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| 1 | Study of the decorporation efficacy and toxicity of tetradentate 3-hydroxy- 2-pyridinone ligands at the cellular level显示文摘Objective:A series of experiments were carried out to study the comparative decorporation efficacy and toxicity of three tetradentate hydroxypyridinone ligands(3LI-1-Cm-3,2-HOPO,5LIO-1-Cm-3,2-HOPO,and 7LIO-1-Cm-3,2-HOPO)with the variation of the linker length and the substituents.Methods:Three ligands were obtained from a 4-step synthesis via the amidation of HOPO unit and different backbones.Potentiometric titrations were carried out to evaluate the formation constants of their corresponding uranyl complexes.CCK-8 and colony formation assays were used to compare the cytotoxicity of the three ligands and uranyl using renal proximal tubular epithelial(NRK-52E)cells.In vitro uranium removal assays were performed to assess decorporation efficiencies of those ligands by co-incubating uranium and chelators with NRK-52E cells for 48 h.Results:Among the three ligands,5LIO-1-Cm-3,2-HOPO exhibits the highest uranyl affinity(logβ110?18.6(7))in comparison to the other two ligands(logβ110?14.9(2)for 3LI-1-Cm-3,2-HOPO and logβ110?16.7(1)for 7LIO-1-Cm-3,2-HOPO).The results of CCK-8 tests and colony formation assays further elucidate that 5LIO-1-Cm-3,2-HOPO and 7LIO-1-Cm-3,2-HOPO both show a similar level of cytotoxicity compared with ZnNa3-DTPA at relatively low ligand concentrations.In contrast,in the 3LI-1-Cm-3,2-HOPO treated group,the cell viability decreased markedly with the increase of the ligand concentrations,and the colony formation capability of NRK-52E cells was inhibited.Furthermore,the comparative decorporation efficacy of the three ligands was obtained from in vitro uranium removal assays,suggesting that these ligands could significantly inhibit the cellular uptake and prompt the cellular release of uranium from NRK-52E cells by the level of 81.9%,91.8%,and 87.1%,respectively.Conclusion:Our current results demonstrate that the linker/backbone species would significantly affect the decorporation efficacy and toxicity of the tetradentate 3-hydroxy-2-pyridinone ligands,which is informative for the future design and modification of novel decorporation ligands. | Xiaomei Wang Cen Shi Manni Gao Ying Xu Yang Jiao Jianmei Wan Jianping Cao Zhifang Chai Juan Diwu | 2020 | Radiation Medicine and Protection2020，1，4： | 1 |
| 2 | Stabilization of Plutonium(V)Within a Crown Ether Inclusion Complex显示文摘Crystalline coordination complexes of actinides,especially in atypical oxidation states,are not only fundamentally important for expanding the notably limited knowledge on the bonding nature of actinides but could also provide critical information toward the development of nuclear fuel cycle,waste management,and national security.Plutonium(Pu)is the only element in the periodic table that could exist in four oxidation states in aqueous solutions simultaneously. | Yaxing Wang Shu-Xian Hu Liwei Cheng Chengyu Liang Xuemiao Yin Hailong Zhang Ao Li Daopeng Sheng Juan Diwu Xiaolin Wang Jun Li Zhifang Chai Shuao Wang | 2020 | CCS Chemistry2020，2，4： | 1 |
| 3 | High sintering ability and electrical conductivity of Zn doped La(Ca)CrO 3 based interconnect ceramics for SOFCs显示文摘 | Mingfei Liu Ling zhao Dehua Dong Songlin Wang Juan Diwu Xingqin Liu Guangyao Meng | 2007 | Journal of Power Sources2007，，2： | 1 |
