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| 1 | Endoscopy-based management decreases the risk of postoperative recurrences in Crohn's disease显示文摘AIM: To investigate whether an endoscopy-based management could prevent the long-term risk of postoperative recurrence.METHODS: From the pathology department database, we retrospectively retrieved the data of all the patients operated on for Crohn's disease(CD) in our center(1986-2015). Endoscopy-based management was defined as systematic postoperative colonoscopy(median time after surgery = 9.5 mo) in patients with no clinical postoperative recurrence at the time of endoscopy. RESULTS: From 205 patients who underwent surgery, 161 patients(follow-up > 6 mo) were included. Endoscopic postoperative recurrence occurred in 67.6%, 79.7%, and 95.5% of the patients, respectively 5, 10 and 20 years after surgery. The rate of clinical postoperative recurrence was 61.4%, 75.9%, and 92.5% at 5, 10 and 20 years, respectively. The rate of surgical postoperative recurrence was 19.0%, 38.9% and 64.7%, respectively, 5, 10 and 20 years after surgery. In multivariate analysis, previous intestinal resection, prior exposure to anti-TNF therapy before surgery, and fistulizing phenotype(B3) were postoperative risk factors. Previous perianal abscess/fistula(other perianal lesions excluded), were predictive of only symptomatic recurrence. In multivariate analysis, an endoscopy-based management(n = 49/161) prevented clinical(HR = 0.4, 95%CI: 0.25-0.66, P < 0.001) and surgical postoperative recurrence(HR = 0.30, 95%CI: 0.13-0.70, P = 0.006).CONCLUSION: Endoscopy-based management should be recommended in all CD patients within the first year after surgery as it highly decreases the long-term risk of clinical recurrence and reoperation. | Anne-Laure Boucher Bruno Pereira Stéphanie Decousus Marion Goutte Felix Goutorbe Anne Dubois Johan Gagniere Corinne Borderon Juliette Joubert Denis Pezet Michel Dapoigny Pierre J Déchelotte Gilles Bommelaer Anthony Buisson | 2016 | World Journal of Gastroenterology2016，22，21： | 3 |
| 2 | Linear β-1,3-glucans are elicitors of defense responses in tobacco显示文摘 | KLARZYNASKI O PLESSE B JOUBERT J M | 2000 | Plant Physiology2000，124，： | 1 |
| 3 | Linear β-1,3-glucanase are elicitors of defense responses in tobacco显示文摘 | Klarzynaski O Plesse B Joubert J M | 2000 | Plant Physiol2000，124，： | 1 |
| 4 | Neutron diffraction study of the ferrimagnetic ilmenite(nickel manganese oxide (NiMnO3)显示文摘 | Pernet M Joubert J C Ferrand B | 1975 | Solid State Communications1975，16，5： | 1 |
| 5 | An investigation of preharvest browning of Litchi peel显示文摘 | Joubert A J Van Lelyveld L J | 1975 | Phytophylactica1975，，7： | 1 |
| 6 | Application of gemini surfactants as diesel fuel wax dispersants显示文摘 | Maithufi M N Joubert D J Klumperman B | 2010 | Energy Fuels2010，25，6： | 1 |
| 7 | Sorption of methane inmoist coal显示文摘 | Joubert J I G rein C T Bienstock D | 1973 | Fue1973，52，2： | 1 |
| 8 | Diagnosing headache显示文摘 | Joubert J | 2005 | Aust Faro Physician2005，34，8： | 1 |
| 9 | From ultrasofl pseudopotentials to the projector augmented-wave method显示文摘 | KRESSE G JOUBERT J | 1999 | Physical Review B1999，59，： | 1 |
| 10 | The effect of Alzheimer's disease and Parkinson's disease on olfaction : a meta-analysis 显示文摘 | Rahayel S Frasnelli J Joubert S | 2012 | Behav Brain Res2012，231，1： | 1 |
| 11 | Diversity of risk factors for stroke:the putative roles and mechanisms of depression and air pollution显示文摘 | Joubert J Cumming TB McLean AJ | | 0，，1： | 1 |
| 12 | Linear β-1,3-glucanase are elicitors of defense responses in tobacco显示文摘 | Klarzynaski O Plesse B Joubert J M | 2000 | Plant Physiol2000，124，： | 1 |
| 13 | Sorption of methane in moist coal 显示文摘 | Joubert J I Grein C T | 1973 | Fuel1973，52，3： | 1 |
| 14 | Effects of essential fatty acids on mild to moderate essential hypertension显示文摘 | Joubert PH Booyens J | 1988 | Prost Leuk EFA1988，33，： | 1 |
| 15 | Determination of aggregation and breakup constants during flocculation显示文摘 | J Haarhoff H Joubert | 1997 | Water Res Tech1997，36，4： | 1 |
| 16 | Flunarizine-effective add-on therapy in reading epilepsy显示文摘 | Durrheim DN Joubert J Griesel RD | 1992 | S Afr Med J1992，82，： | 1 |
| 17 | Continued axillary sampling is unnecessary and provides no further information to sentinel node biopsy in staging breast cancer 显示文摘 | Gui GP Joubert D J Reichert R | 2005 | Eur J Surg Oncol2005，31，7： | 1 |
| 18 | Job demands,job resources,burnout and work engagement of managers at a platinum mine in the North West Province显示文摘 | S ROTHMANN JOUBERT J H M | 2007 | South African Journal Of Business Management2007，38，3： | 1 |
| 19 | C2- and CA-position 17beta-estradiol metabolites and their relation to breast cancer显示文摘 | JOUBERT A VAN Z H LAURENS J | 2009 | Biocell2009，33，3： | 1 |
| 20 | Linear β-1,3-glucans are elicitors of defense responses in tobacco 显示文摘 | KLARZYNASKI O PLESSE B JOUBERT J M | 2000 | Plant Physiology2000，124，： | 1 |
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