 Trx h overexpressed 的大麦种子在显示出加速的萌芽和联系的酶(淀粉酶和 pullulanase ) 的早或提高的表示的实验被补充。当前的学习扩大转基因的工作到小麦。二条途径被跟随在内乳改变 Trx h 基因的表示:(1 ) 一个大麦蛋白倡导者和它指向顺序的蛋白质身体导致了 Trx h5 的 overexpression,并且(2 ) Trx h9 的 antisense 构造导致了那基因(Arabidopsis 指明) 的 cytosolic underexpression。Trx h9 的 Underexpression 导致了对在萌芽的 barleyretardation 为 overexpression Trx h5 观察并且推迟了或减少联系的酶的表示的那些相反的效果。类似的酶变化在开发种子被观察。有 underexpressed Trx 的小麦线看了发芽的推迟的 preharvest 没有减少,什么时候在最后的产量在温室或领域成长。有 overexpressed Trx h5 的小麦显示出与同量的变化在 vitro 工作更早:二硫化物蛋白质的增加的溶解度和麦胶蛋白质部分的更低的 allergenicity。结果是在谷物内乳的 Trx h 的水平决定基本性质以及种子的潜在的应用程序的进一步的证据。 | Yong-Chun Li Jiang-Ping Ren Myeong-Je Cho Su-Mei Zhou Yong-Bum Kim Hong-Xiang Guo Joshua H. Wong Hong-Bin Niu Hyun-Kyung Kim Susumu Morigasaki Peggy G. Lemaux Oscar L. Frick Jun Yin Bob B. Buchanan | 2009 | Molecular Plant2009，2，3： | 5 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | NLRP3 inflammasome activation determines the fibrogenic potential of PM_(2.5) air pollution particles in the lung显示文摘Airborne fine particulate matter(PM_(2.5))is known to cause respiratory inflammation such as chronic obstructive pulmonary disease and lung fibrosis.NLRP3 inflammasome activation has been implicated in these diseases;however,due to the complexity in PM_(2.5)compositions,it is difficult to differentiate the roles of the components in triggering this pathway.We collected eight real-life PM_(2.5)samples for a comparative analysis of their effects on NLRP3 inflammasome activation and lung fibrosis.In vitro assays showed that although the PM_(2.5)particles did not induce significant cytotoxicity at the dose range of 12.5to 100μg/m L,they induced potent TNF-αand IL-1βproduction in PMA differentiated THP-1 human macrophages and TGF-β1 production in BEAS-2B human bronchial epithelial cells.At the dose of 100μg/m L,PM_(2.5)induced NLRP3 inflammasome activation by inducing lysosomal damage and cathepsin B release,leading to IL-1βproduction.This was confirmed by using NLRP3-and ASC-deficient cells as well as a cathepsin B inhibitor,ca-074 ME.Administration of PM_(2.5)via oropharyngeal aspiration at 2 mg/kg induced significant TGF-β1 production in the bronchoalveolar lavage fluid and collagen deposition in the lung at 21days post-exposure,suggesting PM_(2.5)has the potential to induce pulmonary fibrosis.The ranking of in vitro IL-1βproduction correlates well with the in vivo total cell count,TGF-β1 production,and collagen deposition.In summary,we demonstrate that the PM_(2.5)is capable of inducing NLRP3 inflammasome activation,which triggers a series of cellular responses in the lung to induce fibrosis. | Wei Cao Xiang Wang Jiulong Li Ming Yan Chong Hyun Chang Joshua Kim Jinhong Jiang Yu-Pei Liao Shannon Tseng Sydney Kusumoputro Candice Lau Marissa Huang Pengli Han Pengju Lu Tian Xia | 2022 | Journal of Environmental Sciences2022，34，1： | 3 |
| 4 | STIM Is a Ca 2+ Sensor Essential for Ca 2+ -Store-Depletion-Triggered Ca 2+ Influx显示文摘 | Jen Liou Man Lyang Kim Won Do Heo Joshua T. Jones Jason W. Myers James E. Ferrell Tobias Meyer | 2005 | Current Biology2005，，13： | 3 |
| 5 | The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate显示文摘 | Patrick S. Ward Jay Patel David R. Wise Omar Abdel-Wahab Bryson D. Bennett Hilary A. Coller Justin R. Cross Valeria R. Fantin Cyrus V. Hedvat Alexander E. Perl Joshua D. Rabinowitz Martin Carroll Shinsan M. Su Kim A. Sharp Ross L. Levine Craig B. Thompson | 2010 | Cancer Cell2010，，3： | 2 |
| 6 | Efficacy of Neoadjuvant Chemoradiation, Followed by Liver Transplantation, for Perihilar Cholangiocarcinoma at 12 US Centers显示文摘 | Sarwa Darwish Murad W. Ray Kim Denise M. Harnois David D. Douglas James Burton Laura M. Kulik Jean F. Botha Joshua D. Mezrich William C. Chapman Jason J. Schwartz Johnny C. Hong Jean C. Emond Hoonbae Jeon Charles B. Rosen Gregory J. Gores Julie K. Heimbac | 2012 | Gastroenterology2012，，1： | 2 |