| 4 | The development of molecular and nano actinide decorporation agents显示文摘Internal contamination of actinides has led to significant health hazards to the public and workers in the context of nuclear power plant accidents,uranium ore mining,and reprocessing of the used fuel.An effective sequestering agent that is able to remove accidentally incorporated actinides in vivo with low toxicity is always in urgent need.The molecular decorporation ligands have been the most widely researched agents for the past few decades,while preliminary studies of functionalized nanoparticles have shown their clear advantages in metal binding selectivity,toxicity,and oxidative stress alleviation.Herein,the state-of-the-art of those two types of decorporation agents is presented with special attention being paid on the correlation between the solution and solid-state chemistry of those agents with actinides and the corresponding decorporation efficacies. | Xiaomei Wang Cen Shi Jingwen Guan Yemeng Chen Yigong Xu Juan Diwu Shuao Wang | 2022 | Chinese Chemical Letters2022，33，7： | 1 |
| 5 | Improving in vivo Uranyl Removal Efficacy of a Nano-Metal Organic Framework by Interior Functionalization with 3-Hydroxy-2-pyridinone显示文摘The environmental contamination of uranium will occur in scenarios such as nuclear accidents and leakage from nuclear waste storage sites,which eventually leads to the internal uranium exposure of people,causing consequential injuries of renal failure,osteosarcoma,etc.The development of uranyl specific chelating agents that could sequester uranium in vivo is in urgent need and is important for the safe and efficient development of nuclear industry.Metal organic frameworks(MOFs)already serve as efficient uranium depletion materials in solutions of a wide range of pH and ionic strength for nuclear fuel recycling,uranium extraction from seawater,as well as environmental decontamination.Herein,a chromium-based nano-metal organic framework(nano-MOF)functionalized interiorly with 3,2-HOPO ligands,MIL-101-HOPO,is rationally synthesized.In vitro adsorption experiments show that MIL-101-HOPO exhibits high adsorption selectivity and fast adsorption kinetics for uranyl.The results of in vivo uranyl decorporation assays reveal that MIL-101-HOPO with the decoration of HOPO ligands on the interior wall exhibits significantly increased uranyl removal ratio in kidneys comparing to the pristine nMOFs,and is more effective than the clinically used ZnNa_(3)-DTPA.All those results corroborate the interior functionalization of MOFs as an efficient strategy to develop promising uranyl decorporation agents. | Mengping Chen Lang Lang Lei Chen Xiaomei Wang Cen Shi Qiwen Sun Yigong Xu Juan Diwu Shuao Wang | 2022 | Chinese Journal of Chemistry2022，40，17： | 0 |
| 6 | ssDNA functionalized nanodiamonds for uranium decorporation显示文摘The hunt for agents that are suitable for actinide decorporation to reduce the whole-body load of actinide in accidental internal exposure is the ever-lasting goal in radiation protection and medical treatment in nuclear emergency.All current decorporation agents can be categorized as two groups,one is the molecular ligands,and the other is the nanoparticles decorated with molecular ligands.Here in this work,functional nanodiamonds(fN Ds)with ss DNA(the endogenous biomacromolecule rich in phosphate groups)loaded on the NDs is reported,which poses good uranyl adsorption selectivity,high cellular uptake,fast excretion,and effective decorporation of uranyl from rat renal proximal tubular epithelial cells(NRK-52E).All those results corroborate that f NDs can potentially serve as a brand new family of chelators for actinide decorporation. | Qinglong Yan Yu Miao Xiaomei Wang Jifei Ma Juan Diwu Ying Zhu Shuao Wang Chunhai Fan | 2022 | Chinese Chemical Letters2022，33，7： | 0 |
| 7 | Persistent Superprotonic Conductivity in the Order of 10^(−1) S·cm^(−1) Achieved Through Thermally Induced Structural Transformation of a Uranyl Coordination Polymer显示文摘Despite tremendous efforts being made in the explo-ration of new high-performance proton-conducting materials,studies on systems with super protonic conductivity higher than 10^(−1) S·cm^(−1) remain scarce. | Daxiang Gui Wanchun Duan Jie Shu Fuwan Zhai Ning Wang Xiangxiang Wang Jian Xie Hui Li Lanhua Chen Juan Diwu Zhifang Chai Shuao Wang | 2019 | CCS Chemistry2019，1，2： | 0 |
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