| 7 | 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease显示文摘 | Loren F. Hiratzka George L. Bakris Joshua A. Beckman Robert M. Bersin Vincent F. Carr Donald E. Casey Kim A. Eagle Luke K. Hermann Eric M. Isselbacher Ella A. Kazerooni Nicholas T. Kouchoukos Bruce W. Lytle Dianna M. Milewicz David L. Reich Souvik Sen Jul | 2010 | Journal of the American College of Cardiology2010，，14： | 1 |
| 8 | An electrically active microneedle array for electroporation显示文摘 | Seong-O Choi Yeu Chun Kim Jung-Hwan Park Joshua Hutcheson Harvinder S. Gill Yong-Kyu Yoon Mark R. Prausnitz Mark G. Allen | 2010 | Biomedical Microdevices2010，，2： | 1 |
| 9 | Gastroduodenal Ulceration Associated with Radioembolization for the Treatment of Hepatic Tumors: An Institutional Experience and Review of the Literature显示文摘 | Steven Naymagon Richard R. P. Warner Kalpesh Patel Noam Harpaz Josef Machac Joshua L. Weintraub Michelle K. Kim | 2010 | Digestive Diseases and Sciences2010，，9： | 1 |
| 10 | Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme显示文摘 | Colin E. Champ Joshua D. Palmer Jeff S. Volek Maria Werner-Wasik David W. Andrews James J. Evans Jon Glass Lyndon Kim Wenyin Shi | 2014 | Journal of Neuro-Oncology2014，，1： | 1 |
| 11 | Effect of GutGard in the Management of Helicobacter pylori : A Randomized Double Blind Placebo Controlled Study显示文摘 | Sreenivasulu Puram Hyung Chae Suh Seung Un Kim Bharathi Bethapudi Joshua Allan Joseph Amit Agarwal Venkateswarlu Kudiganti Byung-Cheul Shin | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 12 | Totally Laparoscopic Gastric Resection with Extended Lymphadenectomy for Gastric Adenocarcinoma显示文摘 | Eduardo A. Guzman Alessio Pigazzi Byrne Lee Perry A. Soriano Rebecca A. Nelson I. Benjamin Paz Vijay Trisal Joseph Kim Joshua D. I. Ellenhorn | 2009 | Annals of Surgical Oncology2009，，8： | 1 |
| 13 | Efficacy of Neoadjuvant Chemoradiation, Followed by Liver Transplantation, for Perihilar Cholangiocarcinoma at 12 US Centers显示文摘 | Sarwa Darwish Murad W. Ray Kim Denise M. Harnois David D. Douglas James Burton Laura M. Kulik Jean F. Botha Joshua D. Mezrich William C. Chapman Jason J. Schwartz Johnny C. Hong Jean C. Emond Hoonbae Jeon Charles B. Rosen Gregory J. Gores Julie K. Heimbac | 2012 | Gastroenterology2012，，1： | 1 |
| 14 | 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease显示文摘 | Loren F. Hiratzka George L. Bakris Joshua A. Beckman Robert M. Bersin Vincent F. Carr Donald E. Casey Kim A. Eagle Luke K. Hermann Eric M. Isselbacher Ella A. Kazerooni Nicholas T. Kouchoukos Bruce W. Lytle Dianna M. Milewicz David L. Reich Souvik Sen Jul | 2010 | Journal of the American College of Cardiology2010，，14： | 1 |
| 15 | Oxygen therapy in chronic obstructive pulmonary disease显示文摘 | Victor KIM Joshua O Beneit T | 2008 | The Proceedings of the American Thoracic Society2008，5，： | 1 |
| 16 | The Association between Glaucomatous and Other Causes of Optic Neuropathy and Sleep Apnea显示文摘 | Joshua D. Stein Denise S. Kim Kevin M. Mundy Nidhi Talwar Bin Nan Ronald D. Chervin David C. Musch | 2011 | American Journal of Ophthalmology2011，，6： | 1 |
| 17 | Prospective Evaluation of Fetuses With Autoimmune-Associated Congenital Heart Block Followed in the PR Interval and Dexamethasone Evaluation (PRIDE) Study显示文摘 | Deborah M. Friedman Mimi Y. Kim Joshua A. Copel Carolina Llanos Claudine Davis Jill P. Buyon | 2009 | The American Journal of Cardiology2009，，8： | 1 |
| 18 | Evaluation of new compact pretreatment system for high turbidity seawater 显示文摘 | Joshua Joohyen Kim Hyunsoo Yoon Hong Jonghyun | 2013 | Desalination2013，313，： | 1 |
| 19 | Prognostic Value of the Index of Microcirculatory Resistance Measured After Primary Percutaneous Coronary Intervention显示文摘 | William F. Fearon Adrian F. Low Andy S. Yong Ross McGeoch Colin Berry Maulik G. Shah Michael Y. Ho Hyun-Sook Kim Joshua P. Loh Keith G. Oldroyd | 2013 | Circulation2013，，24： | 1 |
| 20 | A conformal,Bio-interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology显示文摘 | Jonathan Viventi Dae-Hyeong Kim Joshua D Moss | | 0，，24： | 1 |
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